Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry最新文献_第6页

The analysis of acid-base balance in haemodialyzed patients and the effect of etiology of chronic renal failure on acid-base parameter values 血液透析患者酸碱平衡分析及慢性肾功能衰竭病因对酸碱参数值的影响

Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry Pub Date : 1900-01-01 DOI: 10.2298/JMH0402175C

E. Čolak, S. Stankovic, N. Majkić-Singh, M. Radović

{"title":"The analysis of acid-base balance in haemodialyzed patients and the effect of etiology of chronic renal failure on acid-base parameter values","authors":"E. Čolak, S. Stankovic, N. Majkić-Singh, M. Radović","doi":"10.2298/JMH0402175C","DOIUrl":"https://doi.org/10.2298/JMH0402175C","url":null,"abstract":"Due to reduced scope of renal function in chronic renal failure (CRF) it is not rare that it comes to marked metabolic acidosis and pathologic catabolism associated with hypoxia. The cause of metabolic acidosis is deminished tubular secretion of ammonia, due to reduced synthesis, stipulated by lower number of renal canaliculi. Acid-base balance was analyzed in 74 patients suffering from CRF who were on haemodialysis program. Heparinised blood was taken from these patients before and after haemodialysis in which the following parameters were measured: pH, pCO2, pO2, HCO-3 ¯, TCO2. The aim of this study was the monitoring of patients' acid-base status before and after haemodilalysis in order to evaluate the degree of stabilization of acid-base balance after haemodilalysis and also to define the correlation between the etiology of CRF and the degree of acid-base balance disorder. In relation to underlying disease resulting in CRF, the patients were divided into five groups: I-tubular interstitial nephrosis (TIN), II-polycystic kidney disease (ADPKD), III-glomerulonephritis (GN), IVhypertension and nephroangio-sclerosis (HTA-Nascl) and V-consisting of patients whose underlying disease was not diagnosed (ERSD). The obtained values of pH, HCO2 and TCO2 after haemodialysis (pH = 7.428 ± 0.06; HCO-3 ¯= 25.4 ± 3.44 mmol/L; TCO2 = 26.57 ± 3.56 mmol/L), were significantly increased (p 0.05) in relation to underlying disease either before or after haemodialysis both in males and females.","PeriodicalId":287983,"journal":{"name":"Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123803561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lupus anticoagulans in patients with recurrent spontaneous abortion and secondary sterility 狼疮抗凝剂在复发性自然流产和继发性不孕症患者中的应用

Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry Pub Date : 1900-01-01 DOI: 10.2298/JMH0501051J

K. Jeremić, M. Ilić, M. Gojnić, S. Petković, A. Ljubić, Ljiljana Nikolić, S. Maslac

引用次数: 1

The importance of urinary enzymes in diagnostic of tubular damage caused by proteinuria

Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry Pub Date : 1900-01-01 DOI: 10.2298/JMH0203287O

R. Obrenović, D. Petrovic, N. Majkić-Singh, M. Poskurica, B. Stojimirović

{"title":"The importance of urinary enzymes in diagnostic of tubular damage caused by proteinuria","authors":"R. Obrenović, D. Petrovic, N. Majkić-Singh, M. Poskurica, B. Stojimirović","doi":"10.2298/JMH0203287O","DOIUrl":"https://doi.org/10.2298/JMH0203287O","url":null,"abstract":"Proteinuria causes damage to proximal tubular cells. To investigate the influence of different levels of glomerular proteinuria, we examined 50 patients (24 male and 26 female). Their creatinine clearance (Ccr) was higher than 50 mL/min (87,29\"31,17 mL/min). According to the proteinuria range level patients were separated in three groups. The first group, with proteinuria less than 0,3 g/24h, included 19 persons (7 man and 12 woman), mean age 45,12\"13,28 years and mean Ccr 94,27\"34,70 mL/min. Proteinuria 0,3’3,0 g/24h is the second group characteristic. This group included 18 patients (8 male and 10 female) mean age 45,39\"12,64 years, with mean 90,07\"31,89 mL/min. Patients with proteinuria higher than 3,0 g/24h were members of third group. Mean age 50,08\"13,73 years and mean Ccr 73,25\"20,44 mL/min are caracteristics of 13 members (9 male and 4 female) of the third group. Enzymes alkaline phosphatase (AP), g-glutamil transpherase (gGT) and Nacetyl- b-D-glucosaminidase (b-NAG) were used as parameters of tubular damage. Gama-glutamil transpherase is more sensitive parameter of tubular damage then alkaline phosphatase. N-acetyl-b-D-glucosaminidase is the most sensitive parameter of tubular damage due to proteinuria.","PeriodicalId":287983,"journal":{"name":"Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130857079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Oxidized LDL and other lipids as risk factors for cardiovascular disease in the patients with metabolic syndrome 氧化LDL和其他脂质作为代谢综合征患者心血管疾病的危险因素

Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry Pub Date : 1900-01-01 DOI: 10.2298/JMH0502099Z

D. Trifunovic, T. Milicic, T. Potpara, E. Čolak

{"title":"Oxidized LDL and other lipids as risk factors for cardiovascular disease in the patients with metabolic syndrome","authors":"D. Trifunovic, T. Milicic, T. Potpara, E. Čolak","doi":"10.2298/JMH0502099Z","DOIUrl":"https://doi.org/10.2298/JMH0502099Z","url":null,"abstract":"Summary: We estimated relationship between lipids, LDL oxidation, antioxidant activity and CRP in diabetic patients with metabolic syndrom (MS), with and without coronary heart disease (CHD), in non diabetic patients with and without CHD and in obese patients, with and without diabetes. We didn’t find significant difference in lipids among diabetic MS patients. Patients from all subgroups have simillar level of oxLDL, but significant higher comparing with healthy control. MS diabetic patients have oxLDL in positive corelation with TC, LDL-C, non HDLC and apo B 100, as vell as with molar ratio LDL-C/HDL-C and TG/HDL-C (p<0.001). Among non diabetics, CHD patients had higher Lp(a), but oxLDL was simillar in both subgroups. In the nondiabetics we found correlation between oxLDL, TC, LDL-C and TG (p<0.01) and apo B 100 (p<0.001), but not with TG/HDL-C molar ratio. Obese patients from both groups had simillar lipids profile but, oxLDL was higher, not significant, in non diabetics. We didn’t find significant differences in antioxidative activity and CRP in both diabetics MS subgroups, and both obese subgroups. Nondiabetics with CHD have lower E-SOD and E-GPX activity and higher level of CRP than non CHD patients (p<0.05). MS diabetics and non diabetics didn't have significant correlation between levels of oxLDL and CRP, but CHD patients (with or without diabetes) had (p<0. 01).","PeriodicalId":287983,"journal":{"name":"Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130749800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

CLINICAL IMPLICATIONS OF BIOCHEMICAL ALTERATIONS INDUCED BY HYPOTHALAMIC THYROTROPHIN HORMONE IN ELDERLY PEOPLE 老年人下丘脑促甲状腺激素引起的生化改变的临床意义

Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry Pub Date : 1900-01-01 DOI: 10.2298/JMH0303243D

S. Djurica, M. Petrovic, M. Rajić, M. Davidović, P. Milosevic

引用次数: 0

ASSOCIATION OF LIPOPROTEIN LIPASE GENE ASN291SER DNA POLYMORPHISM WITH PLASMA LIPID LEVELS AND BLOOD PRESSURE LEVELS IN HEALTHY POPULATION OF SERBIA 塞尔维亚健康人群血脂水平和血压水平与脂蛋白脂肪酶基因asn291ser DNA多态性的关系

Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry Pub Date : 1900-01-01 DOI: 10.2298/JMH0303237G

S. Glišić, S. Stankovic, M. Djuric, D. Zivkovic, D. Stankovic, N. D. Alavantic

引用次数: 5

CHARACTERISTICS OF THE PITUITARY IMMUNOPOSITIVE ACTH CELLS IN RAT FEMALES AFTER CHRONIC EXPOSURE TO CONSTANT LIGHT 慢性恒光照射后雌性大鼠垂体免疫阳性ACTH细胞的特征

Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry Pub Date : 1900-01-01 DOI: 10.2298/JMH0301027M

L. Milosevic, M. Nestorovic, M. N. Negic, R. Filipovic, B. Brkić, P. V. Starcevic

{"title":"CHARACTERISTICS OF THE PITUITARY IMMUNOPOSITIVE ACTH CELLS IN RAT FEMALES AFTER CHRONIC EXPOSURE TO CONSTANT LIGHT","authors":"L. Milosevic, M. Nestorovic, M. N. Negic, R. Filipovic, B. Brkić, P. V. Starcevic","doi":"10.2298/JMH0301027M","DOIUrl":"https://doi.org/10.2298/JMH0301027M","url":null,"abstract":"Summary: The effects of chronic exposure to light of adult female Wistar rats on growth and function of pituitary adrenocorticotropes (ACTH cells) were examined. The animals were exposed to continuous light of 600 lux for 95 days, starting on day 30 of age. Control rats were kept under a 12:12 h light-dark cycle, at ambient temperature. ACTH-producing cells were studied using the peroxidase-antiperoxidase immunohistochemical procedure and blood samples were collected for hormone analyses. In animals exposed to a chronic light-treatment all morphometric parameters measured throughout the present study i.e.: ACTH cell volume, nuclear volume and relative volume density were increased by 22% and the differences between this group and the controls were statistically significant (p<0.05). The concentration of plasma ACTH was elevated by 13% in light-exposed group in comparison with the control and this difference was statistically significant (p<0.05), as well. These findings suggest that continuous exposure to light is specifically involved in growth and secretory activity of ACTH cells of adenohypophysis of rat females.","PeriodicalId":287983,"journal":{"name":"Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128042106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Predictive value of pro- and anti-inflammatory cytokines in assessing severity and outcome of acute pancreatitis 促炎性和抗炎性细胞因子在评估急性胰腺炎严重程度和预后中的预测价值

Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry Pub Date : 1900-01-01 DOI: 10.2298/JMB0504253M

D. Mirković, M. Šurbatović, N. Filipovíc, S. Radakovic

引用次数: 1

Reference interval for calculated total iron-binding capacity using Olympus AU2700 analyzer 使用奥林巴斯AU2700分析仪计算总铁结合容量的参考区间

Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry Pub Date : 1900-01-01 DOI: 10.2298/JMH0501045J

S. Jovičić, S. Ignjatović, M. Dajak, R. Kangrga, N. Majkić-Singh

{"title":"Reference interval for calculated total iron-binding capacity using Olympus AU2700 analyzer","authors":"S. Jovičić, S. Ignjatović, M. Dajak, R. Kangrga, N. Majkić-Singh","doi":"10.2298/JMH0501045J","DOIUrl":"https://doi.org/10.2298/JMH0501045J","url":null,"abstract":"Total iron-binding capacity (TIBC) values are determined on Olympus AU2700 automated chemistry analyzer as the sum of serum iron and unsaturated iron-binding capacity (UIBC) - (calculated TIBC, TIBCcal). Considering that Olympus AU2700 automated analyzer was recently brought in function and TIBC values calculated from serum iron and UIBC values were significantly lower than those obtained by a direct and fully automated TIBC assay, it was necessary to determine the reference interval for TIBC, according to the recommendation that every laboratory should have its own reference ranges. The \"calculation method\" of TIBC determination showed satisfactory accuracy (p > 0.001) and precision, with CV values ranging from 0.91% to 1.63% within-run and from 2.30% to 2.80% day-to-day. The correlation between the TIBC values obtained with the \"calculation method\" using Olympus AU2700 analyzer (y) and those obtained with the direct method (x) was: y = 0.919x + 2.319 mmol/L (r = 0.980; Sy,x = 1.814; p < 0.001; N = 85). The reference interval for TIBC was determined using sera collected from 125 healthy individuals of both sexes, 15 to 80 years old. Since the values did not depend on sex, the reference interval calculated for the whole studied population ranged between 42.0 mmol/L and 64.3 mmol/L.","PeriodicalId":287983,"journal":{"name":"Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127853593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Redox cell signaling genomics and proteomics target place modulators in cancerogenesis: New diagnostic and therapeutic possibilities 氧化还原细胞信号基因组学和蛋白质组学在癌症发生中的靶位调节剂:新的诊断和治疗可能性

Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry Pub Date : 1900-01-01 DOI: 10.2298/JMB0604309P

D. Pavlović, G. Kocić, Tatjana Stoimenov-Jevtovic

{"title":"Redox cell signaling genomics and proteomics target place modulators in cancerogenesis: New diagnostic and therapeutic possibilities","authors":"D. Pavlović, G. Kocić, Tatjana Stoimenov-Jevtovic","doi":"10.2298/JMB0604309P","DOIUrl":"https://doi.org/10.2298/JMB0604309P","url":null,"abstract":"Summary: Within the complex process of signal transduction through the cell under the influence of external factors, signal transmission is initiated through a specific communication, protein-protein interaction (phosphorylation, dephosphorylation, association, dissociation, oxidation, glycation, nitrosylation, proteolysis), determining the biologic response of the cell. Many of the cellular signal transduction pathways, such as JAKSTAT, MAP, PKC-kinase cascade, NF-kB signal transduction pathway, undergo down regulation mediated by N-acetyl-cystein and reduced glutathione, while the decline of GSH concentration and redox stress initiate their activation. Activated redox signaling pathways are the mediators of mitogenic effects in cancerogenesis. Two types of genes, comprising only a small part of the human cell genome, have a key role in cancerogenesis. Proto-oncogene and tumor suppressor gene dysfunction induce disturbances in the regulation of signal transmission pathways which control the cell cycle, apoptosis, genome stability, differentiation and morphogenesis. Alterations in these important physiologic processes are responsible not only for the initiation and promotion of malignant transformation of the cell, but for further tumor progression as well. Free radicals and their oxidatively modified products induce activation of critical sensory loci in the signal pathway proteoma, controling cellular proliferation, apoptosis and cellular phenotype alteration. Therefore, it is vital to define the therapeutic indications for antioxidants and other modulators of target places of redox cell signaling genomics and proteomics as they are all part of a complex network of multifactorial oncogene collaboration in the process of cancerogenesis.","PeriodicalId":287983,"journal":{"name":"Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133138089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0