ACS Nanoscience Au最新文献

{"title":"Efficient and Stable Ligand-Exchange Process Using Perovskite Nanocrystals Synthesized from a Liquid Crystalline Antisolvent","authors":"Myeonggeun Han,&nbsp;Taesu Choi,&nbsp;Jun-Hyung Im,&nbsp;Gwon Byeon,&nbsp;Dong Hyeon Lee,&nbsp;Soohwan Yoo,&nbsp;Kwang-Suk Oh,&nbsp;Yong-Young Noh,&nbsp;Young-Ki Kim","doi":"10.1021/acsnanoscienceau.5c00169","DOIUrl":"10.1021/acsnanoscienceau.5c00169","url":null,"abstract":"<p>Ligand exchange of perovskite nanocrystals (PNCs) isan essentialprocess for optoelectronics applications, but it often causes structuralinstability and degradation of PNCs. In this work, we demonstratethat PNCs synthesized via ligand-assisted reprecipitation (LARP) usinga liquid crystalline (LC) antisolvent, referred to as LC-LARP, enablea significantly more efficient and stable ligand-exchange processcompared with those prepared by conventional LARP using toluene (T-LARP).After ligand exchange, PNCs from the LC-LARP (LC-PNCs) exhibit a dramaticincrease in photoluminescence quantum yield (PLQY) from 29% to 80%,whereas PNCs from T-LARP (T-PNCs) show negligible improvement. Furthermore,LC-PNCs show exceptional stability under ligand-exchange reactions,retaining over 50% PLQY even at high ligand concentrations that triggerthe complete decomposition of T-PNCs. This efficient and stable ligandexchange is attributed to superior ligand passivation and a low densityof surface defects in LC-PNCs. Our approach is versatile and generalizableacross diverse ligands and perovskite compositions. Finally, we demonstratethe practical utility of this method by designing LC-PNC-based light-emittingdiodes (LEDs), which achieve a maximum external quantum efficiency(8.2%), significantly surpassing that of T-PNC-based LEDs (0.5%).</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"6 3","pages":"339–347"},"PeriodicalIF":7.5,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148296520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoupling Physisorption from Chemisorption in Clickable Lipid Nanoparticles","authors":"Taylor V. Brysgel,&nbsp;Elizabeth D. Hood,&nbsp;Aleksa Milosavljevic,&nbsp;Nicolas Marzolini,&nbsp;Marco E. Zamora,&nbsp;Jichuan Wu,&nbsp;Vladimir V. Shuvaev,&nbsp;Tea Shuvaeva,&nbsp;Michael Kegel,&nbsp;Jenna Muscat-Rivera,&nbsp;Drew Weissman,&nbsp;Jilian R. Melamed,&nbsp;Jacob W. Myerson,&nbsp;Jacob S. Brenner,&nbsp;Vladimir R. Muzykantov,&nbsp;Jia Nong","doi":"10.1021/acsnanoscienceau.5c00170","DOIUrl":"10.1021/acsnanoscienceau.5c00170","url":null,"abstract":"<p>Antibody conjugation is essential for targeted lipidnanoparticle(LNP) delivery, but here we show that click-chemistry produces artifactsthat confound accurate measurement of covalent antibody-LNP bonding.We demonstrate that hydrophobic interactions between the most commonclick alkyne linker, dibenzocyclooctyne (DBCO), and the inherentlyhydrophobic LNP surface drive extensive nonspecific antibody physisorption,even in the absence of LNP azide groups. This physisorption yieldsartificially high apparent conjugation efficiencies measured by chromatographicmethods. In contrast, less hydrophobic liposomes exhibit azide-dependentconjugation, highlighting a consequence of nanoparticle surface chemistry.Plasma incubation rapidly displaces physisorbed antibodies from LNPs,confirming their weak, noncovalent association, whereas covalentlybound antibodies remain attached and enable effective <em>in vivo</em> targeting. Substituting DBCO with the less hydrophobic bicyclononyne(BCN) also reduces nonspecific associations. Our findings reveal hydrophobicityas a hidden variable in antibody–LNP conjugation and establishnew standards for quantitative and reproducible measurement of targetedLNPs.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"6 3","pages":"348–356"},"PeriodicalIF":7.5,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148296486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Coherence with a Clock Transition and Dynamical Decoupling in the Cr7Mn Molecular Nanomagnet","authors":"Guanchu Chen,&nbsp;Brendan C. Sheehan,&nbsp;Ilija Nikolov,&nbsp;James W. Logan,&nbsp;Charles A. Collett,&nbsp;Gajadhar Joshi,&nbsp;Grigore A. Timco,&nbsp;Jillian E. Denhardt,&nbsp;Kevin R. Kittilstved,&nbsp;Richard E. P. Winpenny,&nbsp;Jonathan R. Friedman","doi":"10.1021/acsnanoscienceau.5c00192","DOIUrl":"10.1021/acsnanoscienceau.5c00192","url":null,"abstract":"<p>Molecular magnets are attractive as spin qubits due totheir chemicaltunability, addressability through electron-spin resonance techniques,and long coherence times. Clock transitions (CTs), for which the systemis immune to the effect of magnetic-field fluctuations to first order,provide a method to enhance the coherence time <em>T</em>₂, and to reveal mechanisms of decoherence that are not dueto such fluctuations. Here we investigate two variants of Cr₇Mn, a spin-1 molecular nanomagnet, at fields near a zero-field CT.We find that at temperatures ≤2 K, <em>T</em>₂ ∼ 1 μs at the CT using a Hahn-echo pulse sequence.Away from the CT, electron-spin–echo envelope modulation (ESEEM)oscillations due to coupling to nuclear spins are observed and havea <em>T</em>₂ as high as 1.35 μs, indicatinga distinct mechanism of coherence preservation. Dynamical decouplingwith the CPMG pulse sequence yields <em>T</em>₂ ∼ 2.8 μs at the CT and up to ∼3.6 μs inthe ESEEM regime along with a demodulation of the oscillatory behavior.The experimental values of <em>T</em>₂ are largelyindependent of the degree of dilution of the molecules in solventor whether the solvent is deuterated, indicating that much of thedecoherence and ESEEM arises from sources within the molecules themselves.To account for decoherence, we develop a model that includes not onlyfield fluctuations but also fluctuations in the CT transition frequencyitself. Our results can be well explained by treating the environmentas a combination of noise at the nuclear Larmor precession frequencyand 1/<em>f</em> noise in the transverse anisotropy parameter <em>E</em>. Such information about the microscopic origins of decoherencecan aid the rational design of molecular-based spin qubits.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"6 2","pages":"324–338"},"PeriodicalIF":7.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Confinement-Controlled Morphology and Stability of One-Dimensional CrI3 Nanotubes","authors":"Ihsan Çaha,&nbsp;Aqrab ul Ahmad,&nbsp;Francis Leonard Deepak","doi":"10.1021/acsnanoscienceau.5c00164","DOIUrl":"10.1021/acsnanoscienceau.5c00164","url":null,"abstract":"<p>Integrating monolayers derived from 2D van der Waals(vdW) magneticmaterials into next-generation technological applications remainsa significant challenge due to their structural and magnetic instabilityissues. Template-assisted encapsulation is a potential route for thegrowth of stable 2D monolayers aimed at designing novel 1D heterostructures,opening new avenues for studying low-dimensional quantum effects andspin-related phenomena. In this study, we explored the diameter-dependentencapsulation of 2D CrI₃ crystals using multiwalled carbonnanotubes (MWCNTs) as nanoscale host templates. Advanced microscopicanalysis revealed distinct structural transitions, ranging from internalnanorod encapsulation to external shell formation, directly influencedby the host nanotube diameter (2–20 nm). Furthermore, statisticalanalysis of structural morphologies indicates that CrI₃ nanorods preferentially form within MWCNTs with inner diametersfrom 2 to 7 nm, while single-walled CrI₃ nanotubes arestabilized in CNTs with diameters from 3 to 10 nm. For host CNTs exceeding∼10 nm in diameter, CrI₃ predominantly forms surfacecoatings rather than confined one-dimensional structures. In situelectron beam irradiation demonstrates the superior structural stabilityof single-walled CrI₃ confined within MWCNTs, while externallycoated CrI₃ undergoes decomposition into metallic Cr clusters.Prolonged irradiation induces a morphological transformation of CrI₃ nanotubes into nanorods. Encapsulated structures also remainstable under long-term ambient conditions, highlighting the dual protectiverole of CNT confinement. These insights lay the groundwork for engineeringrobust, tunable 1D magnetic heterostructures of CrI₃ forspintronic and data storage applications.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"6 2","pages":"294–304"},"PeriodicalIF":7.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simulated Microgravity Induces Rapid Dielectric Shifts in Erythrocytes of Pancreatic Cancer Patients","authors":"Sai Deepika Reddy Yaram,&nbsp;Alexa Bostic,&nbsp;Ashley Smalley,&nbsp;Soumya K. Srivastava","doi":"10.1021/acsnanoscienceau.5c00130","DOIUrl":"10.1021/acsnanoscienceau.5c00130","url":null,"abstract":"<p>Pancreatic ductal adenocarcinoma (PDAC) is among themost lethalcancers, often diagnosed at advanced stages due to the absence ofearly symptoms and reliable screening tools. Recent studies suggestthat systemic changes in cancer, including inflammation, metabolicalterations, and circulating biomarkers, can affect red blood cells(RBCs) or erythrocytes. Although RBCs lack nuclei, those from cancerpatients exhibit measurable biophysical and biochemical alterations,offering potential for novel diagnostic approaches. However, it isnot known how simulated microgravity might further modulate thesecancer-associated RBC dielectric properties, and the effects of microgravityon RBCs from PDAC patients remain largely unexplored. In this study,we investigate the impact of simulated microgravity (SMG) on the dielectricproperties of human red blood cells from pancreatic ductal adenocarcinoma(PDAC) patients and healthy donors as controls. Cells were exposedto SMG using a clinostat for 3 and 6 h in a suspending medium witha fixed conductivity of 0.01 S/m. Dielectrophoresis (DEP), a label-freeelectrokinetic technique, was used to analyze cellular responses tononuniform electric fields ranging from 0.5 kHz to 45 MHz at a constantpeak-to-peak voltage of 10 <em>V</em>_pp. Significantbiophysical changes were observed as early as 3 h of SMG exposure.Specifically, a statistically significant increase in specific membraneconductance (<em>G</em>_spmem) was obtained (<em>p</em> &lt; 0.0001), and both the force of maximum positive DEP(<em>F</em>_pDEP) and the second crossover frequency(<em>f</em>_<em>x</em>_o2) exhibitedconsistent downshifts, suggesting reduced cytoplasmic conductivityand altered membrane capacitance. Receiver operating characteristic(ROC) analysis indicated that specific membrane capacitance (<em>C</em>_spmem) provides moderate discriminative performanceas a candidate SMG-responsive biomarker. These findings demonstratethat RBCs from PDAC patients undergo rapid dielectric changes undersimulated microgravity, and underscore the utility of DEP for noninvasive,real-time monitoring of cancer-related biophysical alterations, withapplications in both cancer research and space medicine.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"6 2","pages":"224–234"},"PeriodicalIF":7.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gold Nanorods as Effective Modulators of Shape Memory Behavior in Physiological Conditions of PLA/PEG Blends","authors":"Xabier Larrañaga,&nbsp;Sophia C. Bittinger,&nbsp;Uxue Aizarna-Lopetegui,&nbsp;Richard Schönlein,&nbsp;Brian J. Rodriguez,&nbsp;Jose R. Sarasua,&nbsp;Ester Zuza,&nbsp;Dorleta Jimenez de Aberasturi","doi":"10.1021/acsnanoscienceau.5c00142","DOIUrl":"10.1021/acsnanoscienceau.5c00142","url":null,"abstract":"<p>The shape memoryeffect (SME) in poly­(<span>l</span>-lactide)(PLA)has been widely studied for the development of smart bioabsorbablemedical devices. Shape recovery in PLA occurs at its glass transitiontemperature (<em>T</em>_g) at 60 °C and hence,its safe application under physiological conditions remains challenging.In this study, we demonstrate the tunability of the <em>T</em>_g of PLA to a physiologically safe range of 32–42°C by blending it with 6–10 wt % low-molecular weightpoly­(ethylene glycol) (PEG). We characterize the blends using differentialscanning calorimetry (DSC) and dynamic mechanical thermal analysisand study their shape memory behavior. From three programming strainlevels studied, 50, 75 and 100%, the 8 wt % PEG-containing blend showedthe greatest recovery capabilities, reaching 75% shape recovery ratioat 37 °C, up to over 95% at 40 °C. This blend showed theoverall optimal balance between mechanical properties and shape recoveryperformance. Finally, we explore the remote SME activation by incorporatingplasmonic gold nanorods (AuNRs) as heat transducers to the blend anddemonstrate selective near-infrared (NIR) light-triggered shape recovery.We demonstrate that incorporating plasmonic anisotropic nanoparticlesas key modulators in these polymeric blends enables rapid and selectiverecovery under biologically safe conditions, making them suitablefor biological applications. The study highlights the potential ofdeveloping shape memory medical devices based on PLA/PEG and AuNRs,to be safely activated by an external stimulus in physiological conditions.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"6 2","pages":"250–262"},"PeriodicalIF":7.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building 3D Superconductor-Based Josephson Junctions Using a via Transfer Approach","authors":"Cequn Li,&nbsp;Le Yi,&nbsp;Kalana D. Halanayake,&nbsp;Jessica L. Thompson,&nbsp;Yingdong Guan,&nbsp;Kenji Watanabe,&nbsp;Takashi Taniguchi,&nbsp;Zhiqiang Mao,&nbsp;Danielle Reifsnyder Hickey,&nbsp;Morteza Kayyalha,&nbsp;Jun Zhu","doi":"10.1021/acsnanoscienceau.5c00180","DOIUrl":"10.1021/acsnanoscienceau.5c00180","url":null,"abstract":"<p>The coupling of superconductivity to unconventional materialsmaylead to novel quantum states and potential applications. Controllingthe quality of the superconductor-normal metal interface is of crucialimportance to the understanding and engineering of the superconductingproximity effect. In many cases, conventional lithography-based depositionmethods introduce undesirable effects. Using the concept of via contactand dry transfer, we have constructed smooth, van der Waals-like contactbetween 3D superconducting NbN/Pd and graphene with low contact resistanceof approximately 130 Ω μm. Gate-tunable supercurrent,Fraunhofer pattern, and Andreev reflections are observed, the propertiesof which can be understood using an induced superconducting gap Δ′in this planar contact geometry. We discuss potential mechanisms impactingthe magnitude of Δ′ and suggest ways of further increasingthe proximity coupling. This gentle, lithography-free contacting methodcan be applied to air- and damage-sensitive surfaces to engineer novelsuperconducting heterostructures.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"6 2","pages":"216–223"},"PeriodicalIF":7.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recombinant Protein Nanoparticles for Dual-Stage Inhibition of SARS-CoV‑2 Infection","authors":"Giang H. Pham,&nbsp;Hsiang-chi Tseng,&nbsp;Kerolos Agayby,&nbsp;Abby Odle,&nbsp;Daniel A. Hammer,&nbsp;Ricardo Rajsbaum,&nbsp;Rajarshi Chattaraj","doi":"10.1021/acsnanoscienceau.5c00090","DOIUrl":"10.1021/acsnanoscienceau.5c00090","url":null,"abstract":"<p>Recombinant proteins exhibit significant promise as antiviraltherapeutics.Here, we present a nanotherapeutic platform that, owing to its uniqueability to self-assemble, can present multiple functionalities atthe liquid–liquid interface. We genetically modified the sequenceof an amphiphilic plant-derived protein called oleosin to induce spontaneousself-assembly into micellar nanoparticles. Using SARS-CoV-2 as a model,we demonstrate the potential of a recombinant protein nanoparticleto inhibit two different stages of viral infection. Oleosin variantswere engineered to present miniproteins 1) that block the SARS-CoV-2spike protein binding with human ACE2 receptors and 2) that inhibitvirus-cell membrane fusion. Micellar nanoparticles assembled fromthese proteins are multivalent and bifunctional and achieved potentinhibition of the virus with an IC₅₀ of less than 8 nM,which was more than an order of magnitude lower than that from monofunctionalparticles. This strategy demonstrates a promising path for developinga single protein nanoparticle capable of inhibition of multiple stagesof a viral infection using solely recombinant techniques.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"6 2","pages":"184–190"},"PeriodicalIF":7.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defect-Related Photoluminescence in Hydroxyapatite Nanoparticles Modulated by Carbonate Incorporation","authors":"Thales R. Machado,&nbsp;Lívia G. Pacífico,&nbsp;Marylyn S. Arai,&nbsp;Beatriz G. R. da Silva,&nbsp;Angélica M. M. Zapata,&nbsp;Raquel R. C. Vilela,&nbsp;Valtencir Zucolotto","doi":"10.1021/acsnanoscienceau.5c00140","DOIUrl":"10.1021/acsnanoscienceau.5c00140","url":null,"abstract":"<p>The investigationof defect-related photoluminescence in hydroxyapatite(HA) nanoparticles (NPs) is essential for understanding their electronicstructure and charge carrier recombination dynamics. These insightsare important to advancing HA-based materials in photocatalysis, opticaldevices, hard tissue spectroscopy, and cellular bioimaging. In thisstudy, we provide new evidence on the structural and compositionalfactors that govern the intrinsic photoluminescence of HA NPs synthesizedby chemical precipitation at room temperature, and subjected to thermaltreatment at 400 and 450 °C. Carbonate contents ranging from0.6 to 10.9 wt % were introduced into HA nanorods during synthesisthrough AB-type substitution, replacing both OH^– (A-type) and PO₄^3– (B-type) groups.Increasing carbonate incorporation led to enhanced emissions under405 nm excitation, with a primary band centered at 438 nm. Subsequentthermal treatment further amplified the emission intensity, with thestrongest luminescence observed in samples containing higher carbonatecontent, which also exhibited a red-shift of the emission maximumto approximately 583 nm. These changes were mainly attributed to theprogressive increase in carbonate concentration, particularly throughB-type substitution, which promotes structural disorder, reduces crystallitesize, and generates higher densities of vacancies defects, includingV_Ca, V_OH, and V_O in PO₄^3– groups, as well as to the elimination of structuralwater during heating. These results confirm that carbonate, a frequentimpurity in almost all HA NPs obtained by wet methods without strictexperimental conditions (e.g., inert atmosphere), plays a centralrole in modulating the density of defects and, consequently, the photoluminescenceproperties in both as-synthesized and thermally treated forms. Wealso demonstrate the use of citrate-functionalized carbonated HA NPsfor cellular bioimaging with HDFn cells as a model, underscoring theirpotential for biomedical applications.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"6 2","pages":"235–249"},"PeriodicalIF":7.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uptake of Nanoparticles as a Model System for Viruses under the Presence of Chloroquine","authors":"Gan Chen,&nbsp;Dingcheng Zhu,&nbsp;Yaofeng Zhao,&nbsp;Timothy K. Soh,&nbsp;Ruixia Wang,&nbsp;Neus Feliu,&nbsp;Wolfgang J. Parak","doi":"10.1021/acsnanoscienceau.5c00183","DOIUrl":"10.1021/acsnanoscienceau.5c00183","url":null,"abstract":"<p>In the context of fighting SARS-CoV-2 infection, chloroquineandits derivatives have been suggested as treatments. It has been arguedthat the therapeutic effect is based on the modulation of viral uptakeand fate. Similarities to the endocytosis of nanoparticles (NPs) areused here to recapitulate the effect of chloroquine on this process.The possibilities and limits of this approach are discussed. In particular,it is demonstrated that the uptake of NPs can be diminished in thepresence of toxic chloroquine concentrations. Chloroquine furtherreduced acidification of endosomes/lysosomes, which may interferewith the optical readout of fluorescence-labeled NPs. Furthermore,depending on the system used, chloroquine can either increase or decreasetransfection upon particle-based DNA delivery.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"6 2","pages":"305–312"},"PeriodicalIF":7.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}