Chinese Journal of Analytical Chemistry最新文献

{"title":"Quantitative determination of coptisine and berberine hydrochloride in Corydalis conspersa by high-performance liquid chromatography and quality evaluation","authors":"DU Qing","doi":"10.1016/j.cjac.2025.100620","DOIUrl":"10.1016/j.cjac.2025.100620","url":null,"abstract":"<div><div>The key active ingredients of Chinese medicinal materials are often used as indicators in quality standards. <em>Corydalis conspersa</em> is a characteristic plant from the Qinghai-Tibet plateau and contains various of isoquinoline alkaloids. Water content was determinated from diverse parts of <em>Corydalis conspersa</em> according to the Chinese Pharmacopoeia. The component of coptisine and berberine hydrochloride in <em>Corydalis conspersa</em> were extracted using the solvent of methanol-hydrochloric acid and detected by high-performance liquid chromatography. The results of method validation test was stable and reliable. The content of coptisine and berberine hydrochloride in root samples was higher than in herbs. In the sample solutions of stem and leaf, only coptisine was detectable. Thus, the levels of coptisine and berberine hydrochloride in root and herbs can serve as a qualified basis for quality standards of <em>Corydalis conspersa</em>.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 10","pages":"Article 100620"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145216296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In situ produced palladium nanoparticle-catalyzed efficient synthesis of benzo[c]chromenes and analogues under aerobic and ligand-free conditions in water","authors":"Pompy Sarkar ,&nbsp;Jayanta K. Ray ,&nbsp;Atiur Ahmed","doi":"10.1016/j.cjac.2025.100589","DOIUrl":"10.1016/j.cjac.2025.100589","url":null,"abstract":"<div><div>An efficient approach has been discovered towards the preparation of 6<em>H</em>-benzo[<em>c</em>]chromenes and analogues <em>via</em> the <em>in situ</em> developed palladium nanoparticle-catalyzed cascade of Suzuki-Miyaura cross-coupling and intramolecular S_N2 reaction under aerobic conditions. To make the reactions eco-friendly, water was chosen as the solvent along with the use of phosphine ligand was avoided. The reactions were found to be highly efficient with the productions of the chromenes upto the excellent yield of 96 % at 80 °C. Therefore, the several advantages like eco-friendly, mild, easy to handle, tolerance of various functional groups and efficient production of diverse benzo[<em>c</em>]chromenes have made this method as novel.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 10","pages":"Article 100589"},"PeriodicalIF":1.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese medicine Luo Tong Formula attenuates retinal injury in experimental diabetic retinopathy via modulation of DNA methylation: In vivo experiment integrated with molecular docking, ADMET assessment, and molecular dynamics simulation","authors":"Chongxiang XUE ,&nbsp;Sha DI ,&nbsp;Ying CHEN ,&nbsp;Tiange WANG ,&nbsp;Haoran WU ,&nbsp;Xinyi FANG ,&nbsp;Yaguang CHEN ,&nbsp;Min LI","doi":"10.1016/j.cjac.2025.100584","DOIUrl":"10.1016/j.cjac.2025.100584","url":null,"abstract":"<div><h3>Background</h3><div>Diabetic retinopathy (DR) is a leading cause of blindness in the adult population. Luo-Tong formula (LTF), a traditional Chinese medicine prescription, has been frequently employed in the treatment of DR. However, the ability of LTF to prevent retinal injury and disease progression, as well as potential mechanisms, remain unknown.</div></div><div><h3>Objectives</h3><div>To investigate the effect of LTF in alleviating DR and uncover the potential hub targets.</div></div><div><h3>Methods</h3><div>An experimental DR model was established to assess the effect of LTF and elucidate its underlying mechanism. Retinal thickness, morphological changes of retinal microvessels, as well as the numbers of endothelial cells and pericyte ghosts, were examined. Methylation status was evaluated with methylated DNA immunoprecipitation processing. Bioinformatic analysis of array results was used to screen hub genes. Interactions between potential targets and active compounds were assessed by molecular docking. ADMET analysis was used to evaluate drug-likeness characteristics and toxicity. Molecular dynamics (MD) simulation and MMGBSA calculation of binding free energies were conducted for the optimal core active compound-target complexes obtained by molecular docking.</div></div><div><h3>Results</h3><div>The administration of LTF demonstrated improvements in glycolipid metabolic disorder and a significant reduction in oxidative stress and inflammation in DR rats. Additionally, LTF exhibited protective properties against retinal injury. A quantitative analysis of DNA methylation indicated alterations in the composition and quantity of methylated genes following LTF intervention. Four important functional epigenetic modules and six hub genes (<em>Fgfr1, TOX3, Rps9, Rps15, Rpl7, Mrpl36</em>) were identified. Molecular docking identified ten compounds of LTF and 23 binding complexes with lower binding energy (&lt; 7 kcal/mol), while five compounds were excluded after ADMET analysis. Two complexes (Aloe-emodin-<em>TOX3</em>, Panaxatriol-<em>Fgfr1</em>) with the lowest binding energy were further chosen for MD simulation and both complexes have stable and satisfactory binding systems. Finally, MMGBSA calculation of binding free energies revealed that Panaxatriol-<em>Fgfr1</em> complex was identified as the drug-target candidate in the pharmacological treatment of DR.</div></div><div><h3>Conclusions</h3><div>LTF has demonstrated efficacy for DR, and its mechanisms may be associated with the regulation of DNA methylation. Panaxatriol-<em>Fgfr1</em> complex was identified as the drug-target candidate. Epigenetic modifications following LTF intervention have been implicated in the pathogenesis of DR and offer potential therapeutic opportunities for early diagnosis and treatment in the future.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 10","pages":"Article 100584"},"PeriodicalIF":1.3,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of Auricularia auricula doped carbon-nitrogen quantum dots and their application in detecting heavy metal ions","authors":"Haizhi Wu ,&nbsp;Hongfeng Gao","doi":"10.1016/j.cjac.2025.100596","DOIUrl":"10.1016/j.cjac.2025.100596","url":null,"abstract":"<div><div>This paper uses <em>Auricularia auricula</em> as the biological matrix material to synthesize carbon quantum dots (CQDs) with blue fluorescence by one step hydrothermal method. The characterization results by transmission electron microscope (TEM), X-ray diffraction (XRD), fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS) indicate that CQDs are spherical in shape with an average particle size of 6 nm. The surface of CQDs contains hydrophilic groups such as hydroxyl, carboxyl, and amino groups, which have good water solubility. At the same time, CQDs have good fluorescence stability and excellent selectivity and anti-interference properties towards Fe³⁺. They exhibit good linearity in the range of 3–40 μmol/L, with a detection limit of 0.28 μmol/L. CQDs have been used as probes for the detection of Fe³⁺ content in tap water and mineral water, and satisfactory results have been obtained. Therefore, this probe has broad application prospects.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 10","pages":"Article 100596"},"PeriodicalIF":1.3,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological mechanisms and pharmacokinetic analysis of anti-tumor components in Chinese herbal medicine","authors":"Jiayu ZOU ,&nbsp;Yunxin ZHU ,&nbsp;Ning YANG ,&nbsp;Delin XU ,&nbsp;Juanjuan ZHAO","doi":"10.1016/j.cjac.2025.100590","DOIUrl":"10.1016/j.cjac.2025.100590","url":null,"abstract":"<div><div>Tumors continue to pose a significant threat to human health and quality of life, underscoring the need for more affordable, safer, and more effective treatment options. In recent years, Chinese herbal medicine (CHM) has garnered significant attention from researchers and the pharmaceutical industry due to its advantages, including multi-target effects, mild adverse reactions, low cost, and abundant resources for tumor treatment. Moreover, the combination of CHM with chemotherapy agents holds promise for overcoming drug resistance and alleviating the adverse effects associated with conventional treatments. This review systematically examines the academic literature documenting the anti-tumor activity of CHM. It summarizes the key medicinal components exhibiting anti-tumor activity in these CHM, elucidates their pharmacological mechanisms and pharmacokinetic characteristics, and provides a critical evaluation of the current challenges and future research directions within this field. The findings may serve as a critical reference for identifying anti-tumor bioactive compounds within CHM and for developing novel anti-tumor agents.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 9","pages":"Article 100590"},"PeriodicalIF":1.3,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144878169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrothermally tailored hematite nanorods for photo-fenton degradation of 4-nitrophenol: Influence of morphology on catalytic mechanism and environmental safety","authors":"Mashael D. Alqahtani ,&nbsp;Dina Mostafa ,&nbsp;Nabila Shehata ,&nbsp;May N. Bin Jumah ,&nbsp;Nahaa M. Alotaibi ,&nbsp;Hassan A. Rudayni ,&nbsp;Ahmed A. Allam ,&nbsp;Mostafa R. Abukhadra","doi":"10.1016/j.cjac.2025.100585","DOIUrl":"10.1016/j.cjac.2025.100585","url":null,"abstract":"<div><div>Hematite rod nanoparticles were synthesized by alkaline hydrothermal modification of natural laterite for different durations (12, 24, 36, and 48 h). The impact of the modification duration on the morphology and physicochemical properties of the resulting modified varieties of hematite (H.12, H.25, H.36, and H.48) was assessed using different analytic techniques. The four derivatives were applied as potential catalysts during the decontamination of hazardous 4-nitrophenol (4-NP) by photo-Fenton’s oxidation. The modified H.36 displayed the best geometry as nanorods, the highest surface area (154.7 m²/g), and the most effective catalytic performances. The incorporation of H.36 at a dose of 0.4 g/L resulted in complete oxidation for the investigated 4-nitrophenol contaminants within 80 min (5 mg/L), 120 min (10 mg/L), and 180 min (15 mg/L). The mineralization studies validated the successful transformation of 4-NP molecules (5 mg/L) into safe end products over H.36 within 160 min. The mineralization pathway ended by the formation of H₂O, CO₂, NO₂⁻, and NO₃⁻ after a series of oxidation reactions involved interaction with the release of hydroxyl radicals and generation of different intermediaries (<em>p</em>-benzoquinone, hydroquinone, 4-aminophenol, and acetic acid). The eco-toxicity studies for the treated solutions over different durations, considering both chronic (ChV &gt; 10) and acute toxicity (LC50 and EC50 &gt; 100), signify remarkable impact for the applied oxidation reactions using H.36 in reducing the toxicity of 4-NP and inducing the safety of the treated samples, especially after 160 min.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 10","pages":"Article 100585"},"PeriodicalIF":1.3,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, characterization, antioxidant and bioactivity assessment, and thermodynamic analysis of metal ion complexes using a novel azo dye","authors":"Asseel AA. Al-naemi ,&nbsp;Abbas Ali Salih Al-Hamdani ,&nbsp;Susan Duraid Ahmed ,&nbsp;Muhammad Fazle Rabbee ,&nbsp;Nokeun Park ,&nbsp;Wail Al Zoubi","doi":"10.1016/j.cjac.2025.100586","DOIUrl":"10.1016/j.cjac.2025.100586","url":null,"abstract":"<div><div>In this study, the new azo dye,5,5-[1,2-phenylenebis(2,1-biazenediyl)] bis[8-quinolino], was used to synthesize complexes with Co²⁺, Ni²⁺, Cu²⁺, Zn²⁺, and Cd²⁺ ions. The compounds were characterized using ¹H and ¹³C nuclear magnetic resonance (NMR) spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, ultraviolet-visible (UV-Vis) spectroscopy, mass spectrometry, thermo gravimetric analysis (TGA), diffevential scanning calovimltry (DSC), CHN analysis. Further, conductivity, magnetic susceptibility, and metal and chlorine content analysis using FT-IR spectroscopy revealed that the ligand chelates as a bidentate (OH) phenol group and a bidentate (C<img>N) ring group. The ligand exhibited tetradentate behavior, forming tetrahedral complexes. Except for Co and Ni complexes,whichare octahedral, all of them are non-electrolytes. Air-stable complexes with distinct octahedral moieties were created in a 2:1 metal:ligand molar ratio. The effectiveness of both the compounds in inhibiting free radicals was evaluatedbased on their ability to act as antioxidants was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH) as a free radical and gallic acid as a standard substance. The IC₅₀ value indicated that the ligand had higher free radical inhibition ability, and the ability to inhibit the compoundsvaried.The ligand and complexes with Co²⁺, Cu²⁺, and Zn²⁺ were tested against <em>Escherichia coli, Bacillus spp, Penicillium, Aspergillus niger, Fusarium, and Trichoderma</em> at two concentrations, showing varying inhibitory effects on bacterial and fungal growth compared to the control.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 10","pages":"Article 100586"},"PeriodicalIF":1.3,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in plasma metabolome and correlation with urinary metabolome in cardiac surgery-associated acute kidney injury using ultra high-performance liquid chromatography-high resolution mass spectrometry","authors":"Yunpeng BAI ,&nbsp;Yichun JIANG ,&nbsp;Zhenmi LIU ,&nbsp;Ting LIU ,&nbsp;Silin LIANG ,&nbsp;Feng WANG ,&nbsp;Lang ZHANG ,&nbsp;Xin LIU ,&nbsp;Linhui HU ,&nbsp;Chunbo CHEN","doi":"10.1016/j.cjac.2025.100587","DOIUrl":"10.1016/j.cjac.2025.100587","url":null,"abstract":"<div><div>Cardiac surgery-associated acute kidney injury (CSA-AKI) may be related to an increase in mortality in patients in the intensive care unit; therefore, developing potential candidate molecule is particularly important for disease prediction and early diagnosis. This exploratory study investigated the alteration of the plasma metabolome profiles and possible links with the urinary metabolome in six patients with CSA-AKI at different time points, which could screen out the differential plasma metabolites for statistical analysis and altered metabolic pathways. After performing receiver operating characteristic analysis to obtain potential candidate molecules, the differential plasma metabolites with Level 1 were used for correlation analysis with the urinary metabolome. The plasma metabolome of the AKI group could be clearly separated from that of the uninjured kidney or recovered groups, but the plasma samples from recovered and uninjured groups could not be distinguished using statistical analysis. Compared with the uninjured kidney group, significant changes in the plasma metabolome were observed in such patients with CSA-AKI, especially regarding amino acid metabolism, spermidine and spermine biosynthesis, and sulfate/sulfite metabolism. The potential candidate molecules in the plasma metabolome, such as carnitines, exhibited a significantly positive correlation, while carnitines and organic acids in the plasma were involved in the correlation with the urinary metabolome. Plasma metabolic disorders were observed when CSA-AKI occurred, and the systemic status of recovered patients returned to normal after treatment. This exploratory investigation suggests potential candidate molecules in plasma and possible links to the urinary metabolome in CSA-AKI.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 10","pages":"Article 100587"},"PeriodicalIF":1.3,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of recombinant anti-human CD antibodies for diabetes and cancer monitoring using flow cytometry","authors":"Ziyi YANG ,&nbsp;Xinxin XU ,&nbsp;Hua KUANG ,&nbsp;Chuanlai XU","doi":"10.1016/j.cjac.2025.100558","DOIUrl":"10.1016/j.cjac.2025.100558","url":null,"abstract":"<div><div>TBNK cells, namely T, B, Natural Killer (NK) cells, are three major types of lymphocytes in the immune system. Comprehensive analysis of cluster of differentiation (CD) antigens on TBNK cell surface, such as CD3, CD4, CD8, CD16, CD19, CD56, and CD45, contributes to precise immune cell profiling and disease progression tracking. In this study, we prepared recombinant antibodies specifically target CDs markers using the ExpiCHO-Double Plasmid system, which ensured high-yield expression and reproducibility. The antibodies were efficiently conjugated with various fluorescent dyes, including FITC, PE-Cy7, APC<img>Cy7, APC, PE, and PerCP-Cy5.5, to achieve multiplexed flow cytometry analysis of TBNK cell populations. Testing of clinical samples demonstrated that the developed antibody conjugates could effectively distinguish the difference of TBNK cell populations between healthy individuals and patients, analysis of 291 adults showed type 2 diabetes had elevated CD4⁺/CD8⁺ ratios (1.9x) versus reduced ratios in cancer (0.75x), with principal component analysis (PCA) distinguishing groups (PC1 = 47.9 %) indicating their potential for disease monitoring and therapeutic evaluation. Our results underscore the utility of novel immunodiagnostic tools for early detection and personalized management of diabetes and cancer.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 8","pages":"Article 100558"},"PeriodicalIF":1.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction of uranium (VI) with neutral organic phosphorus extractants: A calorimetric and spectroscopic comparison of di(1-methylheptyl) methylphosphonate vs. tri-n-butylphosphate","authors":"Yuyu Liang ,&nbsp;Xiang Xie ,&nbsp;Qingye Zhou ,&nbsp;Shufeng Zhao ,&nbsp;Xiang Li ,&nbsp;Chenchen Yuan ,&nbsp;Zeng Huang ,&nbsp;Jun Tu ,&nbsp;Xingliang Li","doi":"10.1016/j.cjac.2025.100583","DOIUrl":"10.1016/j.cjac.2025.100583","url":null,"abstract":"<div><div>Both tri-<em>n</em>‑butyl phosphate and di(1-methylheptyl) methylphosphonate demonstrate exceptional extraction capabilities for ²³³U from irradiated thorium. While extensive literature exists regarding tri-<em>n</em>‑butyl phosphate-based extraction systems, comparative studies on di(1-methylheptyl) methylphosphonate remain notably limited. This systematic investigation provides a parallel comparison of the chemical behaviors between these two extractants under identical experimental conditions. Results reveal that the di(1-methylheptyl) methylphosphonate system exhibits enhanced hydrophobicity relative to tri-<em>n</em>‑butyl phosphate, correlating with reduced water co-extraction during the uranium recovery process. Raman spectroscopic analysis demonstrated about ∼30 cm^–1 shifts in the uranyl symmetric stretching vibration for di(1-methylheptyl) methylphosphonate complexes compared to ∼15 cm^–1 shifts of tri-<em>n</em>‑butyl phosphate complexes. This significant spectral displacement indicates stronger coordination bonding between phosphoryl oxygen of di(1-methylheptyl) methylphosphonate and uranyl ions. Isothermal titration calorimetry measurements quantified the extraction thermodynamics, yielding enthalpy changes of -12.83 kJ/mol and -11.32 kJ/mol for tri-<em>n</em>‑butyl phosphate and di(1-methylheptyl) methylphosphonate systems, respectively. Di(1-methylheptyl) methylphosphonate exhibits marginally less exothermic enthalpy despite its superior extraction efficiency. The counterintuitive observation suggests distinct thermodynamic compensation mechanisms. This likely involves more favorable entropy contributions in the di(1-methylheptyl) methylphosphonate extraction system and greater energy consumption during desolvation. This comprehensive comparison clarifies fundamental differences in extraction mechanisms between tri-<em>n</em>‑butyl phosphate and di(1-methylheptyl) methylphosphonate extractants, providing critical thermodynamic parameters for optimizing ²³³U recovery processes.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 10","pages":"Article 100583"},"PeriodicalIF":1.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}