Chinese Journal of Analytical Chemistry最新文献

{"title":"Development of LC/LCMS method for estimation of impurities in anti-HIV drug (Bictegravir) using Analytical Quality by Design (AQbD) approach","authors":"Divya Kumar VEMURI ,&nbsp;Rambabu GUNDLA ,&nbsp;Jayaprakash Kanijam RAGHUPATHI ,&nbsp;Nagalakshmi JEEDIMALLA ,&nbsp;Gowri Sankararao BURLE ,&nbsp;Naresh Kumar KATARI ,&nbsp;Sreekantha Babu JONNALAGADDA","doi":"10.1016/j.cjac.2024.100469","DOIUrl":"10.1016/j.cjac.2024.100469","url":null,"abstract":"<div><div>Analytical Quality by Design (AQbD) was used to construct stability indicating linked compounds using the HPLC technique of an anti-human immunodeficiency virus (anti-HIV) medicine (Bictegravir). Process-related and degrading impurities were separated on a Zorbax SB-C8 (150×4.6) mm, 3.5 m column. The buffer pH of the mobile phase was kept at 2.5 by employing potassium dihydrogen phosphate 0.05 M Mobile phase A contains 5 % methanol and 95 % buffer, whereas mobile phase B contains 50 % acetonitrile, 10 % methanol, 25 % tetrahydrofuran, and 15 % water. The completed chromatographic settings were a flow rate of 1.2 mL/min, a detector wavelength of UV at 250 nm, and an injection volume of 20 µL. This approach has been verified in accordance with ICH recommendations. The approach was discovered to be particular, sensitive, linear, exact, and accurate. The limit of quantification for all contaminants was determined to be &lt; 0.05 %, the correlation coefficient for all impurities is between 0.9996 and 1.0000, and the percent recovery for all impurities is between 91 % and 108 % at the LOQ level and 97 % to 113 % at the specification level. Forced degradation experiments in chemical and physical stress tests were performed in accordance with regulatory criteria, and the molecule was discovered to be susceptible to acid and base hydrolysis. Imp-A was the most common degrading impurity in both acid and base hydrolysis.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 2","pages":"Article 100469"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From tradition to innovation: Systematic analysis of quality markers (Q-markers) in traditional Chinese medicine","authors":"Jingru Mu ,&nbsp;Hongwei Li ,&nbsp;Mengwei Xu ,&nbsp;Tingting Luo ,&nbsp;Zhixiu Luo ,&nbsp;Ning Yang ,&nbsp;Delin Xu","doi":"10.1016/j.cjac.2025.100502","DOIUrl":"10.1016/j.cjac.2025.100502","url":null,"abstract":"<div><div>As a cornerstone of Chinese medicine, the quality of Chinese medicinal materials is crucial for ensuring their efficacy and safety. Thus, quality control is of utmost importance in the research and application of Chinese medicine, as it directly impacts the safety and effectiveness of these remedies and the industry's growth. With the globalization of traditional Chinese medicine (TCM), establishing a comprehensive and scientific quality control system has become an urgent priority. Recently, the concept of quality markers (Q-markers) has emerged as a pivotal tool for elevating the quality standards of TCM. However, current research on Q-markers is fragmented and lacks a systematic framework, highlighting the need for a more structured investigation. Through Web of Science, PubMed, CNKI, and other databases, using keywords like “traditional Chinese medicine”, “quality control”, and “quality markers”, this study extensively reviewed the recent advances and characterization methods of Q-markers. This study summarized the chemical properties of Q-markers of 40 common Chinese medicine materials, and flavonoid was ranked first. In addition, five characterization methods of Q-markers were summarized, offering new insights and a scientific foundation for enhancing the quality control of Chinese medicine resources and advancing the modernization and globalization of TCM.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 5","pages":"Article 100502"},"PeriodicalIF":1.2,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of a dual-function prodrug fluorescence probes for melanoma detection and anticancer drug release","authors":"Qianshan Shao ,&nbsp;Wenyun Pan ,&nbsp;Qiao Liang ,&nbsp;Chunxiao Li ,&nbsp;Fei Zhang ,&nbsp;Yuyu Yang ,&nbsp;Shihan Liu ,&nbsp;Guang Chen ,&nbsp;Baolei Fan","doi":"10.1016/j.cjac.2025.100500","DOIUrl":"10.1016/j.cjac.2025.100500","url":null,"abstract":"<div><div>Melanoma is a common malignant tumor, and its accurate detection and treatment are very important in the early stage of the tumor. However, there is no fluorescent probe that can simultaneously detect and treat melanoma. Here, we developed a novel prodrug fluorescent probe (OAC) that can not only visually track tyrosinase in melanoma but also release anticancer drugs on demand. First, when the probe detects tyrosinase, its fluorescence signal changes from blue to green and makes melanoma visible. Secondly, the detected melanoma is subjected to precise light irradiation to induce the release of anticancer drugs. This process is accompanied by a fluorescence transition from green to blue (signal 2), which can monitor drug release in real time. Therefore, the probe can not only detect melanoma in real time, but also release anticancer drugs to kill cancer cells. Furthermore, the probe has high affinity (K_m = 30 μM), high selectivity and low detection limit (0.05 U/mL) for tyrosinase. We also found that the probe showed high phototoxicity in HeLa cells. Finally, we hope that the prodrug fluorescent probe can become an effective tool for biomedical diagnosis and treatment.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 4","pages":"Article 100500"},"PeriodicalIF":1.2,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the potential pharmacological mechanism of Huiyang Zhitong plaster in treating knee osteoarthritis through network pharmacology, molecular docking, and experimental validation","authors":"Qifan Su ,&nbsp;Xiaoyu Chen ,&nbsp;Xiaoming Zhang ,&nbsp;Liangwei Wang ,&nbsp;Guanghui Deng ,&nbsp;Zhilang Xie ,&nbsp;Wei Xiang ,&nbsp;Junjie Qiu ,&nbsp;Linfeng Shi ,&nbsp;Junchao Zeng ,&nbsp;Xiaojun Chen ,&nbsp;Jiaqi Wu ,&nbsp;Houyin Shi","doi":"10.1016/j.cjac.2025.100492","DOIUrl":"10.1016/j.cjac.2025.100492","url":null,"abstract":"<div><div>Knee osteoarthritis (KOA) is a common degenerative disease of the joints, and the Huiyang Zhitong Plaster (HYZTP) formulation exhibits distinct therapeutic advantages in the clinical treatment of KOA. However, the underlying pharmacological mechanisms of HYZTP remain unclear. This study aimed to explore the mechanism underlying the therapeutic effect of HYZTP in the treatment of KOA. Methods: The active components and targets of HYZTP were identified from the TCMSP database, and the KOA-related genes were retrieved from the GeneCards database, Therapeutic Target Database (TDD) database, and Online Mendelian Inheritance in Man (OMIM) database. The potential targets related to both HYZTP and KOA were identified using the online Venny tool. Protein-protein interaction (PPI) network analysis was performed using the online STRING data analysis tool, and the network was optimized using Cytoscape. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were additionally performed using the Oebiotech cloud platform. The interactions between the core targets and active components of HYZTP were investigated by molecular docking, and animal experiments were conducted for investigating the mechanism of action of HYZTP in the treatment of KOA. Results: A total of 138 active components of HYZTP, which are associated with its therapeutic effect in the treatment of KOA, were identified by integrating the results of database search. Of the 129 targets, 39 key genes were found to be significantly enriched in the TNF, IL-17, HIF-1, and Toll-like receptor (TLR) signaling pathways. The results of molecular docking revealed that the key components of HYZTP, namely, beta-sitosterol and stigmasterol, exhibited a favorable binding potential for the targets in the TNF signaling pathway, including TNF-<em>α</em>, IL-1<em>β</em>, and AKT1. Further histopathological analysis revealed that HYZTP repaired cartilage damage in a rabbit model of KOA. The results of western blotting revealed that the expression levels of TNF-<em>α</em>, RIP1, CASP3, and BAX proteins were downregulated in the knee joint cartilage of the HYZTP group, compared to those of the model group. Conclusion: HYZTP likely hinders the progression of KOA by inhibiting the TNF signaling pathway and suppressing cellular apoptosis. The study provides novel insights into the underlying pharmacological mechanism of HYZTP in the treatment of KOA, providing a foundation for further research into the clinical applications of HYZTP.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 4","pages":"Article 100492"},"PeriodicalIF":1.2,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and thermal properties of organic phase change energy storage materials","authors":"Juanjuan YANG ,&nbsp;Xiaoliang WANG","doi":"10.1016/j.cjac.2025.100491","DOIUrl":"10.1016/j.cjac.2025.100491","url":null,"abstract":"<div><div>By integrating lauric acid and palmitic acid as base materials and adding coke powder as a thermal conductivity enhancer, this study aims to develop efficient organic phase change energy storage materials and comprehensively evaluate their thermal properties. The thermal conductivity of the material was optimized by using a melt mixing process and adjusting the coke powder ratio. The thermal stability and thermogravimetric characteristics of the material were analyzed in detail using differential scanning calorimeter (DSC) and thermogravimetric analyzer (TGA) techniques. In addition, the selection of nucleating agents and the influence of the ratio of lauric acid to palmitic acid on the supercooling phenomenon of materials were also explored. The thermal stability of the material was further verified through multiple thermal cycling tests. The research results indicate that the material with a 15% coke powder content has the best thermal conductivity and exhibits good thermal stability. Under the condition of adding 1% sodium hexametaphosphate as a nucleating agent and a ratio of lauric acid to palmitic acid of 8:2, the supercooling problem of the material was effectively solved. After 100 thermal cycles, the thermal performance of the material remains stable, demonstrating its enormous potential as a long-term energy storage material.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 6","pages":"Article 100491"},"PeriodicalIF":1.2,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new coumaric acid diglucoside-sebacic acid glycoside heterozygote compound in Butea monosperma","authors":"Qianghua YUAN ,&nbsp;Jun HAN","doi":"10.1016/j.cjac.2025.100499","DOIUrl":"10.1016/j.cjac.2025.100499","url":null,"abstract":"<div><div>A new heterozygote compound (<strong>3</strong>) of coumaric acid diglucoside and sebacic acid glycoside and two known compounds (<strong>1, 2</strong>) were isolated from the seeds of <em>Butea monosperma</em>. Then, their chemical structures were identified by detailed spectral analysis, including 1D and 2D nuclear magnetic resonance (NMR), mass spectrometry (MS) and infrared (IR) spectroscopy. In addition, the antitumor activity study showed that compound <strong>2</strong> had a significant inhibitory effect on triple negative breast cancer (TNBC) cell line MDA-MB-231, and its IC₅₀ value was 1.546 μmol/L.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 3","pages":"Article 100499"},"PeriodicalIF":1.2,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of nanoscale CeO2 as Fenton-like catalyst in the field of environment and bioscience","authors":"Han XU ,&nbsp;Xiang CHU ,&nbsp;Jing XU ,&nbsp;Meng ZHAO ,&nbsp;Lin PENG ,&nbsp;Lingling ZHANG ,&nbsp;Xiao WANG","doi":"10.1016/j.cjac.2025.100501","DOIUrl":"10.1016/j.cjac.2025.100501","url":null,"abstract":"<div><div>Fenton reaction has been regarded as one of the most potent ways to cost-efficiently degrade organic contaminants and cure cancer by inducing cell apoptosis and necrosis. However, commercial Fe-base catalysts and natural enzymes are suffering from high costs and low durability. Exploring a new catalyst for reducing cost and avoiding secondary pollution is demanding. Recent research illustrates that CeO₂ owns a specific oxygen vacancy structure and Ce³⁺/Ce⁴⁺ redox cycle, which is thought to be the origin of Fenton-like reaction activities. Significantly, inducing heteroatoms promotes the concentration of oxygen vacancy and Ce³⁺ ions, and the electrons transfer between Ce and heteroatoms accelerates the redox cycles. The broad reaction pH value and low biotoxicity endow CeO₂ with enormous potential in organic pollutants’ disposal and artificial enzyme for healthcare. Because of their excellent stability, Ce-base catalysts are more accessible for storage and transformation than natural enzymes. Meanwhile, electro-/photochemistry technologies are believed to reduce subsequent pollution and potentially be applied in biology fields. This review focuses on the Fenton-like reaction process and its application in environmental engineering and life science.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 3","pages":"Article 100501"},"PeriodicalIF":1.2,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143428719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular docking, dynamic molecular simulation and in silico ADMET screening study of novel bidentate tetrazolyl-adipate anti-HIV drugs candidate","authors":"Fatimazohra LENDA ,&nbsp;Mohammed ER-RAJY ,&nbsp;Asmae El CADI ,&nbsp;Hamada IMTARA ,&nbsp;Farhate GUENOUN ,&nbsp;Hassan ALLOUCHI ,&nbsp;Somdutt MUJWAR ,&nbsp;Khalid NAJOUI ,&nbsp;Omar M. NOMAN ,&nbsp;Jean MARTINEZ ,&nbsp;Frédéric LAMATY ,&nbsp;Menana ELHALLAOUI","doi":"10.1016/j.cjac.2025.100498","DOIUrl":"10.1016/j.cjac.2025.100498","url":null,"abstract":"<div><div>In order to develop specific inhibitors of CYP3A4, we chose new derivatives of adipic acid the 2,5-(5-aryl tetrazol-2yl) dimethyl adipate L₁-L₅. During this study, the Ritonavir molecule known as inhibitor of the cytochrome CYP3A4 are chosen as a reference. A molecular docking simulation on the enzyme 7UAZ is conducted for the ligands L₁-L₅, in order to study the predictive binding affinity and the interaction mechanism of the 5-aryltetrazolyl substituents introduced at positions 2 and 5 of adipic acid. A molecular docking study revealed that the relative activation energy level ranged from –10.1 to –7.6 kcal/mol, falling within the range of Ritonavir at –9.0 kcal/mol, which confirms the stability of the ligands within the studied enzyme. The results show that the binding mode of the ligands on the enzyme 7UAZ varies significantly depending on the substituent at the -C5 position of the tetrazole, with the best results obtained for the ligands L₂ and L₅. Then a comparative study based on silico ADMET properties selected only L₂ as a potential inhibitor of CYP3A4. A 100 ns molecular dynamics simulation on the ligand-protein complex highlights the stability of ligand L₂ within the 7UAZ protein.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 3","pages":"Article 100498"},"PeriodicalIF":1.2,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studying the effect of using metal oxide nanofluids on the performance of a single-tube heat exchanger","authors":"Waleed N. Al-DARKAZALI ,&nbsp;Sara S. HAMOOD ,&nbsp;Nassim ALDAHER ,&nbsp;Nazar Sattar HARBI","doi":"10.1016/j.cjac.2025.100497","DOIUrl":"10.1016/j.cjac.2025.100497","url":null,"abstract":"<div><div>The preparation of aluminum oxide from nanofluid (Al₂O₃/H₂O) in three different concentrations using a two-step method was achieved by using an atomic force microscopy (AFM). The AFM images showed that the nanoparticles took on a spherical shape with a range of average diameters and density within the range of 45–55 nm.</div><div>Polyacrylamide (PAAM) was used as a dispersion and suspension agent for aluminum oxide nanoparticles in distilled water at various concentrations (250, 500, 750, 1000) ppm during preparation, followed by determination of the polymer ratio for each sample during preparation, stability assessment by ultraviolet-visible (UV-Vis) spectrophotometer in the wavelength field (200–700) nm for 10 days, and analysis of sample Alumina nanoparticles by dispersion and suspension agent by high-pressure polymers tended M25 resulting in the highest concentrations of the given concentration. By increasing the PAAM concentration, the dispersion and stability of Al₂O₃ nanoparticles in distilled water appear to be improved, and concentrations of 0.25% seemed to be more evenly dispersed and stable over time, with minor sedimentation compared to (0.1%, 0.05%) vol concentrations, where the absorbance peak decreased by 5.5% despite the increase in size of Al₂O₃ nanoparticles and their aggregations, while the absorbance peak in the previous concentrations decreased by (14.2% and 8.8%), respectively of the two previous concentrations of Al₂O₃.</div><div>The study of PAAM polymers demonstrated that their rheological properties were not Newtonian, owing to a higher concentration of the polymer, resulting in viscosity results that resembled non-Newtonian polysaccharides.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 3","pages":"Article 100497"},"PeriodicalIF":1.2,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Egyptian zeolite ore as a novel layered adsorbent for petroleum wastewater treatment","authors":"Wesam Kamal ,&nbsp;Doaa Essam ,&nbsp;Ahmed A. Allam ,&nbsp;Haifa E. Alfassam ,&nbsp;Doaa abd el tawab ,&nbsp;Samah Abdel Moaty ,&nbsp;Rehab Mahmoud","doi":"10.1016/j.cjac.2024.100490","DOIUrl":"10.1016/j.cjac.2024.100490","url":null,"abstract":"<div><div>It is critical to synthesize adsorbents that are highly effective, affordable, highly selective, and excellently recyclable to remove refinery wastewater contaminants. Natural zeolites hold great promise for purifying water that contains heavy metals and organic pollutants, which is a typical representative of refinery wastewater effluents. In this work, a natural Egyptian zeolite ore was investigated as an adsorbent for refinery wastewater treatment applications. X-ray diffraction (XRD), X-ray fluorescence (XRF), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectroscopy (FTIR) and Brunauer–Emmett–Teller (BET) analytical characterization techniques were used to characterize the zeolite ore. Batch adsorption tests were then conducted to investigate the removal efficiency of this zeolite for benzene (Bz) and strontium (Sr), two representative organic pollutants and heavy metals, respectively. This zeolite ore showed maximum adsorption capacities of 492.5 and 1700 mg/g for Sr and Bz, respectively. The Baudu isotherm model was found to be the best fit model in the case of Sr, whereas the Bz Langmuir–Freundlich and Sips models resulted in the highest <em>R</em>² value. Very fast kinetics were observed, and the equilibrium times were estimated to be 10 and 20 min for Sr and Bz, respectively. The current investigation showed that this layered Egyptian zeolite ore can be very promising for refinery wastewater treatment applications. An adsorbent is used to remove pollutants from refinery wastewater.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"53 4","pages":"Article 100490"},"PeriodicalIF":1.2,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}