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2009 IEEE/NIH Life Science Systems and Applications Workshop最新文献

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Privacy protection and authentication for medical images with record-based watermarking 基于记录水印的医学图像隐私保护与身份验证
2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906743
Hsiang-Cheh Huang, W. Fang, Shin-Chang Chen
{"title":"Privacy protection and authentication for medical images with record-based watermarking","authors":"Hsiang-Cheh Huang, W. Fang, Shin-Chang Chen","doi":"10.1109/LISSA.2009.4906743","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906743","url":null,"abstract":"In this paper, we propose a practical scheme for privacy protection and authentication of medical images with the aid of EXIF metadata and associated records of the patients. By using watermarking, the goals mentioned above can be reached. Application for robust watermarking is one of the major branches in digital rights management (DRM) systems. With robust watermarking, it generally alters selected coefficients in the transform domain to accomplish the embedding process. We consider not only the image contents itself, but we also employ the EXIF metadata, which contains the patients' records and serves as the role of watermark, to be integrated into our scheme. By doing so, the false negative probability for obtaining the record can be reduced. Moreover, taking the information that the medical doctor recorded in the EXIF metadata into account, conventional watermarking techniques can be applied to medical images, and watermarked images with good quality can be produced. Even when the marked image has been intentionally modified, the original EXIF with selected information can mostly be recovered from the decoding process. Simulation results present the effectiveness of such an implementation.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124414970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
A novel gene delivery system using magnetic nanodarts 利用磁性纳米飞镖的新型基因传递系统
2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906738
Weibing Lu, H. Gul, P. Xu, W. Ang, J. Xing, Jian Zhang, Jie Chen
{"title":"A novel gene delivery system using magnetic nanodarts","authors":"Weibing Lu, H. Gul, P. Xu, W. Ang, J. Xing, Jian Zhang, Jie Chen","doi":"10.1109/LISSA.2009.4906738","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906738","url":null,"abstract":"One aspect of gene therapy is the efficient transfection of a cell population with DNAs or RNAs (including siRNAs) in order to modulate the expression of genes, to produce cell types for use in gene therapy, or to meet other very important unmet medical needs. Gene therapy has a huge potential in modifying the blueprints of a human cell and giving additional tools for modern medicine. Gene therapy also offers hope in combating lethal genetic diseases, cancer and certain infectious diseases. According to the report “Meeting the challenge: U.S. Industry faces the 21st century: The U.S. biotechnology industry”, the office of technology policy, U.S. Department of Commerce predicted the growth of this industrial sector to be an estimated $5 Billion within the next decade.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131039537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From biophotonics toward nanobiophotonics: Breaking the diffraction barrier in the subwavelength nanoscale 从生物光子学到纳米生物光子学:打破亚波长纳米尺度的衍射势垒
2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906700
I. Ilev
{"title":"From biophotonics toward nanobiophotonics: Breaking the diffraction barrier in the subwavelength nanoscale","authors":"I. Ilev","doi":"10.1109/LISSA.2009.4906700","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906700","url":null,"abstract":"We present fundamental principals and features of novel approaches in biophotonics and nanobiophotonics field for biomedical applications with spatial resolution beyond the diffraction barrier in the subwavelength (below 100 nm) nanoscale range.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124079292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A video-frame based registration using segmentation and graph connectivity for Wireless Capsule Endoscopy 一种基于视频帧的无线胶囊内窥镜配准方法
2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906713
A. Karargyris, N. Bourbakis
{"title":"A video-frame based registration using segmentation and graph connectivity for Wireless Capsule Endoscopy","authors":"A. Karargyris, N. Bourbakis","doi":"10.1109/LISSA.2009.4906713","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906713","url":null,"abstract":"Gastroenterologists using Wireless Capsule Endoscopy (WCE) extract valuable information regarding the health condition of the intestine. WCE produces, however, near 50,000 frames that have to be examined. In this paper a registration methodology is presented to reduce the amount of frames, which are the same or similar. It utilizes a segmentation scheme and a graph method to register similar regions in two consecutive frames. In addition our methodology offers a degree of similarity between two frames using a confidence function of similarity, in order to discard extremely dissimilar frames and thus set a mark of a new series of frames. Finally, a useful feature called Center of Image Similarity is also presented. Illustrative results from the methodology are also given in this paper.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"9 Balneol Climatol Sect 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127922825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Quantitative assessment of macroporous cell scaffold structures using optical coherence tomography (OCT) 光学相干断层扫描(OCT)定量评价大孔细胞支架结构
2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906737
Andrew Paek, Martha W. Betz, James Y. Jiang, A. Cable, J. Fisher, Yu Chen
{"title":"Quantitative assessment of macroporous cell scaffold structures using optical coherence tomography (OCT)","authors":"Andrew Paek, Martha W. Betz, James Y. Jiang, A. Cable, J. Fisher, Yu Chen","doi":"10.1109/LISSA.2009.4906737","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906737","url":null,"abstract":"We present the application of optical coherence tomography (OCT) for non-destructive imaging and quantitative characterization of the macroporous cyclic acetal hydrogel cell scaffolds. High-resolution OCT visualizes the microstructures of the tissue engineering scaffolds in three-dimension. The porosity, pore size, and the interconnectivity of the hydrogel scaffolds were characterized quantitatively using OCT.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125340395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Synthesis and characterization of water-soluble ultrasound sensitive nanoparticles 水溶性超声敏感纳米颗粒的合成与表征
2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906728
Yongde Meng, C. Zou, R. Madiyalakan, Thomas Woo, J. Xing, Jie Chen, Eric Swanson
{"title":"Synthesis and characterization of water-soluble ultrasound sensitive nanoparticles","authors":"Yongde Meng, C. Zou, R. Madiyalakan, Thomas Woo, J. Xing, Jie Chen, Eric Swanson","doi":"10.1109/LISSA.2009.4906728","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906728","url":null,"abstract":"Due to their high quantum yields of singlet oxygen and excellent light-induction attributes, hypocrellins have recently received much research attention.[1][2][3] Hypocrellins, including hypocrellin A (HA) and hypocrellin B (HB), have relatively low absorption in the phototherapeutic window (600–900nm) due to their longest wavelength absorbance band at 584nm. To solve this problem, amino groups are introduced into hypocrellin molecules in order to enhance their absorbance in the visible red band. SL052 is a proprietary HB discovered by Quest PharmaTech Inc. in Edmonton, Canada. SL052 demonstraates an absorbance maximum at 635nm[4] due to optimized intra-molecular charge transfers between the amino- and carbonyl groups.[5] We report the use of nanoparticles to make SL052 water soluble while maintaining the intra-molecular charge transfer chemistry.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126686670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overview of IEEE research in Biomedical Circuits and Systems IEEE生物医学电路与系统研究综述
2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906698
A. Hodge
{"title":"Overview of IEEE research in Biomedical Circuits and Systems","authors":"A. Hodge","doi":"10.1109/LISSA.2009.4906698","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906698","url":null,"abstract":"The recent years have been marked by a surge of interdisciplinary collaborations among scientists, engineers, researchers, and medical practitioners focused on solving complex problems in medicine and related fields. These activities have resulted in the development of bio-inspired silicon, neural prosthetics, image processing systems, sensors and intravenous drug delivery devices that support diagnosis, treatment, and prevention of disease in patients. The IEEE Circuits and Systems (CAS) community has a track record of excellence and has played an active role in the research and design of these and other novel systems. This paper presents an overview of the life sciences and biomedical research under investigation within the Biomedical CAS (BioCAS) technical committee.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123141030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
An 8μW 100kS/s successive approximation ADC for biomedical applications 用于生物医学应用的8μW 100kS/s逐次逼近ADC
2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906739
Yung-Jui Chen, K. Tang, W. Fang
{"title":"An 8μW 100kS/s successive approximation ADC for biomedical applications","authors":"Yung-Jui Chen, K. Tang, W. Fang","doi":"10.1109/LISSA.2009.4906739","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906739","url":null,"abstract":"A successive approximation analog-to-digital converter (SA-ADC) for biomedical application is presented. It is based on 0.18-μm standard CMOS technology and operates at low supply voltage at 1V. Boosted switch for sample-and-hold stage, split capacitor array for DAC, and clocked rail-to-rail comparator are used to achieve low-power consumption. The ADC has signal-to-noise-and-distortion ratio of 53dB for supply voltage of 1V, at sampling rate of 100kS/s and power consumption of 8μW.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114946304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Miniature voltage sensitive dye imaging system for in vivo experiments 用于体内实验的微型电压敏感染料成像系统
2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906712
Joonseok Park, V. Pieribone, E. Culurciello
{"title":"Miniature voltage sensitive dye imaging system for in vivo experiments","authors":"Joonseok Park, V. Pieribone, E. Culurciello","doi":"10.1109/LISSA.2009.4906712","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906712","url":null,"abstract":"Currently, there are no widely used methods of optically recording rapid electrical events over a wide cortical area in freely moving animals. This paper presents an image sensor for recording electrical activity of large regions (4–9 mm2) of the nervous tissue at high speeds (≫ 500 Hz) using voltage sensitive dye imaging (VSDI) in freely moving animals. Each 75 μm x 75 μm pixel consists of a photodiode of 74 μm x 34 μm and a storage capacitor of 788 fF. The image sensor has a signal-to-noise ratio of 76 dB.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132676322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Simultaneous DNA amplification and detection using an electrode array 同时DNA扩增和检测使用电极阵列
2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906734
Teh Huey Fang, N. Ramalingam, J. Chang, Tan Swee Ngin, Hai-Qing Gong
{"title":"Simultaneous DNA amplification and detection using an electrode array","authors":"Teh Huey Fang, N. Ramalingam, J. Chang, Tan Swee Ngin, Hai-Qing Gong","doi":"10.1109/LISSA.2009.4906734","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906734","url":null,"abstract":"We demonstrate herein the implementation of in-situ electrochemical (EC) detection method in a microfluidic flow-through PCR device, where both the amplification of the target nucleic-acid sequence and subsequent EC detection of the PCR amplicon are realized simultaneously at selected PCR cycles in the same device. Our EC detection method is advantageous, when compared to other existing EC methods for PCR amplicon analysis, since our method does not require probe-modified electrodes, or asymmetric PCR, or solid-phase PCR. Key technical issues related to surface passivation, electrochemical measurement, bubble-free PCR, are investigated. By controlling the concentration of MB and the exposure of PCR mixture to the bare metal electrode, we successfully demonstrate electrochemical measurement of MB in solution-phase, symmetric PCR by amplifying a fragment of lambda phage DNA.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134152081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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