Chinese Journal of Analytical Chemistry最新文献

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A highly specific single-atom Fe-NC nanozyme-based colorimetric probe for ultrasensitive visual detection of fluoride 一种高特异性的单原子Fe-NC纳米酶比色探针,用于超灵敏的氟化物视觉检测
IF 1.4 4区 化学
Chinese Journal of Analytical Chemistry Pub Date : 2026-07-01 Epub Date: 2026-03-17 DOI: 10.1016/j.cjac.2026.100727
Yi Yuan, Tingting Deng, Juan Huang, Xiaojing Si, Junping Dong, Yongmei Zhao, Yunyi Lei, Xiaoxia Yan, Liqiang Luo, Haibo He
{"title":"A highly specific single-atom Fe-NC nanozyme-based colorimetric probe for ultrasensitive visual detection of fluoride","authors":"Yi Yuan,&nbsp;Tingting Deng,&nbsp;Juan Huang,&nbsp;Xiaojing Si,&nbsp;Junping Dong,&nbsp;Yongmei Zhao,&nbsp;Yunyi Lei,&nbsp;Xiaoxia Yan,&nbsp;Liqiang Luo,&nbsp;Haibo He","doi":"10.1016/j.cjac.2026.100727","DOIUrl":"10.1016/j.cjac.2026.100727","url":null,"abstract":"<div><div>As the smallest and most electronegative anion, fluoride ion (F<sup>−</sup>) requires precise concentration monitoring due to its significant implications for environmental analysis. Thus, it is necessary to develop a suitable method for the sensitive detection of F<sup>−</sup> in complex matrices. In this work, the single-atom (SA) Fe-NC nanozyme with high oxidase-like activity were prepared and encapsulated within a SiO<sub>2</sub> shell layer to form the nanozyme@SiO<sub>2</sub> core-shell structure. The active sites of SA Fe-NC@SiO<sub>2</sub> nanozyme were exposed through specific etching of the unsintered SiO<sub>2</sub> shell in the presence of fluoride ions, thereby gradually releasing the enzymatic activity to catalyze the oxidation of chromogenic substrate TMB into oxTMB, yielding a visual color change from colorless to deep blue. In the most favorable conditions, the oxTMB absorbance exhibited a good linear correlation with the logarithm F<sup>−</sup> concentration (10–1000 nM), enabling sensitive quantitative detection of F<sup>−</sup> with a detection limit as low as 4.5 nM. Notably, this proposed SA Fe-NC@SiO<sub>2</sub> nanozyme colorimetric probe displayed remarkable specificity towards F<sup>−</sup> over several potentially interfering ions in environmental water, allowing it applicable for complex real samples such as pond water and toothpaste. A portable paper sensor incorporating SA Fe-NC@SiO<sub>2</sub> was subsequently developed, which facilitated an intuitive on-site detection of F<sup>−</sup> in complex matrices by integrating with smartphone-based analysis.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"54 7","pages":"Article 100727"},"PeriodicalIF":1.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148528063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Linguistic features and translation strategies of English for Chemical Science 化学科学英语的语言特点及翻译策略
IF 1.4 4区 化学
Chinese Journal of Analytical Chemistry Pub Date : 2026-07-01 Epub Date: 2026-03-03 DOI: 10.1016/j.cjac.2026.100714
Shang Yang, Yihan Nie
{"title":"Linguistic features and translation strategies of English for Chemical Science","authors":"Shang Yang,&nbsp;Yihan Nie","doi":"10.1016/j.cjac.2026.100714","DOIUrl":"10.1016/j.cjac.2026.100714","url":null,"abstract":"<div><div>This study aims to systematically analyze the linguistic features of English for Chemical Science and to develop a set of practical translation strategies tailored for English-to-Chinese translation. Through a descriptive and applied linguistic analysis, we examine its characteristic lexical and syntactic patterns. The lexical features include systematic terminology with prevalent polysemy, frequent use of abbreviations and symbols, and strict adherence to international nomenclature standards. The syntactic features encompass nominalization, prevalent use of passive voice, employment of complex long sentences for logical integration, and highly precise experimental descriptions. Based on this analysis, we propose targeted translation methods that emphasize terminological accuracy, syntactic conversion, and the logical deconstruction of complex sentences to ensure faithful and intelligible communication across languages. It holds significant practical importance for enhancing the professional English application skills of practitioners and learners in the chemical field, as well as for facilitating knowledge sharing and technical collaboration both domestically and internationally.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"54 7","pages":"Article 100714"},"PeriodicalIF":1.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148528064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-sufficient Fenton-like degradation by Cu-TA encapsulated melamine sponge Cu-TA包封三聚氰胺海绵自给式fenton类降解研究
IF 1.3 4区 化学
Chinese Journal of Analytical Chemistry Pub Date : 2026-06-01 Epub Date: 2025-11-20 DOI: 10.1016/j.cjac.2025.100680
Yan Chen , Pengqian Zhou , Jiwei Wang , Bei Jiang
{"title":"Self-sufficient Fenton-like degradation by Cu-TA encapsulated melamine sponge","authors":"Yan Chen ,&nbsp;Pengqian Zhou ,&nbsp;Jiwei Wang ,&nbsp;Bei Jiang","doi":"10.1016/j.cjac.2025.100680","DOIUrl":"10.1016/j.cjac.2025.100680","url":null,"abstract":"<div><div>Water contamination is a severe and urgent issue, and advanced oxidation processes (AOPs) offer promising solutions for water purification. Among these, copper-based Fenton-like reaction demonstrate advantages such as rapid reaction kinetics and low reduction potential. However, a major limitation of most Fenton-like reactions is their reliance on externally added H<sub>2</sub>O<sub>2</sub>, which poses risks in transportation, storage, and management. To address this, developing self-sufficient Fenton-like systems with in-situ H<sub>2</sub>O<sub>2</sub> generation is critical. In this study, we conjugated copper ions (Cu<sup>2+</sup>) and tannic acid (TA) on a melamine sponge (MS) substrate to fabricate a self-sufficient Fenton-like catalyst (MS-Cu-TA). MS exhibits high porosity and absorbency, which facilitate efficient liquid absorption for the degradation process. The H<sub>2</sub>O<sub>2</sub> content generated by a single MS-Cu-TA sponge was determined as ∼0.19 mmol, which was sufficient to sustain the Fenton-like reaction. Methylene Blue (MB) degradation results showed that MS-Cu-TA achieved comparable degradation efficiency (∼60% within 0.5 h) without exogenous H<sub>2</sub>O<sub>2</sub>. Notably, in this specific dye degradation process, adsorption and degradation occurred simultaneously. Results from reactive oxygen species (ROS) quenching tests and electron paramagnetic resonance (EPR) spectroscopic analysis revealed that the dominant ROS generated is hydroxyl radicals (•OH), which originates from in-situ formed H<sub>2</sub>O<sub>2</sub>. The in-situ H<sub>2</sub>O<sub>2</sub> generation is likely attributed to the auto-oxidation of TA, which acts as both reducing agent and H<sub>2</sub>O<sub>2</sub> precursor. Concurrently, TA reduces Cu<sup>2+</sup> to Cu<sup>+</sup>, which catalyzes H<sub>2</sub>O<sub>2</sub> to generate •OH via a Fenton-like reaction. This work provides valuable insights for developing self-sufficient Fenton-like systems in wastewater treatment.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"54 6","pages":"Article 100680"},"PeriodicalIF":1.3,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Higher education institutions students' exercise habits and their self-reported oxidative-stress perception levels: A survey-based exploratory study 高校学生运动习惯与自我报告氧化应激感知水平:基于调查的探索性研究
IF 1.3 4区 化学
Chinese Journal of Analytical Chemistry Pub Date : 2026-06-01 Epub Date: 2025-11-20 DOI: 10.1016/j.cjac.2025.100675
Binxin Li , Weibin Kong , Hao Chen
{"title":"Higher education institutions students' exercise habits and their self-reported oxidative-stress perception levels: A survey-based exploratory study","authors":"Binxin Li ,&nbsp;Weibin Kong ,&nbsp;Hao Chen","doi":"10.1016/j.cjac.2025.100675","DOIUrl":"10.1016/j.cjac.2025.100675","url":null,"abstract":"<div><div>Exercise habits significantly influence oxidative stress levels among university students, but previous research has often neglected endogeneity issues, leading to biased estimates of these relationships. This cross-sectional study investigated the potential causal relationship between exercise habits and self-reported oxidative-stress perception levels among 1868 university students from China. Data on exercise habits and self-reported oxidative-stress perception were collected using questionnaires, and both the instrumental variable (IV) approach and ordinary least squares (OLS) regression were employed to address endogeneity concerns. The OLS estimates revealed negative associations between exercise habits and self-reported oxidative-stress perception (β = –0.021, <em>p</em> &lt; 0.001), while the IV analysis indicated that exercise habits significantly reduced self-reported oxidative-stress perception in the fatigue–recovery dimension (β = –0.035, <em>p</em> &lt; 0.01). The IV estimates were larger than the OLS estimates, suggesting that traditional regression may underestimate the beneficial effects of exercise habits. Overall, this study provides indicative evidence for a potential causal relationship whereby exercise habits may reduce self-reported oxidative-stress perception levels among university students, offering valuable insights for addressing oxidative stress–related health issues through exercise interventions.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"54 6","pages":"Article 100675"},"PeriodicalIF":1.3,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148242248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comprehensive review of nitrogen-doped MXene quantum dots for fluorescence-based environmental pollutant detection 氮掺杂MXene量子点荧光环境污染物检测研究综述
IF 1.3 4区 化学
Chinese Journal of Analytical Chemistry Pub Date : 2026-06-01 Epub Date: 2026-03-23 DOI: 10.1016/j.cjac.2026.100729
Ghada Al-Assi , Ahlam Jameel Buni , Rekha M M , Subhashree Ray , Talal Aziz Qassem , T. Krithiga , Renu Sharma , Prakhar Tomar , Shayan Mahmoodi
{"title":"A comprehensive review of nitrogen-doped MXene quantum dots for fluorescence-based environmental pollutant detection","authors":"Ghada Al-Assi ,&nbsp;Ahlam Jameel Buni ,&nbsp;Rekha M M ,&nbsp;Subhashree Ray ,&nbsp;Talal Aziz Qassem ,&nbsp;T. Krithiga ,&nbsp;Renu Sharma ,&nbsp;Prakhar Tomar ,&nbsp;Shayan Mahmoodi","doi":"10.1016/j.cjac.2026.100729","DOIUrl":"10.1016/j.cjac.2026.100729","url":null,"abstract":"<div><div>Nitrogen-doped MXene quantum dots (N-MQDs) have recently emerged as a promising class of zero-dimensional nanomaterials for fluorescence-based environmental sensing owing to their unique combination of quantum confinement, high surface-to-volume ratio, and tunable electronic structure. Nitrogen incorporation into the MXene lattice introduces mid-gap states and defect-associated emissive centers, enabling precise modulation of photoluminescence behavior, charge-transfer dynamics, and analyte–probe interactions. This review systematically summarized recent advances in the synthesis, structural engineering, and photophysical regulation of N-MQDs, with particular emphasis on their mechanistic roles in selective pollutant detection. Fundamental sensing pathways, including adsorption-driven fluorescence modulation, electron and energy transfer processes, and coordination-induced intramolecular charge transfer, were critically analyzed in relation to dopant configuration, defect density, and quantum dot size. Furthermore, the performance of N-MQDs in detecting environmentally relevant targets—such as heavy metal ions, redox-active species, and organic contaminants—was discussed across solution-based and solid-state platforms. Current challenges associated with reproducibility, selectivity in complex matrices, and scalable fabrication were highlighted, along with future perspectives for smart and multifunctional sensing systems. Notably, this work represented the comprehensive review dedicated to N-MQDs as tunable fluorescent probes for selective environmental pollutant detection.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"54 6","pages":"Article 100729"},"PeriodicalIF":1.3,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148242246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
UPLC-FT-ICR-MS and mechanistic study reveals the protective effect of Callistephus chinensis flower against alcoholic liver disease UPLC-FT-ICR-MS及机制研究揭示了金盏花对酒精性肝病的保护作用
IF 1.3 4区 化学
Chinese Journal of Analytical Chemistry Pub Date : 2026-06-01 Epub Date: 2026-03-06 DOI: 10.1016/j.cjac.2026.100726
Nan YANG , Xuehan LI , Xiaojun WANG , Kexin HUANG , Weizhuo TANG , Xiaoshu ZHANG
{"title":"UPLC-FT-ICR-MS and mechanistic study reveals the protective effect of Callistephus chinensis flower against alcoholic liver disease","authors":"Nan YANG ,&nbsp;Xuehan LI ,&nbsp;Xiaojun WANG ,&nbsp;Kexin HUANG ,&nbsp;Weizhuo TANG ,&nbsp;Xiaoshu ZHANG","doi":"10.1016/j.cjac.2026.100726","DOIUrl":"10.1016/j.cjac.2026.100726","url":null,"abstract":"<div><h3>Background</h3><div>Liver disease caused by excessive alcohol consumption is a serious threat to human health. Previous studies have shown that <em>Callistephus chinensis</em> flower (CCF) can ameliorate alcoholic liver disease (ALD), but its mechanism remains unreported.</div></div><div><h3>Methods</h3><div>The chemical composition of CCF was identified in vitro by employing ultra-performance liquid chromatography coupled with Fourier transform ion cyclotron resonance mass spectrometry (UPLC-FT-ICR-MS). C57BL/6 J mice were divided into control, ethanol, CCF extract (100, 200 and 400 mg/kg), and silymarin (100 mg/kg) groups. Hepatic pathology and lipid infiltration were assessed via H&amp;E and Oil Red O staining. Commercial kits were used to measure TC, TG, AST, ALT, MDA, and GSH-Px levels. IHC was performed for PPARα, IL-1β, F4/80, and TLR4, while Western blot quantified AMPKα, p-AMPKα, PPARα, CPT1α, ACC, and p-ACC.</div></div><div><h3>Results</h3><div>LC-MS/MS preliminarily identified 23 major compounds, with flavonoids and phenolic acids being the predominant components in CCF extract. CCF administration upregulated p-AMPKα, PPARα, and CPT1α, and downregulated TLR4, p-NF-κB, and p-IκBα. It effectively reduced serum inflammatory factors, decreased lipid accumulation, promoted lipid metabolism, and alleviated liver injury by modulating AMPK and TLR4/NF-κB pathways.</div></div><div><h3>Conclusion</h3><div>This study is the first to demonstrate that CCF ameliorates ALD via AMPK and TLR4/NF-κB pathways, providing a potential candidate for ALD treatment.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"54 6","pages":"Article 100726"},"PeriodicalIF":1.3,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148242247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasensitive detection of aesculetin using a ruthenium nanoparticle-modified carbon fiber microelectrode and mechanistic investigation of its interaction with DNA 纳米钌修饰碳纤维微电极对马尾草素的超灵敏检测及其与DNA相互作用的机理研究
IF 1.4 4区 化学
Chinese Journal of Analytical Chemistry Pub Date : 2026-06-01 Epub Date: 2026-04-03 DOI: 10.1016/j.cjac.2026.100728
Ruiting TIAN, Min SHI, Tao FANG, Uchkun ISHIMOV, Awais IHSAN, Jun LI, Syed Aftab NAQVI, Xianju HUANG, Han CHENG
{"title":"Ultrasensitive detection of aesculetin using a ruthenium nanoparticle-modified carbon fiber microelectrode and mechanistic investigation of its interaction with DNA","authors":"Ruiting TIAN,&nbsp;Min SHI,&nbsp;Tao FANG,&nbsp;Uchkun ISHIMOV,&nbsp;Awais IHSAN,&nbsp;Jun LI,&nbsp;Syed Aftab NAQVI,&nbsp;Xianju HUANG,&nbsp;Han CHENG","doi":"10.1016/j.cjac.2026.100728","DOIUrl":"10.1016/j.cjac.2026.100728","url":null,"abstract":"<div><div>This study presents the development of an ultrasensitive electrochemical sensor based on a ruthenium nanoparticle-modified carbon fiber microelectrode (RuNPs/CFME) for the detection of aesculetin and investigation of its interaction with DNA. The RuNPs/CFME exhibited significantly enhanced electrocatalytic activity, attributed to the large specific surface area and excellent conductivity of RuNPs, resulting in 54.6% decrease in charge transfer resistance compared to the bare electrode. The sensor demonstrated a linear response to aesculetin in the concentration range of 0.01–1 μM, with a detection limit (LOD) of 1.62 nM and a quantification limit (LOQ) of 5.44 nM. The electrode process was adsorption-controlled and involved a two-electron transfer. The modified sensor displayed high selectivity against common interferents, excellent reproducibility (RSD &lt; 2%), and stability (&gt; 95% signal retention after 10 days). Furthermore, the platform was applied to study the interaction between aesculetin and calf thymus dsDNA, revealing a binding mechanism dominated by electrostatic interactions, as evidenced by a negative shift in oxidation potential and current attenuation. The sensor was successfully employed for aesculetin detection in human serum samples, achieving recoveries of 95.7%–102.6%, demonstrating its potential for pharmacological applications and drug-DNA interaction studies.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"54 6","pages":"Article 100728"},"PeriodicalIF":1.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148499792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI-Driven control of large potassium dihydrogen predictive modeling and assisted optimization of DKDP crystal growth using gradient boosted regression trees and crystal height features 利用梯度增强回归树和晶体高度特征,人工智能驱动控制大双氢钾预测建模和辅助优化DKDP晶体生长
IF 1.3 4区 化学
Chinese Journal of Analytical Chemistry Pub Date : 2026-06-01 Epub Date: 2026-01-04 DOI: 10.1016/j.cjac.2026.100695
Haining Li , Jianyu Bai , Zongyi Zhang , Xun Sun
{"title":"AI-Driven control of large potassium dihydrogen predictive modeling and assisted optimization of DKDP crystal growth using gradient boosted regression trees and crystal height features","authors":"Haining Li ,&nbsp;Jianyu Bai ,&nbsp;Zongyi Zhang ,&nbsp;Xun Sun","doi":"10.1016/j.cjac.2026.100695","DOIUrl":"10.1016/j.cjac.2026.100695","url":null,"abstract":"<div><div>This work develops a machine‑learning assisted approach to model and optimize the growth of deuterated potassium dihydrogen phosphate (DKDP) crystals using industrial‑scale data. Conventional models based only on temperature and supersaturation fail to capture multi‑field coupling and size effects in large crystals. Here, crystal height is introduced as an additional physical feature and combined with a gradient boosted regression trees (GBRT) algorithm to predict growth rate. On 15,881 daily records from long‑term DKDP runs, adding crystal height increases the test‑set <em>R</em>² from 0.4916 to 0.8427 and significantly reduces mean squared error (MSE), root mean squared error (RMSE) and mean absolute error (MAE). Feature‑importance analysis shows that temperature, saturation temperature and crystal height contribute 22.39%, 42.58% and 35.03%, highlighting the key role of height in size‑dependent heat‑ and mass‑transfer. The trained GBRT model enables real‑time prediction and anomaly detection, where large prediction deviations are associated with “hair” inclusions and lateral‑expansion defects. This grey‑box strategy offers a practical route to intelligent monitoring and assisted optimization of large DKDP crystal growth.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"54 6","pages":"Article 100695"},"PeriodicalIF":1.3,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148187016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A piperazine derivative for fluorescence recognition of pyrene and colorimetric discrimination of Fe2+/Fe3+system 用于芘荧光识别和Fe2+/Fe3+体系比色鉴别的哌嗪衍生物
IF 1.3 4区 化学
Chinese Journal of Analytical Chemistry Pub Date : 2026-05-01 Epub Date: 2025-12-04 DOI: 10.1016/j.cjac.2025.100688
Sudeshna Chatterjee, Pallabi Mukherjee, Sukriti Mukherjee, Debasis Das
{"title":"A piperazine derivative for fluorescence recognition of pyrene and colorimetric discrimination of Fe2+/Fe3+system","authors":"Sudeshna Chatterjee,&nbsp;Pallabi Mukherjee,&nbsp;Sukriti Mukherjee,&nbsp;Debasis Das","doi":"10.1016/j.cjac.2025.100688","DOIUrl":"10.1016/j.cjac.2025.100688","url":null,"abstract":"<div><div>A piperazine derivative, namely, (2‑hydroxy-naphthalen-1-ylmethylene)-[3-(4-{3-[(2‑hydroxy-naphthalen-1-ylmethylene)-amino]-propyl}-piperazin-1-yl)-propyl]-amine (<strong>L4</strong>) has been synthesized, structurally characterized by single crystal X-ray diffraction analysis and employed for selective fluorescence detection of pyrene along with colorimetric discrimination of Fe<sup>2+</sup> and Fe<sup>3+</sup>. Fluorescence turn on process is attributed to the water assisted aggregation, in combination with <em>π</em>–<em>π</em> stacking of pyrene units. The lowest detection limit for pyrene is 2.5 × 10<sup>–9</sup> M whiles the association constant being 6.4 × 10<sup>4</sup> M<sup>–</sup><sup>1</sup>.The colorimetric detection limits for Fe<sup>2+</sup> and Fe<sup>3+</sup> are 2.34 and 1.22 μM, respectively. <strong>L4</strong> efficiently removes pyrene from real samples by solid phase extraction.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"54 5","pages":"Article 100688"},"PeriodicalIF":1.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147799616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Theviridoside, Alcesefoliside, and Cycloolivil as natural compounds: Discovery of new HMG-CoA reductase, alpha glucosidase inhibitors and anti-gastric potential 毒苷、Alcesefoliside和Cycloolivil作为天然化合物:发现新的HMG-CoA还原酶、α葡萄糖苷酶抑制剂和抗胃潜能
IF 1.3 4区 化学
Chinese Journal of Analytical Chemistry Pub Date : 2026-05-01 Epub Date: 2026-01-03 DOI: 10.1016/j.cjac.2026.100693
Liping Feng , Jing Chen , Dongwen You , Xianjing Zeng , Chunlin Song
{"title":"Theviridoside, Alcesefoliside, and Cycloolivil as natural compounds: Discovery of new HMG-CoA reductase, alpha glucosidase inhibitors and anti-gastric potential","authors":"Liping Feng ,&nbsp;Jing Chen ,&nbsp;Dongwen You ,&nbsp;Xianjing Zeng ,&nbsp;Chunlin Song","doi":"10.1016/j.cjac.2026.100693","DOIUrl":"10.1016/j.cjac.2026.100693","url":null,"abstract":"<div><div>One of the deadliest and most prevalent cancers in the world is gastric cancer, also known as stomach cancer. According to GLOBOCAN 2018 data, stomach cancer ranks third globally in terms of cancer mortality, behind colorectal and lung cancer. Gastric cancer is the fifth most prevalent type of cancer overall. Gastric cancer is one of the most well-known and dangerous tumors, with a poor prognosis and a high total mortality rate from malignant progression. Additionally, Alpha-glucosidase inhibitors are widely used oral antidiabetic medications that regulate the breakdown of carbohydrates into simple sugars that the intestines can absorb. HMG CoA reductase and α-glucosidase were inhibited in this study by Theviridoside, Alcesefoliside, and Cycloolivil molecules, with IC50 values of 1.70 ± 0.03 and 26.71 ± 1.04 µM for Theviridoside, 0.98 ± 0.01 and 4.35 ± 0.06 µM for Alcesefoliside, and 6.27 ± 0.02 and 41.20 ± 0.87 µM for Cycloolivil, respectively. The anti-cancer properties of the compounds were assessed using the SNU1 (IC50: 65.32 ± 2.70, 76.31 ± 1.44 and 20.52 ± 1.25 µM), AGS (IC50: 61.35 ± 2.73, 89.46 ± 1.06 and 11.76 ± 0.63 µM), and MKN45 (IC50: 56.71 ± 0.98, 83.50 ± 2.62 and 14.87 ± 1.12 µM) cell lines, respectively. The binding affinity and interactions of theviridoside, alcesefoliside, and cycloolivil against HMG-CoA reductase and α-glucosidase were assessed by using computational methods such as MM/GBSA calculations, molecular modeling, and molecular dynamics (MD) simulations. Moreover, their activity against three gastric cancer cell lines, SNU1, AGS, and MKN45 was evaluated. Their interactions and affinities with multiple surface receptor proteins, such as CD44, estrogen receptor, and EGFR, were investigated using computational methods. Based on the results, these compounds can form strong interactions with the target enzymes and receptors. Therefore, Alcesefoliside, theviridoside, and cycloolivil can effectively inhibit the activity of these enzymes and cancer cell lines.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"54 5","pages":"Article 100693"},"PeriodicalIF":1.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147799667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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