International Journal of Cardiology Cardiovascular Risk and Prevention最新文献

{"title":"Associations of low-density lipoprotein cholesterol and hemoglobin A1C with cardiovascular events and mortality in breast and prostate cancer patients","authors":"Yen-Chou Chen ,&nbsp;Jhih-Yuan Lu ,&nbsp;Chun-Yao Huang ,&nbsp;Yu-Hsuan Joni Shao","doi":"10.1016/j.ijcrp.2025.200468","DOIUrl":"10.1016/j.ijcrp.2025.200468","url":null,"abstract":"<div><h3>Background</h3><div>Cardiovascular disease is a major non-cancer cause of morbidity in cancer patients. Low-density lipoprotein cholesterol (LDL) and hemoglobin A1C (HbA1C) are shared risk factors for cancer and cardiovascular disease. However, optimal management for these factors in cancer patients remains unclear.</div></div><div><h3>Methods</h3><div>This retrospective cohort study investigated associations between LDL and HbA1C levels with major cardiovascular events, all-cause mortality, and cancer recurrence in patients with breast and prostate cancer. The analysis included 832 breast cancer and 593 prostate cancer patients from the Taipei Medical University Clinical Research Database (2011–2020), using Cox proportional hazard models with time-dependent covariates. The findings were validated using the TriNetX research network, using a propensity score matching method.</div></div><div><h3>Results</h3><div>Elevated LDL levels (≥130 mg/dL) were associated with a higher risk of major cardiovascular events, particularly in prostate cancer patients. A U-shaped association was observed between LDL levels and all-cause mortality, with the lowest risk in the 100–129 mg/dL range (propensity score matching risk ratios for all-cause mortality with LDL ≥130 mg/dL: 1.05 [95 % confidence interval 1.02–1.09] for breast cancer and 1.08 [95 % confidence interval 1.04–1.12] for prostate cancer). Elevated levels of HbA1C (≥6 %) were also associated with increased risks of cardiovascular events, with a potential U-shaped association with mortality.</div></div><div><h3>Conclusion</h3><div>Higher levels of LDL and HbA1C are associated with increased risks of cardiovascular events and all-cause mortality in breast and prostate cancer patients, supporting current cardio-oncologic guidelines in cancer survivors.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200468"},"PeriodicalIF":1.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mislabelling, misclassification, misinterpretation: A critical appraisal of mortality trends in Alzheimer's and ischemic heart disease","authors":"Hammad Jehangir","doi":"10.1016/j.ijcrp.2025.200464","DOIUrl":"10.1016/j.ijcrp.2025.200464","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200464"},"PeriodicalIF":1.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic impact of angiography-derived index of microcirculatory resistance in patients with dilated cardiomyopathy","authors":"Takayuki Kawamura,&nbsp;Koichiro Matsumura,&nbsp;Haruka Minami,&nbsp;Nobuhiro Yamada,&nbsp;Shohei Hakozaki,&nbsp;Yohei Funauchi,&nbsp;Naoko Soejima,&nbsp;Mana Okune,&nbsp;Kazuyoshi Kakehi,&nbsp;Masafumi Ueno,&nbsp;Gaku Nakazawa","doi":"10.1016/j.ijcrp.2025.200467","DOIUrl":"10.1016/j.ijcrp.2025.200467","url":null,"abstract":"<div><h3>Background</h3><div>Coronary microvascular dysfunction (CMD) has recently been associated with adverse cardiovascular events in patients with heart failure. We investigated the relationship between late gadolinium enhancement (LGE) and CMD, as well as the prognostic value of CMD in predicting long-term prognosis in patients with dilated cardiomyopathy (DCM).</div></div><div><h3>Methods</h3><div>Patients with DCM who underwent both cardiac magnetic resonance imaging and coronary angiography were consecutively enrolled. CMD was evaluated using the angiography-derived index of microcirculatory resistance (angio-IMR). The primary endpoint was composite endpoints of all-cause mortality or heart failure hospitalization within 3 years.</div></div><div><h3>Results</h3><div>Among 108 patients (median age, 64 years; women, 27 %), 18 % (19 patients) experienced composite endpoints. The median angio-IMR was 45 U, and LGE was identified in 23 %. Angio-IMR was significantly higher in patients with LGE than in those without LGE. When patients were stratified based on the combined presence of LGE and angio-IMR, significant differences in composite endpoints were observed among the three groups (LGE absence and low angio-IMR: 4.3 % vs. LGE presence or high angio-IMR: 22.2 % vs. LGE presence and high angio-IMR: 41.2 %, log-rank test p &lt; 0.01). In multivariable Cox proportional hazards model for composite endpoints, LGE presence and angio-IMR &gt;45 U was an independent predictor: hazards ratio 12.20, 95 % confidence interval 2.40–62.10, p = 0.001.</div></div><div><h3>Conclusion</h3><div>CMD evaluated using angio-IMR was associated with LGE and long-term prognosis in patients with DCM. Further investigations are needed to elucidate the relationship among CMD, LGE, and prognosis.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200467"},"PeriodicalIF":1.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral artery disease In West Africans with diabetes: a risk factor profile analysis","authors":"Joachim Amoako ,&nbsp;Matthan Fayia Saa ,&nbsp;Emmanuel Bannerman-Williams ,&nbsp;Anastasia Naa Koshie Bruce ,&nbsp;Maame Boatemaa Ansong ,&nbsp;Alexander Danquah ,&nbsp;Abraham Ablorh ,&nbsp;Wills Nii Adjetey Kwaw ,&nbsp;Michael Adjei ,&nbsp;Emmanuel K. Awuttey ,&nbsp;Isabella D. Dakubo ,&nbsp;Patience Akos Vormatu ,&nbsp;Isaac Ekow Ennin ,&nbsp;Charles Frederick Hayfron-Benjamin","doi":"10.1016/j.ijcrp.2025.200469","DOIUrl":"10.1016/j.ijcrp.2025.200469","url":null,"abstract":"<div><h3>Background</h3><div>Globally, peripheral artery disease (PAD) affects &gt;200 million people, disproportionately affecting people with diabetes. Prior studies characterizing the risk profile of PAD in diabetes have excluded West Africans, whose vascular biology is relevantly different. This study characterized the aggregate effect of modifiable risk factors on PAD in West Africans with diabetes.</div></div><div><h3>Methods</h3><div>This was a cross-sectional study among 803 Ghanaian adults with diabetes. PAD was defined as ankle-brachial pressure index ≤0.90 and/or intermittent claudication. A multivariate logistic regression model was built to identify modifiable PAD risk factors, which were used to define the number of risk factors for each participant. The odds of PAD were determined based on the number of modifiable risk factors.</div></div><div><h3>Results</h3><div>The mean age, diabetes duration, and HbA₁c concentrations were 59.81(±9.95) years, 13.66(±7.89) years, and 8.45(±1.94) %, respectively. PAD prevalence was 25.8 %. In a multivariable regression model, hypertension [odds ratio 2.00, 95 % confidence interval 1.33–3.01], chronic kidney disease [1.54(1.11–2.14)], central obesity [1.58(1.05–2.39)], and elevated LDL-cholesterol concentration [1.42(1.02–1.97)] were independently associated with PAD. After adjustment for age, sex, and diabetes duration, the odds of PAD increased with each additional risk factor from a 2.02-fold increase [OR 2.02, 95 %CI 0.69–5.97) in the presence of two risk factors, to 3.51-fold [3.51(1.20–10.24)] for three risk factors, and nearly five-fold [4.80 (1.57–14.67)] for four risk factors.</div></div><div><h3>Conclusion</h3><div>West Africans with diabetes are very sensitive to the cumulative effect of hypertension, chronic kidney disease, central obesity, and elevated LDL cholesterol concentration for PAD. These findings provide data to guide PAD screening/treatment strategies.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200469"},"PeriodicalIF":1.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No death gap, but a care gap: Rethinking gender and heart failure in India and the Philippines","authors":"Jose Eric M. Lacsa,&nbsp;Andylyn M. Simeon","doi":"10.1016/j.ijcrp.2025.200461","DOIUrl":"10.1016/j.ijcrp.2025.200461","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200461"},"PeriodicalIF":1.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144563806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From classroom to clinic: Social determinants of adolescent cardiometabolic health in the Global South","authors":"Jose Eric M. Lacsa","doi":"10.1016/j.ijcrp.2025.200462","DOIUrl":"10.1016/j.ijcrp.2025.200462","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200462"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144536130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a predictive model for in-hospital mortality in patients with coronary heart disease and renal insufficiency","authors":"Yahui Li ,&nbsp;Hongsen Cai ,&nbsp;Wei Zheng ,&nbsp;Meijie Wang ,&nbsp;Man Huang ,&nbsp;Luyun Wang ,&nbsp;Daowen Wang ,&nbsp;Chunxia Zhao ,&nbsp;Wenguang Hou ,&nbsp;Hu Ding ,&nbsp;Yan Wang ,&nbsp;Hongling Zhu","doi":"10.1016/j.ijcrp.2025.200463","DOIUrl":"10.1016/j.ijcrp.2025.200463","url":null,"abstract":"<div><h3>Background</h3><div>Coronary Heart Disease (CHD) with renal insufficiency is a significant global health issue. This study aimed to develop and validate a predictive model for in-hospital mortality to enable early risk identification in these patients.</div></div><div><h3>Methods</h3><div>We analyzed data from 11,830 CHD patients with renal insufficiency treated at Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei Province, China (1994–2023). Among 113 clinical variables, five key features—age, high-sensitivity C-reactive protein (hs-CRP), estimated glomerular filtration rate (eGFR), creatine kinase (CK), and blood urea—were selected using Recursive Feature Elimination. Six machine learning models (Random Forest, XGBoost, Decision Tree, Neural Network, Logistic Regression, and Support Vector Machine) were developed and assessed for discrimination, calibration, and clinical utility. Temporal validation was performed using data from May 16, 2023 to October 31, 2024. SHapley Additive exPlanations (SHAP) were used for model interpretation.</div></div><div><h3>Results</h3><div>Of the 11,830 patients, 694 (5.9 %) died during hospitalization. Among the six models, XGBoost showed the best overall performance in the test set, achieving the highest AUC (0.926), lowest Brier score (0.034), highest accuracy (0.957), and balanced sensitivity (0.381) and F1 score (0.512). Decision curve analysis confirmed its superior clinical utility. In a temporally independent validation cohort of 5983 patients, XGBoost maintained strong predictive performance (AUC = 0.901), demonstrating excellent robustness and generalizability.</div></div><div><h3>Conclusions</h3><div>The XGBoost-based model accurately predicts in-hospital mortality in CHD patients with renal insufficiency, supporting early risk stratification and clinical decision-making.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200463"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144524324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ITACARE-P/SIGG/SIGOT/SICGE position paper on elderly cardiac patient referral to cardiac rehabilitation","authors":"Francesco Giallauria ,&nbsp;Angela Sciacqua ,&nbsp;Alessandra Pratesi ,&nbsp;Claudio De Lucia ,&nbsp;Dario Leosco ,&nbsp;Enrico Occhiuzzi ,&nbsp;Angelo Scuteri ,&nbsp;Andrea Ungar ,&nbsp;Carlo Vigorito ,&nbsp;Francesco Fattirolli ,&nbsp;Samuele Baldasseroni (Document Reviewers) ,&nbsp;Luigina Guasti (Document Reviewers) ,&nbsp;Francesco Maranta (Document Reviewers) ,&nbsp;Gian Francesco Mureddu (Document Reviewers) ,&nbsp;Matteo Ruzzolini (Document Reviewers) ,&nbsp;Maria Vittoria Silverii (Document Reviewers) ,&nbsp;Elio Venturini (Document Reviewers) ,&nbsp;Francesco Vetta (Document Reviewers) ,&nbsp;Alessandro Boccanelli (Document Reviewers) ,&nbsp;Lorenzo Palleschi (Document Reviewers) ,&nbsp;Marco Ambrosetti (Document Reviewers)","doi":"10.1016/j.ijcrp.2025.200454","DOIUrl":"10.1016/j.ijcrp.2025.200454","url":null,"abstract":"<div><div>The Italian Association for Cardiovascular Rehabilitation and Prevention (ITACARE-P) together with the Società Italiana di Gerontologia e Geriatria (SIGG); Società Italiana di Geriatria Ospedale e Territorio (SIGOT); SICGE, Società Italiana di Cardiologia Geriatrica (SICGE) released a joint position paper to guide referrals of elderly cardiovascular patients discharged from Geriatric wards to Cardiac Rehabilitation (CR) facilities. The document provides rationale and operative recommendations for appropriateness (i.e. qualifying diagnosis) and priority criteria to overcome mismatch between potential demand and effective supply of CR programmes. In case of no-referral due to logistic restraints, the document recommends the adoption of best alternatives to CR for disability reduction, better prognosis, and improvement of quality of life. The joint position paper is also aimed at promoting the consideration of Geriatric Medicine as a potential stakeholder of CR.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200454"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting circadian syndrome by obesity indices in middle-aged and older Chinese: evidence from the China Health and Retirement Longitudinal Study","authors":"Nian Liu ,&nbsp;Siyan Jia","doi":"10.1016/j.ijcrp.2025.200465","DOIUrl":"10.1016/j.ijcrp.2025.200465","url":null,"abstract":"<div><h3>Objective</h3><div>To predict the optimal cut-off values for screening and predicting circadian syndrome (CircS) in a middle-aged and older population using 11 obesity-related indices.</div></div><div><h3>Methods</h3><div>Data was obtained from the China Health and Retirement Longitudinal Study (CHARLS) database, including 9265 middle-aged and older people. We examined 11 indices, including waist circumference (WC), body mass index (BMI), waist-height ratio (WHtR), visceral adiposity index (VAI), a body shape index (ABSI), body roundness index (BRI), lipid accumulation product index (LAP), conicity index (CI), Chinese visceral adiposity index (CVAI), weight-adjusted-waist index (WWI), and cardiometabolic index (CMI). The receiver operating characteristic curve (ROC) was used to determine the usefulness of indicators for screening for CircS in middle-aged. Binary logistic regression analysis was performed to analyze the correlations between 11 obesity-related indices and CircS as well as its components.</div></div><div><h3>Results</h3><div>A total of 9265 middle-aged and older people were included in this study, and the CircS prevalence was 35.60 %. The percentage of males diagnosed with CircS was 25.99 %, and the females was 44.08 %. In males, CMI had the highest AUC. In females, CVAI was the best predictor. Logistic analysis revealed all obesity-related indices were significantly associated with CircS in both males and females (all <em>P</em> &lt; 0.001), and the correlations were stronger in females than in males.</div></div><div><h3>Conclusion</h3><div>All 11 obesity-related indices had good predictive power, with CMI and CVAI performing as the best predictor, and ABSI was the weakest predictor in males and females, respectively. In addition, the associations among all obesity-related indices and CircS were stronger in females than in males.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200465"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of mHealth on health literacy in patients after cardiac rehabilitation","authors":"Ioannis Skalidis,&nbsp;Serigne Cheikh Tidiane Ndao,&nbsp;Thierry Unterseeh,&nbsp;Stephane Champagne,&nbsp;Philippe Garot","doi":"10.1016/j.ijcrp.2025.200460","DOIUrl":"10.1016/j.ijcrp.2025.200460","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"26 ","pages":"Article 200460"},"PeriodicalIF":1.9,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}