Chinese Journal of Analytical Chemistry最新文献

{"title":"Revisiting fatty acid fragmentation: New insights into structural identification by high-resolution and multi-stage mass spectrometry","authors":"Yufan WANG ,&nbsp;Jianya ZHAO ,&nbsp;Ying LU ,&nbsp;Chunhua WAN ,&nbsp;Weibing ZHANG ,&nbsp;Shuang ZHANG ,&nbsp;Xu LI","doi":"10.1016/j.cjac.2025.100638","DOIUrl":"10.1016/j.cjac.2025.100638","url":null,"abstract":"<div><div>High-resolution, multi-stage mass spectrometry data acquired at multiple collision energies for 41 fatty acids were obtained from the mzCloud database, and their fragmentation patterns were reanalyzed. Characteristic fragment ions, including [(M-H)-2H]⁻, [(M-H)-H₂O]⁻, [(M-H)-H₂O-2H]⁻, [(M-H)-2H₂O]⁻, and [(M-H)-2H₂O-2H]⁻ in MS² spectra, as well as [(M-H-H₂O)-2H]⁻, [(M-H-H₂O)-H₂O]⁻, and [(M-H-H₂O)-H₂O-2H]⁻ in MS³ spectra, were identified as diagnostic markers for carboxylic acid groups. A novel structural configuration was proposed for the [(M-H)-H₂O]⁻, in which the C<img>C double bond between C-2 and C-3 forms a conjugated system with the carbonyl (C<img>O) group. A new parameter, characteristic collision energy, was introduced and utilized to discriminate fatty acids with various chain lengths and unsaturation degrees. It also demonstrated potential for distinguishing isomers with different double-bond positions. This work enhances the interpretability of fatty acid mass spectral data and facilitates more confident structural determination.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"54 3","pages":"Article 100638"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated removal of theophylline and multidrug-resistant Escherichia coli from poultry wastewater using copper-iron-yttrium layered double oxides: A dual-action nanotechnology approach","authors":"Kholoud KHALED ,&nbsp;Rehab MAHMOUD ,&nbsp;Ahmed A. ALLAM ,&nbsp;Haifa E. ALFASSAM ,&nbsp;Nada ELGIDDAWY ,&nbsp;Salama A.S. SHANY ,&nbsp;Samar M. MAHGOUB ,&nbsp;Sahar Abdel Aleem Abdel AZIZ ,&nbsp;Roushdy MM","doi":"10.1016/j.cjac.2025.100627","DOIUrl":"10.1016/j.cjac.2025.100627","url":null,"abstract":"<div><div>Poultry wastewater (PWW) presents serious environmental and public health risks due to pharmaceutical contaminants like theophylline and multidrug-resistant (MDR) <em>Escherichia coli</em> (<em>E. coli</em>), which form biofilms and disseminate resistance genes. This study developed Cu-Fe and yttrium-doped Cu-Fe-Y layered double oxides (LDOs) as dual-functional agents for synergistic adsorption and bacterial inactivation. Materials were synthesized via coprecipitation–calcination and characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Brunauer–Emmett–Teller (BET), and scanning electron microscopy/energy dispersive X-ray spectroscopy (SEM/EDX). Adsorption was optimized across pH, dosage, temperature, and time. Maximum removal occurred at pH 5 (Cu-Fe-Y: 70.85%; Cu-Fe: 57.20%) and 0.30 g dosage (90.12% and 72.07%, respectively), with decreased efficiency at elevated temperatures (Cu-Fe-Y: 80.60% at 25 °C to 60.12% at 55 °C), confirming exothermic behavior. Thermodynamic analysis showed negative Δ<em>H</em>° (−27.27 kJ/mol for Cu-Fe-Y, −21.64 kJ/mol for Cu-Fe) and ΔG°, indicating spontaneous adsorption. Isotherm modeling showed best fits with Langmuir-Freundlich and Sips models, with <em>q</em>_max up to 380.14 mg/g (Cu-Fe-Y) and 208.20 mg/g (Cu-Fe). Kinetics followed pseudo-first-order and mixed-order models, suggesting multi-step mechanisms involving surface complexation, electrostatic attraction, hydrogen bonding, <em>π</em>–<em>π</em> interactions, and intraparticle diffusion. Cu-Fe-Y LDO showed superior antimicrobial activity (Minimum Inhibitory concentration (MIC): 10.40 μg/mL; zone of inhibition (ZOI): 19.33 mm) and 75.5% biofilm inhibition at 1000 μg/mL via reactive oxygen species (ROS) generation and metal ion release. Molecular screening revealed &gt; 76% of isolates harbored blaTEM and biofilm genes. This study introduces an efficient, multifunctional nanomaterial for pharmaceutical and microbial contaminant removal from PWW, where yttrium doping critically enhances both adsorption and disinfection, supporting sustainable wastewater treatment and reuse.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"54 3","pages":"Article 100627"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hg²+ recognition by 2-naphthol: Experimental and quantum computational insights","authors":"Joardar GIM ,&nbsp;Most Tahera KHATUN ,&nbsp;Triporna SAHA ,&nbsp;Zannatul KOWSER ,&nbsp;Nasim MAHUD ,&nbsp;Rajib HASAN ,&nbsp;Md. Abdullah Al MAMUN ,&nbsp;Rashedul ISLAM ,&nbsp;Mohammad Tanvir AHMED","doi":"10.1016/j.cjac.2025.100650","DOIUrl":"10.1016/j.cjac.2025.100650","url":null,"abstract":"<div><div>Mercury is regarded as a particularly dangerous metal ion because of its fatal effects on humans and the ecosystem. Herein, we have reported the synthesis of a novel chemosensor, <strong>L</strong>, including a 2-naphthol-derived azo framework, which has been designed and evaluated for the selective and sensitive detection of mercury (II) ions (Hg²⁺). The complexation behavior of <strong>L</strong> with Hg²⁺ is validated using UV–Vis, ATR-FTIR, NMR and FESEM studies. Job’s plot indicates a 1:1 binding stoichiometry. The association constant (<em>K</em>ₐ) of 1.07 × 10⁴ M⁻¹ and a detection limit of 6.21 × 10⁻⁷ M, demonstrating robust affinity and elevated sensitivity. DFT calculations clarify the binding affinity and electronic rearrangement, while frontier molecular orbital (FMO) and density of states (DOS) analysis reveal substantial orbital overlap indicative of a metal-to-ligand charge transfer (MLCT) mechanism. Topological analyses (QTAIM, NCI, RDG, ELF, LOL) provide additional characterization of noncovalent interactions and electron density redistribution. Molecular docking with estrogen receptor-<em>α</em> (PDB ID: 3ERT) demonstrates a favorable binding energy of −7.8 kcal/mol, underscoring the sensor's potential biological significance.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"54 3","pages":"Article 100650"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147402220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LC-MS/MS-based pharmacokinetic and toxicokinetic analysis of a good cadmium repellent GMDTC in dogs","authors":"Zhiyong ZHONG ,&nbsp;Riping XIAO ,&nbsp;Wei HU ,&nbsp;Yiran KANG ,&nbsp;Guowei LI ,&nbsp;Hehe SHI ,&nbsp;Guangming HE ,&nbsp;Yuqin LUO ,&nbsp;Jianhao PAN ,&nbsp;Xiaojiang TANG ,&nbsp;Dongmei SUN","doi":"10.1016/j.cjac.2025.100652","DOIUrl":"10.1016/j.cjac.2025.100652","url":null,"abstract":"<div><div>Sodium (S)-2-(dithiocarboxylato((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)amino)-4(methylthio)butanoate (GMDTC) is a promising compound effectively removing cadmium from renal tubular cells. Quantifying GMDTC in biological matrices is challenging due to its high polarity, hydrophilicity, and instability. Herein, we report the first development and validation of a sensitive and robust LC-MS/MS method for the quantification of GMDTC in beagle dog plasma. Acetonitrile-water-ammonia solution (70:30:0.1, <em>v</em>/<em>v</em>/<em>v</em>) and 50% ammonia solution (<em>v</em>/<em>v</em>) were used to pretreat blood samples. The liquid chromatographic separation of GMDTC was achieved on a Waters XBridge® C₁₈ column, with a 5 min gradient system using a mobile phase composed of acetonitrile-water solution (95:5, <em>v</em>/<em>v</em>) and ammonium bicarbonate-water (10 mmol/L, <em>w</em>/<em>v</em>). The method showed good linearity in the concentration range of 50–5000 ng/mL for GMDTC (<em>r</em> = 0.9975). The lower limit of quantification (LLOQ) of GMDTC was 50 ng/mL. The precision and accuracy of intra-day and inter-day for GMDTC were below 15%. The extraction recovery, matrix effect, carryover effect, dilution effect, and stability were all within the acceptable range. Pharmacokinetic and toxicokinetic studies were then successfully conducted in beagle dogs using this method. The pharmacokinetic parameters revealed a nonlinear increase in exposure with escalating doses and efficient elimination of GMDTC and in dogs. No significant gender differences were observed in the exposure levels of GMDTC. Toxicokinetic assessment after 28 days of repeated dosing showed no significant accumulation of GMDTC, as evidenced by mean C_max and AUC_0-t ratios (Day 28/Day 1) ranging from 0.69 to 1.24 and 0.69 to 1.41, respectively. This study offered valuable foundational insights into the pharmacokinetic and toxicokinetic profiles of GMDTC in beagle dogs, facilitating further metabolic investigations and potential clinical applications of GMDTC for cadmium poisoning.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"54 3","pages":"Article 100652"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrids models to predict density of methyl diethanolamine","authors":"Xun YUAN ,&nbsp;Raed H.C. ALFILH ,&nbsp;Farag M.A. ALTALBAWY ,&nbsp;Suranjana V. MAYANI ,&nbsp;Anupam YADAV ,&nbsp;Subbulakshmi GANESAN ,&nbsp;Mayank KUNDLAS ,&nbsp;Aseel SMERAT ,&nbsp;Subhashree RAY ,&nbsp;Aashna SINHA ,&nbsp;Ahmad ABUMALEK ,&nbsp;Mukhlisa SOLIYEVA","doi":"10.1016/j.cjac.2025.100637","DOIUrl":"10.1016/j.cjac.2025.100637","url":null,"abstract":"<div><div>The density of methyl diethanolamine (MDEA), governed by temperature and pressure, plays a crucial role in optimizing chemical engineering processes, demanding precise predictive models. This research utilizes a gradient boosting decision tree (GBDT) framework, enhanced by four advanced optimization techniques: batch Bayesian optimization (BBO), evolution strategies (ES), Bayesian probability improvement (BPI), and Gaussian processes optimization (GPO). The algorithm is developed utilizing a dataset of 160 experimental samples, with 90% designated for training and 10% for testing, employing temperature and pressure as input parameters to estimate MDEA density. To counter overfitting, k-fold cross-validation is implemented throughout training procedure. The effectiveness of every optimization method is evaluated through computational runtime and performance indicators, including <em>R</em>-squared (<em>R</em>²), mean squared error (MSE), and average absolute relative error (AARE%). Correlation analysis indicates a significant negative relationship between temperature and MDEA density (correlation coefficient: –0.71), while pressure shows a moderate positive association (0.56). Among the optimization strategies, GBDT-BBO yields the highest precision, with an <em>R</em>² of 0.996223 for the training set and 0.982056 for the test set, outperforming other methods. In terms of computational efficiency, GPO proves the fastest, requiring 147.9 seconds, while BBO is the slowest at 199.5 seconds. Sensitivity analysis highlights the effect of every input variable on MDEA density, demonstrating the robustness of data-driven approaches in tackling complex systems. These models provide dependable tools for predicting MDEA density, minimizing requirement for expensive, time-intensive, and labor-heavy experimental methods.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"54 2","pages":"Article 100637"},"PeriodicalIF":1.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluoride-selective sensing by thiocarbohydrazone derivative: Combined spectroscopic and computational investigation","authors":"Sarathi NATARAJAN ,&nbsp;Ashok Kumar Saravana LOGANATHAN ,&nbsp;Saravana Kumar MOORTHY ,&nbsp;Satheesh Kumar NAGARAJ ,&nbsp;Rajalakshmi RAMARAJAN","doi":"10.1016/j.cjac.2025.100629","DOIUrl":"10.1016/j.cjac.2025.100629","url":null,"abstract":"<div><div>The chemosensor 1,5-bis(2-acetylpyrrole)thiocarbohydrazone was investigated as a dual-mode optical chemosensor for fluoride ions in DMSO. Upon addition of fluoride, the chemosensor solution showed a distinct color change from colorless to yellow, accompanied by significant fluorescence quenching. Ultraviolet-visible (UV–vis) and fluorescence titration experiments confirmed a 1:2 chemosensor-to-fluoride binding stoichiometry, supported by Job’s plot and Benesi–Hildebrand analysis, with association constants in the range of 10³–10⁴ (mol L^–1). Density functional theory (DFT) calculations provided further insight into the binding mechanism, revealing strong hydrogen bonding or partial deprotonation at NH sites and a decrease in the HOMO–LUMO energy gap, consistent with an intramolecular charge-transfer process. The chemosensor displayed high selectivity toward fluoride over other common anions such as Cl⁻, Br⁻, I⁻, ClO₄⁻, H₂PO₄⁻ and AcO⁻. Importantly, the sensor also retained a measurable response in DMSO:H₂O mixtures, indicating that fluoride recognition remains effective even in aqueous environments. Together, these findings establish 1,5-bis(2-acetylpyrrole)thiocarbohydrazone as an effective and selective dual-mode chemosensor for fluoride detection, with a low detection limit of 3.2 µmol L^–1 and strong anti-interference performance, demonstrating its potential utility in practical applications.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"54 2","pages":"Article 100629"},"PeriodicalIF":1.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of geochemical composition and heavy metals related occupational health risks of Ambo sandstone quarry sites, West Shewa of Ethiopia","authors":"Chala Mellese ,&nbsp;Birhanu Mekassa ,&nbsp;Lemessa B. Merga ,&nbsp;Bayissa Leta Danno","doi":"10.1016/j.cjac.2025.100628","DOIUrl":"10.1016/j.cjac.2025.100628","url":null,"abstract":"<div><div>Prolonged exposure to sandstone dust from quarry sites has been associated with adverse health hazards. This study was aimed to evaluate the geochemistry (major oxides and trace heavy metal(loid)s) of Ambo sandstone, and human health risks of heavy metals due to exposure to the sandstone dust from main quarry sites of West Shewa, Ethiopia. Lithium metaborate fusion-FAAS and wet acid digestion-ICP-OES were used for major oxides and heavy metal(loid)s determination, respectively. The mean concentration of major oxides in the sandstones was in decreasing order of: SiO₂ &gt; Al₂O₃ &gt; Na₂O &gt; Fe₂O₃ &gt; K₂O &gt; CaO &gt; MgO &gt; MnO. Geochemical results of Ambo sandstones indicated that they are mineralogically immature and classified into Greywacke. The mean levels of heavy metal(loid)s in Ambo sandstone were ranged 10.37‒28.20, 9.37‒19.07, 1.71‒8.15, 12.20‒15.28, 5.89‒15.38 and 100.35‒138.92 in mg/kg for Pb, Zn, Cd, Cu, Ni and Cr, respectively. Hazard quotient and hazard index were &lt; 1, signifying no non-carcinogenic health risks due to exposure to Ambo sandstone dusts. The cancer risk values for the individual metal(loid)s (Cd, Ni, Cr, Pb and As) is within the tolerable range or insignificant (ILCR <span><math><mo>≤</mo></math></span> 1.0 × 10^–4). However, total cancer risks resulting from exposure to multiple elements exceeded the acceptable threshold value of cancer risk (2.1 × 10^–4 (Senkelle) and 1.05 × 10^–4 (Aleltu)), demonstrating possible carcinogenic risk to the exposed workforces. Carcinogenic risk result revealed that Cr contributed the most significant risk with ingestion route as the primary exposure pathway. The finding signifies the requirement of strict regulatory control by all stakeholders to mitigate the carcinogenic health risks. It also highlights the need for awareness creation of the potential dangers due to prolonged exposure to the sandstone dust. Continuous surveillance and research on metal(loid)s accumulation in sandstone dust, agricultural soil and vegetables near quarry sites are vital to safeguard public health.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"54 2","pages":"Article 100628"},"PeriodicalIF":1.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of H₂SO₄ and HNO₃ electrolytes on the bubble evolution on a platinum microelectrode in water electrolysis","authors":"Peng KONG,&nbsp;Liang HAO,&nbsp;Ming GAO,&nbsp;Wu-Han DONG,&nbsp;Qi-Rong ZUO","doi":"10.1016/j.cjac.2025.100631","DOIUrl":"10.1016/j.cjac.2025.100631","url":null,"abstract":"<div><div>In water electrolysis, achieving smaller bubble detachment diameters and shorter detachment times could enhances the efficiency of the electrolysis process. This study investigates the impact of H₂SO₄ and HNO₃ electrolytes on the detachment of both oxygen and hydrogen bubbles from a platinum microelectrode with a diameter of 50 μm, using high-speed photography and electrochemical measurements. The experiments show that oxygen bubbles exhibit shorter lifetimes and smaller detachment diameters than hydrogen bubbles in 1 mol/L H₂SO₄ electrolytes. Conversely, in 1 mol/L HNO₃ electrolytes, hydrogen bubbles have shorter lifetimes and smaller detachment diameters than oxygen bubbles. The results indicate that Marangoni convection plays a critical role in the detachment of bubbles. These insights provide a new approach to accelerating bubble detachment from electrode surfaces during electrochemical bubble formation.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"54 2","pages":"Article 100631"},"PeriodicalIF":1.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymer blend functionalization of MnFe₂O₄ nanoparticles: magnetic, structural and photocatalytic impacts","authors":"Shabnam DAN ,&nbsp;Amit CHATTREE ,&nbsp;Jishnu NASKAR ,&nbsp;Suantak KAMSONLIAN","doi":"10.1016/j.cjac.2025.100636","DOIUrl":"10.1016/j.cjac.2025.100636","url":null,"abstract":"<div><div>Superparamagnetic nanocomposites based on poly(methyl methacrylate) (PMMA) and polyethylene glycol (PEG), functionalized on manganese ferrite (MnFe₂O₄), were synthesized via a facile chemical co-precipitation method to develop an efficient analytical platform for dye adsorption in aqueous systems. The synthesized PMMA-PEG-MF nanoparticles were systematically characterized using particle size analysis (PSA), Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), transmission and scanning electron microscopy (TEM, SEM), energy-dispersive X-ray spectroscopy (EDX), thermogravimetric analysis (TGA), and vibrating sample magnetometry (VSM) to confirm their morphology, crystallinity, thermal stability, and magnetic behaviour. The nanocomposites exhibited a plate-like morphology with an average particle size of ∼70 nm and retained superparamagnetic properties suitable for facile separation. Analytical evaluation of dye removal efficiency of methylene blue (MB) revealed a maximum adsorption efficiency of 77% for PMMA-PEG-MF NPs and 93% for bare MnFe₂O₄ NPs. These results demonstrate the potential of the PMMA-PEG-MF system as an analytical tool for quantitative assessment and remediation of dye contaminants in water, contributing to environmentally focused analytical methodologies.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"54 2","pages":"Article 100636"},"PeriodicalIF":1.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astragaloside IV alleviates metabolic associated fatty liver disease by regulating ferroptosis via the SLC7A11/GPX4 pathway","authors":"Sitong CHEN ,&nbsp;Hanying XU ,&nbsp;Zipei ZHANG ,&nbsp;Xiaonan LI ,&nbsp;Xiaolei TANG ,&nbsp;Dashi YING","doi":"10.1016/j.cjac.2025.100625","DOIUrl":"10.1016/j.cjac.2025.100625","url":null,"abstract":"<div><div>Metabolic associated fatty liver disease (MAFLD), characterized by hepatic steatosis and metabolic dysregulation, is the most prevalent chronic liver disease worldwide, yet effective therapeutic strategies remain limited due to its complex pathogenesis. Astragaloside IV (AST IV), a bioactive saponin derived from Astragalus membranaceus, has demonstrated hypoglycemic, lipid-modulating, antioxidative, and hepatoprotective properties—though its specific mechanisms against MAFLD are not fully elucidated. In this study, we established high-fat diet-induced mouse and free fatty acid-induced HepG2 cell models of MAFLD to evaluate the efficacy of AST IV. Serum biochemical analyses revealed that AST IV significantly improved glucolipid metabolism and reduced hepatic injury. Combining network pharmacology prediction with experimental validation, we identified ferroptosis as a key pathway targeted by AST IV. Specifically, AST IV upregulates SLC7A11 and GPX4 expression while downregulating ACSL4, thereby inhibiting ferroptosis. Molecular docking further confirmed strong binding affinities between AST IV and these core proteins. In conclusion, our findings demonstrate that AST IV alleviates MAFLD by suppressing ferroptosis, highlighting its potential as a novel phytochemical candidate for MAFLD intervention.</div></div>","PeriodicalId":277,"journal":{"name":"Chinese Journal of Analytical Chemistry","volume":"54 2","pages":"Article 100625"},"PeriodicalIF":1.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145839707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}