Chinese Journal of Analytical Chemistry最新文献

{"title":"Study on the plasma metabolomics of Schisandra chinensis polysaccharide against ulcerative colitis and its correlation with gut microbes metabolism","authors":"Guangji ZHANG ,&nbsp;Jiuba ZHANG ,&nbsp;Shuai YAN ,&nbsp;Min HAO ,&nbsp;Chenghao FEI ,&nbsp;De JI ,&nbsp;Chunqin MAO ,&nbsp;Huangjin TONG ,&nbsp;Tulin LU ,&nbsp;Lianlin SU","doi":"10.1016/j.cjac.2023.100244","DOIUrl":"https://doi.org/10.1016/j.cjac.2023.100244","url":null,"abstract":"<div><p>In our previous study, the efficacy of <em>Schisandra chinensis</em> polysaccharide (SCP) against ulcerative colitis (UC) has been evaluated. At the same time, the mechanism of action was studied from the structure and composition of intestinal flora and the metabolism of short chain fatty acids (SCFAs). Metabolomics method was used to study the mechanism of SCP against UC which needed further analysis, and research results were carried out to conduct correlation analysis in order to further and systematically reveal the mechanism of SCP in the intervention of UC based on previous studies. In the study of metabolomics, 32 potential biomarkers including Sphinganine, PG (18:0/16:0), PE (P-16:0/16:0), LysoPC (18:1(9Z)/0:0), LysoPE (0:0/18:4(6Z,9Z,12Z,15Z)), Vitamin D2 3-glucuronide, etc. were identified in plasma, which were assigned to glycerol phospholipid metabolism, sphingolipid metabolism, ether lipid metabolism, and linoleic acid metabolism. These pathways are associated with diseases such as intestinal dysfunction, inflammatory syndromes, and neurological dysfunction. In addition, SCP was able to significantly improve the imbalance of gut microbiota, which was closely related to SCFAs. Based on the above research, we can draw a conclusion that SCP has pharmacological effects on UC, and its mechanism may be related to the gut microbes, plasma biomarkers and short-chain fatty acids.</p></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"51 9","pages":"Article 100244"},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1894803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorescence and surface enhanced Raman scattering dual-model PCR for the detection of DNA barcoding of Asarum heterotropoides","authors":"Chunhao WEI,&nbsp;Aihong WU,&nbsp;Lingling GUO,&nbsp;Liqiang LIU,&nbsp;Chuanlai XU,&nbsp;Hua KUANG,&nbsp;Xinxin XU","doi":"10.1016/j.cjac.2023.100304","DOIUrl":"10.1016/j.cjac.2023.100304","url":null,"abstract":"<div><p>Asarum plants containing many functional substances are widely used in traditional prescriptions and tonics. DNA barcoding is a relatively short specific gene segment in the genome which can be used for species identification purposes. The present work selected RNA transcriber type II intron shear enzyme gene (matK) as the target and developed a novel fluorescence and surface enhanced Raman scattering (SERS) dual-model PCR for the detection of <em>Asarum heterotropoides</em> (AH) in plants. The dual-model method achieved specific AH DNA detection with a limit of detection (LOD) of 10⁻³ ng/µL for the fluorescence signal and 10⁻⁴ ng/µL for the SERS signal in the range of 10⁻⁴−10 ng/µL. Agarose gel electrophoresis results and qPCR results showed the novel method was highly specific for AH detection and only the AH was successfully amplified.</p></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"51 9","pages":"Article 100304"},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1872204023000786/pdfft?md5=f75c2129821405a2c0004102d1aa101f&pid=1-s2.0-S1872204023000786-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83850557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and application of an underwater mass spectrometer for in situ detection of deep-sea dissolved gases","authors":"Han WANG ,&nbsp;Lei SHAO ,&nbsp;Chenguang YANG ,&nbsp;Jian ZHANG ,&nbsp;Changjie LIU ,&nbsp;Zhangxu WU ,&nbsp;Haiyun SONG ,&nbsp;Chilai CHEN","doi":"10.1016/j.cjac.2023.100299","DOIUrl":"https://doi.org/10.1016/j.cjac.2023.100299","url":null,"abstract":"<div><p>The rapid and accurate analysis of dissolved gases in the deep sea has great significance for studying the geological profile of the Earth, searching for oil and gas resources, and studying global climate change. In this research, we developed a deep-sea mass spectrometer for in situ dissolved gases detection. The deep-sea mass spectrometer uses 24 V DC power and has an average power consumption of less than 60 W during operation and less than 10 W during standby. Its physical size is <em>φ</em>240 mm×1300 mm, with a core mass of 14.2 kg. The detectable mass range is 1–200 Da, with a mass resolution of less than 1 Da and the scanning time for a single mass is less than 15 ms. The detection limits for dissolved N₂, O₂, Ar, and CO₂ under atmospheric pressure are 0.021 μg/L, 0.068 μg/L, 0.017 μg/L, and 0.014 μg/L. The deep-sea mass spectrometer operated continuously and stably for more than 8 h under a simulated water depth of 5800 m, and it also achieved continuous online detection for 25.8 h in the sea area of −1388 m depth in the South China Sea, obtaining dissolved gas concentration-time and depth-concentration curves. This research provides key technological support for deep-sea exploration and information reference for other deep-sea detection technologies.</p></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"51 9","pages":"Article 100299"},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1874953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-target screening and identification of the significant quality markers in the wild and cultivated Cordyceps sinensis using OPLS-DA and feature-based molecular networking","authors":"Jing WANG ,&nbsp;Qinyu XIAO ,&nbsp;Hongbo HUANG ,&nbsp;Dan WU ,&nbsp;Guangfeng ZENG ,&nbsp;Wenrui CHEN ,&nbsp;Yiwen TAO ,&nbsp;Bo DING","doi":"10.1016/j.cjac.2023.100302","DOIUrl":"10.1016/j.cjac.2023.100302","url":null,"abstract":"<div><p><em>Cordyceps sinensis</em> is a rare traditional Chinese herbal material. The cultivated <em>cordyceps sinensis</em> instead of the wild is a potential important development trend. Assessing the consistency of the wild and cultivated <em>cordyceps sinensis</em> is a very significant attention. The method of non-target screening and mining of the significant quality markers in the wild and cultivated <em>cordyceps sinensis</em> samples was established by liquid chromatography-quadrupole time-of-flight high resolution mass spectrometry (LC-Q-TOF-MS) combined with feature-based molecular networking (FBMN) and the model of orthogonal partial least square discriminant analysis model (OPLS-DA). Forty-seven training samples, including thirty-three wild <em>cordyceps sinensis</em> samples and fourteen cultivated <em>cordyceps sinensis</em> samples, were firstly used to build the OPLS-DA original model based on the 6827 feature <em>m/z</em> peaks. The 1144 feature <em>m/z</em> peaks of dimensionality reduction were built the OPLS-DA optimized model, which were acquired by the variable projected importance (VIP) of the OPLS-DA original model. Twenty nine significant markers were mined by using the S-plot of the OPLS-DA optimized model. Moreover, 17 of 29 significant markers were identified by the non-target screening of FBMN, including eight wild markers and nine cultivated markers. Finally, an overall correct rate of 95.5% (twenty two test samples) was obtained for classification of the wild and cultivated <em>cordyceps sinensis</em> samples based on the twenty nine significant markers. It is indicated that the significant quality markers of <em>cordyceps sinensis</em> could be mined and identified based on the non-target screening of FBMN coupled with OPLS-DA.</p></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"51 9","pages":"Article 100302"},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1872204023000762/pdfft?md5=434fb0d0484c86543923679f83f5ff9d&pid=1-s2.0-S1872204023000762-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91074050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening and identification of active compounds of GanZhiRong granule based on liquid chromatography-mass spectrometry and biomolecular networks","authors":"Si-Tong CHEN ,&nbsp;Zhuang XIONG ,&nbsp;Chenxu JING ,&nbsp;Ran XIA ,&nbsp;Xue QU ,&nbsp;Tie-Jun LIU ,&nbsp;Yang-Yang LIU","doi":"10.1016/j.cjac.2023.100294","DOIUrl":"https://doi.org/10.1016/j.cjac.2023.100294","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the mechanism of GanZhiRong granule(GZR)in the treatment of type 2 diabetes mellitus (T2DM).</p></div><div><h3>Methods</h3><p>Network pharmacology was used to explore the target and signal pathway of GZR in T2DM. Cell experiments were conducted to observe the inhibitory effects of GZR on oxaloacetic acid on pyruvate glycoisogenesis, triglyceride and glucose release, and the inhibitory effects of GZR on palmitic acid (PA) induced apoptosis of HepG2 cells. The main components in GZR were identified and compared by liquid chromatography-mass spectrometry.</p></div><div><h3>Results</h3><p>Network pharmacological methods were used to explore the targets and signaling pathways of T2DM treated with GZR, and it was found that CA4, CA7, CA2, AKR1B1 and other targets were closely related to T2DM treated with GZR. Gene Ontology (GO) and Kyoto Encyclopedia Genes and Genomes (KEGG) pathway enrichment analysis indicated that GZR may directly regulate the development of T2DM through lipid atherosclerosis and apoptosis. <em>In vitro</em> results showed that GZR has a certain protective effect on PA-induced damage of HepG2 cells in a dose-dependent manner. In addition, GZR can effectively inhibit the increase of triglyceride and glucose contents in PA-induced HepG2 cells, decrease the contents of pyruvate and oxaloacetic acid, and significantly increase the content of acetyl-coA. The main components were identified and compared. 32 components were identified, including salvianolic acid B, D-hydrothreose, proanthocyanidin, shikimic acid, salvianolic acid A, salvianolic acid C, 7 glycosides of calycoflavone, 3′-methoxy puerarin, 3′-hydroxypuerarin, apigenin-7-o-β-D.</p></div><div><h3>Conclusion</h3><p>The treatment of T2DM with GZR is related to lipid metabolism and cell apoptosis.</p></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"51 9","pages":"Article 100294"},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3338877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-time detection of the transport of water cluster across cytomembrane with piezoelectric sensor","authors":"Peihui Yang,&nbsp;Yeyan Zhu,&nbsp;Yan Hao","doi":"10.1016/j.cjac.2023.100307","DOIUrl":"https://doi.org/10.1016/j.cjac.2023.100307","url":null,"abstract":"<div><p>Acquiring insight into the transport of water clusters across cytomembrane is vital and essential for elucidating cell functions and water channels. Herein, A highly sensitive living cell analysis platform was developed for monitoring the transport dynamics of water clusters through water channels by combining the piezoelectric transducer and the hypotonicity-caused cell volume regulation. The various drinking water was used as the hypotonic perfusate to stimulate vascular endothelial cells and the temporal frequency response to cells was obtained to analyze the transport rate of the influx and efflux of water clusters which is related to water structure. The sensor is capable to distinguish the transport dynamics of different water clusters in five drinking water which the transport rates of water influx of cells are 5.1 ± 0.40, 6.6 ± 0.96, 7.4 ± 0.46, 8.1 ± 0.86, and 8.4 ± 0.80 Hz min⁻¹ (<em>n</em> = 3), respectively, showed that they are ranked in the increasing order: M-water, C-water, S-water, RO-water, <span>d</span>-water. Moreover, inhibitor of HgCl₂ was used to block water channels to reveal the water transport via water channels. Conductivity and infrared spectroscopy assays further confirmed the differences of transport dynamics between these drinking water due to the structure or size of water clusters caused by the mineral substance or the electromagnetic field. Therefore, this work provides a novel, simple and effective method for monitoring the transport of different water cluster across cytomembrane.</p></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"51 12","pages":"Article 100307"},"PeriodicalIF":1.2,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71725984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly selective detection of formaldehyde and its analogs in clams based on unique and specific conjugation reactions via ultraviolet-visible absorptions","authors":"Yuru Min ,&nbsp;Donglei Fu ,&nbsp;Honglei Liu ,&nbsp;Chenyao Yuan ,&nbsp;Lei Wang ,&nbsp;Mengyu Cao ,&nbsp;Aowei Sun ,&nbsp;Wenrong Yang ,&nbsp;Jingquan Liu","doi":"10.1016/j.cjac.2023.100287","DOIUrl":"https://doi.org/10.1016/j.cjac.2023.100287","url":null,"abstract":"<div><p>Although formaldehyde has been widely used in industry, the excessive or residual formaldehyde has been proven to cause irreversible harm to human beings due to its high toxicity. To solve this problem, we studied oxalyldihydrazide as an analytical reagent to determine formaldehyde by ultraviolet and visible (UV-vis) spectrophotometry. In this study, hydrazine compounds with –NH–NH₂ structures can react with formaldehyde to form hydrazone (including –NH–N=CH–), water is the only by-product. Therefore, oxalyldihydrazide can not only react with formaldehyde but also sense its analogs such as acetaldehyde, acetone, and benzaldehyde in solution, and detect them by UV-vis spectrophotometry at 220 nm, 226 nm, 262 nm, and 257 nm respectively. Among them, the limit of detection (LOD) of formaldehyde is calculated to be 0.03 ppm (LOQ = 0.03 ppm) with the relative standard deviation (RSD) of 1.58%. Meanwhile, the above-mentioned method can be used for detecting formaldehyde in clams with excellent selectivity and sensitivity.</p></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"51 8","pages":"Article 100287"},"PeriodicalIF":1.2,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1553843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of unsaturated lipids with high structural specificity by coupling epoxidation with tandem mass spectrometry","authors":"Wenbo CAO,&nbsp;Jun TAN","doi":"10.1016/j.cjac.2023.100290","DOIUrl":"https://doi.org/10.1016/j.cjac.2023.100290","url":null,"abstract":"<div><p>Comprehensive characterization of lipid structures is of significance, as they play a key role in numerous biological processes. Mass spectrometry (MS) emerges as a preferred tool for lipid analysis, providing good performance in sensitivity and accuracy. However, characterization of unsaturated lipids still has certain difficulties due to structural diversity. In this work, combining epoxidation and tandem MS was developed for unsaturated lipids analysis with high structural specificity. By using the proposed method, it could simultaneously produce high-abundance diagnostic ions specific to lipid C=C locations and <em>sn</em>-positions, facilitating lipid isomers identification. Determining C=C location and <em>sn</em>-position isomers of lipid in a single spectrum can be achieved, which is valuable for discovery of great structural diversity. The capability of this approach in characterizing unsaturated lipids at high structural level has been illustrated with different standards including a lipid extract from complex biological sample. The relative quantitation capability of C=C location and <em>sn</em>-position isomers was also demonstrated based on diagnostic ion intensities.</p></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"51 8","pages":"Article 100290"},"PeriodicalIF":1.2,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1875766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in metal-organic frameworks synthesis and characterization with a focus on electrochemical determination of biological and food compounds, and investigation of their antibacterial performance","authors":"Mehdi Khalaf Mohammad MAHJOOB ,&nbsp;Mahshid AKBARIZADEH ,&nbsp;Paria HASHEMAN ,&nbsp;Natthaporn RATTANAPAN ,&nbsp;Ali MORADI-GHOLAMI ,&nbsp;Hawraz Ibrahim M. AMIN ,&nbsp;Abduladheem Turki JALIL ,&nbsp;Marwan Mahmood SALEH","doi":"10.1016/j.cjac.2023.100286","DOIUrl":"https://doi.org/10.1016/j.cjac.2023.100286","url":null,"abstract":"<div><p>Metal-organic frameworks (MOFs) are hybrid materials composed of both organic and inorganic elements. MOF materials, because of their unique structures and properties, such as controllable pore size, large surface area, excellent catalytic activity, and high density of active sites, are applied in electrochemical sensors systems for the sensitive, quick, and low-cost detection of multiple analytes. MOFs, with their high specific surface area, controllable shape, and adjustable pore volume, will provide strong interaction with compounds via abundant functional groups, leading to increased selectivity for electrochemical determination of a wide range of compounds. In this review, the structure, synthesis methods, characterization, and the applications of MOFs in recent years as sensing material in fabricating sensors for detecting drugs, pesticides, heavy metals, food additives, and other contaminants are summarized, compared, and discussed. Also, MOFs were used in numerous antibacterial application areas due to their long-term release pore volume, capability, and stretch ability when integrated with a wide range of compounds and/or substances (including nanostructures, phytochemicals, antibiotics, and polymers). This review also provides a comprehensive overview of the antibacterial uses of MOFs and one's composite materials, with a focus on the different kinds of MOF nanocomposite and their antibacterial influence in various uses.</p></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"51 8","pages":"Article 100286"},"PeriodicalIF":1.2,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"2639226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large-scale enrichment of RNA-binding proteins and binding site identification using the psoralen cycloaddition reaction","authors":"Haofan Sun ,&nbsp;Weibing Zhang ,&nbsp;Ping Xu ,&nbsp;Weijie Qin","doi":"10.1016/j.cjac.2023.100291","DOIUrl":"https://doi.org/10.1016/j.cjac.2023.100291","url":null,"abstract":"<div><p>RNA-binding proteins (RBPs) play central roles in the regulation of gene expression in eukaryotes. The elucidation of complex RNA‒protein interaction patterns and specific binding sites has been the subject of intensive research in recent years. However, large-scale RNA‒protein binding site (RBS) identification remains an urgent issue due to the lack of broad and unbiased RBP enrichment methods. In this study, a novel strategy for RBS identification was developed by using a psoralen probe (PP) for large-scale RBP enrichment. A total of 1957 high-confidence RBPs with good reproducibility were identified via mass spectrometry. A total of 1783 protein groups (91.1%) were previously annotated as RBPs. To identify RBSs, the enriched RBPs were treated with two different methods: digestion via ribonucleases (RNases) or hydrofluoric acid (HF). A total of 448 high-confidence RBSs were identified by using the former strategy, and 1301 high-confidence RBSs were identified by using the latter method. By comparing the identification results of cross-linking sites in both methods, it was observed that the binding of RNA to RBP was less likely to occur on acidic amino acids. Furthermore, the HF method can identify RBS in a more unbiased manner than the RNase method. The above mentioned results suggest the potential of both methods for large-scale RBS identification.</p></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"51 8","pages":"Article 100291"},"PeriodicalIF":1.2,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3198713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}