{"title":"Adaptive image sensor for optical spike detection","authors":"A. Haas","doi":"10.1109/LISSA.2009.4906732","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906732","url":null,"abstract":"We report a novel active pixel sensor with adaptive in-pixel thresholding for optical spike detection. The adaptive threshold is set by ultra-low-power current-mode CMOS circuits which continuously compute the mean and standard deviation of the photocurrents generated by eight representative pixels in real-time. Sensor pixels discriminate between light and dark by integrating onto the photodiode junction capacitance the difference between the photocurrent and an opposing bias current whose magnitude is set by the mean and standard deviation circuits. We have characterized the active pixel sensor with and without an integrated fluorescence filter for biosensing applications and measured results agree with theory and simulations.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114558450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Faezipour, Tarun Tiwari, A. Saeed, M. Nourani, L. Tamil
{"title":"Wavelet-based denoising and beat detection of ECG signal","authors":"M. Faezipour, Tarun Tiwari, A. Saeed, M. Nourani, L. Tamil","doi":"10.1109/LISSA.2009.4906719","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906719","url":null,"abstract":"This paper presents the design and implementation of an automatic ECG beat detection system. We proposed modifications to the existing Pan-Tompkins algorithm by introducing only one set of adaptive threshold computations to reduce the amount of data processing significantly. LabVIEW signal processing tools were used to test the performance of wavelet based analysis for denoising and feature extraction of the ECG signal. Our design achieved an overall accuracy of 99.51% when applied on the MIT/BIH Arrhythmia Database, which is far better than the old method of digital filtering.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131962165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Surface-mounted dry electrode and analog-front-end systems for physiological signal measurements","authors":"C.W. Chang, J. Chiou","doi":"10.1109/LISSA.2009.4906721","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906721","url":null,"abstract":"In this paper, we present a new analog-front-end system including surface-mounted dry electrode by MEMS dry electrode (MDE) and instrumentation amplifier by chopper-stabilized differential difference amplifier (CHDDA) for physiological signal recording applications. Comparing to traditional electrodes, proposed MDE shows its superior advantages for low electrode skin interface impedance and need not to use electrolytic gel. Moreover, the measured results of the presented CHDDA demonstrated the low power, denoise capability for physiological signal recording. The full AFE system is 4.5*7cm2 in size, weight 35g and can be operated for 200Hr by 2 AAA batteries. Finally, the actual 4 channel AFE recording of EEG, EOG, ECG and EMG proves the practicability of the proposed system.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"375 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133766449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nikita V. Orlov, John D. Delaney, D. Eckley, L. Shamir, I. Goldberg
{"title":"Pattern recognition for biomedical imaging and image-guided diagnosis","authors":"Nikita V. Orlov, John D. Delaney, D. Eckley, L. Shamir, I. Goldberg","doi":"10.1109/LISSA.2009.4906724","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906724","url":null,"abstract":"Pattern recognition techniques can potentially be used to quantitatively analyze a wide variety of biomedical images. A challenge in applying this methodology is that biomedical imaging uses many imaging modalities and subjects. Pattern recognition relies on numerical image descriptors (features) to describe image content. Thus, the application of pattern recognition to biomedical imaging requires the development of a wide variety of image features. In this study we compared the efficacy of different techniques for constructing large feature spaces. A two-stage method was employed where several types of derived images were used as inputs for a bank of feature extraction algorithms. Image pyramids, subband filters, and image transforms were used in the first-stage. The feature bank consisted of polynomial coefficients, textures, histograms and statistics as previously described [1]. The basis for comparing the performance of these feature sets was the biological imaging benchmark described in [2]. Our results show that a set of image transforms (Fourier, Wavelet, Chebyshev) performed significantly better than a set of image filters (image pyramids, sub-band filters, and spectral decompositions). The transform technique was used to analyze images of H&E-stained tissue biopsies from two cancers: lymphoma (three types of malignancies) and melanoma (benign, primary, and five secondary tumor sites). The overall classification accuracy for these cancer data sets was 97%.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"18 21","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133424953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ear type circuit and system simulating the auditory brainstem response for auditory disorder characterization","authors":"K. Limpaphayom, R. Newcomb, P. Isipradit","doi":"10.1109/LISSA.2009.4906711","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906711","url":null,"abstract":"A use of auditory brainstem response in auditory disorder diagnosis is investigated in this paper leading to a proposed characterization method of the human auditory system. A modified nonlinear continuous time Hopfield neural type system is able to model the system yielding the simulated response in good agreement with the measured one. Both Simulink and PSpice simulation are investigated as well as the implementation of the system using a transistorized circuit. This opens a new possibility in improved means of noninvasive correction of auditory disorder which can be developed as the very large scale integrated hearing aid type chip.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125458675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fei Zhang, Xiaoyu Liu, S. A. Hackworth, R. Sclabassi, Mingui Sun
{"title":"In vitro and in vivo studies on wireless powering of medical sensors and implantable devices","authors":"Fei Zhang, Xiaoyu Liu, S. A. Hackworth, R. Sclabassi, Mingui Sun","doi":"10.1109/LISSA.2009.4906715","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906715","url":null,"abstract":"This paper investigates wireless electricity (witricity) and its application to medical sensors and implantable devices. Several coupling scenarios of resonators are analyzed theoretically. In vitro experiments are conducted in open air and through an agar phantom of the human head. An in vivo animal experiment is also carried out. Our studies indicate that witricity is a suitable tool for providing wireless power to a variety of medical sensors and implanted devices.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129141394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multi-input silicon neuron with weighting adaptation","authors":"Ming-ze Li, Po Ping-Wang, K. Tang, W. Fang","doi":"10.1109/LISSA.2009.4906744","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906744","url":null,"abstract":"This paper presents a biologically inspired “integrate-and-fire (I&F) neuron” which has multiple input dendrites for adaptive weight storage. By using a capacitor-free integrator, longer time constant and smaller chip area can be achieved. A low-power Schmitt Trigger is used to implement the feedback loop to achieve smaller power consumption. Weights are stored by using floating gate MOS transistors as nonvolatile analog memory. Simulation results show that this I&F neuron can be utilized in an analog VLSI neural network system.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117255365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hai Li, Z. Xue, Jiong Xing, Lei Guo, Stephen T. C. Wong
{"title":"Analyzing the diffusion patterns for follow-up study of Glioblastoma multiforme using Diffusion Tensor Imaging","authors":"Hai Li, Z. Xue, Jiong Xing, Lei Guo, Stephen T. C. Wong","doi":"10.1109/LISSA.2009.4906717","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906717","url":null,"abstract":"Studying the growth/recurrence of Glioblastoma multiforme (GBM) is very important not only for diagnosis but also for understanding and detecting the recurrence of GBM after surgery. In this paper, a novel DTI-based method is proposed to analyze the recurrence pattern of GBM based on serial Magnetic Resonance Imaging (MRI). After detecting the tumor shapes from T1-weighted images, the diffusion pattern around the tumor can be calculated from the Diffusion Tensor Imaging (DTI) data. This diffusion pattern is then compared with the tumor shapes detected in the follow-up studies, and a quantitative analysis is performed to find the relationship between the morphological changes of the tumor and the diffusion pattern calculated from DTI images. Using the postsurgical longitudinal GBM data acquired from The Methodist Hospital, it has been found that the recurrence patterns of GBM are correlated with the diffusion patterns calculated from DTI images. This finding suggests that the combination of the quantitative measures of both longitudinal morphological and diffusion pattern changes provides more accurate measures about the growth or recurrence of GBM. The proposed method can be used in the follow-up study of GBM as well as in clinical trials of various treatment methods.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"55 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120816919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Song, P. Xu, Yongde Meng, Jie Chen, Xiaoyan Yang, W. Roa, B. Kong, J. Xing
{"title":"Systematic study of enhanced cytotoxicity effects of gold-based nanoparticles in targeted cancer radiotherapy","authors":"K. Song, P. Xu, Yongde Meng, Jie Chen, Xiaoyan Yang, W. Roa, B. Kong, J. Xing","doi":"10.1109/LISSA.2009.4906702","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906702","url":null,"abstract":"Worldwide, cancers are the leading causes of human mortality. To successfully treat advanced-stage cancers, it is important to increase cytotoxicity of targeted tumor cells while reducing side effects on normal cells during radiotherapy. Nanotechnology provides a promising solution to achieve this targeted treatment[1–3]. An ideal strategy is to develop effective nanoscale radio-sensitizers targeting specifically at tumor cells. In this paper, we focus on gold-based nanoparticles as radio-sensitizers. Naked gold nanoparticles (GNPs) can accumulate at tumor tissues based on passively targeting mechanism and thus it can be used as a radio-sensitizer to kill cancers. However, GNPs conjugated with tumor-specific ligands are more promising for tumor diagnosis and treatment at the molecular scale. We have designed glucose-capped GNPs (or Glu-GNPs) to achieve specific targeting. Our preliminary results show a remarkable increase in cell-uptake of Glu-GNPs and also a significant increase of radiation cytotoxicity after applying irradiations.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126619955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tae-Young Choi, Wing-Fai Loke, T. Maleki, B. Ziaie, L. Papiez, B. Jung
{"title":"Wireless magnetic tracking system for radiation therapy","authors":"Tae-Young Choi, Wing-Fai Loke, T. Maleki, B. Ziaie, L. Papiez, B. Jung","doi":"10.1109/LISSA.2009.4906731","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906731","url":null,"abstract":"This paper presents a wireless position and orientation tracking system for radiation therapy. The proposed system uses only four transmitting coils and an implantable wireless transponder. The four transmitting coils generate magnetic field which is sensed and measured by a bi-axial sensor in the transponder in the tumor. A wireless transmitter in the transponder transmits the information back to a computer to determine the position and orientation of the transponder and hence, to track the tumor in real time. The algorithm of tracking is implemented using MATLAB, and simulation results and analysis are presented. Each calculation of the position tracking takes 20 ms, which makes the proposed system suitable for real-time tracking of the transponder for radiation assessment and delivery.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125830685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}