ACS Nanoscience AuPub Date : 2022-06-24DOI: 10.1021/acsnanoscienceau.2c00021
Chen-Yu Chang, Roberto Prado-Rivera, Mimi Liu, Cheng-Yu Lai* and Daniela R. Radu*,
{"title":"Colloidal Synthesis and Photocatalytic Properties of Cu3NbS4 and Cu3NbSe4 Sulvanite Nanocrystals","authors":"Chen-Yu Chang, Roberto Prado-Rivera, Mimi Liu, Cheng-Yu Lai* and Daniela R. Radu*, ","doi":"10.1021/acsnanoscienceau.2c00021","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.2c00021","url":null,"abstract":"<p >Niobium sulvanites Cu<sub>3</sub>NbX<sub>4</sub> (X = S, Se) have been theoretically predicted as promising candidates for solar photovoltaics and photocatalytic water splitting. This report outlines the first synthesis of Cu<sub>3</sub>NbS<sub>4</sub> and Cu<sub>3</sub>NbSe<sub>4</sub> in a nanocrystalline form. The crystal structures were investigated by X-ray diffraction, identity was confirmed by Raman spectroscopy, and the optoelectronic properties and morphology of Cu<sub>3</sub>NbS<sub>4</sub> and Cu<sub>3</sub>NbSe<sub>4</sub> nanocrystals were examined by UV–vis spectroscopy and transmission electron microscopy, respectively. To gain insight into the Cu<sub>3</sub>NbX<sub>4</sub> formation, a mechanistic study was conducted for Cu<sub>3</sub>NbSe<sub>4</sub> monitoring the nanoparticles’ formation as a function of reaction time. Methylene blue photodegradation tests were conducted to evaluate the photoactivity of Cu<sub>3</sub>NbS<sub>4</sub> and Cu<sub>3</sub>NbSe<sub>4</sub>. The degradation rates, 2.81 × 10<sup>–2</sup> min<sup>–1</sup> and 1.22 × 10<sup>–2</sup> min<sup>–1</sup> proved the photocatalysts’ potential of nanoscale Cu<sub>3</sub>NbX<sub>4</sub>.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"2 5","pages":"440–447"},"PeriodicalIF":0.0,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsnanoscienceau.2c00021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71621678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Nanoscience AuPub Date : 2022-06-23DOI: 10.1021/acsnanoscienceau.2c00013
Pradheebha Surendiran, Christoph Robert Meinecke, Aseem Salhotra, Georg Heldt, Jingyuan Zhu, Alf Månsson, Stefan Diez, Danny Reuter, Hillel Kugler, Heiner Linke and Till Korten*,
{"title":"Solving Exact Cover Instances with Molecular-Motor-Powered Network-Based Biocomputation","authors":"Pradheebha Surendiran, Christoph Robert Meinecke, Aseem Salhotra, Georg Heldt, Jingyuan Zhu, Alf Månsson, Stefan Diez, Danny Reuter, Hillel Kugler, Heiner Linke and Till Korten*, ","doi":"10.1021/acsnanoscienceau.2c00013","DOIUrl":"10.1021/acsnanoscienceau.2c00013","url":null,"abstract":"<p >Information processing by traditional, serial electronic processors consumes an ever-increasing part of the global electricity supply. An alternative, highly energy efficient, parallel computing paradigm is network-based biocomputation (NBC). In NBC a given combinatorial problem is encoded into a nanofabricated, modular network. Parallel exploration of the network by a very large number of independent molecular-motor-propelled protein filaments solves the encoded problem. Here we demonstrate a significant scale-up of this technology by solving four instances of Exact Cover, a nondeterministic polynomial time (NP) complete problem with applications in resource scheduling. The difficulty of the largest instances solved here is 128 times greater in comparison to the current state of the art for NBC.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"2 5","pages":"396–403"},"PeriodicalIF":0.0,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9350934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Nanoscience AuPub Date : 2022-06-22DOI: 10.1021/acsnanoscienceau.2c00015
Marco Ballabio, and , Enrique Cánovas*,
{"title":"Electron Transfer at Quantum Dot–Metal Oxide Interfaces for Solar Energy Conversion","authors":"Marco Ballabio, and , Enrique Cánovas*, ","doi":"10.1021/acsnanoscienceau.2c00015","DOIUrl":"10.1021/acsnanoscienceau.2c00015","url":null,"abstract":"<p >Electron transfer at a donor–acceptor quantum dot–metal oxide interface is a process fundamentally relevant to solar energy conversion architectures as, e.g., sensitized solar cells and solar fuels schemes. As kinetic competition at these technologically relevant interfaces largely determines device performance, this Review surveys several aspects linking electron transfer dynamics and device efficiency; this correlation is done for systems aiming for efficiencies up to and above the ∼33% efficiency limit set by Shockley and Queisser for single gap devices. Furthermore, we critically comment on common pitfalls associated with the interpretation of kinetic data obtained from current methodologies and experimental approaches, and finally, we highlight works that, to our judgment, have contributed to a better understanding of the fundamentals governing electron transfer at quantum dot–metal oxide interfaces.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"2 5","pages":"367–395"},"PeriodicalIF":0.0,"publicationDate":"2022-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40658049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Nanoscience AuPub Date : 2022-06-22DOI: 10.1021/acsnanoscienceau.2c00002
Vadim Bogatyr, Andreas S. Biebricher, Giulia Bergamaschi, Erwin J. G. Peterman and Gijs J. L. Wuite*,
{"title":"Quantitative Acoustophoresis","authors":"Vadim Bogatyr, Andreas S. Biebricher, Giulia Bergamaschi, Erwin J. G. Peterman and Gijs J. L. Wuite*, ","doi":"10.1021/acsnanoscienceau.2c00002","DOIUrl":"10.1021/acsnanoscienceau.2c00002","url":null,"abstract":"<p >Studying cellular mechanics allows important insights into its cytoskeletal composition, developmental stage, and health. While many force spectroscopy assays exist that allow probing of mechanics of bioparticles, most of them require immobilization of and direct contact with the particle and can only measure a single particle at a time. Here, we introduce quantitative acoustophoresis (QAP) as a simple alternative that uses an acoustic standing wave field to directly determine cellular compressibility and density of many cells simultaneously in a contact-free manner. First, using polymeric spheres of different sizes and materials, we verify that our assay data follow the standard acoustic theory with great accuracy. We furthermore verify that our technique not only is able to measure compressibilities of living cells but can also sense an artificial cytoskeleton inside a biomimetic vesicle. We finally provide a thorough discussion about the expected accuracy our approach provides. To conclude, we show that compared to existing methods, our QAP assay provides a simple yet powerful alternative to study the mechanics of biological and biomimetic particles.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"2 4","pages":"341–354"},"PeriodicalIF":0.0,"publicationDate":"2022-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/36/ea/ng2c00002.PMC9389611.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40435892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Nanoscience AuPub Date : 2022-06-07DOI: 10.1021/acsnanoscienceau.2c00011
Yan Xie, Shelley D. Minteer, Scott Banta and Scott Calabrese Barton*,
{"title":"Markov State Study of Electrostatic Channeling within the Tricarboxylic Acid Cycle Supercomplex","authors":"Yan Xie, Shelley D. Minteer, Scott Banta and Scott Calabrese Barton*, ","doi":"10.1021/acsnanoscienceau.2c00011","DOIUrl":"10.1021/acsnanoscienceau.2c00011","url":null,"abstract":"<p >The high efficiency of cascade reactions in supramolecular enzyme nanoassemblies, known as metabolons, has attracted substantial attention in various fields ranging from fundamental biochemistry and molecular biology to recent applications in biofuel cells, biosensors, and chemical synthesis. One reason for the high efficiency of metabolons is the structures formed by sequential enzymes that allow the direct transport of intermediates between consecutive active sites. The supercomplex of malate dehydrogenase (MDH) and citrate synthase (CS) is an ideal example of the controlled transport of intermediates via electrostatic channeling. Here, using a combination of molecular dynamics (MD) simulations and a Markov state model (MSM), we examined the transport process of the intermediate oxaloacetate (OAA) from MDH to CS. The MSM enables the identification of the dominant transport pathways of OAA from MDH to CS. Analysis of all pathways using a hub score approach reveals a small set of residues that control OAA transport. This set includes an arginine residue previously identified experimentally. MSM analysis of a mutated complex, where the identified arginine is replaced by alanine, led to a 2-fold decrease in transfer efficiency, also consistent with experimental results. This work provides a molecular-level understanding of the electrostatic channeling mechanism and will enable the further design of catalytic nanostructures utilizing electrostatic channeling.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"2 5","pages":"414–421"},"PeriodicalIF":0.0,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/77/b8/ng2c00011.PMC10125334.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9357326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Nanoscience AuPub Date : 2022-06-03DOI: 10.1021/acsnanoscienceau.1c00044
Adrian Gheata, Geoffrey Gaulier, Gabriel Campargue, Jérémy Vuilleumier, Simon Kaiser, Ivan Gautschi, Florian Riporto, Sandrine Beauquis, Davide Staedler, Dario Diviani, Luigi Bonacina and Sandrine Gerber-Lemaire*,
{"title":"Photoresponsive Nanocarriers Based on Lithium Niobate Nanoparticles for Harmonic Imaging and On-Demand Release of Anticancer Chemotherapeutics","authors":"Adrian Gheata, Geoffrey Gaulier, Gabriel Campargue, Jérémy Vuilleumier, Simon Kaiser, Ivan Gautschi, Florian Riporto, Sandrine Beauquis, Davide Staedler, Dario Diviani, Luigi Bonacina and Sandrine Gerber-Lemaire*, ","doi":"10.1021/acsnanoscienceau.1c00044","DOIUrl":"10.1021/acsnanoscienceau.1c00044","url":null,"abstract":"<p >Nanoparticle-based drug delivery systems have the potential for increasing the efficiency of chemotherapeutics by enhancing the drug accumulation at specific target sites, thereby reducing adverse side effects and mitigating patient acquired resistance. In particular, photo-responsive nanomaterials have attracted much interest due to their ability to release molecular cargos on demand upon light irradiation. In some settings, they can also provide complementary information by optical imaging on the (sub)cellular scale. We herein present a system based on lithium niobate harmonic nanoparticles (LNO HNPs) for the decoupled multi-harmonic cell imaging and near-infrared light-triggered delivery of an erlotinib derivative (<b>ELA</b>) for the treatment of epidermal growth factor receptor (EGFR)-overexpressing carcinomas. The <b>ELA</b> cargo was covalently conjugated to the surface of silica-coated LNO HNPs through a coumarinyl photo-cleavable linker, achieving a surface loading of the active molecule of 27 nmol/mg NPs. The resulting nanoconjugates (<b>LNO-CM-ELA</b> NPs) were successfully imaged upon pulsed laser excitation at 1250 nm in EGFR-overexpressing human prostate cancer cells DU145 by detecting the second harmonic emission at 625 nm, in the tissue transparency window. Tuning the laser at 790 nm resulted in the uncaging of the <b>ELA</b> cargo as a result of the second harmonic emission of the inorganic HNP core at 395 nm. This protocol induced a significant growth inhibition in DU145 cells, which was only observed upon specific irradiation at 790 nm, highlighting the promising capabilities of <b>LNO-CM-ELA</b> NPs for theranostic applications.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"2 4","pages":"355–366"},"PeriodicalIF":0.0,"publicationDate":"2022-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40435890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Nanoscience AuPub Date : 2022-05-09DOI: 10.1021/acsnanoscienceau.2c00019
Mohit Sharma, Artur P. Biela, Agnieszka Kowalczyk, Kinga Borzęcka-Solarz, Bernard M. A. G. Piette, Szymon Gaweł, Joshua Bishop, Philipp Kukura, Justin L. P. Benesch, Motonori Imamura, Simon Scheuring and Jonathan G. Heddle*,
{"title":"Shape-Morphing of an Artificial Protein Cage with Unusual Geometry Induced by a Single Amino Acid Change","authors":"Mohit Sharma, Artur P. Biela, Agnieszka Kowalczyk, Kinga Borzęcka-Solarz, Bernard M. A. G. Piette, Szymon Gaweł, Joshua Bishop, Philipp Kukura, Justin L. P. Benesch, Motonori Imamura, Simon Scheuring and Jonathan G. Heddle*, ","doi":"10.1021/acsnanoscienceau.2c00019","DOIUrl":"10.1021/acsnanoscienceau.2c00019","url":null,"abstract":"Artificial protein cages are constructed from multiple protein subunits. The interaction between the subunits, notably the angle formed between them, controls the geometry of the resulting cage. Here, using the artificial protein cage, “TRAP-cage”, we show that a simple alteration in the position of a single amino acid responsible for Au(I)-mediated subunit–subunit interactions in the constituent ring-shaped building blocks results in a more acute dihedral angle between them. In turn, this causes a dramatic shift in the structure from a 24-ring cage with an octahedral symmetry to a 20-ring cage with a C2 symmetry. This symmetry change is accompanied by a decrease in the number of Au(I)-mediated bonds between cysteines and a concomitant change in biophysical properties of the cage.","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"2 5","pages":"404–413"},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40658050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Nanoscience AuPub Date : 2022-05-03DOI: 10.1021/acsnanoscienceau.2c00005
Dingguan Wang*, Zishen Wang, Shaofei Wu, Arramel, Xinmao Yin, Chi Sin Tang, Yuan Ping Feng, Jishan Wu* and Andrew T. S. Wee*,
{"title":"Realizing Two-Dimensional Supramolecular Arrays of a Spin Molecule via Halogen Bonding","authors":"Dingguan Wang*, Zishen Wang, Shaofei Wu, Arramel, Xinmao Yin, Chi Sin Tang, Yuan Ping Feng, Jishan Wu* and Andrew T. S. Wee*, ","doi":"10.1021/acsnanoscienceau.2c00005","DOIUrl":"10.1021/acsnanoscienceau.2c00005","url":null,"abstract":"<p >Well-ordered spin arrays are desirable for next-generation molecule-based magnetic devices, yet their synthetic method remains a challenging task. Herein, we demonstrate the realization of two-dimensional supramolecular spin arrays on surfaces via halogen-bonding molecular self-assembly. A bromine-terminated perchlorotriphenylmethyl radical with net carbon spin was synthesized and deposited on Au(111) to achieve two-dimensional supramolecular spin arrays. By taking advantage of the diversity of halogen bonds, five supramolecular spin arrays form and are probed by low-temperature scanning tunneling microscopy at the single-molecule level. First-principles calculations verify that the formation of three distinct types of halogen bonds can be used to tailor supramolecular spin arrays via molecular coverage and annealing temperature. Our work suggests that supramolecular self-assembly can be a promising method to engineer two-dimensional molecular spin arrays.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"2 4","pages":"333–340"},"PeriodicalIF":0.0,"publicationDate":"2022-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bf/e2/ng2c00005.PMC10125333.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9362355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Nanoscience AuPub Date : 2022-04-14DOI: 10.1021/acsnanoscienceau.1c00062
Elham Pishavar, Martina Trentini, Federica Zanotti, Francesca Camponogara, Elena Tiengo, Ilaria Zanolla, Massimo Bonora and Barbara Zavan*,
{"title":"Exosomes as Neurological Nanosized Machines","authors":"Elham Pishavar, Martina Trentini, Federica Zanotti, Francesca Camponogara, Elena Tiengo, Ilaria Zanolla, Massimo Bonora and Barbara Zavan*, ","doi":"10.1021/acsnanoscienceau.1c00062","DOIUrl":"10.1021/acsnanoscienceau.1c00062","url":null,"abstract":"<p >In the past few decades, nanomedicine research has advanced dramatically. In spite of this, traditional nanomedicine faces major obstacles, such as blood–brain barriers, low concentrations at target sites, and rapid removal from the body. Exosomes as natural extracellular vesicles contain special bioactive molecules for cell-to-cell communications and nervous tissue function, which could overcome the challenges of nanoparticles. Most recently, microRNAs, long noncoding RNA, and circulating RNA of exosomes have been appealing because of their critical effect on the molecular pathway of target cells. In this review, we have summarized the important role of exosomes of noncoding RNAs in the occurrence of brain diseases.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"2 4","pages":"284–296"},"PeriodicalIF":0.0,"publicationDate":"2022-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c6/56/ng1c00062.PMC10125174.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9357316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Nanoscience AuPub Date : 2022-04-04DOI: 10.1021/acsnanoscienceau.2c00001
Kyryl Zagorovsky, Maria Teresa Fernández-Argüelles, Diane Bona, Ashraf Mohamed Elshawadfy, Abdullah Muhammad Syed, Pranav Kadhiresan, Tony Mazzulli, Karen L. Maxwell and Warren C.W. Chan*,
{"title":"Gold Nanoparticle Smartphone Platform for Diagnosing Urinary Tract Infections","authors":"Kyryl Zagorovsky, Maria Teresa Fernández-Argüelles, Diane Bona, Ashraf Mohamed Elshawadfy, Abdullah Muhammad Syed, Pranav Kadhiresan, Tony Mazzulli, Karen L. Maxwell and Warren C.W. Chan*, ","doi":"10.1021/acsnanoscienceau.2c00001","DOIUrl":"10.1021/acsnanoscienceau.2c00001","url":null,"abstract":"<p >Current urinary tract infection (UTI) diagnostic methods are slow or provide limited information, resulting in prescribing antibiotic therapy before bacterial pathogen identification. Here, we adapted a gold nanoparticle colorimetric approach and developed a smartphone platform for UTI detection. We show the parallel identification of five major UTI pathogens at clinically relevant concentrations of 10<sup>5</sup> bacteria/mL using bacteria-specific and universal probes. We validated the diagnostic technology using 115 positive and 19 negative samples from patients with <i>Escherichia coli</i>, <i>Proteus mirabilis,</i> and <i>Klebsiella pneumoniae</i> infections. The assay successfully identified the infecting pathogen (specificity: >98% and sensitivity: 51–73%) in 3 h. Our platform is faster than culturing and can wirelessly store and transmit results at the cost of $0.38 per assay.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"2 4","pages":"324–332"},"PeriodicalIF":0.0,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9a/b0/ng2c00001.PMC9389610.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40435891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}