{"title":"用于体内实验的微型电压敏感染料成像系统","authors":"Joonseok Park, V. Pieribone, E. Culurciello","doi":"10.1109/LISSA.2009.4906712","DOIUrl":null,"url":null,"abstract":"Currently, there are no widely used methods of optically recording rapid electrical events over a wide cortical area in freely moving animals. This paper presents an image sensor for recording electrical activity of large regions (4–9 mm2) of the nervous tissue at high speeds (≫ 500 Hz) using voltage sensitive dye imaging (VSDI) in freely moving animals. Each 75 μm x 75 μm pixel consists of a photodiode of 74 μm x 34 μm and a storage capacitor of 788 fF. The image sensor has a signal-to-noise ratio of 76 dB.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Miniature voltage sensitive dye imaging system for in vivo experiments\",\"authors\":\"Joonseok Park, V. Pieribone, E. Culurciello\",\"doi\":\"10.1109/LISSA.2009.4906712\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Currently, there are no widely used methods of optically recording rapid electrical events over a wide cortical area in freely moving animals. This paper presents an image sensor for recording electrical activity of large regions (4–9 mm2) of the nervous tissue at high speeds (≫ 500 Hz) using voltage sensitive dye imaging (VSDI) in freely moving animals. Each 75 μm x 75 μm pixel consists of a photodiode of 74 μm x 34 μm and a storage capacitor of 788 fF. The image sensor has a signal-to-noise ratio of 76 dB.\",\"PeriodicalId\":285171,\"journal\":{\"name\":\"2009 IEEE/NIH Life Science Systems and Applications Workshop\",\"volume\":\"1 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-04-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2009 IEEE/NIH Life Science Systems and Applications Workshop\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/LISSA.2009.4906712\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2009 IEEE/NIH Life Science Systems and Applications Workshop","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/LISSA.2009.4906712","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Miniature voltage sensitive dye imaging system for in vivo experiments
Currently, there are no widely used methods of optically recording rapid electrical events over a wide cortical area in freely moving animals. This paper presents an image sensor for recording electrical activity of large regions (4–9 mm2) of the nervous tissue at high speeds (≫ 500 Hz) using voltage sensitive dye imaging (VSDI) in freely moving animals. Each 75 μm x 75 μm pixel consists of a photodiode of 74 μm x 34 μm and a storage capacitor of 788 fF. The image sensor has a signal-to-noise ratio of 76 dB.
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