2009 IEEE/NIH Life Science Systems and Applications Workshop最新文献_第4页

Common-path fourier-domain optical coherence tomography in ophthalmology applications 共程傅里叶域光学相干断层扫描在眼科中的应用

2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906735

Jae‐Ho Han, Xuan Liu, Kang Zhang, Jin U. Kang

引用次数: 3

Endomicroscopy and biocompatible fluorescent nanocomplexes for clinical translation of high-resolution optical molecular imaging 用于高分辨率光学分子成像临床翻译的内镜显微镜和生物相容性荧光纳米复合物

2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906706

Jiefeng Xi, Yicong Wu, Tae Hee Kim, Yongping Chen, Desheng Zheng, Li Huo, M. Cobb, S. Pun, J. Hwang, Xingde Li

{"title":"Endomicroscopy and biocompatible fluorescent nanocomplexes for clinical translation of high-resolution optical molecular imaging","authors":"Jiefeng Xi, Yicong Wu, Tae Hee Kim, Yongping Chen, Desheng Zheng, Li Huo, M. Cobb, S. Pun, J. Hwang, Xingde Li","doi":"10.1109/LISSA.2009.4906706","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906706","url":null,"abstract":"This paper reports on our recent development of two-types of all-fiber-optic scanning endomicroscopy technologies for high-resolution optical imaging of internal organs. The first one is an OCT balloon catheter technology that permits systematic imaging of fine architectural morphologies of internal luminal organs over a large area. The second is a two-photon fluorescence endomicroscopy technology that enables assessment of tissue biochemical/metabolic information with a superb spatial resolution. Both endomicroscopes have a small diameter (1.2–2.4 mm) and can be readily integrated with a standard clinical gastroscope, providing complementary information about tissue structure and function and helping improve diagnostic yield. We will discuss the basic design principles, major engineering challenges, solutions, and some preliminary results. In addition, we will also present our approach in developing near infrared (NIR) fluorescent nanocomplexes (ICG-micelles), which can be functionalized for active molecular targeting to improve molecular specificity and imaging contrast. These nanocomplexes, made of FDA approved building blocks, are biocompatible and very promising for clinical translation. Ultimately the NIR nanocomplexes can be used in conjunction with endomicroscopy technologies for performing high-resolution optical molecular imaging in vivo and in real time.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124673004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of polyps in Wireless Capsule Endoscopy videos using Log Gabor filters 利用Log Gabor滤波器识别无线胶囊内窥镜视频中的息肉

2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906730

A. Karargyris, N. Bourbakis

引用次数: 50

Bioimaging: A new frontier area for signal processing research 生物成像:信号处理研究的新前沿领域

2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906701

J. Olivo-Marin

引用次数: 0

Wireless power and data transmission with ASK demodulator and power regulator for a biomedical implantable SOC 无线电源和数据传输与ASK解调器和功率调节器的生物医学植入式SOC

2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906740

Chen-Hua Kao, K. Tang

引用次数: 18

Large-scale high-performance cell membrane perforation, with nanoimprinted mass producible perforator 大规模高性能细胞膜穿孔，纳米印迹可批量生产的穿孔器

2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906695

T. Saito, O. Suekane, T. Akagi, A. Taguchi, T. Ichiki

{"title":"Large-scale high-performance cell membrane perforation, with nanoimprinted mass producible perforator","authors":"T. Saito, O. Suekane, T. Akagi, A. Taguchi, T. Ichiki","doi":"10.1109/LISSA.2009.4906695","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906695","url":null,"abstract":"The importance of developing methods in which certain materials can be introduced into a group of cells has been gaining considerable attention. However, owing to safety concerns accompanying the use of conventional viral-vector-based transfection and the low efficiency of plasmid-vector-based transfection, the development of a high performance nonbiological method has been expected. Currently available nonbiological methods such as electroporation generally have a low success rate and limited to low-molecular-weight molecules. For other methods that employ cellar uptake like phagocytosis, such as the cationic liposome method, these efficiencies largely depend on the nature of the target cells. In contrast, we found that submicron level cell membrane perforations could be made by inducing the local oxidations in the cell membrane while most of the treated cells were viable. We applied the perforation to the microinjection method and found that the injection of a functional dye, an antibody, and mRNA to the cells resulted in almost 100% survival as well as the successful manifestation of individual functions of these injected molecules. In the recent study, we extended the perforation process in a large number of cells. A nanobrush- shaped soft-polymer sheets formed by the nanoimprinting, which contained a photosensitizer, are used as the cell membrane perforator. We could automate the process by the robotics technology for the high-throughput operation. In future studies, we will extend the cell processing system for multi-purpose practical instruments for e.g. novel cell therapy, systematic cell differentiation.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115398406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

A carbon nanotube cortical neuron with excitatory and inhibitory dendritic computations 具有兴奋性和抑制性树突计算的碳纳米管皮质神经元

2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906727

J. Joshi, Chih-Chieh Hsu, A. C. Parker, Pankaj Deshmukh

引用次数: 25

He-Ne laser enhanced cellular hydrogen peroxide production and induced modulations in metabolic activity in malignant human brain cancer: Evidence for a “by-stander” effect He-Ne激光增强细胞过氧化氢的产生并诱导恶性人类脑癌代谢活动的调节:“旁观者”效应的证据

2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906729

D. Tata, R. Waynant

{"title":"He-Ne laser enhanced cellular hydrogen peroxide production and induced modulations in metabolic activity in malignant human brain cancer: Evidence for a “by-stander” effect","authors":"D. Tata, R. Waynant","doi":"10.1109/LISSA.2009.4906729","DOIUrl":"https://doi.org/10.1109/LISSA.2009.4906729","url":null,"abstract":"Continuous-wave He-Ne laser exposures (Intensity=35 mW/cm2, λ=632.8nm, Fluence range: 1J/cm2 to 50 J/cm2) on non-confluent and actively dividing human malignant glioblastoma cells was found to increase the cellular production levels of H2O2. Modulations in the cellular metabolic activity were detected (through the MTS assay) three days after laser irradiation. The metabolic activity was found to be dependent on the laser dose of exposure (i.e., fluence). In addition, three days after the laser exposure, the potential laser induced “bystander” effect was tested through the transfer of growth media from laser irradiated cells onto non-irradiated cells. After two additional days of incubation (5 days post exposure), the non-laser irradiated cells were found to have a significant increase in their metabolic activities. Modulations in the metabolic activities in the non-irradiated cells were found to be fluence dependent from the initial laser exposed cells treatment conditions. The results herein support the hypothesis of an important functional role for light enhanced cellular H2O2 generation to yield bio-modulatory effects locally and at a distance. The classical “bi-phasic” modulation response of cells to light irradiation is hypothesized to depend upon the quantity of light-enhanced H2O2 molecules generated from the mitochondria and the number of cells which interact with the H2O2 molecules.","PeriodicalId":285171,"journal":{"name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115890136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A wireless biomedical sensor network using IEEE802.15.4 采用IEEE802.15.4的无线生物医学传感器网络

2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906741

Shao-Yen Tseng, Chung-Han Tsai, Yu-Sheng Lai, W. Fang

引用次数: 12

Microscale technologies for tissue engineering 组织工程的微尺度技术

2009 IEEE/NIH Life Science Systems and Applications Workshop Pub Date : 2009-04-09 DOI: 10.1109/LISSA.2009.4906708

A. Khademhosseini, B. Chung

引用次数: 12