中国西南地区老年人心血管疾病连续体中不断演变的多病模式：一项纵向队列研究

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

International Journal of Cardiology Cardiovascular Risk and Prevention Pub Date : 2025-05-01 DOI:10.1016/j.ijcrp.2025.200417

Xiaoya Qi , Ziyue Zhang , Meng Jia , Yangping Zhang , Shuang Feng , Ruixue Bai , Siyao Wang , Jinning Mao , Shu Su

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引用次数: 0

摘要

背景：中国老年心血管疾病患者的多病进展尚不清楚。本研究调查了该人群中心血管疾病连续体（CVDC）相关多病模式的纵向演变。方法观察性研究分析2010年1月1日至2022年12月31日在重庆医科大学第二附属医院定期体检的65岁及以上老年人的体检报告。研究了CVDC的多重发病模式。基于Spearman相关分析构建多病网络，可视化性别差异的演变。计算了CVDC与非CVDC发生多重发病的比值比（ORs）。通过生存分析和多变量cox比例风险回归来估计累积概率并确定多病的危险因素。结果共纳入10052例符合条件的个体，其中1835例（18.26%）在基线时诊断为CVDC。在初始（男性= 0.208，女性= 0.244）和最终（男性= 0.312，女性= 0.248）检查中，CVDC与肥胖相关疾病之间存在最强的正相关。生存分析显示，随着时间的推移，高血压、血脂异常和动脉粥样硬化等代谢性疾病多重发病的累积概率增加；相应的调整后hr （95% ci）分别为1.322（1.219,1.433）、1.553（1.413,1.706）、1.460（1.361,1.567）。心血管疾病相关多重发病风险的增加主要归因于高盐饮食习惯（AHR = 1.336, 95% CI: 1.239, 1.411）。结论随着时间的推移，与CVDC相关的多种疾病模式和疾病网络变得越来越复杂，尤其是代谢性疾病。高盐饮食显著增加cdc相关多病的风险。

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Evolving multimorbidity patterns among ageing adults with cardiovascular disease continuum in Southwest China: A longitudinal cohort study

Background

The progression of multimorbidity in Chinese ageing adults with cardiovascular diseases remains inadequately understood. This study investigates the longitudinal evolution of cardiovascular disease continuum (CVDC)-related multimorbidity patterns in this population.

Methods

The observational study analyzed medical examination reports from individuals aged 65 and older who underwent regular physical examinations during January 1, 2010 to December 31, 2022 at the Second Affiliated Hospital of Chongqing Medical University. Multimorbidity patterns of CVDC were examined. The construction of the multimorbidity network was based on Spearman correlation analyses to visualize the evolution of gender differences. Odds ratios (ORs) for developing multimorbidity in CVDC in compared to non-CVDC were calculated. Survival analysis and multivariate cox proportional hazards regression were performed to estimate the cumulative probability and identify risk factors for multimorbidity.

Results

A total of 10,052 eligible individuals with 1835 (18.26 %) diagnosed with CVDC at baseline were included. The strongest positive correlation was observed between CVDC and obesity related diseases during both the initial (r_males = 0.208, r_females = 0.244) and final (r_males = 0.312, r_females = 0.248) examinations. Survival analysis revealed that the cumulative probability of multimorbidity of metabolic diseases in hypertension, dyslipidemia and atherosclerosis had increased over time; the corresponding adjusted HRs (95 % CIs) were 1.322 (1.219, 1.433), 1.553 (1.413, 1.706), and 1.460 (1.361, 1.567), respectively. The increasing risks of CVDC-related multimorbidity were primarily attributable to salty dietary habit (AHR = 1.336, 95 % CI: 1.239, 1.411).

Conclusions

Multimorbidity patterns and disease networks associated with CVDC have become more complex over time, especially with metabolic diseases. A high-salty diet significantly increased the risk of CVDC-related multimorbidity.

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来源期刊

International Journal of Cardiology Cardiovascular Risk and Prevention Cardiology and Cardiovascular Medicine

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

72 days