ACS Nanoscience Au最新文献

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Robust Nanoparticle-Derived Lubricious Antibiofilm Coating for Difficult-to-Coat Medical Devices with Intricate Geometry 坚固的纳米颗粒衍生的有色抗生素膜涂层,用于难以涂覆复杂几何形状的医疗设备
ACS Nanoscience Au Pub Date : 2022-10-28 DOI: 10.1021/acsnanoscienceau.2c00040
Hossein Yazdani-Ahmadabadi, Kai Yu, Sara Khoddami, Demian F. Felix, Han H. Yeh, Haiming D. Luo, Igor Moskalev, Qiong Wang, Rizhi Wang, Dana Grecov, Ladan Fazli, Dirk Lange* and Jayachandran N. Kizhakkedathu*, 
{"title":"Robust Nanoparticle-Derived Lubricious Antibiofilm Coating for Difficult-to-Coat Medical Devices with Intricate Geometry","authors":"Hossein Yazdani-Ahmadabadi,&nbsp;Kai Yu,&nbsp;Sara Khoddami,&nbsp;Demian F. Felix,&nbsp;Han H. Yeh,&nbsp;Haiming D. Luo,&nbsp;Igor Moskalev,&nbsp;Qiong Wang,&nbsp;Rizhi Wang,&nbsp;Dana Grecov,&nbsp;Ladan Fazli,&nbsp;Dirk Lange* and Jayachandran N. Kizhakkedathu*,&nbsp;","doi":"10.1021/acsnanoscienceau.2c00040","DOIUrl":"10.1021/acsnanoscienceau.2c00040","url":null,"abstract":"<p >A major medical device-associated complication is the biofilm-related infection post-implantation. One promising approach to prevent this is to coat already commercialized medical devices with effective antibiofilm materials. However, developing a robust high-performance antibiofilm coating on devices with a nonflat geometry remains unmet. Here, we report the development of a facile scalable nanoparticle-based antibiofilm silver composite coating with long-term activity applicable to virtually any objects including difficult-to-coat commercially available medical devices utilizing a catecholic organic–aqueous mixture. Using a screening approach, we have identified a combination of the organic–aqueous buffer mixture which alters polycatecholamine synthesis, nanoparticle formation, and stabilization, resulting in controlled deposition of in situ formed composite silver nanoparticles in the presence of an ultra-high-molecular-weight hydrophilic polymer on diverse objects irrespective of its geometry and chemistry. Methanol-mediated synthesis of polymer–silver composite nanoparticles resulted in a biocompatible lubricious coating with high mechanical durability, long-term silver release (∼90 days), complete inhibition of bacterial adhesion, and excellent killing activity against a diverse range of bacteria over the long term. Coated catheters retained their excellent activity even after exposure to harsh mechanical challenges (rubbing, twisting, and stretching) and storage conditions (&gt;3 months stirring in water). We confirmed its excellent bacteria-killing efficacy (&gt;99.999%) against difficult-to-kill bacteria (<i>Proteus mirabilis</i>) and high biocompatibility using percutaneous catheter infection mice and subcutaneous implant rat models, respectively, <i>in vivo</i>. The developed coating approach opens a new avenue to transform clinically used medical devices (e.g., urinary catheters) to highly infection-resistant devices to prevent and treat implant/device-associated infections.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/65/5c/ng2c00040.PMC9936578.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10774192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Interaction of the Staphylococcus aureus Surface Protein FnBPB with Corneodesmosin Involves Two Distinct, Extremely Strong Bonds 金黄色葡萄球菌表面蛋白FnBPB与角膜粘连蛋白的相互作用涉及两个不同的,极强的键
ACS Nanoscience Au Pub Date : 2022-10-18 DOI: 10.1021/acsnanoscienceau.2c00036
Telmo O. Paiva, Albertus Viljoen, Thaina M. da Costa, Joan A. Geoghegan* and Yves F. Dufrêne*, 
{"title":"Interaction of the Staphylococcus aureus Surface Protein FnBPB with Corneodesmosin Involves Two Distinct, Extremely Strong Bonds","authors":"Telmo O. Paiva,&nbsp;Albertus Viljoen,&nbsp;Thaina M. da Costa,&nbsp;Joan A. Geoghegan* and Yves F. Dufrêne*,&nbsp;","doi":"10.1021/acsnanoscienceau.2c00036","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.2c00036","url":null,"abstract":"<p >Attachment of <i>Staphylococcus aureus</i> to human skin corneocyte cells plays a critical role in exacerbating the severity of atopic dermatitis (AD). Pathogen-skin adhesion is mediated by bacterial cell-surface proteins called adhesins, including fibronectin-binding protein B (FnBPB). FnBPB binds to corneodesmosin (CDSN), a glycoprotein exposed on AD patient corneocytes. Using single-molecule experiments, we demonstrate that CDSN binding by FnBPB relies on a sophisticated two-site mechanism. Both sites form extremely strong bonds with binding forces of ∼1 and ∼2.5 nN albeit with faster dissociation rates than those reported for homologues of the adhesin. This previously unidentified two-binding site interaction in FnBPB illustrates its remarkable variety of adhesive functions and is of biological significance as the high strength and short bond lifetime will favor efficient skin colonization by the pathogen.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsnanoscienceau.2c00036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49768721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Importance of Metal Biotransformation in Cell Response to Metallic Nanoparticles: A Transcriptomic Meta-analysis Study 金属生物转化在细胞对金属纳米颗粒反应中的重要性:一项转录组meta分析研究
ACS Nanoscience Au Pub Date : 2022-09-30 DOI: 10.1021/acsnanoscienceau.2c00035
Alice Balfourier, Anne-Pia Marty and Florence Gazeau*, 
{"title":"Importance of Metal Biotransformation in Cell Response to Metallic Nanoparticles: A Transcriptomic Meta-analysis Study","authors":"Alice Balfourier,&nbsp;Anne-Pia Marty and Florence Gazeau*,&nbsp;","doi":"10.1021/acsnanoscienceau.2c00035","DOIUrl":"10.1021/acsnanoscienceau.2c00035","url":null,"abstract":"<p >Metallic nanoparticles are increasingly present in our environment, raising concerns on their interactions with living organisms and potential toxicity. Indeed, metallic nanoparticles release metal ions that can be toxic, bioessential, therapeutically active, or combine several of these features. However, human cell responses to different metallic nanoparticles and ions have rarely been compared so far. We propose here a meta-analysis of the transcriptomic responses of human cells to nanoparticles and ions of various metals (titanium, iron, copper, zinc, silver, cadmium, platinum, gold), in order to identify the commonalities and differences between cell responses to these compounds. This analysis revealed that the chemical properties of metals are more important than their known biological functions (i.e., essential metals, toxicity) in governing the cell transcriptome. Particularly, we evidence that the response to nanoparticles is dominated by the response to the ions they contain, and depend on the nanoparticles’ solubility. The formulation as nanoparticles impacts the cell response at lower intensity than the released ions, by altering genes related to vesicle intracellular transport and the cytoskeleton. Moreover, we put into light that several metals (i.e., copper, zinc, silver, cadmium, and gold) trigger a common cell response governed by metallothioneins, which coexist with singular signatures that are specific to a given element.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/14/ce/ng2c00035.PMC9936776.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10765032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Graphene and Beyond: Recent Advances in Two-Dimensional Materials Synthesis, Properties, and Devices 石墨烯及其以外:二维材料合成、性质和器件的最新进展
ACS Nanoscience Au Pub Date : 2022-09-16 DOI: 10.1021/acsnanoscienceau.2c00017
Yu Lei, Tianyi Zhang, Yu-Chuan Lin, Tomotaroh Granzier-Nakajima, George Bepete, Dorota A. Kowalczyk, Zhong Lin, Da Zhou, Thomas F. Schranghamer, Akhil Dodda, Amritanand Sebastian, Yifeng Chen, Yuanyue Liu, Geoffrey Pourtois, Thomas J. Kempa, Bruno Schuler, Mark T. Edmonds, Su Ying Quek, Ursula Wurstbauer, Stephen M. Wu, Nicholas R. Glavin, Saptarshi Das, Saroj Prasad Dash, Joan M. Redwing, Joshua A. Robinson* and Mauricio Terrones*, 
{"title":"Graphene and Beyond: Recent Advances in Two-Dimensional Materials Synthesis, Properties, and Devices","authors":"Yu Lei,&nbsp;Tianyi Zhang,&nbsp;Yu-Chuan Lin,&nbsp;Tomotaroh Granzier-Nakajima,&nbsp;George Bepete,&nbsp;Dorota A. Kowalczyk,&nbsp;Zhong Lin,&nbsp;Da Zhou,&nbsp;Thomas F. Schranghamer,&nbsp;Akhil Dodda,&nbsp;Amritanand Sebastian,&nbsp;Yifeng Chen,&nbsp;Yuanyue Liu,&nbsp;Geoffrey Pourtois,&nbsp;Thomas J. Kempa,&nbsp;Bruno Schuler,&nbsp;Mark T. Edmonds,&nbsp;Su Ying Quek,&nbsp;Ursula Wurstbauer,&nbsp;Stephen M. Wu,&nbsp;Nicholas R. Glavin,&nbsp;Saptarshi Das,&nbsp;Saroj Prasad Dash,&nbsp;Joan M. Redwing,&nbsp;Joshua A. Robinson* and Mauricio Terrones*,&nbsp;","doi":"10.1021/acsnanoscienceau.2c00017","DOIUrl":"10.1021/acsnanoscienceau.2c00017","url":null,"abstract":"<p >Since the isolation of graphene in 2004, two-dimensional (2D) materials research has rapidly evolved into an entire subdiscipline in the physical sciences with a wide range of emergent applications. The unique 2D structure offers an open canvas to tailor and functionalize 2D materials through layer number, defects, morphology, moiré pattern, strain, and other control knobs. Through this review, we aim to highlight the most recent discoveries in the following topics: theory-guided synthesis for enhanced control of 2D morphologies, quality, yield, as well as insights toward novel 2D materials; defect engineering to control and understand the role of various defects, including <i>in situ</i> and <i>ex situ</i> methods; and properties and applications that are related to moiré engineering, strain engineering, and artificial intelligence. Finally, we also provide our perspective on the challenges and opportunities in this fascinating field.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/20/7e/ng2c00017.PMC9782807.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9339529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
High-Performance Indium–Tin Oxide (ITO) Electrode Enabled by a Counteranion-Free Metal–Polymer Complex 由无反阴离子金属-聚合物络合物实现的高性能氧化铟锡(ITO)电极
ACS Nanoscience Au Pub Date : 2022-08-31 DOI: 10.1021/acsnanoscienceau.2c00027
Gyeongbae Park, Dongbeom Kim, Geonwoo Kim and Unyong Jeong*, 
{"title":"High-Performance Indium–Tin Oxide (ITO) Electrode Enabled by a Counteranion-Free Metal–Polymer Complex","authors":"Gyeongbae Park,&nbsp;Dongbeom Kim,&nbsp;Geonwoo Kim and Unyong Jeong*,&nbsp;","doi":"10.1021/acsnanoscienceau.2c00027","DOIUrl":"10.1021/acsnanoscienceau.2c00027","url":null,"abstract":"<p >Although multicomponent inorganic thin films (metal-oxides, -carbides, -nitrides, and -chalcogenides) have been synthesized by polymer-assisted deposition (PAD), synthesis of high-performance transparent conducting oxides (TCOs) has been rarely reported. TCO requires (i) removal of impurities, (ii) high-density oxide film, (iii) homogeneity in crystal structures and film morphology, and (iv) controllable elemental doping. This study performs a systematic investigation on preparation of stable multicomponent metal–polymer complex solutions by removing the counteranions in the solution. This study also proposes accurate acid–base titration for each metal species in order to minimize the amount of PEI, thus maximizing the density of the film. As a representative TCO, Sn-doped In<sub>2</sub>O<sub>3</sub> (ITO) films have been achieved. The ITO film has an excellent sheet resistance (24.5 Ω/sq) at 93% optical transparency, with a figure of merit of 2.1 × 10<sup>–2</sup> Ω<sup>–1</sup>, which is comparable to the best.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/58/c4/ng2c00027.PMC10125366.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9349331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Observation of the Multilayer Growth Mode in Ternary InGaAs Nanowires 三元InGaAs纳米线多层生长模式的观察
ACS Nanoscience Au Pub Date : 2022-08-30 DOI: 10.1021/acsnanoscienceau.2c00028
Robin Sjökvist*, Marcus Tornberg, Mikelis Marnauza, Daniel Jacobsson and Kimberly A. Dick, 
{"title":"Observation of the Multilayer Growth Mode in Ternary InGaAs Nanowires","authors":"Robin Sjökvist*,&nbsp;Marcus Tornberg,&nbsp;Mikelis Marnauza,&nbsp;Daniel Jacobsson and Kimberly A. Dick,&nbsp;","doi":"10.1021/acsnanoscienceau.2c00028","DOIUrl":"10.1021/acsnanoscienceau.2c00028","url":null,"abstract":"<p >Au-seeded semiconductor nanowires have classically been considered to only grow in a layer-by-layer growth mode, where individual layers nucleate and grow one at a time with an incubation step in between. Recent <i>in situ</i> investigations have shown that there are circumstances where binary semiconductor nanowires grow in a multilayer fashion, creating a stack of incomplete layers at the interface between a nanoparticle and a nanowire. In the current investigation, the growth behavior in ternary InGaAs nanowires has been analyzed <i>in situ</i>, using environmental transmission electron microscopy. The investigation has revealed that multilayer growth also occurs for ternary nanowires and appears to be more common than in the binary case. In addition, the size of the multilayer stacks observed is much larger than what has been reported previously. The investigation details the implications of multilayers for the overall growth of the nanowires, as well as the surrounding conditions under which it has manifested. We show that multilayer growth is highly dynamic, where the stack of layers regularly changes size by transporting material between the growing layers. Another observation is that multilayer growth can be initiated in conjunction with the formation of crystallographic defects and compositional changes. In addition, the role that multilayers can have in behaviors such as growth failure and kinking, sometimes observed when creating heterostructures between GaAs and InAs <i>ex situ</i>, is discussed. The prevalence of multilayer growth in this ternary material system implies that, in order to fully understand and accurately predict the growth of nanowires of complex composition and structure, multilayer growth has to be considered.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9711182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Homogeneous Nanoparticles of Multimetallic Phosphides via Precursor Tuning: Ternary and Quaternary M2P Phases (M = Fe, Co, Ni) 通过前体调节的多金属磷酸盐的均匀纳米颗粒:三元和四元M2P相(M=Fe,Co,Ni)
ACS Nanoscience Au Pub Date : 2022-08-09 DOI: 10.1021/acsnanoscienceau.2c00025
Tepora Su’a, Mikaylah N. Poli and Stephanie L. Brock*, 
{"title":"Homogeneous Nanoparticles of Multimetallic Phosphides via Precursor Tuning: Ternary and Quaternary M2P Phases (M = Fe, Co, Ni)","authors":"Tepora Su’a,&nbsp;Mikaylah N. Poli and Stephanie L. Brock*,&nbsp;","doi":"10.1021/acsnanoscienceau.2c00025","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.2c00025","url":null,"abstract":"<p >Transition metal phosphides (TMPs) are a highly investigated class of nanomaterials due to their unique magnetic and catalytic properties. Although robust and reproducible synthetic routes to narrow polydispersity monometallic phosphide nanoparticles (M<sub>2</sub>P; M = Fe, Co, Ni) have been established, the preparation of multimetallic nanoparticle phases (M<sub>2–<i>x</i></sub>M′<sub><i>x</i></sub>P; M, M′ = Fe, Co, Ni) remains a significant challenge. Colloidal syntheses employ zero-valent metal carbonyl or multivalent acetylacetonate salt precursors in combination with trioctylphosphine as the source of phosphorus, oleylamine as the reducing agent, and additional solvents such as octadecene or octyl ether as “noncoordinating” cosolvents. Understanding how these different metal precursors behave in identical reaction environments is critical to assessing the role the relative reactivity of the metal precursor plays in synthesizing complex, homogeneous multimetallic TMP phases. In this study, phosphorus incorporation as a function of temperature and time was evaluated to probe how the relative rate of phosphidation of organometallic carbonyl and acetylacetonate salt precursors influences the homogeneous formation of bimetallic phosphide phases (M<sub>2–<i>x</i></sub>M′<sub><i>x</i></sub>P; M, M′ = Fe, Co, Ni). From the relative rate of phosphidation studies, we found that where reactivity with TOP for the various metal precursors differs significantly, prealloying steps are necessary to isolate the desired bimetallic phosphide phase. These insights were then translated to establish streamlined synthetic protocols for the formation of new trimetallic Fe<sub>2–<i>x</i>–<i>y</i></sub>Ni<sub><i>x</i></sub>Co<sub><i>y</i></sub>P phases.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsnanoscienceau.2c00025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71557350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Guiding the High-Yield Synthesis of NHC-Ligated Gold Nanoclusters by 19F NMR Spectroscopy 用19F NMR光谱指导高产率合成NHC连接的金纳米团簇
ACS Nanoscience Au Pub Date : 2022-08-09 DOI: 10.1021/acsnanoscienceau.2c00026
Hui Shen, Xiongkai Tang, Qingyuan Wu, Yuhao Zhang, Chuxin Ma, Zhen Xu, Boon K. Teo and Nanfeng Zheng*, 
{"title":"Guiding the High-Yield Synthesis of NHC-Ligated Gold Nanoclusters by 19F NMR Spectroscopy","authors":"Hui Shen,&nbsp;Xiongkai Tang,&nbsp;Qingyuan Wu,&nbsp;Yuhao Zhang,&nbsp;Chuxin Ma,&nbsp;Zhen Xu,&nbsp;Boon K. Teo and Nanfeng Zheng*,&nbsp;","doi":"10.1021/acsnanoscienceau.2c00026","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.2c00026","url":null,"abstract":"<p >Optimizing the synthesis of atomically precise metal nanoclusters by virtue of molecular tools is highly desirable but quite challenging. Herein we report how <sup>19</sup>F NMR spectroscopy can be used to guide the high-yield synthesis of N-heterocyclic carbene (NHC)-stabilized gold nanoclusters. In spite of little difference, <sup>19</sup>F NMR signals of fluoro-incorporated NHCs (<sup>F</sup>NHC) are highly sensitive to the tiny change in their surrounding chemical environments with different N-substituents, metals, or anions, thus providing a convenient strategy to discriminate species in reaction mixtures. By using <sup>19</sup>F NMR, we first disclosed that the one-pot reduction of <sup>F</sup>NHC-Au-X (X is halide) yields multiple compounds, including cluster compounds and also a large amount of highly stable [Au(<sup>F</sup>NHC)<sub>2</sub>]<sup>+</sup> byproduct. The detailed quantitative <sup>19</sup>F NMR analyses over the reductive synthesis of NHC-stabilized Au nanoclusters reveal that the formation of the di-NHC complex is deleterious to the high-yield synthesis of NHC-stabilized Au nanoclusters. With the understanding, the reaction kinetic was then slowed by controlling the reduction rate to achieve the high yield of a [Au<sub>24</sub>(<sup>F</sup>NHC)<sub>14</sub>X<sub>2</sub>H<sub>3</sub>]<sup>3+</sup> nanocluster with a unique structure. The strategy demonstrated in this work is expected to provide an effective tool to guide the high-yield synthesis of organic ligand-stabilized metal nanoclusters.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsnanoscienceau.2c00026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71557351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Influence of Cell Type on the Efficacy of Plasmonic Photothermal Therapy 细胞类型对等离子体光热治疗效果的影响
ACS Nanoscience Au Pub Date : 2022-07-27 DOI: 10.1021/acsnanoscienceau.2c00023
Helena Villuendas, Clara Vilches* and Romain Quidant*, 
{"title":"Influence of Cell Type on the Efficacy of Plasmonic Photothermal Therapy","authors":"Helena Villuendas,&nbsp;Clara Vilches* and Romain Quidant*,&nbsp;","doi":"10.1021/acsnanoscienceau.2c00023","DOIUrl":"10.1021/acsnanoscienceau.2c00023","url":null,"abstract":"<p >In plasmonic photothermal therapy (PPTT), illuminated gold nanoparticles are locally heated to produce selective damage in cells. While PPTT is expected to strongly depend on the cell line, available data are sparse and critical parameters remain unclear. To elucidate this pivotal aspect, we present a systematic study of diseased and nondiseased cells from different tissues to evaluate cytotoxicity, uptake of gold nanorods (AuNRs), and viability after PPTT. We identified differences in uptake and toxicity between cell types, linking AuNR concentrations to toxicity. Furthermore, the cell death mechanism is shown to depend on the intensity of the irradiated light and hence the temperature increase. Importantly, the data also underline the need to monitor cell death at different time points. Our work contributes to the definition of systematic protocols with appropriate controls to fully comprehend the effects of PPTT and build meaningful and reproducible data sets, key to translate PPTT to clinical settings.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/15/24/ng2c00023.PMC10125312.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9726273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Increase Your Impact: Writing Tips to Reach a Broader Audience 增加你的影响力:写作技巧,以达到更广泛的受众
ACS Nanoscience Au Pub Date : 2022-07-26 DOI: 10.1021/acsnanoscienceau.2c00030
Raymond E. Schaak*, 
{"title":"Increase Your Impact: Writing Tips to Reach a Broader Audience","authors":"Raymond E. Schaak*,&nbsp;","doi":"10.1021/acsnanoscienceau.2c00030","DOIUrl":"10.1021/acsnanoscienceau.2c00030","url":null,"abstract":"better, as it mentions that the properties are optical and that different particle sizes are included. The third Title, however, incorporates all of these descriptors (with even greater specificity) while also being more intriguing. The third Title is most likely to appeal to a larger number of readers. Abstract. The Abstract provides a summary of the article and is often limited to 150 − 250 words. While this may seem like a lot of text, it is actually quite short when considering all aspects of an article that could be summarized! Authors sometimes focus almost exclusively on the technical content so that all of the results are adequately described. It is always important to include the key results in the Abstract, of course, but if one of the goals of a paper is also to appeal to a broader audience, it is important to draw in additional readers by providing context that specialists in the field may not need. Including a one-line","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0c/bc/ng2c00030.PMC10114862.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9414259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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