ACS Nanoscience Au最新文献_第10页

Inverse-Designed Metaphotonics for Hypersensitive Detection 超敏检测的反设计变形学

ACS Nanoscience Au Pub Date : 2022-07-25 DOI: 10.1021/acsnanoscienceau.2c00009

Maxim Elizarov, Yuri S. Kivshar and Andrea Fratalocchi*,

{"title":"Inverse-Designed Metaphotonics for Hypersensitive Detection","authors":"Maxim Elizarov, Yuri S. Kivshar and Andrea Fratalocchi*, ","doi":"10.1021/acsnanoscienceau.2c00009","DOIUrl":"10.1021/acsnanoscienceau.2c00009","url":null,"abstract":"Controlling the flow of broadband electromagnetic energy at the nanoscale remains a critical challenge in optoelectronics. Surface plasmon polaritons (or plasmons) provide subwavelength localization of light but are affected by significant losses. On the contrary, dielectrics lack a sufficiently robust response in the visible to trap photons similar to metallic structures. Overcoming these limitations appears elusive. Here we demonstrate that addressing this problem is possible if we employ a novel approach based on suitably deformed reflective metaphotonic structures. The complex geometrical shape engineered in these reflectors emulates nondispersive index responses, which can be inverse-designed following arbitrary form factors. We discuss the realization of essential components such as resonators with an ultrahigh refractive index of n = 100 in diverse profiles. These structures support the localization of light in the form of bound states in the continuum (BIC), fully localized in air, in a platform in which all refractive index regions are physically accessible. We discuss our approach to sensing applications, designing a class of sensors where the analyte directly contacts areas of ultrahigh refractive index. Leveraging this feature, we report an optical sensor with sensitivity two times higher than the closest competitor with a similar micrometer footprint. Inversely designed reflective metaphotonics offers a flexible technology for controlling broadband light, supporting optoelectronics’ integration with large bandwidths in circuitry with miniaturized footprints.","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/59/11/ng2c00009.PMC10125296.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9357329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

White-Light Spectral Interferometry for Characterizing Inhomogeneity in Solutions and Nanocolloids 白光光谱干涉法表征溶液和纳米胶体中的不均匀性

ACS Nanoscience Au Pub Date : 2022-07-18 DOI: 10.1021/acsnanoscienceau.2c00014

Aparna Praturi, Stefan Schrod, Bhanu Pratap Singh and Parinda Vasa*,

引用次数: 0

Termination-Property Coupling via Reversible Oxygen Functionalization of MXenes 通过可逆氧官能化MXenes的终止-性质耦合

ACS Nanoscience Au Pub Date : 2022-06-28 DOI: 10.1021/acsnanoscienceau.2c00024

James L. Hart, Kanit Hantanasirisakul, Yury Gogotsi and Mitra L. Taheri*,

{"title":"Termination-Property Coupling via Reversible Oxygen Functionalization of MXenes","authors":"James L. Hart, Kanit Hantanasirisakul, Yury Gogotsi and Mitra L. Taheri*, ","doi":"10.1021/acsnanoscienceau.2c00024","DOIUrl":"10.1021/acsnanoscienceau.2c00024","url":null,"abstract":"MXenes are a growing family of 2D transition-metal carbides and nitrides, which display excellent performance in myriad of applications. Theoretical calculations suggest that manipulation of the MXene surface termination (such as ═O or −F) could strongly alter their functional properties; however, experimental control of the MXene surface termination is still in the developmental stage. Here, we demonstrate that annealing MXenes in an Ar + O2 low-power plasma results in increased ═O functionalization with minimal formation of secondary phases. We apply this method to two MXenes, Ti2CTx and Mo2TiC2Tx (Tx represents the mixed surface termination), and show that in both cases, the increased ═O content increases the electrical resistance and decreases the surface transition-metal’s electron count. For Mo2TiC2Ox, we show that the O content can be reversibly altered through successive vacuum and plasma annealing. This work provides an effective way to tune MXene surface functionalization, which may unlock exciting surface-dependent properties.","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/54/75/ng2c00024.PMC9585631.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40658048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Colloidal Synthesis and Photocatalytic Properties of Cu3NbS4 and Cu3NbSe4 Sulvanite Nanocrystals Cu3NbS4和Cu3NbSe4硫化矿纳米晶的胶体合成及其光催化性能

ACS Nanoscience Au Pub Date : 2022-06-24 DOI: 10.1021/acsnanoscienceau.2c00021

Chen-Yu Chang, Roberto Prado-Rivera, Mimi Liu, Cheng-Yu Lai* and Daniela R. Radu*,

{"title":"Colloidal Synthesis and Photocatalytic Properties of Cu3NbS4 and Cu3NbSe4 Sulvanite Nanocrystals","authors":"Chen-Yu Chang, Roberto Prado-Rivera, Mimi Liu, Cheng-Yu Lai* and Daniela R. Radu*, ","doi":"10.1021/acsnanoscienceau.2c00021","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.2c00021","url":null,"abstract":"Niobium sulvanites Cu3NbX4 (X = S, Se) have been theoretically predicted as promising candidates for solar photovoltaics and photocatalytic water splitting. This report outlines the first synthesis of Cu3NbS4 and Cu3NbSe4 in a nanocrystalline form. The crystal structures were investigated by X-ray diffraction, identity was confirmed by Raman spectroscopy, and the optoelectronic properties and morphology of Cu3NbS4 and Cu3NbSe4 nanocrystals were examined by UV–vis spectroscopy and transmission electron microscopy, respectively. To gain insight into the Cu3NbX4 formation, a mechanistic study was conducted for Cu3NbSe4 monitoring the nanoparticles’ formation as a function of reaction time. Methylene blue photodegradation tests were conducted to evaluate the photoactivity of Cu3NbS4 and Cu3NbSe4. The degradation rates, 2.81 × 10–2 min–1 and 1.22 × 10–2 min–1 proved the photocatalysts’ potential of nanoscale Cu3NbX4.","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsnanoscienceau.2c00021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71621678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Solving Exact Cover Instances with Molecular-Motor-Powered Network-Based Biocomputation 用分子马达驱动的基于网络的生物计算求解精确覆盖实例

ACS Nanoscience Au Pub Date : 2022-06-23 DOI: 10.1021/acsnanoscienceau.2c00013

Pradheebha Surendiran, Christoph Robert Meinecke, Aseem Salhotra, Georg Heldt, Jingyuan Zhu, Alf Månsson, Stefan Diez, Danny Reuter, Hillel Kugler, Heiner Linke and Till Korten*,

引用次数: 4

Electron Transfer at Quantum Dot–Metal Oxide Interfaces for Solar Energy Conversion 太阳能转换中量子点-金属氧化物界面的电子转移

ACS Nanoscience Au Pub Date : 2022-06-22 DOI: 10.1021/acsnanoscienceau.2c00015

Marco Ballabio, and , Enrique Cánovas*,

引用次数: 2

Quantitative Acoustophoresis 定量Acoustophoresis

ACS Nanoscience Au Pub Date : 2022-06-22 DOI: 10.1021/acsnanoscienceau.2c00002

Vadim Bogatyr, Andreas S. Biebricher, Giulia Bergamaschi, Erwin J. G. Peterman and Gijs J. L. Wuite*,

{"title":"Quantitative Acoustophoresis","authors":"Vadim Bogatyr, Andreas S. Biebricher, Giulia Bergamaschi, Erwin J. G. Peterman and Gijs J. L. Wuite*, ","doi":"10.1021/acsnanoscienceau.2c00002","DOIUrl":"10.1021/acsnanoscienceau.2c00002","url":null,"abstract":"Studying cellular mechanics allows important insights into its cytoskeletal composition, developmental stage, and health. While many force spectroscopy assays exist that allow probing of mechanics of bioparticles, most of them require immobilization of and direct contact with the particle and can only measure a single particle at a time. Here, we introduce quantitative acoustophoresis (QAP) as a simple alternative that uses an acoustic standing wave field to directly determine cellular compressibility and density of many cells simultaneously in a contact-free manner. First, using polymeric spheres of different sizes and materials, we verify that our assay data follow the standard acoustic theory with great accuracy. We furthermore verify that our technique not only is able to measure compressibilities of living cells but can also sense an artificial cytoskeleton inside a biomimetic vesicle. We finally provide a thorough discussion about the expected accuracy our approach provides. To conclude, we show that compared to existing methods, our QAP assay provides a simple yet powerful alternative to study the mechanics of biological and biomimetic particles.","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/36/ea/ng2c00002.PMC9389611.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40435892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Markov State Study of Electrostatic Channeling within the Tricarboxylic Acid Cycle Supercomplex 三羧酸循环超配合物静电通道的马尔可夫状态研究

ACS Nanoscience Au Pub Date : 2022-06-07 DOI: 10.1021/acsnanoscienceau.2c00011

Yan Xie, Shelley D. Minteer, Scott Banta and Scott Calabrese Barton*,

{"title":"Markov State Study of Electrostatic Channeling within the Tricarboxylic Acid Cycle Supercomplex","authors":"Yan Xie, Shelley D. Minteer, Scott Banta and Scott Calabrese Barton*, ","doi":"10.1021/acsnanoscienceau.2c00011","DOIUrl":"10.1021/acsnanoscienceau.2c00011","url":null,"abstract":"The high efficiency of cascade reactions in supramolecular enzyme nanoassemblies, known as metabolons, has attracted substantial attention in various fields ranging from fundamental biochemistry and molecular biology to recent applications in biofuel cells, biosensors, and chemical synthesis. One reason for the high efficiency of metabolons is the structures formed by sequential enzymes that allow the direct transport of intermediates between consecutive active sites. The supercomplex of malate dehydrogenase (MDH) and citrate synthase (CS) is an ideal example of the controlled transport of intermediates via electrostatic channeling. Here, using a combination of molecular dynamics (MD) simulations and a Markov state model (MSM), we examined the transport process of the intermediate oxaloacetate (OAA) from MDH to CS. The MSM enables the identification of the dominant transport pathways of OAA from MDH to CS. Analysis of all pathways using a hub score approach reveals a small set of residues that control OAA transport. This set includes an arginine residue previously identified experimentally. MSM analysis of a mutated complex, where the identified arginine is replaced by alanine, led to a 2-fold decrease in transfer efficiency, also consistent with experimental results. This work provides a molecular-level understanding of the electrostatic channeling mechanism and will enable the further design of catalytic nanostructures utilizing electrostatic channeling.","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/77/b8/ng2c00011.PMC10125334.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9357326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photoresponsive Nanocarriers Based on Lithium Niobate Nanoparticles for Harmonic Imaging and On-Demand Release of Anticancer Chemotherapeutics 基于铌酸锂纳米粒子的光响应纳米载体用于谐波成像和抗癌化疗药物的按需释放

ACS Nanoscience Au Pub Date : 2022-06-03 DOI: 10.1021/acsnanoscienceau.1c00044

Adrian Gheata, Geoffrey Gaulier, Gabriel Campargue, Jérémy Vuilleumier, Simon Kaiser, Ivan Gautschi, Florian Riporto, Sandrine Beauquis, Davide Staedler, Dario Diviani, Luigi Bonacina and Sandrine Gerber-Lemaire*,

{"title":"Photoresponsive Nanocarriers Based on Lithium Niobate Nanoparticles for Harmonic Imaging and On-Demand Release of Anticancer Chemotherapeutics","authors":"Adrian Gheata, Geoffrey Gaulier, Gabriel Campargue, Jérémy Vuilleumier, Simon Kaiser, Ivan Gautschi, Florian Riporto, Sandrine Beauquis, Davide Staedler, Dario Diviani, Luigi Bonacina and Sandrine Gerber-Lemaire*, ","doi":"10.1021/acsnanoscienceau.1c00044","DOIUrl":"10.1021/acsnanoscienceau.1c00044","url":null,"abstract":"Nanoparticle-based drug delivery systems have the potential for increasing the efficiency of chemotherapeutics by enhancing the drug accumulation at specific target sites, thereby reducing adverse side effects and mitigating patient acquired resistance. In particular, photo-responsive nanomaterials have attracted much interest due to their ability to release molecular cargos on demand upon light irradiation. In some settings, they can also provide complementary information by optical imaging on the (sub)cellular scale. We herein present a system based on lithium niobate harmonic nanoparticles (LNO HNPs) for the decoupled multi-harmonic cell imaging and near-infrared light-triggered delivery of an erlotinib derivative (ELA) for the treatment of epidermal growth factor receptor (EGFR)-overexpressing carcinomas. The ELA cargo was covalently conjugated to the surface of silica-coated LNO HNPs through a coumarinyl photo-cleavable linker, achieving a surface loading of the active molecule of 27 nmol/mg NPs. The resulting nanoconjugates (LNO-CM-ELA NPs) were successfully imaged upon pulsed laser excitation at 1250 nm in EGFR-overexpressing human prostate cancer cells DU145 by detecting the second harmonic emission at 625 nm, in the tissue transparency window. Tuning the laser at 790 nm resulted in the uncaging of the ELA cargo as a result of the second harmonic emission of the inorganic HNP core at 395 nm. This protocol induced a significant growth inhibition in DU145 cells, which was only observed upon specific irradiation at 790 nm, highlighting the promising capabilities of LNO-CM-ELA NPs for theranostic applications.","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40435890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Shape-Morphing of an Artificial Protein Cage with Unusual Geometry Induced by a Single Amino Acid Change 由单个氨基酸变化诱导的具有不寻常几何形状的人工蛋白质笼的形状-变形

ACS Nanoscience Au Pub Date : 2022-05-09 DOI: 10.1021/acsnanoscienceau.2c00019

Mohit Sharma, Artur P. Biela, Agnieszka Kowalczyk, Kinga Borzęcka-Solarz, Bernard M. A. G. Piette, Szymon Gaweł, Joshua Bishop, Philipp Kukura, Justin L. P. Benesch, Motonori Imamura, Simon Scheuring and Jonathan G. Heddle*,

引用次数: 4