A new coumaric acid diglucoside-sebacic acid glycoside heterozygote compound in Butea monosperma

IF 1.2 4区化学 Q4 CHEMISTRY, ANALYTICAL

Chinese Journal of Analytical Chemistry Pub Date : 2025-01-20 DOI:10.1016/j.cjac.2025.100499

Qianghua YUAN , Jun HAN

引用次数: 0

Abstract

A new heterozygote compound (3) of coumaric acid diglucoside and sebacic acid glycoside and two known compounds (1, 2) were isolated from the seeds of Butea monosperma. Then, their chemical structures were identified by detailed spectral analysis, including 1D and 2D nuclear magnetic resonance (NMR), mass spectrometry (MS) and infrared (IR) spectroscopy. In addition, the antitumor activity study showed that compound 2 had a significant inhibitory effect on triple negative breast cancer (TNBC) cell line MDA-MB-231, and its IC₅₀ value was 1.546 μmol/L.

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一个新的香豆酸二糖苷-癸二酸糖苷杂合子化合物

从单精子植物Butea monosperma种子中分离到香豆酸二糖苷和癸二酸糖苷新杂合子化合物(3)和两个已知化合物（1,2）。然后，通过详细的光谱分析，包括1D和2D核磁共振（NMR）、质谱（MS）和红外（IR）光谱，鉴定了它们的化学结构。此外，抗肿瘤活性研究表明，化合物2对三阴性乳腺癌（TNBC）细胞株MDA-MB-231具有显著的抑制作用，其IC50值为1.546 μmol/L。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chinese Journal of Analytical Chemistry 化学-分析化学

CiteScore

3.60

自引率

25.00%

发文量

17223

审稿时长

35 days

期刊介绍： Chinese Journal of Analytical Chemistry(CJAC) is an academic journal of analytical chemistry established in 1972 and sponsored by the Chinese Chemical Society and Changchun Institute of Applied Chemistry, Chinese Academy of Sciences. Its objectives are to report the original scientific research achievements and review the recent development of analytical chemistry in all areas. The journal sets up 5 columns including Research Papers, Research Notes, Experimental Technique and Instrument, Review and Progress and Summary Accounts. The journal published monthly in Chinese language. A detailed abstract, keywords and the titles of figures and tables are provided in English, except column of Summary Accounts. Prof. Wang Erkang, an outstanding analytical chemist, academician of Chinese Academy of Sciences & Third World Academy of Sciences, holds the post of the Editor-in-chief.