ACS Nanoscience Au最新文献_第8页

Optimization of Eudragit RS100 Nanocapsule Formulation for Encapsulating Perillyl Alcohol and Temozolomide Using Design of Experiments 用实验设计优化紫苏醇和替莫唑胺包封的乌龙茶RS100纳米胶囊配方

IF 4.8

ACS Nanoscience Au Pub Date : 2025-01-28 DOI: 10.1021/acsnanoscienceau.4c0005710.1021/acsnanoscienceau.4c00057

Ariane K. Padilha Lorenzett, Tatiane P. Babinski, Vanderlei A. de Lima and Rubiana M. Mainardes*,

{"title":"Optimization of Eudragit RS100 Nanocapsule Formulation for Encapsulating Perillyl Alcohol and Temozolomide Using Design of Experiments","authors":"Ariane K. Padilha Lorenzett, Tatiane P. Babinski, Vanderlei A. de Lima and Rubiana M. Mainardes*, ","doi":"10.1021/acsnanoscienceau.4c0005710.1021/acsnanoscienceau.4c00057","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.4c00057https://doi.org/10.1021/acsnanoscienceau.4c00057","url":null,"abstract":"Glioblastoma, an aggressive intracranial tumor, presents significant therapeutic challenges due to the restrictive nature of the blood–brain barrier (BBB), which limits the effectiveness of conventional treatments. This study aimed to develop and optimize a nanoencapsulated system for intranasal delivery of temozolomide (TMZ) and perillyl alcohol (POH), designed to circumvent BBB limitations, utilizing Eudragit RS100 as the encapsulation matrix. A factorial design approach optimized key parameters, including Eudragit RS100 concentration, POH amount, drip rate, and organic-to-aqueous phase ratio. The nanocapsules were characterized by dynamic light scattering, zeta potential analysis, scanning electron microscopy, and high-performance liquid chromatography. The optimized nanocapsules demonstrated a mean diameter of 253 ± 52 nm and a polydispersity index of 0.145 ± 0.037, indicating uniform size distribution. A zeta potential of approximately +20 mV supported colloidal stability. Encapsulation efficiencies were 3.7% for POH and 28.5% for TMZ. This nanoencapsulated delivery system offers a promising approach for glioblastoma treatment, potentially enhancing clinical outcomes and reducing treatment-associated toxicity.","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"5 2","pages":"70–83 70–83"},"PeriodicalIF":4.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsnanoscienceau.4c00057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143832878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phase Controlled Metalorganic Chemical Vapor Deposition Growth of Wafer-Scale Molybdenum Ditelluride. 晶圆级钼的相控金属有机化学气相沉积生长。

IF 4.8

ACS Nanoscience Au Pub Date : 2025-01-13 eCollection Date: 2025-02-19 DOI: 10.1021/acsnanoscienceau.4c00050

Bum Jun Kim, Derick Tseng, David Dang, Jiayun Liang, Vitali Soukhoveev, Andrei Osinsky, Ke Wang, Ho Wai Howard Lee, Zakaria Y Al Balushi

{"title":"Phase Controlled Metalorganic Chemical Vapor Deposition Growth of Wafer-Scale Molybdenum Ditelluride.","authors":"Bum Jun Kim, Derick Tseng, David Dang, Jiayun Liang, Vitali Soukhoveev, Andrei Osinsky, Ke Wang, Ho Wai Howard Lee, Zakaria Y Al Balushi","doi":"10.1021/acsnanoscienceau.4c00050","DOIUrl":"10.1021/acsnanoscienceau.4c00050","url":null,"abstract":"Metalorganic chemical vapor deposition (MOCVD) has become a pivotal technique for developing wafer-scale transition metal dichalcogenide (TMD) 2D materials. This study investigates the impact of MOCVD growth conditions on achieving uniform and selective polymorph phase control of MoTe2 over large wafers. We demonstrated the controlled and uniform growth of few-layer MoTe2 in pure 2H, 1T', and mixed phases at various temperatures on up to 4 in. C-plane sapphire wafers with hexagonal boron nitride templates. At 600 °C, high-quality 2H-MoTe2 was obtained within a narrow temperature window, verified with absorption and TEM analysis. In addition, we observed strong exciton-phonon coupling effects in multiwavelength Raman spectroscopy when the excitation wavelength was in resonance with the C-exciton. Our findings indicate that temperature-induced Te vacancies play a crucial role in determining the MoTe2 phase. This study highlights the importance of precise control over the MOCVD growth temperature to engineer the MoTe2 phase of interest for device applications.","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"5 1","pages":"1-8"},"PeriodicalIF":4.8,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phase Controlled Metalorganic Chemical Vapor Deposition Growth of Wafer-Scale Molybdenum Ditelluride 晶圆级钼的相控金属有机化学气相沉积生长

IF 4.8

ACS Nanoscience Au Pub Date : 2025-01-13 DOI: 10.1021/acsnanoscienceau.4c0005010.1021/acsnanoscienceau.4c00050

Bum Jun Kim, Derick Tseng, David Dang, Jiayun Liang, Vitali Soukhoveev, Andrei Osinsky, Ke Wang, Ho Wai Howard Lee and Zakaria Y. Al Balushi*,

{"title":"Phase Controlled Metalorganic Chemical Vapor Deposition Growth of Wafer-Scale Molybdenum Ditelluride","authors":"Bum Jun Kim, Derick Tseng, David Dang, Jiayun Liang, Vitali Soukhoveev, Andrei Osinsky, Ke Wang, Ho Wai Howard Lee and Zakaria Y. Al Balushi*, ","doi":"10.1021/acsnanoscienceau.4c0005010.1021/acsnanoscienceau.4c00050","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.4c00050https://doi.org/10.1021/acsnanoscienceau.4c00050","url":null,"abstract":"Metalorganic chemical vapor deposition (MOCVD) has become a pivotal technique for developing wafer-scale transition metal dichalcogenide (TMD) 2D materials. This study investigates the impact of MOCVD growth conditions on achieving uniform and selective polymorph phase control of MoTe2 over large wafers. We demonstrated the controlled and uniform growth of few-layer MoTe2 in pure 2H, 1T′, and mixed phases at various temperatures on up to 4 in. C-plane sapphire wafers with hexagonal boron nitride templates. At 600 °C, high-quality 2H-MoTe2 was obtained within a narrow temperature window, verified with absorption and TEM analysis. In addition, we observed strong exciton–phonon coupling effects in multiwavelength Raman spectroscopy when the excitation wavelength was in resonance with the C-exciton. Our findings indicate that temperature-induced Te vacancies play a crucial role in determining the MoTe2 phase. This study highlights the importance of precise control over the MOCVD growth temperature to engineer the MoTe2 phase of interest for device applications.","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"5 1","pages":"1–8 1–8"},"PeriodicalIF":4.8,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsnanoscienceau.4c00050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Heavy Water in the Synthesis and Nanocatalytic Activity of Gold Nanoparticles 重水在金纳米颗粒合成中的作用及其纳米催化活性

IF 4.8

ACS Nanoscience Au Pub Date : 2025-01-07 DOI: 10.1021/acsnanoscienceau.4c0006910.1021/acsnanoscienceau.4c00069

Nathaniel E. Larm*, Christopher D. Stachurski, Paul C. Trulove, Xiaonan Tang, Yun Shen, David P. Durkin and Gary A. Baker*,

{"title":"Role of Heavy Water in the Synthesis and Nanocatalytic Activity of Gold Nanoparticles","authors":"Nathaniel E. Larm*, Christopher D. Stachurski, Paul C. Trulove, Xiaonan Tang, Yun Shen, David P. Durkin and Gary A. Baker*, ","doi":"10.1021/acsnanoscienceau.4c0006910.1021/acsnanoscienceau.4c00069","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.4c00069https://doi.org/10.1021/acsnanoscienceau.4c00069","url":null,"abstract":"Heavy water (D2O) has found extensive application as a moderator in nuclear reactors. Additionally, it serves as a substitute for regular water (H2O) in biological or spectroscopic experiments, providing a deuterium source and addressing challenges related to solvent opacity or contrast. This is particularly relevant in experiments involving neutron scattering, infrared absorption, or nuclear magnetic resonance. However, replacing H2O with D2O is not always a straightforward or harmless substitution and can instead have unintended chemical consequences. In this study, we highlight the significant impact of solvent deuteration on two common gold nanoparticle syntheses─borohydride reduction and ascorbic acid reduction─by comparing reactions in D2O and H2O and mixtures thereof. The resulting colloids exhibit differences in size and spectral characteristics, and their effectiveness as nanocatalysts in the widely used 4-nitrophenol reduction benchmark reaction is adversely affected by the presence of D2O during both particle synthesis and as the catalytic medium. Ultimately, these results underscore a critical awareness often overlooked by scientists and engineers: despite its widespread and sometimes indispensable use in analytical spectroscopy, cellular imaging, biophysics, and organic chemistry, D2O cannot truly replace H2O without significantly altering the chemical environment of a reaction.","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"5 1","pages":"52–59 52–59"},"PeriodicalIF":4.8,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsnanoscienceau.4c00069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Heavy Water in the Synthesis and Nanocatalytic Activity of Gold Nanoparticles. 重水在金纳米颗粒合成中的作用及其纳米催化活性。

IF 4.8

ACS Nanoscience Au Pub Date : 2025-01-07 eCollection Date: 2025-02-19 DOI: 10.1021/acsnanoscienceau.4c00069

Nathaniel E Larm, Christopher D Stachurski, Paul C Trulove, Xiaonan Tang, Yun Shen, David P Durkin, Gary A Baker

{"title":"Role of Heavy Water in the Synthesis and Nanocatalytic Activity of Gold Nanoparticles.","authors":"Nathaniel E Larm, Christopher D Stachurski, Paul C Trulove, Xiaonan Tang, Yun Shen, David P Durkin, Gary A Baker","doi":"10.1021/acsnanoscienceau.4c00069","DOIUrl":"10.1021/acsnanoscienceau.4c00069","url":null,"abstract":"Heavy water (D2O) has found extensive application as a moderator in nuclear reactors. Additionally, it serves as a substitute for regular water (H2O) in biological or spectroscopic experiments, providing a deuterium source and addressing challenges related to solvent opacity or contrast. This is particularly relevant in experiments involving neutron scattering, infrared absorption, or nuclear magnetic resonance. However, replacing H2O with D2O is not always a straightforward or harmless substitution and can instead have unintended chemical consequences. In this study, we highlight the significant impact of solvent deuteration on two common gold nanoparticle syntheses-borohydride reduction and ascorbic acid reduction-by comparing reactions in D2O and H2O and mixtures thereof. The resulting colloids exhibit differences in size and spectral characteristics, and their effectiveness as nanocatalysts in the widely used 4-nitrophenol reduction benchmark reaction is adversely affected by the presence of D2O during both particle synthesis and as the catalytic medium. Ultimately, these results underscore a critical awareness often overlooked by scientists and engineers: despite its widespread and sometimes indispensable use in analytical spectroscopy, cellular imaging, biophysics, and organic chemistry, D2O cannot truly replace H2O without significantly altering the chemical environment of a reaction.","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"5 1","pages":"52-59"},"PeriodicalIF":4.8,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid Nanoparticle Delivery of mRNA and siRNA for Concurrent Restoration of Tumor Suppressor and Inhibition of Tumorigenic Driver in Prostate Cancer 脂质纳米颗粒递送mRNA和siRNA用于前列腺癌肿瘤抑制因子的同步恢复和致瘤驱动因子的抑制

IF 6.3

ACS Nanoscience Au Pub Date : 2024-12-26 DOI: 10.1021/acsnanoscienceau.4c00066

Ryan A. Farokhzad, Jing Luo, Li Jia, Yang Zhang* and Jinjun Shi*,

{"title":"Lipid Nanoparticle Delivery of mRNA and siRNA for Concurrent Restoration of Tumor Suppressor and Inhibition of Tumorigenic Driver in Prostate Cancer","authors":"Ryan A. Farokhzad, Jing Luo, Li Jia, Yang Zhang* and Jinjun Shi*, ","doi":"10.1021/acsnanoscienceau.4c00066","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.4c00066","url":null,"abstract":"Cancer is commonly caused by a gain of function in proto-oncogenes and a simultaneous loss of function in tumor suppressor genes. Advanced prostate cancer (PCa) is often linked with changes in the activity or expression of phosphatase and tensin homologue deleted on chromosome 10 (PTEN), a well-known tumor suppressor, and androgen receptor (AR), a pro-tumorigenic transcription factor. However, no therapies exist for the simultaneous correction of tumorigenic promotion and suppressor depletion. Here, we report that concurrent PTEN restoration and AR silencing by lipid nanoparticle (LNP) delivery of PTEN messenger RNA (mPTEN) and AR small interfering RNA (siAR) elicited synergistic therapeutic effects in PCa cells. We screened various LNP formulations for the optimal delivery of both RNAs. In C4-2 and LNCaP cells, both of which are AR-positive and PTEN-null PCa cell lines, the combinatorial treatment of siAR and mPTEN LNPs resulted in much stronger cytotoxicity in vitro than the treatment of either alone. Western blot analyses revealed concurrent regulation of phosphatidylinositol 3-kinase-protein kinase B (PI3K-AKT) and extracellular signal-regulated kinase (ERK) pathways, leading to increased caspase-3 cleavage-mediated apoptosis. Our findings suggest that the strategy of RNA-mediated concurrent restoration of tumor suppressors and inhibition of tumorigenic drivers could lead to the more effective treatment of PCa and potentially other malignancies.","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"5 4","pages":"284–292"},"PeriodicalIF":6.3,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsnanoscienceau.4c00066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144863015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 4.8

ACS Nanoscience Au Pub Date : 2024-12-18

Zechariah Mengrani, Weiying Hong and Matteo Palma*,

引用次数: 0

IF 4.8

ACS Nanoscience Au Pub Date : 2024-12-18

Junnosuke Motoori, Tomokazu Kinoshita, Hongxin Chai, Ming-Shuang Li, Song-Meng Wang, Wei Jiang and Gaku Fukuhara*,

引用次数: 0

IF 4.8

ACS Nanoscience Au Pub Date : 2024-12-18

Shireesha Manturthi, Sara El-Sahli, Yuxia Bo, Emma Durocher, Melanie Kirkby, Alyanna Popatia, Karan Mediratta, Redaet Daniel, Seung-Hwan Lee, Umar Iqbal, Marceline Côté, Lisheng Wang* and Suresh Gadde*,

引用次数: 0

IF 4.8

ACS Nanoscience Au Pub Date : 2024-12-18

引用次数: 0