The analysis of acid-base balance in haemodialyzed patients and the effect of etiology of chronic renal failure on acid-base parameter values

Due to reduced scope of renal function in chronic renal failure (CRF) it is not rare that it comes to marked metabolic acidosis and pathologic catabolism associated with hypoxia. The cause of metabolic acidosis is deminished tubular secretion of ammonia, due to reduced synthesis, stipulated by lower number of renal canaliculi. Acid-base balance was analyzed in 74 patients suffering from CRF who were on haemodialysis program. Heparinised blood was taken from these patients before and after haemodialysis in which the following parameters were measured: pH, pCO2, pO2, HCO-3 ¯, TCO2. The aim of this study was the monitoring of patients' acid-base status before and after haemodilalysis in order to evaluate the degree of stabilization of acid-base balance after haemodilalysis and also to define the correlation between the etiology of CRF and the degree of acid-base balance disorder. In relation to underlying disease resulting in CRF, the patients were divided into five groups: I-tubular interstitial nephrosis (TIN), II-polycystic kidney disease (ADPKD), III-glomerulonephritis (GN), IVhypertension and nephroangio-sclerosis (HTA-Nascl) and V-consisting of patients whose underlying disease was not diagnosed (ERSD). The obtained values of pH, HCO2 and TCO2 after haemodialysis (pH = 7.428 ± 0.06; HCO-3 ¯= 25.4 ± 3.44 mmol/L; TCO2 = 26.57 ± 3.56 mmol/L), were significantly increased (p 0.05) in relation to underlying disease either before or after haemodialysis both in males and females.