Trends in coronary artery disease mortality among hyperlipidemic patients: Geographic, gender, and racial insights from CDC WONDER data (1999–2020)

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

International Journal of Cardiology Cardiovascular Risk and Prevention Pub Date : 2025-05-03 DOI:10.1016/j.ijcrp.2025.200416

Muhammad Abdullah Naveed , Sivaram Neppala , Himaja Dutt Chigurupati , Bazil Azeem , Ahila Ali , Faizan Ahmed , Sabin Zafar , Muhammad Omer Rehan , Rabia Iqbal , Manahil Mubeen , Hassaan Abid , Anum Mubasher , Timir Paul

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Abstract

Background

Coronary artery disease (CAD) in hyperlipidemia is a significant cause of mortality among adults in the United States. This study investigates trends in CAD-related mortality in hyperlipidemia among adults aged 25 and older, focusing on geographic, gender, and racial/ethnic disparities from 1999 to 2020.

Methods

A retrospective analysis was conducted using the CDC WONDER database from 1999 to 2020. Age-adjusted mortality rates (AAMRs), annual percent change (APC), and average annual percentage change (AAPC) were calculated per 100,000 persons, stratified by year, sex, race/ethnicity, and geographical region.

Results

Between 1999 and 2020, CAD in hyperlipidemia led to 407,667 deaths among US adults aged 25+. The AAMR for CAD in hyperlipidemia rose from 4.1 in 1999 to 12.1 in 2020, with an AAPC of 4.44 (95 % CI: 3.69 to 5.48, p < 0.000001). Men had higher AAMRs (12.4) than women (5.6), with significant increases for both sexes over time. Racial/ethnic disparities showed the highest AAMRs in Whites (8.9), followed by American Indians/Alaska Natives (8.6). Geographically, AAMRs varied from 3.8 in Alabama to 16.0 in Vermont, with the Midwest showing the highest rates (9.7). Nonmetropolitan areas exhibited higher AAMRs (9.6) than metropolitan areas (8.3), with a more significant increase in nonmetropolitan areas (AAPC: 5.82, p < 0.000001).

Conclusion

This study highlights significant disparities in CAD in hyperlipidemia-related mortality among US adults by race, gender, and geography. The overall increase in AAMRs from 1999 to 2020 underscores the need for targeted public health interventions to address these growing inequities.

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高脂血症患者冠状动脉疾病死亡率趋势：来自CDC WONDER数据的地理、性别和种族见解（1999-2020）

背景：在美国，高脂血症合并冠状动脉疾病（CAD）是导致成人死亡的一个重要原因。本研究调查了1999年至2020年25岁及以上成人冠心病相关高脂血症死亡率的趋势，重点关注地理、性别和种族/民族差异。方法对1999 ~ 2020年CDC WONDER数据库进行回顾性分析。计算每10万人的年龄调整死亡率（AAMRs）、年变化百分比（APC）和年平均变化百分比（AAPC），并按年份、性别、种族/民族和地理区域分层。结果1999年至2020年间，冠心病合并高脂血症导致美国25岁以上成年人死亡407667例。高脂血症患者CAD的AAMR从1999年的4.1上升到2020年的12.1，AAPC为4.44 （95% CI: 3.69 ~ 5.48）。0.000001)。男性的aamr（12.4）高于女性（5.6），随着时间的推移，男女的aamr都显著增加。种族/民族差异显示，白人的aamr最高（8.9），其次是美洲印第安人/阿拉斯加原住民（8.6）。从地理上看，aamr从阿拉巴马州的3.8到佛蒙特州的16.0不等，中西部地区的比率最高（9.7）。非都市圈的aamr（9.6）高于都市圈（8.3），其中非都市圈的AAPC（5.82）增加更为显著(p <；0.000001)。结论：本研究强调了美国成人高脂血症相关冠心病死亡率在种族、性别和地理上的显著差异。从1999年到2020年，不良药物耐药性总体增加，这突出表明需要采取有针对性的公共卫生干预措施，以解决这些日益严重的不平等现象。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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