Chinese Journal of Analytical Chemistry最新文献

{"title":"Human health risk assessment of selected heavy metals in tanker water: A study from Kudlu, Bengaluru","authors":"Atreyee SARKAR,&nbsp;Santhee Devi KARRI","doi":"10.1016/j.cjac.2023.100337","DOIUrl":"10.1016/j.cjac.2023.100337","url":null,"abstract":"<div><p>The current study aims to assess the risk in humans due to six heavy metals, namely zinc, iron, copper, cadmium, arsenic, and lead, present in the tanker water supplied in the rural area of Bangalore called Kudlu village. Water samples were analyzed for a total period of 18 months between September 2021 to February 2023. Physicochemical and microbiological parameters were assessed for the collected water samples that included 04 tanker water and 01 purified water. Chlorine, pH, alkalinity, cyanuric acid, total hardness, conductivity, temperature, sodium, potassium, total dissolved solids, calcium, and magnesium was taken into consideration. Further bacteriological contamination by <em>E.coli</em> was also tested. Water Quality Indices were calculated based on these parameters. Water quality indices of the tanker water samples indicated that the quality of water was not suitable for drinking. The indices like exposure frequency, Hazard coefficient, carcinogenic and non-carcinogenic risks were calculated for both adults and infants for these heavy metals. The results indicated that the heavy metal concentration observed during the studied time period poses no risk to human health.</p></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"51 12","pages":"Article 100337"},"PeriodicalIF":1.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1872204023001111/pdfft?md5=55a31e492ab6e14f18b2ca6acf02b0ff&pid=1-s2.0-S1872204023001111-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135516025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the inhibition of dexmedetomidine (DEX) on malignant development of breast cancer by synchrotron radiation infrared spectroscopy","authors":"Chao YANG,&nbsp;Hui JI,&nbsp;Feng JIANG","doi":"10.1016/j.cjac.2023.100343","DOIUrl":"https://doi.org/10.1016/j.cjac.2023.100343","url":null,"abstract":"<div><h3>Objectives</h3><p>The topic of the relationship between analgesia and cancer recurrence inoncology surgery is a subject of debate in the field. Administering analgesic drugs after breast cancer surgery could potentially impact the long-term outcomes for patients. During breast cancer surgery, DEX, a potent α2 adrenergic receptoragonist, is often administered as an analgesic. Despite its common use, the analgesic effect of DEX and its potential impact on the progression of breast cancer remain uncertain.</p></div><div><h3>Methods</h3><p>To investigate the impact of DEX on breast cancer cells, cells exposed to DEX were collected and analyzed through cell apoptosis detection and synchrotron radiation micro-infrared spectroscopy.</p></div><div><h3>Results</h3><p>Following DEX treatment, the absorption peaks of MDA-MB-231 and MCF-7 cell lines showed significant redshift at 1230–1250 cm⁻¹ and 1380–1420 cm⁻¹ bands (<em>p</em>&lt;0.05). The absorption peak in the 1500–1700 cm⁻¹ band decreased (<em>p</em>&lt;0.05), while the 2910–2990 cm⁻¹ absorption peak increased, along with other apoptotic characteristics (<em>p</em>&lt;0.05). Our cell experiment results demonstrated that DEX was capable of protecting cell immunity via the down-regulation of TLR-4 receptor and effectively hindered the growth of breast cancer cells.</p></div><div><h3>Conclusion</h3><p>The cell and spectrum experiments' results indicate that DEX can encourage tumor cell apoptosis. These findings suggest that DEX is safe to use for breast cancer surgery and pain management.</p></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"51 12","pages":"Article 100343"},"PeriodicalIF":1.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1872204023001172/pdfft?md5=d738ef8bd2a079d6f18d8f1eb6c1ebdc&pid=1-s2.0-S1872204023001172-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138467640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Large-scale enrichment of RNA-binding proteins and binding site identification using the psoralen cycloaddition reaction’ [Chinese Journal of Analytical Chemistry 51 (2023) 100291]","authors":"Haofan Sun ,&nbsp;Weibing Zhang ,&nbsp;Ping Xu ,&nbsp;Weijie Qin","doi":"10.1016/j.cjac.2023.100308","DOIUrl":"https://doi.org/10.1016/j.cjac.2023.100308","url":null,"abstract":"","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"51 12","pages":"Article 100308"},"PeriodicalIF":1.2,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1872204023000828/pdfft?md5=34bfff41ad4037220afba44381ad73dd&pid=1-s2.0-S1872204023000828-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138453699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of dimedone-derived compounds as inhibitors against human colon cancer: Insights from 2D-QSAR, ADMET prediction, Osiris, Molinspiration, and molecular modeling","authors":"Khaoula Mkhayar ,&nbsp;Kaouakeb Elkhattabi ,&nbsp;Rachida Elkhalabi ,&nbsp;Rachid Haloui ,&nbsp;Ossama Daoui ,&nbsp;Emmanuel Israel Edache ,&nbsp;Samir Chtita ,&nbsp;Souad Elkhattabi","doi":"10.1016/j.cjac.2023.100330","DOIUrl":"https://doi.org/10.1016/j.cjac.2023.100330","url":null,"abstract":"<div><p>For this research, we performed a 2D-QSAR analysis on a set of 34 molecules derived from dimedone with inhibitory activity against human colon cancer (HT-29). The investigation incorporated principal component analysis (PCA), multiple linear regression (MLR), multiple non-linear regression (MNLR), and artificial neural network (ANN). The evaluations of the QSAR models demonstrated high predictive power (<em>R</em>²_MLR = 0.884; <em>R</em>²_CV (MLR) = 0.86), (<em>R</em>²_MNLR = 0.810; <em>R</em>²_CV (MNLR) = 0.879), and (<em>R</em>²_ANN = 0.9; <em>R</em>²_CV (ANN) = 0.89). The reliability of the models was validated through internal, external, Y-randomization, and validation domain applicability assessments. Utilizing the QSAR model predictions, we designed four new molecular structures that exhibited superior inhibitory activity against the HT-29 human colon cancer cell line compared to the 34 previously tested compounds. Subsequently, we examined the ADMET predictions, Molinspiration, and Osiris properties of the four compounds. The results revealed excellent ADMET predictions and Molinspiration for all four compounds, while only one designed compound fulfilled all Osiris properties. Molecular docking was employed to investigate the bindings between the newly designed molecule C and the c-Met protein. The findings indicated that the newly designed compound exhibited high stability in c-Met. Finally, MD simulations were employed to assess the stability and binding modes of compound C. Based on the MD results, compound C shows promise as a potential c-Met agonist candidate. Overall, our results suggest that this investigated compound has the potential to serve as a novel inhibitor against human colon cancer.</p></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"51 11","pages":"Article 100330"},"PeriodicalIF":1.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71725843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A sustainable electrochemical analytical platform for rapid detection of indole-3-acetic acid in Marchantia polymorpha","authors":"Xiangran Zhang ,&nbsp;Peng-Fei Yu ,&nbsp;Qi Zhou,&nbsp;Ya-Hong Wang,&nbsp;Xiang-Kai Zhuge,&nbsp;Ning Bao","doi":"10.1016/j.cjac.2023.100328","DOIUrl":"https://doi.org/10.1016/j.cjac.2023.100328","url":null,"abstract":"<div><p>Auxin (mainly indole-3-acetic acid, IAA) is one of the most essential phytohormones with various roles for land plants at different evolution stages and its polar transportation in plants suggested the importance of obtaining its amounts in different plant tissues. Because <em>Marchantia polymorpha</em> is at the entry evolution level, the IAA contents in its tissues would be useful for the study of IAA evolution. Although electrochemical detection offers a possible method for the measurement of IAA amounts, the cost for fabrication of electrochemical sensors is still high given the amounts of IAA tests in the future. Herein a low-cost disposable electrochemical analytical platform was constructed for analysis of IAA in tiny plant samples. Specifically, disposable carbon electrodes were prepared by modifying stainless steel wire mesh with inexpensive carbon ink because of less amounts of materials. The electrode was then integrated with a paper-based analytical device to form a disposable and low-cost platform for rapid electrochemical detection of IAA. For the modified electrode, the highest electrochemical responses for IAA could be obtained when the carbon ink was diluted for 3.5 times. The optimized pH value of the buffer solution for testing was 7.0, which is close to the physiological condition. Coupled with sample treatment using zirconium beads, this approach could successfully differentiate IAA in different tissues of <em>Marchantia polymorpha</em>. The obtained results agreed well with previous reports. This study suggested a sustainable electrochemical analytical detection platform for the study of IAA in practical applications.</p></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"51 11","pages":"Article 100328"},"PeriodicalIF":1.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71725844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron-poly(tannic acid) biomimetic nanoparticles for targeted magnetic resonance imaging and drug delivery","authors":"Tingting YIN ,&nbsp;Zhijian CHEN ,&nbsp;Zeyuan WEI ,&nbsp;Yushu LU ,&nbsp;Reheman AIKEBAIER ,&nbsp;Yan CHEN","doi":"10.1016/j.cjac.2023.100331","DOIUrl":"https://doi.org/10.1016/j.cjac.2023.100331","url":null,"abstract":"<div><p>The artificial nanomaterials with surface modification are promising platform in targeted therapy, but the nanomaterials are easily tracked by the reticuloendothelial system (RES) before reaching the target sites. Here we report a biomimetic camouflage system, macrophage membrane (MM) coated iron-poly(tannic acid) nanoparticels (Fe-PTA NPs) for targeted drug delivery and magnetic resonance imaging (MRI). The MM inherits the surface protein profiles from macrophage (RAW 264.7 cells), which would escape from RES and target the homotypic cells. The anticancer drug doxorubicin (DOX) was loaded into MM-Fe-PTA NPs, and demonstrated pH-responsive release ability. In addition, the MM-Fe-PTA NPs can be used as <em>T</em>₁-weighted MRI contrast agents for targeted MRI. This cell membrane camouflage strategy has great potential and challenge for clinic targeted therapy.</p></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"51 11","pages":"Article 100331"},"PeriodicalIF":1.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71725846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New approach into NOx removal from flue gas by carbohydrazide","authors":"Gan CHEN ,&nbsp;Zhenzhen GUAN ,&nbsp;Dezhen CHEN ,&nbsp;Liu HONG","doi":"10.1016/j.cjac.2023.100335","DOIUrl":"https://doi.org/10.1016/j.cjac.2023.100335","url":null,"abstract":"<div><p>Selective non-catalytic reduction (SNCR) is a proven technique to reduce nitrogen oxide (NO<em>_x</em>) emissions from stationary sources. The process utilizes NH₃ or urea as a reducing agent, which is only effective in a narrow and high temperature range with the maximum NO<em>_x</em> abatement falling with the increase of the O₂ content. In large industrial boilers, the effectiveness of the deNO<em>_x</em> process may be decreased with boiler load variations and excess O₂. This study investigated carbohydrazide as a reagent to improve SNCR performance. NO reduction by carbohydrazide was experimentally investigated in a pilot-scale flow reactor. The effect of reaction temperature, molar ratio of NH₂ to NO (normalized stoichiometric ratio, NSR) on the NO reduction was determined. Moreover, the promotion effect of carbohydrazide on the reactivity of NH₃ and urea was also investigated. The experimental results indicated that NO reduction by carbohydrazide occurred in a relatively low temperature range of 650–850 °C, and the optimum reaction temperature was about 730 °C at NSR of 2.0, the O₂ content of 11.5%–16.6% and the initial NO<em>_x</em> concentration of 635 mg/m³. After adding a small amount of carbohydrazide to an NH₃ or urea solution, the data showed that carbohydrazide could shift the temperature window of NH₃ to the left, but had no positive effect on urea deNO<em>_x</em> and the NO conversion efficiencies of NH₃ deNO<em>_x</em>. Consequently, carbohydrazide is a potential reducing agent for NO<em>_x</em>, but was not adapted to improve the deNO<em>_x</em> performance with NH₃ and urea.</p></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"51 11","pages":"Article 100335"},"PeriodicalIF":1.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1872204023001093/pdfft?md5=d050f1150055dde1bec9f5beb4c56407&pid=1-s2.0-S1872204023001093-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92048306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-assembly method of glucose oxidase in a fully packaged microfluidic glucose biosensor","authors":"Zhen PENG ,&nbsp;Zongyuan LI ,&nbsp;Zhimi ZHANG ,&nbsp;Jingru LIAO ,&nbsp;Mingzhe XIE ,&nbsp;Yuanlin XIA ,&nbsp;Cao XIA ,&nbsp;Zhuqing WANG","doi":"10.1016/j.cjac.2023.100329","DOIUrl":"https://doi.org/10.1016/j.cjac.2023.100329","url":null,"abstract":"<div><p>In this work, a self-assembly approach is proposed to bio-functionalize the fully packaged microfluidic biosensors for catalyzing glucose based on the designed and fabricated microfluidic chip with suspending structure by micro-electro-mechanical system technology. Glucose oxidase is successfully immobilized on the surface of microelectrodes to build composite layers by the proposed self-assembly approach, with cysteamine applied as a functional linker. The biological activity and stability of glucose oxidase is optimized by the electrodeposition of chitosan membrane. Experiments results suggest that the fully packaged microfluidic biosensor integrated with self-assembled glucose oxidase can effectively detect the existence of glucose in sample solution. The detection range of glucose concentration is 0–10 mM. With SNR of 3, the detection limit is 51.2 μM and sensitivity is 23.47 ± 1.36 μA·cm⁻²·mM⁻¹ within low concentration range of 0–0.1 mM, while the detection limit is 497 μM and the sensitivity is 10.63 ± 1.28 μA·cm⁻²·mM⁻¹ among high concentration range of 0.1–10 mM. The proposed study provides a straightforward method to construct a microfluidic biosensor, which is promising in miniaturized clinical medical device.</p></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"51 11","pages":"Article 100329"},"PeriodicalIF":1.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71725845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Sb(V) in water samples via solid-phase extraction based on Mg–Al layered double hydroxide sorbents prior to ICP-MS","authors":"Lei XU,&nbsp;Lingxi ZHAO,&nbsp;Xia WANG,&nbsp;Rusong ZHAO","doi":"10.1016/j.cjac.2023.100333","DOIUrl":"https://doi.org/10.1016/j.cjac.2023.100333","url":null,"abstract":"<div><p>Solid-phase extraction (SPE) is an effective method for detecting trace metals. Mg-Al-layered double hydroxide (Mg-Al LDH) materials as an effective adsorbent for SPE because of its large anion exchange capacity, high yield and low cost. A new method was developed for detecting Sb(V) with SPE coupled with inductively coupled plasma mass spectrometry. Mg-Al LDH was synthesized via a simple coprecipitation method and characterized using scanning electron microscopy, Fourier transform infrared spectrometry, X-ray diffractometry, and X-ray photoelectron spectroscopy. Factors affecting the Sb(V) extraction efficiency, such as the eluent type and volume, solution pH, loading flow rate, sample volume, adsorbent weight, and salt concentration, were optimized. Under optimal conditions, the SPE method exhibited good linearity (<em>R</em>² ≥ 0.999) in the range of 0.1–100 μg L⁻¹ with a limit of detection equal to 0.017 μg L⁻¹, good repeatability and reproducibility, and intraday and interday relative standard deviations of 1.84% and 1.48%, respectively. Furthermore, the method was applied to determine traces of antimony in drinking water and bottled water, and findings revealed recoveries between 82.7%–92.1%.</p></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"51 11","pages":"Article 100333"},"PeriodicalIF":1.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S187220402300107X/pdfft?md5=370a258a6e3848bae565b052cff07db0&pid=1-s2.0-S187220402300107X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92040507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular dynamics simulations of supramolecular complexes under influence of an external force","authors":"Waleed N. AL-DARKAZALI ,&nbsp;Omar HACHIM","doi":"10.1016/j.cjac.2023.100332","DOIUrl":"https://doi.org/10.1016/j.cjac.2023.100332","url":null,"abstract":"<div><p>This work investigates the dynamics of supramolecular complexes Calix[<em>n</em>]arenes that are formed by weak forces. These interactions are important for the structure and function of biological molecules and for the design of synthetic host-guest systems. Molecular dynamics simulations are used to explore the reversible binding under of these complexes external force at the atomic level and to complement experimental methods.</p></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"51 12","pages":"Article 100332"},"PeriodicalIF":1.2,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1872204023001068/pdfft?md5=d574bc0d3fabd8f3eb692583832c77ab&pid=1-s2.0-S1872204023001068-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91641613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}