International Journal of Cardiology Cardiovascular Risk and Prevention最新文献

{"title":"Efficacy and safety of drugs in residual cardiovascular risk: A systematic review of the literature","authors":"Mario Andres Hernandez-Sómerson ,&nbsp;Fernando Montoya-Agudelo ,&nbsp;Gustavo Huertas-Rodriguez","doi":"10.1016/j.ijcrp.2024.200298","DOIUrl":"10.1016/j.ijcrp.2024.200298","url":null,"abstract":"<div><h3>Background</h3><p>The objective of this research is to evaluate the efficacy and safety of drugs in the residual risk in any of its three components: lipid, inflammatory and thrombotic risk.</p></div><div><h3>Methods</h3><p>A systematic review was conducted of randomized clinical trials that included as a primary outcome, at least one of the conditions related to atherosclerotic cardiovascular disease. The databases used were PUBMED/MEDLINE, Scopus and <span>ClinicalTrials.gov</span><svg><path></path></svg>. The risk of bias of the studies was assessed using the Risk of Bias 2 tool.</p></div><div><h3>Results</h3><p>and discussion: 18 studies were included in the analysis. Half of the studies had low risk of bias or some concerns. Several drugs were effective in reducing the primary outcome: ethyl eicosapentaenoeic acid (17.2 % E-EPA versus 22 % placebo HR: 0.75; 95 % CI 0.68–0.83; p &lt; 0.001), colchicine in stable coronary artery disease (6.8 % vs placebo 9.6 %, HR 0.59, 95 % CI 0.57–0.83; p &lt; 0.001), Canakinumab (150 mg vs placebo ARR 15 %, HR 0.85, 95 % CI 0.74–0.98; p = 0.021) and Rivaroxaban with Aspirin in stable atherosclerotic disease (4.1 % versus aspirin 5.4 %, HR 0.76, 95 % CI 0.66–0.86, P &lt; 0.001). Serious adverse events did not differ between study groups, except for a higher rate of bleeding with the use of combination antithrombotic therapy.</p></div><div><h3>Conclusion</h3><p>The residual risk can be reduced through the use of different drugs that act by modifying atherogenic lipid levels, modulating inflammatory pathways and the risk of thrombosis, with an acceptable safety profile in most studies.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"22 ","pages":"Article 200298"},"PeriodicalIF":1.9,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000631/pdfft?md5=c9368d4e4e6a0f6d57a6fbec4dc758df&pid=1-s2.0-S2772487524000631-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141409322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoprotein (a) and lipid-lowering treatment from the perspective of a cardiac surgeon. An impact on the prognosis in patients with aortic valve replacement and after heart transplantation","authors":"Stanisław Surma ,&nbsp;Michał O. Zembala ,&nbsp;Bogusław Okopień ,&nbsp;Maciej Banach","doi":"10.1016/j.ijcrp.2024.200297","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200297","url":null,"abstract":"<div><p>Lipoprotein(a) is a recognized risk factor for ASCVD. There is still no targeted therapy for Lp(a), however, drugs such as pelacarsen, olpasiran, zerlasiran, lepodisiran and muvalaplin are in clinical trials and have been shown to be effective in significantly reducing Lp(a) levels. Moreover, elevated Lp(a) levels significantly affect the prognosis of patients after aortic valve replacement (AVR) and heart transplantation (HTx). Therefore, the assessment of Lp(a) concentration in these patients will allow for a more accurate stratification of their cardiovascular risk, and the possibility of lowering Lp(a) will allow for the optimization of this risk. In this article, we summarized the most important information regarding the role of Lp(a) and lipid-lowering treatment in patients after AVR and HTx.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"22 ","pages":"Article 200297"},"PeriodicalIF":2.3,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277248752400062X/pdfft?md5=ece16801c983d7af3acc1740f98b7385&pid=1-s2.0-S277248752400062X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141290803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Referral of the heart failure patient from cardiology and internal medicine department: Same patients and same rehabilitative approach?","authors":"Venturini Elio","doi":"10.1016/j.ijcrp.2024.200277","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200277","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200277"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000424/pdfft?md5=d664969e5f258bb09759e9db694b9fc5&pid=1-s2.0-S2772487524000424-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What the ITACARE-P Light-Heart and Sweet-Heart projects have taught us","authors":"Bruno Passaretti","doi":"10.1016/j.ijcrp.2024.200274","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200274","url":null,"abstract":"<div><p>Sweet Heart and Light Heart represent the first two educational formats of ITACARE-P, a recently established scientific association that joins various professionals with the aim of promoting all activities related to Cardiac Prevention and Rehabilitation. These educational formats represent opportunities for updating, comparing and sharing ideas among experts in order to standardize behaviors on hot topics. Pathologies in the metabolic field were chosen: diabetes mellitus and obesity, especially due to the cardiologist's possibility of prescribing drugs belonging to the SGLT2-i and GLP-RA classes, which have been shown to have a cardioprotective and nephroprotective effect, thus carrying a favorable influence on cardiovascular mortality. Sweet Heart and Light Heart were structured in a series of lectures alternated with “peer-to-peer” discussions; the possibilities offered by Italian National Health Service refundability in the prescription of these drugs and the difficulties that can be encountered in communicating this therapy to patients, particularly in the case of obesity where the purchase of the drug is at the patient's own expense, were examined. The results of this initiative was the drafting and publication of a position paper involving the entire Scientific Committee of the Association concerning the management of the patient suffering from diabetes mellitus in Cardiac Rehabilitation, with the peculiarities that concern the approach to the patient in this setting, such as the prescription of physical exercise in the same way as a drug, the introduction of process and outcome indicators, and the search for an anti-atherogenic or rather hemodynamic effect.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200274"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000394/pdfft?md5=fba3dc824fa9bdca53c39b96b93f35b9&pid=1-s2.0-S2772487524000394-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced machine learning for estimating vascular occlusion percentage in patients with ischemic heart disease and periodontitis","authors":"Pradeep Kumar Yadalam,&nbsp;Santhosh B. Shenoy,&nbsp;Raghavendra Vamsi Anegundi,&nbsp;Seyed Ali Mosaddad,&nbsp;Artak Heboyan","doi":"10.1016/j.ijcrp.2024.200291","DOIUrl":"10.1016/j.ijcrp.2024.200291","url":null,"abstract":"<div><h3>Objective</h3><p>The study aimed to assess the efficacy of advanced machine learning algorithms in estimating the percentage of vascular occlusion in ischemic heart disease (IHD) cases with periodontitis.</p></div><div><h3>Methods</h3><p>This study involved 300 IHD patients aged 45 to 65 with stage III periodontitis undergoing coronary angiograms. Dental and periodontal examinations assessed various factors. Coronary angiograms categorized patients into three groups based on artery stenosis. Clinical data were processed, outliers were identified, and machine learning algorithms were applied for analysis using the orange tool, including confusion matrices and receiver operating characteristic (ROC) curves for assessment.</p></div><div><h3>Results</h3><p>The results showed that Random Forest, Naïve Bayes, and Neural Networks were 97 %, 84 %, and 92 % accurate, respectively. Random Forest did exceptionally well in identifying the severity of conditions, with 95.70 % accuracy for mild cases, 84.80 % for moderate cases, and a perfect 100.00 % for severe cases.</p></div><div><h3>Conclusions</h3><p>The current study, using Periodontal Inflammatory Surface Area (PISA) scores, revealed that the Random Forest model accurately predicted the percentage of vascular occlusion.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200291"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000564/pdfft?md5=c8cfbdc7eccef6e783d03ba3ec286019&pid=1-s2.0-S2772487524000564-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141138296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex and gender differences in patients with acute coronary syndromes","authors":"Alessandra Pratesi","doi":"10.1016/j.ijcrp.2024.200276","DOIUrl":"10.1016/j.ijcrp.2024.200276","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200276"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000412/pdfft?md5=b731f7b4008453124b5c5571502c5e0d&pid=1-s2.0-S2772487524000412-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141041858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of the biomarker score in determining the risk of heart failure in diabetics in Goma, North Kivu in the Democractic Republic of the Congo","authors":"Ferdinand Ng'ekieb Mukoso,&nbsp;Aliocha Natuhoyila Nkodila,&nbsp;Hippolyte Nani tuma Situakibanza,&nbsp;Stannislas Okitotsho Wembonyama,&nbsp;Zacharie Kibendelwa Tsongo","doi":"10.1016/j.ijcrp.2024.200263","DOIUrl":"10.1016/j.ijcrp.2024.200263","url":null,"abstract":"<div><h3>Background</h3><p>The use of biomarkers, such as N-terminal pro-brain natriuretic peptide (NTpBNP), high-sensitivity C-reactive protein (hs-CRP) and high-sensitivity troponin (hs-TnI) is an alternative approach to detect the risk of heart failure (HF), but data on this approach are fragmentary in sub-Saharan Africa. The objective of this study is to determine the correlation between the risk of heart failure and the score of biomarkers in the population of asymptomatic diabetics in the city of GOMA.</p></div><div><h3>Methods</h3><p>Asymptomatic diabetics in the city of Goma were cross-sectionally recruited at the Center of the Association of Diabetics in Congo (ADIC) in Goma, DRC during the period from February 5 to 19, 2023. The risk of insufficiency heart rate at 5 years was determined using pulse pressure. The biomarker score was calculated using NTproBNP, hs-CRP, hs-troponin and left ventricular hypertrophy (LVH). The association between the risk of heart failure and the biomarker score was evaluated using the logistic regression test at the threshold of p &lt; 0.05.</p></div><div><h3>Results</h3><p>Of a total of 408 diabetic patients examined, 29.9% had presented a risk of heart failure. The risk of heart failure was higher in patients with a high biomarker score (57.7%), in patients with type 1 diabetes (60%) and in patients with type 2 diabetes (57.1%). Independent risk of biomarker score on occurrence of heart failure. The risk of heart failure was multiplied by 2 if the biomarker score was intermediate (OR: 2.19, 95% CI: 1.11–4.34) and by 5 if the biomarker score was high (OR: 4.73, 95% CI: 1.84–6.20).</p></div><div><h3>Conclusion</h3><p>The biomarker score is associated with the risk of heart failure in our study via the increase in the score elements as reported in European studies.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200263"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277248752400028X/pdfft?md5=5c0ab8482917b84a04eebd6a9889188b&pid=1-s2.0-S277248752400028X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140399853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender difference in long-term effect of cardiac rehabilitation; data from CRAGE-extra study","authors":"Giulia Nicolaio ,&nbsp;Samuele Baldasseroni ,&nbsp;Maria Vittoria Silverii ,&nbsp;Francesca Marchetti ,&nbsp;Costanza Burgisser ,&nbsp;Davide Montini ,&nbsp;Francesco Orso ,&nbsp;Alessandra Pratesi ,&nbsp;Andrea Ungar ,&nbsp;Niccolò Marchionni ,&nbsp;Francesco Fattirolli","doi":"10.1016/j.ijcrp.2024.200273","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200273","url":null,"abstract":"<div><h3>Introduction</h3><p>The positive effect of cardiac rehabilitation (CR) is demonstrated in younger and older patients. However, it is quite debated whether the beneficial effect is similarly maintained in both genders during follow-up.</p></div><div><h3>Aim</h3><p>to determine if the improvement obtained after CR remained significant at 1-year follow-up in older population, testing the influence of gender on this outcome.</p></div><div><h3>Methods</h3><p>All patients aged 75+ years consecutively referred to Cardiac Rehabilitation outpatient Unit at Careggi University Hospital were screened for eligibility. All patients attended a CR program, based on 5-day-per-week aerobic training sessions for 4 weeks and they were evaluated at the end of CR at 6 and 12 months of follow-up.</p></div><div><h3>Results</h3><p>361 patients with a mean age 80.6 ± 4.4 years with a complete 1-year follow-up were enrolled in the study, 87.5 % of them had an acute coronary event, and 27.6 % were females. The increase in exercise capacity at the end of CR and at 1-year follow-up was statistically significant (VO2 peak: +8.7 % in males p &lt; 0.001, +8.5 % in females p &lt; 0.001; distance walked at 6-min test: +7.3 % in males p &lt; 0.001, +10.2 % in females p &lt; 0.001, respectively); the trajectory of exercise improvement at 6 and 12 months of FU was similar in men and women without significant decrease (VO2 peak-ml/kg/min: CR discharge vs 1 year FU = 15.2 vs 15,0 p: NS; distance walked-meters: CR discharge vs 1 year FU = 445.5 vs 440.6, p: NS) from end of CR to 1-year.</p></div><div><h3>Conclusions</h3><p>the improvement in exercise tolerance obtained with CR program is still maintained at 1-year FU without significant influence of gender in our very old population.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200273"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000382/pdfft?md5=987bf53d191bc025b8a7fe073f1ce788&pid=1-s2.0-S2772487524000382-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of atherosclerotic cardiovascular disease (ASCVD) and Framingham risk scores (FRS) in an Iranian population","authors":"Matin Sepehrinia ,&nbsp;Hossein Pourmontaseri ,&nbsp;Mehrab Sayadi ,&nbsp;Mohammad Mehdi Naghizadeh ,&nbsp;Reza Homayounfar ,&nbsp;Mojtaba Farjam ,&nbsp;Azizallah Dehghan ,&nbsp;Abdulhakim Alkamel","doi":"10.1016/j.ijcrp.2024.200287","DOIUrl":"10.1016/j.ijcrp.2024.200287","url":null,"abstract":"<div><h3>Background</h3><p>Framingham risk score (FRS) and Atherosclerotic Cardiovascular Disease risk score (ASCVDrs) are widely used tools developed based on the American population. This study aimed to compare the ASCVDrs and FRS in an Iranian population.</p></div><div><h3>Method</h3><p>The participants of the Fasa Adult Cohort Study and the patients of the cardiovascular database of Vali-Asr Hospital of Fasa, aged 40–80 years, were involved in the present cross-sectional study. After excluding non-eligible participants, the individuals with a history of myocardial infarction or admission to the cardiology ward due to heart failure were considered high-risk, and the others were considered low-risk. The discriminative ability of FRS and ASCVDrs was evaluated and compared using receiver operating characteristic curve analysis. The correlation and agreement of ASCVDrs and FRS were tested using Cohen Kappa and Spearman.</p></div><div><h3>Results</h3><p>Finally, 8983 individuals (mean age:53.9 ± 9.5 y, 49.2 % male), including 1827 high-risk participants, entered the study. ASCVDrs detected a greater portion of participants as high-risk in comparison with FRS (28.7 % vs. 15.7 %). ASVD (AUC:0.794) had a higher discriminative ability than FRS (AUC:0.746), and both showed better discrimination in women. Optimal cut-off points for both ASCVDrs (4.36 %) and FRS (9.05 %) were lower than the original ones and in men. Compared to FRS, ASCVDrs had a higher sensitivity (79.3 % vs. 71.6 %) and lower specificity (64.5 % vs. 65.1 %). FRS and ASCVDrs had a moderate agreement (kappa:0.593,<em>p</em>-value&lt;0.001) and were significantly correlated (Spearman:0.772,<em>p</em>-value&lt;0.001).</p></div><div><h3>Conclusions</h3><p>ASCVDrs had a more accurate prediction of cardiovascular events and identified a larger number of people as high-risk in the Iranian population.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200287"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000527/pdfft?md5=9b720b85c13a848f10fdf7f8fbb6b239&pid=1-s2.0-S2772487524000527-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141143378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of obesity with liraglutide in cardiovascular prevention: Case series by the “ITACARE-P Light-Heart Lab” working group","authors":"Francesco Maranta ,&nbsp;Francesca Buffoli ,&nbsp;Vittorio Giudici ,&nbsp;Gabriella Malfatto ,&nbsp;Alessandro Maloberti ,&nbsp;Luigi Maresca ,&nbsp;Bruno Passaretti ,&nbsp;Anna Torri ,&nbsp;Roberto Turato ,&nbsp;Marco Ambrosetti","doi":"10.1016/j.ijcrp.2024.200272","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200272","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200272"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000370/pdfft?md5=8cdaeda168f6dedddc27e2ef49cb3172&pid=1-s2.0-S2772487524000370-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}