Chinese Journal of Analytical Chemistry最新文献

{"title":"Apoptosis-inducing effects of aqueous extract of Eleutherococcus senticosus on non-small cell lung cancer cell proliferation","authors":"Xuekun KOU ,&nbsp;Yufeng LI ,&nbsp;Lei WANG ,&nbsp;Xin SONG ,&nbsp;Dan LI ,&nbsp;Zhuo WANG ,&nbsp;Yuanyuan ZHAO ,&nbsp;Xiaohui ZHANG ,&nbsp;Jingwu LI ,&nbsp;Zhaobin XING","doi":"10.1016/j.cjac.2025.100510","DOIUrl":"10.1016/j.cjac.2025.100510","url":null,"abstract":"<div><div>Non-small cell lung cancer is a malignant tumor with high morbidity and mortality worldwide. <em>Eleutherococcus senticosus</em> can induce apoptosis in non-small cell lung cancer cells, but the mechanism remains unclear. This study aimed to elucidate the role of <em>Eleutherococcus senticosus</em> in inducing apoptosis in non-small cell lung cancer cells and analyze its potential active constituents, targets, and molecular mechanisms. The results of network pharmacology analysis showed that <em>Eleutherococcus senticosus</em> contained 49 active ingredients that induced apoptosis in non-small cell lung cancer cells, and these components could act on 66 apoptosis-related targets. Compared to the control group, <em>Eleutherococcus senticosus</em> significantly increased apoptosis in A549 cells with increasing concentration (<em>p &lt;</em> 0.05). The results of transcriptome and metabolomic analyses showed that <em>Eleutherococcus senticosus</em> significantly changed 5836 genes and 418 metabolites in A549 cells (<em>p &lt;</em> 0.05), with the most significant changes in 18 genes and 34 metabolites related to apoptosis. qRT-PCR and Western blot results showed that, after <em>Eleutherococcus senticosus</em> treatment, the mRNA and protein expression of <em>EGFR, MAPK3</em>, and <em>ICAM1</em> significantly increased, while <em>CTSK</em> decreased (<em>p &lt;</em> 0.01 or <em>p &lt;</em> 0.001). Correlation analysis and molecular docking results indicated that calycanthoside and oleanolic acid can directly modify the expression levels of the transcription factors <em>POU2F3, FOXS1</em>, and <em>TGIF2LY</em> or indirectly influence the binding affinity of these transcription factors to the promoters of key target genes, ultimately leading to the activation of <em>EGFR, MAPK3, ICAM1</em>, and <em>CTSK</em>, which triggers apoptosis in non-small cell lung cancer cells.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 3","pages":"Article 100510"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous qualitative and quantitative analysis to explore the material basis for different formulations of Dachengqi decoction to produce different efficacy by UPLC-QTOF-MS and UFLC-QQQ-MS","authors":"Hai-Zhen LI ,&nbsp;Yan LOU ,&nbsp;Ying-Ying SHU ,&nbsp;Wan-Ting JIN ,&nbsp;Xiao-Xuan YAO ,&nbsp;Jie SONG ,&nbsp;Yin-Fang CHEN ,&nbsp;Bin NIE","doi":"10.1016/j.cjac.2024.100488","DOIUrl":"10.1016/j.cjac.2024.100488","url":null,"abstract":"<div><div>Dachengqi Decoction (DCQD) is a well-known prescription of catharsis in “Shang Han Lun”, composed of 4 traditional Chinese medical ingredients: Radix et Rhizoma Rhei (Dahuang), Cortex Magnoliae officinalis (Houpo), Fructus Aurantii Immaturus (Zhishi) and Natrii Sulfas (Mangxiao). Due to the complexity of its composition and inconsistencies in the traditional decocting process, maintaining the quality and exploring the material basis for efficacy of DCQD are challenging. In this study, we established an integrating ultra-high-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) and ultra-fast-performance liquid chromatography equipped with triple quadrupole mass spectrometry (UFLC-QQQ-MS) method to perform qualitative and quantitative analyses of different DCQD formulations. The methods of quality control and content detection of the main components of different formulations were improved by optimizing the parameters of mobile phase composition, gradient and velocity. By optimizing of the method, the separation ability of structurally similar substances such as aloe-emodin, emodin and Apigenin is greatly improved. As a result, in the qualitative analysis, 190 components were detected of which 27 compounds were unambiguously identified by comparison with reference compounds by chromatographic behavior and mass spectrum, and the remaining compounds were tentatively assigned by comparison with fragmentation pathways and characteristic fragment ions in published literature or known databases. In the quantitative analysis, the contents of 19 key ingredients across 10 formulations were determined. The results showed that some components were roughly distributed according to the proportion of Chinese herbs, such as rhein, gallic acid, physcion, hesperetin and limonin. However, the distribution of most components differed greatly from that of Chinese herbs, such as emodin, hesperidin, synephrine and honokiol, producing solubilization effect or inhibition of dissolution effect, which could explainned the varied effects of different formulations in treating conditions like intestinal obstruction and pancreatitis. This study provides a simple, fast and accurate method to identify and quantify the main components in DCQD, and makes preparations for exploring the mechanism of different formulations of DCQD to produce different efficacy in gastrointestinal disease.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 2","pages":"Article 100488"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crossed-linked chitosan coated cuprous oxide microspheres for iodide adsorption via one-step in-situ generation","authors":"Min LI ,&nbsp;Qing LI ,&nbsp;Lijie LI ,&nbsp;Zixuan XU ,&nbsp;Jie AN ,&nbsp;Gaohong HE ,&nbsp;Zhifang WU ,&nbsp;Sijin LI ,&nbsp;Wenjun ZHANG","doi":"10.1016/j.cjac.2024.100487","DOIUrl":"10.1016/j.cjac.2024.100487","url":null,"abstract":"<div><div>Radioactive iodine waste generated from nuclear power and radioactive medical treatments has become a serious environmental issue, raising concerns about public health. Cross-linked chitosan adsorbed iodide anions through electrostatic attraction yet limit-efficiently. To achieve better adsorption performance, chitosan-coated cuprous oxide microspheres (Cu₂O@CM) was proposed via one-step in-situ liquid-phase method. Both Cu₂O@CM-e cross-linked with epichlorohydrin and Cu₂O@CM-g cross-linked with glutaraldehyde, performing rough and spherical morphology, exhibited rapid iodine removal capacities of 0.1843 mmol/g for Cu₂O@CM-e and 0.1819 mmol/g for Cu₂O@CM-g within just 10 min. The adsorption process occurred through a combination of physical multilayer adsorption and chemical monolayer adsorption, driven spontaneously and endothermically. After four regeneration cycles, Cu₂O@CM-e and Cu₂O@CM-g maintained almost identical adsorption efficiencies, highlighting their reusability. Considering the interference of Cl^– and CO₃^2–, both adsorbents showed significant selectivity towards competing ions. Thus, both adsorbents showed promising potential for the removal of iodine waste</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 2","pages":"Article 100487"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qiyu Granules ameliorate insulin resistance via modulating PI3K/AKT/FoxO1 pathway and AMPK/PPARγ pathway in diabetic KKAy mice","authors":"Xiaoxu FAN ,&nbsp;Jiaqi LIU ,&nbsp;Jian HUA,&nbsp;Zhen WANG,&nbsp;Yiwei SHEN,&nbsp;Danyue SHAO,&nbsp;Zhenhui JIN,&nbsp;Jingxia WANG","doi":"10.1016/j.cjac.2024.100489","DOIUrl":"10.1016/j.cjac.2024.100489","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the protective effect and mechanism of Qiyu Granules in alleviating insulin resistance in KKAy mice.</div></div><div><h3>Methods</h3><div>The chemical ingredients of Qiyu Granules were analyzed using ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). Network pharmacology and animal experiments were used to verify the pharmacological effects of Qiyu Granules in alleviating insulin resistance in diabetic KKAy mice and to explore its mechanism of action. High-sugar, high-fat chow was fed to KKAy mice for modeling. After 12 weeks, indicators of glucose metabolism (FBG, AUC), lipid metabolism (TC, TG, LDL, HDL, FFA), liver function (ALT, AST) and insulin resistance (FINS, HOMA-IR, HOMA-<em>β</em>, ISI) were detected. Pathological changes in pancreatic and liver tissues were observed by hematoxylin-eosin (H&amp;E) and Oil Red O staining. Hepatic glycogen levels were analyzed using enzyme-linked immunosorbent assay (ELISA) method and periodic acid-Schiff (PAS) staining. Western blot was used to detect the protein expression levels of InsR, p-PI3 K, p-AKT, FoxO1, PEPCK, G6pase, p-AMPK, p-GSK-3β, GLUT2, PPAR<em>γ</em> and PPAR<em>α</em>.</div></div><div><h3>Results</h3><div>FBG, AUC, HOMA-IR, TC, TG, LDL, FFA, ALT, AST and hepatic index were decreased in mice treated with Qiyu Granules; while FINS, HOMA-<em>β</em>, ISI, HDL and hepatic glycogen content were increased. Qiyu Granules also improved histopathological changes in the pancreas and liver of KKAy mice. Besides, Qiyu Granules up-regulated the expression levels of InsR, p-PI3 K, p-AKT, p-AMPK, GLUT2 and PPAR<em>α</em> proteins in the livers of mice in the model group. However, Qiyu Granules down-regulated the expression levels of FoxO1, PEPCK, G6Pase, p-GSK-3<em>β</em> and PPAR<em>γ</em> proteins.</div></div><div><h3>Conclusion</h3><div>Qiyu Granules may regulate the InsR/PI3K/AKT/FoxO1 pathway, AMPK pathway, and PPAR<em>γ</em>/PPAR<em>α</em> pathway to ameliorate insulin resistance. Therefore, Qiyu Granules is a promising hypoglycaemic agent for the treatment of DM.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 2","pages":"Article 100489"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety analysis of Kaiyu Jiangzhuo Tongzhi prescription for the treatment of pre-diabetic overweight/obese patients: A multicentre randomised controlled clinical study protocol and statistical analysis plan","authors":"Xiaoxuan XU ,&nbsp;Boxun ZHANG ,&nbsp;Xue QU ,&nbsp;Dongqi QU ,&nbsp;Hang LIU ,&nbsp;Wenlin ZHANG ,&nbsp;Rui SUN ,&nbsp;Linhua ZHAO ,&nbsp;Jixiang REN ,&nbsp;Ying ZHANG ,&nbsp;Yangyang LIU","doi":"10.1016/j.cjac.2024.100468","DOIUrl":"10.1016/j.cjac.2024.100468","url":null,"abstract":"<div><div>The Chinese Academy of traditional Chinese medicine (TCM)’s academician Xiaolin Tong developed the Kaiyu Jiangzhuo Tongzhi prescription (KYJZ) in response to prediabetes'’s “yu” mechanism. This study plans to thoroughly evaluate the safety and effectiveness of KYJZ in treating prediabetes and preventing diabetes mellitus. This study is a multicenter, randomized, double-blind, placebo-controlled trial in which 598 patients with pre-diabetes were randomly assigned in a 1:1 ratio to either the KYJZ or the placebo group. The primary outcome was to assess the incidence of diabetes at the end of 48 weeks. Secondary outcomes included the rate of normal conversion to glucose tolerance at the end of 48 weeks, indicators of glucose-fat metabolism, body mass index (BMI), waist circumference (WC), and Diabetes Symptom Rating Scale (DSRS), as well as body composition analysis (BCA) and diabetes risk score (DRS). Record all adverse events that occur and analyze the data collected. The results of this study will provide strong evidence for the efficacy and safety of KYJZ in reducing the incidence of diabetes mellitus in overweight/obese patients with prediabetes.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 2","pages":"Article 100468"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of LC/LCMS method for estimation of impurities in anti-HIV drug (Bictegravir) using Analytical Quality by Design (AQbD) approach","authors":"Divya Kumar VEMURI ,&nbsp;Rambabu GUNDLA ,&nbsp;Jayaprakash Kanijam RAGHUPATHI ,&nbsp;Nagalakshmi JEEDIMALLA ,&nbsp;Gowri Sankararao BURLE ,&nbsp;Naresh Kumar KATARI ,&nbsp;Sreekantha Babu JONNALAGADDA","doi":"10.1016/j.cjac.2024.100469","DOIUrl":"10.1016/j.cjac.2024.100469","url":null,"abstract":"<div><div>Analytical Quality by Design (AQbD) was used to construct stability indicating linked compounds using the HPLC technique of an anti-human immunodeficiency virus (anti-HIV) medicine (Bictegravir). Process-related and degrading impurities were separated on a Zorbax SB-C8 (150×4.6) mm, 3.5 m column. The buffer pH of the mobile phase was kept at 2.5 by employing potassium dihydrogen phosphate 0.05 M Mobile phase A contains 5 % methanol and 95 % buffer, whereas mobile phase B contains 50 % acetonitrile, 10 % methanol, 25 % tetrahydrofuran, and 15 % water. The completed chromatographic settings were a flow rate of 1.2 mL/min, a detector wavelength of UV at 250 nm, and an injection volume of 20 µL. This approach has been verified in accordance with ICH recommendations. The approach was discovered to be particular, sensitive, linear, exact, and accurate. The limit of quantification for all contaminants was determined to be &lt; 0.05 %, the correlation coefficient for all impurities is between 0.9996 and 1.0000, and the percent recovery for all impurities is between 91 % and 108 % at the LOQ level and 97 % to 113 % at the specification level. Forced degradation experiments in chemical and physical stress tests were performed in accordance with regulatory criteria, and the molecule was discovered to be susceptible to acid and base hydrolysis. Imp-A was the most common degrading impurity in both acid and base hydrolysis.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 2","pages":"Article 100469"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paper-based immunosensor for quantitative detection of African swine fever virus p54 protein","authors":"Ling-Ling GUO,&nbsp;Xin-Xin XU,&nbsp;Li-Qiang LIU,&nbsp;Hua KUANG,&nbsp;Chuan-Lai XU","doi":"10.1016/j.cjac.2024.100477","DOIUrl":"10.1016/j.cjac.2024.100477","url":null,"abstract":"<div><div>African swine fever virus (ASFV) has resulted in significant economic detriment to the livestock industry in recent years. Highly sensitive and accurate detection methods are currently the most effective means for ASFV prevention and control. In this work, the ASFV p54 recombinant protein was successfully expressed by plasmid construction, prokaryotic expression and purification. Monoclonal antibodies (mAbs) were obtained using hybridoma cell technology. Through pair analysis, mAb-6E5 and mAb-4D7 were selected for p54 detection, both exhibiting high affinity and no cross-reactivity with other ASFV proteins. Based on the sandwich colloidal gold immunochromatographic assay principle, a p54 test strip was constructed using 6E5 as the capture antibody and 2D7 as the detection antibody, with a limit of detection of 1.51 ng/mL. The intra- and inter-assay recoveries ranged from 87.8% to 110.6%, with variable coefficient of less than 11.1%. Positive serum samples further confirmed the accuracy of the assay. This developed test strip has the potential to serve as an effective tool for ASFV detection and could play a crucial role in the prevention and management of African Swine Fever (ASF) outbreaks.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 2","pages":"Article 100477"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new coumaric acid diglucoside-sebacic acid glycoside heterozygote compound in Butea monosperma","authors":"Qianghua YUAN ,&nbsp;Jun HAN","doi":"10.1016/j.cjac.2025.100499","DOIUrl":"10.1016/j.cjac.2025.100499","url":null,"abstract":"<div><div>A new heterozygote compound (<strong>3</strong>) of coumaric acid diglucoside and sebacic acid glycoside and two known compounds (<strong>1, 2</strong>) were isolated from the seeds of <em>Butea monosperma</em>. Then, their chemical structures were identified by detailed spectral analysis, including 1D and 2D nuclear magnetic resonance (NMR), mass spectrometry (MS) and infrared (IR) spectroscopy. In addition, the antitumor activity study showed that compound <strong>2</strong> had a significant inhibitory effect on triple negative breast cancer (TNBC) cell line MDA-MB-231, and its IC₅₀ value was 1.546 μmol/L.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 3","pages":"Article 100499"},"PeriodicalIF":1.2,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular docking, dynamic molecular simulation and in silico ADMET screening study of novel bidentate tetrazolyl-adipate anti-HIV drugs candidate","authors":"Fatimazohra LENDA ,&nbsp;Mohammed ER-RAJY ,&nbsp;Asmae El CADI ,&nbsp;Hamada IMTARA ,&nbsp;Farhate GUENOUN ,&nbsp;Hassan ALLOUCHI ,&nbsp;Somdutt MUJWAR ,&nbsp;Khalid NAJOUI ,&nbsp;Omar M. NOMAN ,&nbsp;Jean MARTINEZ ,&nbsp;Frédéric LAMATY ,&nbsp;Menana ELHALLAOUI","doi":"10.1016/j.cjac.2025.100498","DOIUrl":"10.1016/j.cjac.2025.100498","url":null,"abstract":"<div><div>In order to develop specific inhibitors of CYP3A4, we chose new derivatives of adipic acid the 2,5-(5-aryl tetrazol-2yl) dimethyl adipate L₁-L₅. During this study, the Ritonavir molecule known as inhibitor of the cytochrome CYP3A4 are chosen as a reference. A molecular docking simulation on the enzyme 7UAZ is conducted for the ligands L₁-L₅, in order to study the predictive binding affinity and the interaction mechanism of the 5-aryltetrazolyl substituents introduced at positions 2 and 5 of adipic acid. A molecular docking study revealed that the relative activation energy level ranged from –10.1 to –7.6 kcal/mol, falling within the range of Ritonavir at –9.0 kcal/mol, which confirms the stability of the ligands within the studied enzyme. The results show that the binding mode of the ligands on the enzyme 7UAZ varies significantly depending on the substituent at the -C5 position of the tetrazole, with the best results obtained for the ligands L₂ and L₅. Then a comparative study based on silico ADMET properties selected only L₂ as a potential inhibitor of CYP3A4. A 100 ns molecular dynamics simulation on the ligand-protein complex highlights the stability of ligand L₂ within the 7UAZ protein.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 3","pages":"Article 100498"},"PeriodicalIF":1.2,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of nanoscale CeO2 as Fenton-like catalyst in the field of environment and bioscience","authors":"Han XU ,&nbsp;Xiang CHU ,&nbsp;Jing XU ,&nbsp;Meng ZHAO ,&nbsp;Lin PENG ,&nbsp;Lingling ZHANG ,&nbsp;Xiao WANG","doi":"10.1016/j.cjac.2025.100501","DOIUrl":"10.1016/j.cjac.2025.100501","url":null,"abstract":"<div><div>Fenton reaction has been regarded as one of the most potent ways to cost-efficiently degrade organic contaminants and cure cancer by inducing cell apoptosis and necrosis. However, commercial Fe-base catalysts and natural enzymes are suffering from high costs and low durability. Exploring a new catalyst for reducing cost and avoiding secondary pollution is demanding. Recent research illustrates that CeO₂ owns a specific oxygen vacancy structure and Ce³⁺/Ce⁴⁺ redox cycle, which is thought to be the origin of Fenton-like reaction activities. Significantly, inducing heteroatoms promotes the concentration of oxygen vacancy and Ce³⁺ ions, and the electrons transfer between Ce and heteroatoms accelerates the redox cycles. The broad reaction pH value and low biotoxicity endow CeO₂ with enormous potential in organic pollutants’ disposal and artificial enzyme for healthcare. Because of their excellent stability, Ce-base catalysts are more accessible for storage and transformation than natural enzymes. Meanwhile, electro-/photochemistry technologies are believed to reduce subsequent pollution and potentially be applied in biology fields. This review focuses on the Fenton-like reaction process and its application in environmental engineering and life science.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 3","pages":"Article 100501"},"PeriodicalIF":1.2,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143428719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}