Chinese Journal of Analytical Chemistry最新文献

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Identifying the active antioxidant ingredients in Arisaema Cum Bile aqueous extract on the basis of spectrum-effect relationships
IF 1.2 4区 化学
Chinese Journal of Analytical Chemistry Pub Date : 2024-12-01 DOI: 10.1016/j.cjac.2024.100453
Congyou DENG , Xinhe LEI , Minyou HE , Guowei LI , Xiangdong CHEN , Dongmei SUN , Qing DING , Jiang MENG , Xiaozhou JIA , Minyu WANG
{"title":"Identifying the active antioxidant ingredients in Arisaema Cum Bile aqueous extract on the basis of spectrum-effect relationships","authors":"Congyou DENG ,&nbsp;Xinhe LEI ,&nbsp;Minyou HE ,&nbsp;Guowei LI ,&nbsp;Xiangdong CHEN ,&nbsp;Dongmei SUN ,&nbsp;Qing DING ,&nbsp;Jiang MENG ,&nbsp;Xiaozhou JIA ,&nbsp;Minyu WANG","doi":"10.1016/j.cjac.2024.100453","DOIUrl":"10.1016/j.cjac.2024.100453","url":null,"abstract":"<div><div>At present, the research on <em>Arisaema Cum Bile</em> mainly focuses on the analysis of its components and changes in pharmacological effects. The chemical composition of the water extract, the material basis and mechanism of its anti-oxidation and anti-febrile convulsion are still unclear. In this study, fingerprint-pharmacological relationships were used to determine the pharmacodynamic and pharmacological material basis of the antioxidant effects of <em>Arisaema Cum Bile</em> aqueous extract.</div></div><div><h3>Methods</h3><div>The High Performance Liquid Chromatography (HPLC) fingerprint of the aqueous extract of <em>Arisaema Cum Bile</em> was established by determining the common peaks, recording the peak areas and evaluating the similarities between different batches. Moreover, the antioxidant capacity of each batch of processed <em>Arisaema Cum Bile</em> extracts was determined, and spectrum-effect relationship analysis and screening were conducted on the basis of the fingerprint. The antioxidant activities of the <em>Arisaema Cum Bile</em> aqueous extract ingredients were verified by evaluating the isolated compounds.</div></div><div><h3>Results</h3><div>The HPLC fingerprints of 15 batches of aqueous extracts of <em>Arisaema Cum Bile</em> aqueous extracts were established via ultraviolet (UV) and evaporative light scattering detection methods. There was a total of 22 common peaks, 11 of which were identified as uracil, hypoxanthine, xanthine, uridine, guanosine, adenosine, shaftoside, isoschaftoside, taurohyodeoxycholic acid, taurochenodeoxycholic acid and glycinechenodeoxycholic acid. Spectrum-effect relationship analysis revealed that shaftoside, isoschaftoside, taurochenodeoxycholic acid and glycochenodeoxycholic acid may be the active antioxidant ingredients in this extract, which was verified since all four ingredients displayed dose-dependent antioxidant effects when tested individually.</div></div><div><h3>Conclusion</h3><div>A fingerprint of the aqueous extract of <em>Arisaema Cum Bile</em> aqueous extract was established, the antioxidant capacities of the extracts were measured, and the active antioxidant ingredients were identified through spectrum-effect relationship analysis.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"52 12","pages":"Article 100453"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on the anti-colon cancer effect of Renshen Yangrong decoction based on network pharmacology, molecular docking, and in vivo and in vitro experiments
IF 1.2 4区 化学
Chinese Journal of Analytical Chemistry Pub Date : 2024-12-01 DOI: 10.1016/j.cjac.2024.100464
Wen HE , Jia-Le JU , Ying-Hua WU , Yu-Xi ZHANG , Jun-Feng ZHANG , Chen-Chen LI , Yan-Li WANG
{"title":"Study on the anti-colon cancer effect of Renshen Yangrong decoction based on network pharmacology, molecular docking, and in vivo and in vitro experiments","authors":"Wen HE ,&nbsp;Jia-Le JU ,&nbsp;Ying-Hua WU ,&nbsp;Yu-Xi ZHANG ,&nbsp;Jun-Feng ZHANG ,&nbsp;Chen-Chen LI ,&nbsp;Yan-Li WANG","doi":"10.1016/j.cjac.2024.100464","DOIUrl":"10.1016/j.cjac.2024.100464","url":null,"abstract":"<div><div>Renshen Yangrong Decoction (RSYRD) is a traditional Chinese medicinal compound widely used as an adjuvant in colon cancer treatment. However, the specific role of RSYRD in anti-colon cancer remains unclear. This study aimed to investigate the anti-colon cancer effects of RSYRD using network pharmacology, molecular docking, and <em>in vitro</em> and <em>in vivo</em> experiments. The active ingredients and targets of RSYRD were identified utilizing databases, and RSYRD-ingredient-target and protein-protein interaction (PPI) networks were constructed. Gene Ontology (GO) functional analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were performed on the anti-colon cancer targets of RSYRD, followed by molecular docking using AutoDockTools 1.5.6. <em>In vitro</em> and <em>in vivo</em> experiments were conducted to explore the mechanism of RSYRD and evaluate its inhibitory efficacy on colon cancer. A total of 233 active ingredients and 88 colon cancer-related targets were identified, including 9 core targets. GO functional analysis revealed that RSYRD exerts anti-tumor effects through processes such as oxidative reactions, closely associated with intracellular reactive oxygen species (ROS). KEGG enrichment analysis indicated that the anti-tumor effect of RSYRD involved the interaction of cancer-related and viral disease-associated pathways, as well as the IL-17, TNF, and PI3K-AKT signaling pathways. Molecular docking showed stable ligand-receptor binding, with binding energies below −5.0 kcal/mol. <em>In vitro</em> experiments demonstrated that RSYRD increased ROS levels, reduced mitochondrial membrane potential (MMP), and promoted apoptosis in SW620 cells, thereby inhibiting cell proliferation and migration. <em>In vivo</em> experiments showed that RSYRD significantly suppressed colon cancer proliferation. This study identified Quercetin, Kaempferol, 7-Methoxy-2-methyl-isoflavone, Licochalcone-a, and Isorhamnetin as core ingredients in RSYRD, likely exerting anti-colon cancer effects by inhibiting proteins such as ESR1, HSP90AA1, NCOA2, and MAPK14, and suppressing the PI3K-AKT signaling pathway, thereby regulating tumor cell proliferation, migration, and apoptosis.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"52 12","pages":"Article 100464"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A molecular beacon detects CLDN18.2 for precision medicine in gastric cancer
IF 1.2 4区 化学
Chinese Journal of Analytical Chemistry Pub Date : 2024-12-01 DOI: 10.1016/j.cjac.2024.100452
Jieyuan CAI , Xiaoyi CHONG , Linyang FAN , Qin LI , Xiaotian ZHANG
{"title":"A molecular beacon detects CLDN18.2 for precision medicine in gastric cancer","authors":"Jieyuan CAI ,&nbsp;Xiaoyi CHONG ,&nbsp;Linyang FAN ,&nbsp;Qin LI ,&nbsp;Xiaotian ZHANG","doi":"10.1016/j.cjac.2024.100452","DOIUrl":"10.1016/j.cjac.2024.100452","url":null,"abstract":"<div><h3>Purpose</h3><div>CLDN18.2 has emerged as a promising therapeutic target for gastric cancer (GC). However, conventional CLDN18.2 diagnosis based on immunohistochemistry (IHC) has limits due to its dependency of biopsy sample and biases from experiments and pathologists. To address this, we propose using a molecular beacon (MB) to detect CLDN18.2 RNA of circulating tumor cells (CTCs), which can be applied in clinical practice as a supplementary diagnostic method.</div></div><div><h3>Methods</h3><div>We constructed an easily prepared and cost-effective DNA MB to detect CLDN18.2 RNA. Afterwards, we verified the function of semi quantification of CLDN18.2 RNA by fluorescence signal of the MB. We then evaluated CLDN18.2 RNA levels in the CTCs of three patients, which was compared with tissue expression using IHC.</div></div><div><h3>Results</h3><div>Our results show that this technique has excellent sensitivity and specificity, making it suitable for application in platforms with CTCs. We found consistent results between CLDN18.2 RNA from CTCs and tissue expression levels in three patients. This demonstrates the potential of the CLDN18.2 MB method in accurately detecting CLDN18.2 in clinical practice.</div></div><div><h3>Conclusions</h3><div>The CLDN18.2 MB holds significant promise for various clinical applications in patients with GC, including complementary diagnostics, drug adaptability testing, and disease progression evaluation.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"52 12","pages":"Article 100452"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “A pilot study on the mechanism of Guasha in treating Parkinson's disease based on molecular level and ultra-trace proteomics analysis” [Chinese Journal of Analytical Chemistry 52 (2024) 1–14/100402] 基于分子水平和超痕量蛋白质组学分析的刮痧治疗帕金森病机制的试验研究》[《中国分析化学杂志》52 (2024) 1-14/100402] 勘误表
IF 1.2 4区 化学
Chinese Journal of Analytical Chemistry Pub Date : 2024-11-25 DOI: 10.1016/j.cjac.2024.100455
Qiuqin WANG , Li ZHANG , Heng WENG , Qing WANG , Penglu CHEN , Hua CHEN , Rongrong JIANG , Guihua XU , Yamei BAI , Xi CHEN
{"title":"Corrigendum to “A pilot study on the mechanism of Guasha in treating Parkinson's disease based on molecular level and ultra-trace proteomics analysis” [Chinese Journal of Analytical Chemistry 52 (2024) 1–14/100402]","authors":"Qiuqin WANG ,&nbsp;Li ZHANG ,&nbsp;Heng WENG ,&nbsp;Qing WANG ,&nbsp;Penglu CHEN ,&nbsp;Hua CHEN ,&nbsp;Rongrong JIANG ,&nbsp;Guihua XU ,&nbsp;Yamei BAI ,&nbsp;Xi CHEN","doi":"10.1016/j.cjac.2024.100455","DOIUrl":"10.1016/j.cjac.2024.100455","url":null,"abstract":"","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"52 12","pages":"Article 100455"},"PeriodicalIF":1.2,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A highly selective and sensitive carbazole-based fluorescent probe for peroxynitrite detection and cellular imaging 一种高选择性、高灵敏度的咔唑基荧光探针,用于过亚硝酸盐检测和细胞成像
IF 1.2 4区 化学
Chinese Journal of Analytical Chemistry Pub Date : 2024-11-01 DOI: 10.1016/j.cjac.2024.100456
Said ALAM , Linchuan LU , Xuanzuo TAO , Yanxia MAO , Shaojun ZHENG , Chunhui JIANG , Shu-Yang CHEN , Hongfei LU
{"title":"A highly selective and sensitive carbazole-based fluorescent probe for peroxynitrite detection and cellular imaging","authors":"Said ALAM ,&nbsp;Linchuan LU ,&nbsp;Xuanzuo TAO ,&nbsp;Yanxia MAO ,&nbsp;Shaojun ZHENG ,&nbsp;Chunhui JIANG ,&nbsp;Shu-Yang CHEN ,&nbsp;Hongfei LU","doi":"10.1016/j.cjac.2024.100456","DOIUrl":"10.1016/j.cjac.2024.100456","url":null,"abstract":"<div><div>Peroxynitrite, a colorless and odorless reactive nitrogen species, plays a critical role in various physiological processes within biological systems. Therefore, developing a reliable method for quantitative detection of peroxynitrite in living systems is essential. In this study, we synthesized a simple, two-step, reaction-based fluorescent probe, designated as <strong>EHMC</strong>, specifically for peroxynitrite detection. The synthesis involved the use of 4-(9-phenyl-9H-carbazol-3-yl)benzaldehyde as the fluorophore and 2-hydrazineylpyridine as the recognition group, both of which exhibit inherently weak fluorescence. Upon oxidation of the C = N bond by peroxynitrite, <strong>EHMC</strong> undergoes conversion into an aldehyde, resulting in a significant fluorescence response. <strong>EHMC</strong> demonstrated high selectivity and sensitivity, achieving a detection limit of 5.43 µM under physiological conditions. Additionally, <strong>EHMC</strong> was successfully applied to HeLa cellular models, where it exhibited excellent cellular imaging capability for peroxynitrite detection in living systems.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"52 11","pages":"Article 100456"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A flexible electrochemical sensor based on AuBi bimetal for detection of Cd ions in packaged drinking water 基于金铋双金属的柔性电化学传感器,用于检测包装饮用水中的镉离子
IF 1.2 4区 化学
Chinese Journal of Analytical Chemistry Pub Date : 2024-11-01 DOI: 10.1016/j.cjac.2024.100457
Mei WANG , Fang LIU , Yingkuan SUN , Liying JIANG
{"title":"A flexible electrochemical sensor based on AuBi bimetal for detection of Cd ions in packaged drinking water","authors":"Mei WANG ,&nbsp;Fang LIU ,&nbsp;Yingkuan SUN ,&nbsp;Liying JIANG","doi":"10.1016/j.cjac.2024.100457","DOIUrl":"10.1016/j.cjac.2024.100457","url":null,"abstract":"<div><div>Heavy metal ion Cd, as a toxic pollutant, can accumulate in human body through the bioaccumulation effect of food chain and poses a threat to human health. Packaged drinking water is one of the main water sources for many people, making it crucial to detect their cadmium ion levels. In this work, an AuBi bimetal film was electrodeposited onto a flexible screen-printed electrode to construct highly sensitive cadmium ion sensors. The prepared sensor could enrich trace cadmium ions in the target electrolyte, followed by sensitive detection of cadmium ions using stripping wave voltammetry. The electrochemical results demonstrated that the developed sensor based on AuBi bimetal exhibited a significant linear response to cadmium ions in the range of 50 μg/L to 800 μg/L, with a low detection limit of 11.68 μg/L (S/N = 3), and it also showed good repeatability. The prepared flexible electrochemical sensor was employed to detect the cadmium ion level in five common types of packaged drinking water available on the market, and the relative standard deviation (RSD) and recovery were within normal ranges, indicating that it could achieve rapid and sensitive detection of cadmium ion level in drinking water and other foodstuffs.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"52 11","pages":"Article 100457"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142698758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolomics analysis reveals that Qingxiangyin improves central precocious puberty through 13S-hydroxyoctadecadienoic acid mediated linoleic acid metabolic for regulating the PPAR pathways 代谢组学分析揭示清香药通过13S-羟基十八碳二烯酸介导的亚油酸代谢改善中枢性性早熟,从而调节PPAR通路
IF 1.2 4区 化学
Chinese Journal of Analytical Chemistry Pub Date : 2024-11-01 DOI: 10.1016/j.cjac.2024.100454
Yiyuan CHEN, Jing LI
{"title":"Metabolomics analysis reveals that Qingxiangyin improves central precocious puberty through 13S-hydroxyoctadecadienoic acid mediated linoleic acid metabolic for regulating the PPAR pathways","authors":"Yiyuan CHEN,&nbsp;Jing LI","doi":"10.1016/j.cjac.2024.100454","DOIUrl":"10.1016/j.cjac.2024.100454","url":null,"abstract":"<div><div>The occurrence of central precocious puberty (CPP) among children which is induced by untimely activation of the hypothalamic-pituitary-gonadal (HPG) axis is increasing gradually. Traditional Chinese Medicine endeavors to eradicate or mitigate the underlying factors and thereby reestablish the balance within the physiological system, Qingxiangyin (QXY) is a Chinese medicine that can effectively improve CPP via balancing Yin and Yang. However, the metabolic regulation mechanism of QXY on CPP is still unclear. Here, we established a CPP mouse model, and carried out Leuprorelin (lep), Qingxiangyin high (QXY-h), middle (QXY-M) and low (QXY-L) treatment. The metabolic profile of hypothalamus was evaluated by LC-MS/MS. The major differentially expressed metabolites (DEMs) between the CPP model and blank group were (<em>S</em>)-Abscisic acid, Methylmalonic acid, 2-Oxo-4-methylthiobutanoic acid. The main metabolites in QXY-h vs model were pyridoxal phosphate, phenylpyruvate and palmitoylcarnitine. There were 14 distinct metabolites in the model vs. QXY-M group, among which 3 were up-regulated and 11 were down-regulated. The principal metabolite was succinic acid, phenylpyruvic acid and 13S‑hydroxy-octanadienoic acid. QXY-L induced alterations in 20 metabolites in CPP, with 5 metabolites up-regulated and 15 metabolites down-regulated. The major metabolites were 13S-hydroxyoctaenodienoic acid, benzoylamine, cyclohexanamine and palmitic acid. QXY-mediated metabolites were involved in “PPAR signaling pathway”, “linoleic acid metabolism”, “Lysine degradation” in CPP. In conclusion, the 13S-hydroxyoctadecadienoic acid mediateed linoleic acid metabolism for regulating the PPAR signaling pathway is the key mechanisms by which QXY affects CPP. Our results provide insights into the study of QXY therapy for CPP.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"52 11","pages":"Article 100454"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142698757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renal protective effect of Isaria felina mycelium powder on diet and STZ-induced diabetes mice and the identification of major chemical constituents 鱼腥草菌丝粉对饮食和 STZ 诱导的糖尿病小鼠的肾脏保护作用及主要化学成分的鉴定
IF 1.2 4区 化学
Chinese Journal of Analytical Chemistry Pub Date : 2024-11-01 DOI: 10.1016/j.cjac.2024.100451
Ziyang HUANG , Jingjing CHEN , Lili ZHAO , Lixia CHEN , Yuxin YANG , Junjun LI , Jing WANG , Yongming YANG , Lei YAN , Guoyan YU , Xiaowei SHI , Yiyin ZHANG , Yanlin YU , Sujiao LIANG , Xihua YANG
{"title":"Renal protective effect of Isaria felina mycelium powder on diet and STZ-induced diabetes mice and the identification of major chemical constituents","authors":"Ziyang HUANG ,&nbsp;Jingjing CHEN ,&nbsp;Lili ZHAO ,&nbsp;Lixia CHEN ,&nbsp;Yuxin YANG ,&nbsp;Junjun LI ,&nbsp;Jing WANG ,&nbsp;Yongming YANG ,&nbsp;Lei YAN ,&nbsp;Guoyan YU ,&nbsp;Xiaowei SHI ,&nbsp;Yiyin ZHANG ,&nbsp;Yanlin YU ,&nbsp;Sujiao LIANG ,&nbsp;Xihua YANG","doi":"10.1016/j.cjac.2024.100451","DOIUrl":"10.1016/j.cjac.2024.100451","url":null,"abstract":"<div><div>Type 2 diabetes is a group of metabolic diseases mainly characterized by chronic hyperglycemia. Diabetic kidney disease is the most common microvascular complication of diabetes.</div><div>The aim of this study was to investigate the therapeutic effect of <em>Isaria felina</em> mycelium powder (IFMP) on diet and streptozotocin (STZ)-induced diabetic mouse model. And we analyze the main chemical constituents of <em>Isaria felina</em> mycelium powder.</div><div>The main chemical constituents of the alcohol-soluble IFMP were prepared and identified by high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS). The fasting blood glucose and renal index of the mouse model was determined. Serum levels of triglyceride (TG), total cholesterol (TC), serum creatinine (Scr) and blood urea nitrogen (BUN) were detected. The levels of CD2AP and nephrin proteins in the kidney were detected by ELISA kits.</div><div>A total of 32 compounds were identified, including nucleosides (16 types), amino acids (13 types), sterols (one type) and glycosides (two types). The experimental results showed that compared with the diabetes model group, IFMP reduced fasting blood glucose, food intake and water intake. Biochemical analysis indicated that IFMP reduced the serum levels of TG, TC, BUN and Scr, and increased the levels of CD2AP and nephrin proteins in the kidneys.</div><div>Therefore, IFMP has the potential to treat diabetes and prevent kidney damage induced by hyperglycemia.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"52 11","pages":"Article 100451"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determination of microplastic release from disposable plastic containers in Isfahan 测定伊斯法罕一次性塑料容器中的微塑料释放量
IF 1.2 4区 化学
Chinese Journal of Analytical Chemistry Pub Date : 2024-11-01 DOI: 10.1016/j.cjac.2024.100448
Roya KELISHADI , Ali AGHABABAI BENI , Karim EBRAHIMPOUR , Motahar HEIDARI-BENI
{"title":"Determination of microplastic release from disposable plastic containers in Isfahan","authors":"Roya KELISHADI ,&nbsp;Ali AGHABABAI BENI ,&nbsp;Karim EBRAHIMPOUR ,&nbsp;Motahar HEIDARI-BENI","doi":"10.1016/j.cjac.2024.100448","DOIUrl":"10.1016/j.cjac.2024.100448","url":null,"abstract":"<div><div>The widespread release of microplastics from disposable food containers raises significant concerns for health and the environment. This study aimed to elucidate the underlying mechanisms of microplastic release by exploring various factors, including temperature variations and the impact of spoon contact on disposable utensils. A total of 30 samples of disposable polystyrene containers were randomly selected from markets in Isfahan, Iran. Advanced analytical techniques, including Fourier transform infrared spectroscopy, field emission scanning electron microscopy, dynamic light scattering, X-ray diffraction, and Raman spectroscopy, were employed for comprehensive analysis. The results unequivocally established the chemical and structural similarity between the microplastics released from these containers and polystyrene. Furthermore, the study revealed that both elevated temperatures and the physical agitation caused by spoon contact significantly increased the release of microplastics from the containers. The maximum amount of microplastics released was 30 mg at 120 °C when only water was circulated in the container, while it increased to 56 mg at 120 °C when the spoon was also moved inside the containers.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"52 11","pages":"Article 100448"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A development in greener microextraction methods for analysis of pesticide residues in environmental water samples: A review 用于分析环境水样中农药残留的绿色微萃取方法的发展:综述
IF 1.2 4区 化学
Chinese Journal of Analytical Chemistry Pub Date : 2024-11-01 DOI: 10.1016/j.cjac.2024.100458
Endalkachew ETANA , Birhanu MEKASSA
{"title":"A development in greener microextraction methods for analysis of pesticide residues in environmental water samples: A review","authors":"Endalkachew ETANA ,&nbsp;Birhanu MEKASSA","doi":"10.1016/j.cjac.2024.100458","DOIUrl":"10.1016/j.cjac.2024.100458","url":null,"abstract":"<div><div>Pesticide residues in water are gaining prominence as one of the most serious water quality challenges. Their analysis requires advanced sample preparation and instrumental techniques. However, there is a continuing challenge mainly because of the trace quantities as well as the high amount of interfering substances which can be co-extracted with them, frequently leading to method errors and damages the efficiency of analytical instruments. Thus, the development of greener microextraction techniques for pesticide analysis is very important since it reduces overall sample preparation time, use fewer organic solvents, produce less wastes, has adequate extraction and clean up capacity for the target analytes, and removes interferents from the complex sample that can affect instrumental performance. This paper focuses on reviewing greener microextraction methods used in the analysis of pesticide residues in environmental water samples. The microextraction methods include: liquid phase microextraction (LPME), solid phase microextraction (SPME), dispersive liquid-liquid microextraction (DLLME), hollow fiber liquid phase microextraction (HF-LPME), stir bar sorptive extraction (SBSE) and single drop microextraction (SDME). This review paper also presents the development, advantage and disadvantage, green aspects and sample preparation technique of each microextraction methods for analysis of pesticide residues in water matrix. Moreover, the different analytical techniques used for determination of the required analyte from water matrix after extraction steps were also addressed.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"52 11","pages":"Article 100458"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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