2009 IEEE/NIH Life Science Systems and Applications Workshop最新文献

RF-powered Li-ion battery charger for biomedical applications 用于生物医学应用的射频供电锂离子电池充电器

2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906742

Chih-Wen Chuang, E. Go Chua, Yu-Sheng Lai, W. Fang

引用次数: 7

A VLSI-inspired image reconstruction algorithm for continuous-wave diffuse optical tomography systems 一种基于vlsi的连续波漫射光学层析成像系统图像重建算法

2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906716

Y. Hsu, Chih-Chung Fu, W. Fang, T. Sang

引用次数: 8

Low-noise wide dynamic range readout circuit for multi-stage microfluidic cell sorting systems 用于多级微流体分选系统的低噪声宽动态范围读出电路

2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906704

Benjamin R. Geheb, M. M. Grafton, J. Jang, L. Reece, J. Leary, Jong-Kee Kwon, B. Jung

引用次数: 4

On-chip whole-animal manipulation for high-throughput subcellular-resolution in-vivo drug/genetic screening 芯片上全动物操作高通量亚细胞分辨率体内药物/遗传筛选

2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906707

Christopher Rohde, C. Gilleland, C. Samara, M. Yanik

{"title":"On-chip whole-animal manipulation for high-throughput subcellular-resolution in-vivo drug/genetic screening","authors":"Christopher Rohde, C. Gilleland, C. Samara, M. Yanik","doi":"10.1109/LISSA.2009.4906707","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906707","url":null,"abstract":"Techniques for rapid and automated small-animal manipulation and immobilization are necessary for high-throughput in vivo genetic/drug screens using cellular and sub-cellular features in multicellular organisms. We present a suite of technologies for complex high-throughput whole-animal genetic and drug screens. We demonstrate a high-speed microfluidic sorter that can isolate and immobilize Caenorhabditis elegans in a well-defined geometry, an integrated chip containing individually addressable screening chambers for incubation and exposure of individual animals to biochemical compounds, and a device for delivery of compound libraries in standard multiwell plates to microfluidic devices. The immobilization stability obtained by these devices is comparable to that of chemical anesthesia and the immobilization process does not affect lifespan, progeny production, or other aspects of animal health. The high-stability enables the use of a variety of key optical techniques. We use this to demonstrate femtosecond-laser nanosurgery and three-dimensional multiphoton microscopy to study neural regeneration at sub-cellular resolution in vivo.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124315878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in integrated polarization image sensors 集成偏振图像传感器的研究进展

2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906710

V. Gruev, J. van der Spiegel, N. Engheta

引用次数: 18

Detecting molecules using a surface impedance imaging technique 利用表面阻抗成像技术检测分子

2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906733

K. Foley, X. Shan, Yuyuan Tian

引用次数: 1

Modeling a fixed-fixed beam nano biosensor using equivalent electrical circuit technique 利用等效电路技术对固定-固定光束纳米生物传感器进行建模

2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906709

R. Bajpai, M. Zaghloul

引用次数: 3

Prostate cancer biomarker identification using MALDI-MS DATA: Initial results 使用MALDI-MS数据鉴定前列腺癌生物标志物:初步结果

2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906723

V. Mantena, Wenjuan Jiang, Jiang Li, Rick McKenzie

引用次数: 11

HeartToGo: A Personalized medicine technology for cardiovascular disease prevention and detection HeartToGo:用于心血管疾病预防和检测的个性化医疗技术

2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906714

Zhanpeng Jin, Joseph Oresko, Shimeng Huang, A. Cheng

{"title":"HeartToGo: A Personalized medicine technology for cardiovascular disease prevention and detection","authors":"Zhanpeng Jin, Joseph Oresko, Shimeng Huang, A. Cheng","doi":"10.1109/LISSA.2009.4906714","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906714","url":null,"abstract":"To date, cardiovascular disease (CVD) is the first leading cause of global death. The Electrocardiogram (ECG) is the most widely adopted clinical tool that measures and records the electrical activity of the heart from the body surface. The mainstream resting ECG machines for CVD diagnosis and supervision can be ineffective in detecting abnormal transient heart activities, which may not occur during an individual's hospital visit. Common Holter-based portable solutions offer 24-hour ECG recording, containing hundreds of thousands of heart beats that not only are tedious and time-consuming to analyze manually but also miss the capability to provide any real-time feedback. In this study, we seek to establish a cell phone-based personalized medicine technology for CVD, capable of performing continuous monitoring and recording of ECG in real time, generating individualized cardiac health summary report in layman's language, automatically detecting abnormal CVD conditions and classifying them at any place and anytime. Specifically, we propose to develop an artificial neural network (ANN)-based machine learning technique, combining both individualized medical information and clinical ECG database data, to train the cell phone to learn to adapt to its user's physiological conditions to achieve better ECG feature extraction and more accurate CVD classification results.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123689610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 89

Ligand-functionalized gold nanorods as theragnostic agents 配体功能化金纳米棒作为诊断剂

2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906697

A. Wei, Ji‐Xin Cheng

{"title":"Ligand-functionalized gold nanorods as theragnostic agents","authors":"A. Wei, Ji‐Xin Cheng","doi":"10.1109/LISSA.2009.4906697","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906697","url":null,"abstract":"Plasmon-resonant gold nanorods have been examined as multifunctional agents for imaging and photoactivated therapies. Au nanorods can be imaged with single-particle sensitivity by two-photon luminescence (TPL) when excited by pulsed NIR laser irradiation, and have been detected in vivo while passing through blood vessels at subpicomolar concentrations. TPL imaging can also be used to characterize the targeted delivery of ligand-functionalized nanorods to tumor cells. Nanorods were coated with oligoethyleneglycol (OEG) units using in situ dithiocarbamate formation, a novel and robust method of surface functionalization. Nanorods coated with OEG were shielded from nonspecific cell uptake, whereas those functionalized with folate-terminated OEG chains accumulated on the surface of tumor cells expressing their cognate receptor. Cells labeled with folate-conjugated nanorods can mediate photothermal effects when irradiated at NIR wavelengths, often resulting in a dramatic blebbing of the cell membrane, which was determined to be caused indirectly by the influx of extracellular Ca2+ following perforation of the cell membrane. With respect to preclinical testing, a protocol has been developed for the exhaustive removal of CTAB, a cytotoxic surfactant used in nanorod synthesis. Treatment with polystyrenesulfonate can yield “CTAB-free” nanorods with negligible toxicity.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125983430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2