International Journal of Cardiology Cardiovascular Risk and Prevention最新文献

{"title":"The use of polypills in cardiovascular disease management: Benefits vs challenges","authors":"Yamaan Adil, Shanezehra Siddiqui","doi":"10.1016/j.ijcrp.2024.200313","DOIUrl":"10.1016/j.ijcrp.2024.200313","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"22 ","pages":"Article 200313"},"PeriodicalIF":1.9,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000783/pdfft?md5=8c09cc71982f7fa6735ed6b8167b09b4&pid=1-s2.0-S2772487524000783-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141703046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of stress hormones and the risk of cardiovascular diseases systematic review and meta-analysis","authors":"Szu-Ying Tsai ,&nbsp;Jui-Yun Hsu ,&nbsp;Ching-Huang Lin ,&nbsp;Yen-Chun Kuo ,&nbsp;Chi-Han Chen ,&nbsp;Hsing-Yuan Chen ,&nbsp;Shu-Jung Liu ,&nbsp;Kuo-Liong Chien","doi":"10.1016/j.ijcrp.2024.200305","DOIUrl":"10.1016/j.ijcrp.2024.200305","url":null,"abstract":"<div><h3>Background</h3><p>The roles of endogenous stress hormones (norepinephrine, epinephrine, and cortisol) in cardiovascular diseases have been discussed. However, the higher versus lower level of stress hormones in relation to cardiovascular risks remained uncertain.</p></div><div><h3>Methods</h3><p>We searched databases from their inception to 31, March 2023. We conducted a meta-analysis to estimate the effect of higher to lower level of stress hormones with random effect model. Subgroup and meta-regression analysis were done to clarify the heterogeneity.</p></div><div><h3>Results</h3><p>In total, 33 studies involving 43641 participants were included. With regard to cardiovascular disease risks, a higher risk for individuals with higher level of all stress hormones (risk ratio (RR), 1.63; 95 % Confidence intervals (CIs): 1.36, 1.97) was noted compared with lower level of all stress hormones. The meta-regression showed that as the follow-up year increased per year, the impact of higher level of all stress hormones on the risk of cardiovascular disease declined significantly (RR, −0.09; 95 % CIs: 0.15, −0.03, p = 0.006). A significantly higher risk of cardiovascular diseases for individuals with higher level of norepinephrine (RR, 1.68; 95 % CIs: 1.37, 2.06), with higher level of epinephrine (RR, 1.58; 95 % CIs: 1.10, 2.26), and with higher level of cortisol (RR, 1.60; 95 % CIs: 1.04, 2.26) were noted compared with a lower level of each stress hormone.</p></div><div><h3>Conclusion</h3><p>Higher levels of stress hormones were significantly associated with higher risks of cardiovascular diseases compared with lower levels of stress hormones.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200305"},"PeriodicalIF":1.9,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000709/pdfft?md5=248a134c730ba9ff34f11283f5a5d3d0&pid=1-s2.0-S2772487524000709-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141689552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relative impact of components of high residual risk on the long-term prognosis after AMI","authors":"Gian Francesco Mureddu ,&nbsp;Paola D'Errigo ,&nbsp;Stefano Rosato ,&nbsp;Pompilio Faggiano ,&nbsp;Gabriella Badoni ,&nbsp;Roberto Ceravolo ,&nbsp;Vito Altamura ,&nbsp;Mirko Di Martino ,&nbsp;Marco Ambrosetti ,&nbsp;Fabrizio Oliva ,&nbsp;Paola Ciccarelli ,&nbsp;Giovanni Baglio","doi":"10.1016/j.ijcrp.2024.200310","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200310","url":null,"abstract":"<div><h3>Background</h3><p>The reduction in long-term mortality after acute myocardial infarction (AMI) is less pronounced than that of in-hospital mortality among patients with AMI complicated by heart failure (HF) and/or in those with a high residual thrombotic risk (HTR).</p></div><div><h3>Aim</h3><p>To investigate the relative prognostic significance of HTR and HF in AMI survivors.</p></div><div><h3>Methods</h3><p>This retrospective cohort study enrolled patients admitted for AMI in 2014–2015 in all Italian hospitals. HTR was defined as at least one of the following conditions: previous AMI, ischemic stroke or other vascular disease, type 2 diabetes, renal failure. Patients were classified into four categories: uncomplicated AMI; AMI with HTR; AMI with HF and AMI with both HTR and HF (HTR + HF). Cox proportional hazard model was used to evaluate the impact of HTR, HF and HTR + HF on the 5-year prognosis. A time-varying coefficient analysis was performed to estimate the 5-year trend of HR for major averse cardiac and cerebrovascular events (MACCE).</p></div><div><h3>Results</h3><p>a total of 174.869 AMI events were identified. The adjusted 5-year HR for MACCE was 1.74 (p &lt; 0.0001) and 1.75 (p &lt; 0.0001) in HTR and HF patients vs uncomplicated patients, respectively. The coexistence of HTR and HF furtherly increased the risk of MACCE (HR = 2.43, p &lt; 0.0001) over the first 3 years after AMI.</p></div><div><h3>Conclusion</h3><p>Either HRT and HF confer an increased 5-year hazard of MACCE after AMI. The coexistence of HTR and HF doubled the overall 5-year risk of MACCE after AMI.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"22 ","pages":"Article 200310"},"PeriodicalIF":1.9,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000758/pdfft?md5=631ba80830f06f4b9b7beffcfd155973&pid=1-s2.0-S2772487524000758-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141596166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Impact of heart failure severity and major bleeding events after percutaneous coronary intervention on subsequent major adverse cardiac events” [Int. J. Cardiol. Cardiovasc. Risk and Prev. 2023 Jun 25:18:200193]","authors":"So Ikebe ,&nbsp;Masanobu Ishii ,&nbsp;Yasuhiro Otsuka ,&nbsp;Taishi Nakamura ,&nbsp;Kenichi Tsujita ,&nbsp;Tetsuya Matoba ,&nbsp;Takahide Kohro ,&nbsp;Yusuke Oba ,&nbsp;Tomoyuki Kabutoya ,&nbsp;Yasushi Imai ,&nbsp;Kazuomi Kario ,&nbsp;Arihiro Kiyosue ,&nbsp;Yoshiko Mizuno ,&nbsp;Kotaro Nochioka ,&nbsp;Masaharu Nakayama ,&nbsp;Takamasa Iwai ,&nbsp;Yoshihiro Miyamoto ,&nbsp;Hisahiko Sato ,&nbsp;Naoyuki Akashi ,&nbsp;Hideo Fujita ,&nbsp;Ryozo Nagai","doi":"10.1016/j.ijcrp.2024.200304","DOIUrl":"10.1016/j.ijcrp.2024.200304","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"22 ","pages":"Article 200304"},"PeriodicalIF":1.9,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000692/pdfft?md5=443f6f9998071e71cb1e4d4ec231de9f&pid=1-s2.0-S2772487524000692-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141708366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of uncontrolled hypertension among type 2 diabetic patients in Ethiopia: Multicenter cross-sectional study","authors":"Leteslase Hagos Gebreziher ,&nbsp;Melak Gedamu Beyene ,&nbsp;Desalew Mekonnen ,&nbsp;Assefa Mulu Baye","doi":"10.1016/j.ijcrp.2024.200308","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200308","url":null,"abstract":"<div><h3>Background</h3><p>Hypertension (HTN) is the commonest comorbidity among people with type 2 diabetes mellitus (T2DM). Uncontrolled HTN is a major risk factor for several diseases. This study aimed to determine the magnitude and predictors of uncontrolled HTN among T2DM patients.</p></div><div><h3>Methods</h3><p>A multicenter cross-sectional study was conducted among hypertensive from September 19, 2021 to 17 December 2021. Logistic regression model was conducted to identify predictors of uncontrolled HTN. Uncontrolled BP was defined by systolic BP of ≥130 mmHg and/or diastolic BP of ≥80 mmHg.</p></div><div><h3>Results</h3><p>A total of 400 study participants were included in the analysis, of which 208 (52 %) were females. The mean age of the participants was 60.6 with SD of 10.25 years. The target blood pressure achieved in 156 (39 %) of participants. Age, non-adherence to medications (OR; 2.0; 95 % CI: 1.1–3.6; P = 0.02), not reducing dietary salt (OR; 2.4; 95 % CI: 1.5–3.8; P &lt; 0.001), uncontrolled blood sugar (OR:2.4; 95 % CI: 1.4–4.3; P = 0.002), obesity (OR; 3.2; 95 % CI:1.2–8.7; P = 0.03) and having every fourth month and above follow up (OR; 2.3; 95 % CI:1.3–4.3; P = 0.049) were significantly associated with uncontrolled blood pressure.</p></div><div><h3>Conclusions</h3><p>The target blood pressure achieved was suboptimal. Hypertensive T2DM patients who were younger, non-adherent to their medications, not reducing dietary salt, obese, with a longer frequency of follow-up, and with poor glycemic control were more likely to have uncontrolled blood pressure. Improving medication adherence, dietary salt reduction, frequent follow up and glycemic control are important to control hypertension.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"22 ","pages":"Article 200308"},"PeriodicalIF":1.9,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000734/pdfft?md5=5bc5eb22de402c6c95605223cedb6c56&pid=1-s2.0-S2772487524000734-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141542928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal trends in acute decompensated heart failure outcomes: A single-center 11-year retrospective analysis","authors":"Gil Marcus ,&nbsp;Mohammad Najjar ,&nbsp;Antionette Monayer ,&nbsp;Ady Orbach ,&nbsp;Shiri L. Maymon ,&nbsp;Eran Kalmanovich ,&nbsp;Gil Moravsky ,&nbsp;Avishay Grupper ,&nbsp;Shmuel Fuchs ,&nbsp;Sa'ar Minha","doi":"10.1016/j.ijcrp.2024.200306","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200306","url":null,"abstract":"<div><h3>Background</h3><p>Acute Decompensated Heart Failure (ADHF) is associated with frequent hospitalizations, posing a significant health and economic burden globally. Despite advancements in heart failure management, studies delineating temporal trends in ADHF outcomes are sparse.</p><p>Methods: in this retrospective analysis, ADHF patients admitted to Shamir Medical Center from 2007 to 2017 were categorized into two cohorts: early (2007–2011) and recent (2012–2017). Clinical characteristics, in-hospital interventions, and outcomes were compared. Survival analysis was performed using Kaplan-Meier methods with log-rank tests.</p></div><div><h3>Results</h3><p>8332 admitted patients were analyzed, 4366 (52.4 %) in the early period, and 3966 (47.6 %) in the recent period. In the recent cohort, ischemic heart disease decreased significantly (from 45.2 % to 34.7 %), while hypertension and smoking rates increased. Additionally, a significant increase in coronary artery bypass grafting (from 0.8 % to 3.5 %) and beta-blockers prescription (from 45.5 % to 63.4 %) post-discharge was observed. However, no substantial improvement in in-hospital mortality (8.9 % in early vs. 8.0 % in recent), 30-day (3.2 % in early vs. 3.1 % in recent), 1-year (23.3 % in early vs. 23.8 % in recent), or 5-year survival rates was noted between cohorts. A subset analysis of patients admitted to cardiology departments showed a significant reduction in in-hospital mortality in the recent cohort (12.3 % in early vs. 6.3 % in recent), yet without a corresponding long-term survival benefit.</p></div><div><h3>Conclusions</h3><p>Advancements in heart failure management over the 11-year study period did not demonstrate an improvement in clinical outcomes for ADHF patients, highlighting the challenge of translating advancements in the medical care of ADHF patients into long-term survival benefits.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"22 ","pages":"Article 200306"},"PeriodicalIF":1.9,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000710/pdfft?md5=d39564b9ef9ea497e9696c75470623e1&pid=1-s2.0-S2772487524000710-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141542871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct circulating cytokine levels in patients with angiography-proven coronary artery disease compared to disease-free controls","authors":"Eveliina Maaniitty ,&nbsp;Sami Sinisilta ,&nbsp;Juho Jalkanen ,&nbsp;Tuija Vasankari ,&nbsp;Fausto Biancari ,&nbsp;Jarmo Gunn ,&nbsp;Sirpa Jalkanen ,&nbsp;K.E. Juhani Airaksinen ,&nbsp;Maija Hollmén ,&nbsp;Tuomas Kiviniemi","doi":"10.1016/j.ijcrp.2024.200307","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200307","url":null,"abstract":"<div><h3>Background</h3><p>Systemic inflammation has a critical role in the development of symptomatic coronary artery disease (CAD). Identification of inflammatory pathways may provide a platform for novel therapeutic approaches. We sought to determine whether there are differences in circulating cytokine profiles between patients with CAD and disease-free controls as well as according to the severity of the disease.</p></div><div><h3>Methods</h3><p>Case-control study's population consisted of 452 patients who underwent diagnostic invasive coronary angiography due to clinical indications. We measured the serum concentrations of 48 circulating cytokines. Extent of CAD was assessed using the SYNTAX Score in 116 patients. Cytokine differences between groups were tested using Mann-Whitney <em>U</em> test and associations with CAD were explored using a logistic regression model.</p></div><div><h3>Results</h3><p>Overall, 310 patients had angiographically verified CAD whereas 142 had no angiographically-detected coronary atherosclerosis. In multivariable logistic regression models adjusted for age, sex, hypertension, atrial fibrillation, history of smoking and treatment for diabetes and hyperlipidemia, increased levels of interleukin 9 (OR 1.359, 95%CI 1.046–1.766, <em>p</em> = 0.022), IL-17 (1.491, 95%CI 1.115–1.994, <em>p</em> = 0.007) and tumor necrosis factor alpha (TNF-α) (OR 1.440, 95%CI 1.089–1.904, <em>p</em> = 0.011) were independently associated with CAD. Patients with SYNTAX Score&gt;22 had increased levels of stromal cell-derived factor 1 alfa (SDF-1α), beta-nerve growth factor (β-NGF), IL-3 and decreased level of IL-17 compared to those with score ≤22 when adjusted for smoking and use of beta-blockers.</p></div><div><h3>Conclusions</h3><p>Patients with CAD have distinct circulating cytokine profiles compared to disease-free controls. Distinct cytokines may have pivotal roles at different stages of coronary atherosclerosis. <span>ClinicalTrials.gov</span><svg><path></path></svg> Identifier: NCT03444259 (<span>https://clinicaltrials.gov/study/NCT03444259</span><svg><path></path></svg>).</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"22 ","pages":"Article 200307"},"PeriodicalIF":1.9,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000722/pdfft?md5=3c2869e4ce91881c6183f5789fa858b5&pid=1-s2.0-S2772487524000722-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141596165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial infarction & C-reactive protein levels among Mexican adults with arthritis: Findings from the Mexican Health and Aging Study","authors":"Alan F. Villarreal Rizzo ,&nbsp;Elizabeth I. Davis ,&nbsp;Wissam I. Khalife ,&nbsp;M. Kristen Peek ,&nbsp;Brian Downer","doi":"10.1016/j.ijcrp.2024.200309","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200309","url":null,"abstract":"<div><h3>Background</h3><p>Studies of adult populations in high-income countries have found an association between arthritis and myocardial infarction (MI) due to high levels of systemic inflammation. Our objectives were to examine the association between arthritis and MI among Mexican adults and to assess the mediating effect of C-reactive protein (CRP) on this association.</p></div><div><h3>Methods</h3><p>Data came from the 2012, 2015, and 2018 observation waves of the Mexican Health and Aging Study. Our sample included 11,707 participants aged 50 and older with no prior MI before 2012. We used self-reported information for arthritis, joint pain, medication use, and limitations to daily activities in 2012. Logistic regression was used to model the association between arthritis and self-reported MI in 2015 or 2018. We used a sub-sample of 1602 participants to assess the mediating effect of CRP.</p></div><div><h3>Results</h3><p>In the full sample, participants with arthritis that limited their daily activities had higher odds of MI than participants with no arthritis (OR = 1.40; 95 % CI = 1.04–1.88). In the sub-sample, arthritis that limited daily activities was associated with higher mean CRP (5.2 mg/dL; 95 % CI = 4.10–6.21) than arthritis with no limitations (3.5 mg/dL; 95 % CI = 2.93–4.01). However, CRP levels had a small mediating effect, and the relationship between arthritis with physical limitations and MI remained statistically significant.</p></div><div><h3>Conclusion</h3><p>Mexican adults with arthritis that limits their daily activities are at an increased risk for MI. Continued research is needed to identify factors that contribute to this increased risk.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"22 ","pages":"Article 200309"},"PeriodicalIF":1.9,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000746/pdfft?md5=16b93f4385fc33b3cd0c511b237d8b16&pid=1-s2.0-S2772487524000746-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141542929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific associations between prolonged serum uric acid levels and risk of major adverse cardiovascular events","authors":"Hsiu-Ting Chien ,&nbsp;Yu-Wen Lin ,&nbsp;Li-Jiuan Shen ,&nbsp;Song-Chou Hsieh ,&nbsp;Lian-Yu Lin ,&nbsp;Yi-An Chen ,&nbsp;Fang-Ju Lin","doi":"10.1016/j.ijcrp.2024.200302","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200302","url":null,"abstract":"<div><h3>Background</h3><p>While hyperuricemia has been correlated with cardiovascular (CV) diseases, further evidence is required to evaluate the implications of stable serum uric acid (sUA) levels, especially concerning low sUA. This study aimed to investigate prolonged stable sUA levels and CV events/mortality.</p></div><div><h3>Methods</h3><p>We conducted a retrospective cohort study at a medical center using electronic medical records linked with the national claims database. Patients with at least two sUA measurements, with intervals ranging from 6 months to 4 years, were included. The mean of the first two eligible sUA measurements were analyzed, stratified by sex. Outcomes of interest comprised major adverse cardiovascular events (MACE), heart failure hospitalization, CV and all-cause mortality.</p></div><div><h3>Results</h3><p>This study included 33,096 patients (follow-up: men 6.6 years, women 6.4 years). After multivariable adjustment, cubic spline models showed that long-term high sUA levels were consistently associated with a higher risk of MACE, heart failure hospitalization, CV and all-cause mortality. A U-shaped association was observed between sUA levels and all-cause mortality in both sexes and between sUA levels and CV mortality in women. The impact of sUA, especially lower levels, on CV events and mortality was more pronounced in women than in men.</p></div><div><h3>Conclusion</h3><p>Long-term high sUA levels are consistently associated with increased risk of CV events and mortality. A U-shaped association between sUA levels and all-cause mortality was observed in both men and women and was pronounced in women. The findings underscore the importance of considering sUA levels, especially in women, when assessing CV risk.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"22 ","pages":"Article 200302"},"PeriodicalIF":1.9,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000679/pdfft?md5=ede070c0ce1ee0a2af145d4bde585efc&pid=1-s2.0-S2772487524000679-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141480887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of overweight and obesity with coronary risk factors and the presence of multivessel disease in patients with obstructive coronary artery disease – A nationwide registry study","authors":"Maria Hang Xuan Pham ,&nbsp;Daniel Mølager Christensen ,&nbsp;Andreas Torp Kristensen ,&nbsp;Charlotte Middelfart ,&nbsp;Caroline Sindet-Pedersen ,&nbsp;Gunnar Gislason ,&nbsp;Niels Thue Olsen","doi":"10.1016/j.ijcrp.2024.200299","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200299","url":null,"abstract":"<div><h3>Background</h3><p>The growing prevalence of obesity is expected to increase the burden of coronary artery disease. This study examined the prevalence of overweight and obesity in patients with a first-time diagnosis of obstructive coronary artery disease in a contemporary population. The association of body-mass-index (BMI) with age, traditional risk factors, and the presence of multivessel disease were explored.</p></div><div><h3>Methods and results</h3><p>Using the Danish Nationwide registries, we identified 49,733 patients with a first-time diagnosis of obstructive coronary artery disease in the period 2012–2018. We investigated the association between BMI and coronary risk factors by multivariate logistic regression. Mean age was 65.8 ± 11.8 years, mean BMI was 27.5 kg/m² ± 7.2, and 73.2 % were men. 66.3 % had a BMI ≥25 kg/m² and 1.3 % were underweight. The prevalence of patients with BMI ≥25 kg/m² decreased with increasing age and was 69 % in patients &lt;50 year vs. 46.2 % in patients ≥80 years (<em>p &lt; 0.001</em>). In all age groups, higher odds of BMI ≥25 kg/m² were observed in males, former smokers, and patients with hypertension. In multivariate logistic regression, BMI ≥25 kg/m² was not associated with presence of multivessel disease <em>(p = 0.74)</em>.</p></div><div><h3>Conclusion</h3><p>In this large, nationwide study, 66.3 % of patients with first time diagnosis of obstructive coronary disease had BMI ≥25 kg/m². Young patients had higher BMI and were more likely to be current smokers. Overweight or obesity was independently associated with the presence of diabetes and hypertension. BMI ≥25 kg/m² was not independently associated with the presence of multivessel disease.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"22 ","pages":"Article 200299"},"PeriodicalIF":1.9,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000643/pdfft?md5=85024e12e26730f89f6d0708190e1d1b&pid=1-s2.0-S2772487524000643-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141434189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}