Chemical Engineering Journal最新文献_第2页

Electron injection and interlayer modification for synergistically enhanced thermoelectric properties of flexible cesium-intercalated MoS2

IF 15.1 1区工程技术

Chemical Engineering Journal Pub Date : 2025-03-05 DOI: 10.1016/j.cej.2025.161291

Jia Liang, Zhencheng Meng, Shujia Yin, Yi Li, Faji Fang, Linbin Jiang, Chunlei Wan

{"title":"Electron injection and interlayer modification for synergistically enhanced thermoelectric properties of flexible cesium-intercalated MoS2","authors":"Jia Liang, Zhencheng Meng, Shujia Yin, Yi Li, Faji Fang, Linbin Jiang, Chunlei Wan","doi":"10.1016/j.cej.2025.161291","DOIUrl":"https://doi.org/10.1016/j.cej.2025.161291","url":null,"abstract":"Thermoelectric conversion has attracted wide attention as a clean and efficient power generation technology, and extensive research has been done into flexible thermoelectric materials and generators. To take full advantage of the unique optimization mechanisms in hybrid superlattice intercalated materials and simultaneously avoid the decomposing or volatilization of unstable organic components at high working temperatures, a facile approach composed of electrochemical intercalation and heat treatment was proposed in this work to fabricate the flexible cesium-intercalated molybdenum disulfide (MoS2/Cs) thermoelectric material with higher thermostability compared to the organic-intercalated counterpart. The electron injection turned the MoS2 crystal into an n-type semiconductor without a great decrease in the absolute Seebeck coefficient of MoS2/Cs, leading to an optimized power factor of 89.5 μW m−1 K−2 from 35.2 μW m−1 K−2 in MoS2 at room temperature due to the improved carrier concentration. The intercalated structure with plenty of interlayer micro gaps significantly enhances phonon scattering and dramatically reduces lattice thermal conductivity in the inorganic-intercalated MoS2/Cs materials. Therefore, MoS2/Cs exhibits an improved zT value, an order of magnitude higher than that of MoS2 through simultaneous carrier concentration optimization and interlayer modification. Meanwhile, with higher thermostability than organic-intercalated counterparts, the cesium-intercalation brings about superior flexibility in MoS2, paving the way for applications in flexible thermoelectric conversion at high working temperatures. This work will guide future research on the inorganic-intercalated structure design for flexible thermoelectric materials and other flexible electronics.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":"47 1 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Superhydrophobic and recyclable passive daytime radiative cooling fabric prepared via electrospinning

IF 15.1 1区工程技术

Chemical Engineering Journal Pub Date : 2025-03-05 DOI: 10.1016/j.cej.2025.161274

Mingyu Xu, Jing Li, Jun Ren, Jingru Wang, Liqiang Xu, Weiwen Wang, Sheng Sun, Hui Li, Jihai Zhang, Jianxun Wu

{"title":"Superhydrophobic and recyclable passive daytime radiative cooling fabric prepared via electrospinning","authors":"Mingyu Xu, Jing Li, Jun Ren, Jingru Wang, Liqiang Xu, Weiwen Wang, Sheng Sun, Hui Li, Jihai Zhang, Jianxun Wu","doi":"10.1016/j.cej.2025.161274","DOIUrl":"https://doi.org/10.1016/j.cej.2025.161274","url":null,"abstract":"Passive daytime radiative cooling (PDRC) is a highly promising sustainable cooling technology, due to its characteristic of not requiring additional energy input. However, the manufacturing processes of most PDRC fabrics are still expensive or complex, and they still face challenges related to outdoor contamination and recyclability. Herein, we report a simple and cost-effective method to fabricate a novel superhydrophobic and recyclable radiative cooling fabric (SRCF) based on styrene-ethylene/butylene-styrene (SEBS) electrospun fabric (SEF) and octadecyltrichlorosilane (OTS) modified silica (O-SiO2) nanoparticles. The reasonable fiber diameter and particle size distributions enabled SRCF to achieve high solar reflectance (91.5 %) and strong infrared emissivity (91.3 %), resulting in a sub-ambient temperature drop of ∼9.3 °C under direct sunlight. The incorporation of O-SiO2 imparted SRCF with superhydrophobic and self-cleaning properties, ensuring stable cooling performance even after 30 days of outdoor exposure. Additionally, SRCF exhibited recyclability, addressing critical sustainability challenges for large-scale applications. This work demonstrates the first PDRC fabric integrating superhydrophobicity and recyclability, offering a promising solution for energy-saving and environmentally sustainable applications.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":"44 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterisation of litre-scale wave-mixed bioreactors using colourimetric method adaptation: Mixing performance, flow regime and scale change study

IF 15.1 1区工程技术

Chemical Engineering Journal Pub Date : 2025-03-05 DOI: 10.1016/j.cej.2025.161295

Mateusz Bartczak, Tuğba Yılmaz, Mateusz Sączek, Agnieszka Anderson, Kamil Wierzchowski, Maciej Pilarek

{"title":"Characterisation of litre-scale wave-mixed bioreactors using colourimetric method adaptation: Mixing performance, flow regime and scale change study","authors":"Mateusz Bartczak, Tuğba Yılmaz, Mateusz Sączek, Agnieszka Anderson, Kamil Wierzchowski, Maciej Pilarek","doi":"10.1016/j.cej.2025.161295","DOIUrl":"https://doi.org/10.1016/j.cej.2025.161295","url":null,"abstract":"The paper presents a new digitally-enhanced adaptation of the colourimetric method for mixing time measurement in small-scale, 2-litre and 10-litre disposable culture bags of a wave-mixed single-use bioreactor. Wave-mixed single-use bioreactors are a modern, well-established group of devices applied for manufacturing advanced and valuable products, mainly for the biopharmaceutical sector. The innovative original colourimetric method adaptation consisted of a self-designed mounting solution for a digital camera to obtain a high-quality image of the rocking bioreactor platform and an in-house algorithm for image processing and data analysis. Mixing time characteristics and influence of operational parameters in 2-litre and 10-litre vessels are presented. The obtained video footage was additionally processed to retrieve data about the features of the liquid surface during the rocking oscillatory motion, which were used to compare the flow development and regime between both examined culture bags. A valuable result of the work is the developed scale-change correlation equation for predicting process parameter values based on a selected mixing time ratio. The work extends currently available experimental techniques in wave-mixed bioreactors and offers the development potential for expanding the presented model equations to other important process parameters, like the mass transfer coefficient.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":"30 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrooxidation of biomass-derived 5-hydroxymethylfurfural into the 2,5-furandicarboxylic acid in microfluidic device with different path design

IF 15.1 1区工程技术

Chemical Engineering Journal Pub Date : 2025-03-05 DOI: 10.1016/j.cej.2025.161280

Ümran Ünlü, M.Enes Oruç, Özgün Yücel

{"title":"Electrooxidation of biomass-derived 5-hydroxymethylfurfural into the 2,5-furandicarboxylic acid in microfluidic device with different path design","authors":"Ümran Ünlü, M.Enes Oruç, Özgün Yücel","doi":"10.1016/j.cej.2025.161280","DOIUrl":"https://doi.org/10.1016/j.cej.2025.161280","url":null,"abstract":"The polymer industry is constantly growing and becoming indispensable due to the ease of production and usage. However, the fact that many commercially produced polymers are derived from petroleum leads to a depletion of natural resources and significant environmental problems. As a result, there is a growing increase in the demand for environmentally friendly bio-based polymers as an alternative to conventional plastics. A bio-based polymer called polyethylene 2,5-furan dicarboxylate (PEF) is considered as a promising polymer due to its improved barrier and mechanical characteristics relative to polyethylene terephthalate (PET). The monomer of PEF is the 2,5-furan dicarboxylic acid (FDCA), which can be obtained by oxidation of bio-based 5-(hydroxymethyl) furfural (HMF). In this study, the electrochemical HMF oxidation to FDCA was performed, providing a green process compared to the conventional approach. At the same time, microfluidic electrochemical cells were designed because could be integrated into larger-scale systems with fewer steps. On the basis of this investigation, different designs were developed to investigate the effect of changes in flow rate (10–25 mL min−1) and diffusion path (straight, nodal, vertical and horizontal serpentine type path). The straight design (20 mL min−1) resulted in shorter process times and improved efficiency (99.3 %), compared to the performance of the batch system.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":"11 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iron phosphide/carbon nanotube composite with high-performance and decoupled areal capacity as negative electrodes for asymmetric supercapacitors

IF 15.1 1区工程技术

Chemical Engineering Journal Pub Date : 2025-03-05 DOI: 10.1016/j.cej.2025.161278

Huohong Zhong, Chengtao Zheng, Shuyang Zheng, Shichuang Huang, Wei Zhou, Boyi Lan, Bin Wei, Nan Zhang

{"title":"Iron phosphide/carbon nanotube composite with high-performance and decoupled areal capacity as negative electrodes for asymmetric supercapacitors","authors":"Huohong Zhong, Chengtao Zheng, Shuyang Zheng, Shichuang Huang, Wei Zhou, Boyi Lan, Bin Wei, Nan Zhang","doi":"10.1016/j.cej.2025.161278","DOIUrl":"https://doi.org/10.1016/j.cej.2025.161278","url":null,"abstract":"The imbalance in the development of positive and negative electrode materials remains a key issue hindering the advancement of high-performance asymmetric supercapacitors (ASCs). Transition metal phosphides (TMPs), as attractive electrode materials, are anticipated to compensate for the limitations of carbon materials in the application of negative electrodes for ASCs. To this end, we successfully synthesize well-arranged FeP nanorod arrays on carbon nanotube films (CNTFs) substrate via a facile and effective two-step method and identify that it exhibits low reduction valence transition processes, which can serve as high-performance binder-free ASC negative electrode. Due to the transition between Fe0 and Fe3+, the FeP@CNTF electrode shows significantly enhanced electrochemical properties. Moreover, benefiting from the 3D highly conductive network of the CNTFs and the excellent electrochemical activity of FeP nanorod arrays modified on the surface, the FeP@CNTF electrode exhibits a high specific capacity of 1209 C g−1 (0.96 C cm−2). Particularly, a high areal specific capacity of 17.47 C cm−2 can be easily achieved by further folding the CNTF, thereby resolving the issue of mutual restriction between areal loading and specific capacity posed by the conventional binder-free electrodes. In addition, utilizing FeP@CNTF as negative electrode and Ni2P@CNTF as positive electrode, the as-assembled ASC presents excellent electrochemical performance, with energy density up to 67.9 Wh kg−1 at the power density of 800 W kg−1 and exceptional cycling stability. This work demonstrates the promising application prospects of FeP for use in high-performance ASC negative electrode materials.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":"11 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translational paradigm in nanodiagnostics applications of functionalized zinc oxide nanoforms interface for pathogenic virus diagnostics 功能化氧化锌纳米形式界面在纳米诊断学中的转化应用范例，用于病原体病毒诊断

IF 15.1 1区工程技术

Chemical Engineering Journal Pub Date : 2025-03-05 DOI: 10.1016/j.cej.2025.161260

Abha Gupta, Apoorv Kirti, Rudra Narayan Sahoo, Sudakshya S. Lenka, Anu Yadav, Anmol Choudhury, Adrija Sinha, Aditya Nandi, Nirmal Mohakud, Swadheena Patro, Aishee Ghosh, Nagendra Kumar Kaushik, Mrutyunjay Suar, Suresh K. Verma

{"title":"Translational paradigm in nanodiagnostics applications of functionalized zinc oxide nanoforms interface for pathogenic virus diagnostics","authors":"Abha Gupta, Apoorv Kirti, Rudra Narayan Sahoo, Sudakshya S. Lenka, Anu Yadav, Anmol Choudhury, Adrija Sinha, Aditya Nandi, Nirmal Mohakud, Swadheena Patro, Aishee Ghosh, Nagendra Kumar Kaushik, Mrutyunjay Suar, Suresh K. Verma","doi":"10.1016/j.cej.2025.161260","DOIUrl":"https://doi.org/10.1016/j.cej.2025.161260","url":null,"abstract":"The frequent emergence of viral infectious diseases and their acute effects on public health and the world economy has pushed the boundaries of current science and technologies. The convergence of nanotechnology with virology has opened multiple windows for different applications in biomedical and environmental sciences related to the virus. The use of various nanoparticles and their conjugates is important in diagnostics and treatment of viral diseases. This review explores the translational potential of zinc oxide (ZnO) nanoparticles in virus detection techniques and methodologies with comparative scrutiny of the time-consuming nature and limitations of traditional methods. It highlights the acuteness of viral diseases by illustrating the mechanistic pathogenesis of different virus types and underscores the need for rapid and accurate diagnostic techniques. The study entails the advantages of ZnO NPs over traditional diagnostic methods in both clinical and research settings addressing profusely different issues like false negative and positive signals. Challenges and future directions are sightseen entailing the optimization, sensitivity, and integration of ZnO NP-based diagnostics with existing platforms. The study illuminates the intricate amalgamation of nanotechnology with virology for the development of innovative diagnostic techniques as a promise to reshape the diagnostics and management of the disease.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":"71 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143547017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A mussel-inspired wet-adhesive prolonged-acting antibacterial hydrogels for the treatment of periodontitis

IF 15.1 1区工程技术

Chemical Engineering Journal Pub Date : 2025-03-05 DOI: 10.1016/j.cej.2025.161262

Menglin Fan, Jiaojiao Yang, Li Zhen, Jieyu Zhu, Kunneng Liang, Jiyao Li

{"title":"A mussel-inspired wet-adhesive prolonged-acting antibacterial hydrogels for the treatment of periodontitis","authors":"Menglin Fan, Jiaojiao Yang, Li Zhen, Jieyu Zhu, Kunneng Liang, Jiyao Li","doi":"10.1016/j.cej.2025.161262","DOIUrl":"https://doi.org/10.1016/j.cej.2025.161262","url":null,"abstract":"The local application of antibacterial agents is an essential anti-infective therapeutical adjunct for periodontitis. However, the dynamic aqueous micromilieu of the periodontal pocket makes it tough for the local antibacterial preparations to keep in place and provide sustained drug release. Herein, we construct a wet-adhesive antimicrobial drug delivery system tannic acid-silk fibroin-minocycline hydrochloride (TA-SF-MCH, TSM) with reliable wet adhesion capacity in the periodontal microenvironment, which sustainably delivers MCH motivated by diffusion and swelling for up to 28 days. It demonstrates effective antiseptic activity against major periodontal pathogens P. gingivalis and F. nucleatum, with satisfying inhibition rates of 97.10 ± 0.11 % and 87.87 ± 9.16 % before and after 4 w aging, respectively. Moreover, TSM exhibits desirable adhesion ability to periodontal tissue with prolonged residence time, and reduces the local bacterial load significantly in vivo, thus effectively inhibiting the progression of periodontitis and reducing the destruction of periodontal tissue. Collectively, it is promising to serve as a periodontal topical medication, which is of great significance for controlling periodontal infection and improving the clinical outcome.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":"3 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxy-polishing of gas from chemical looping combustion: Fuel-nitrogen transformation and model-aided gas purity optimization

IF 15.1 1区工程技术

Chemical Engineering Journal Pub Date : 2025-03-05 DOI: 10.1016/j.cej.2025.161267

Daofeng Mei, Anders Lyngfelt, Tobias Mattisson, Carl Linderholm

{"title":"Oxy-polishing of gas from chemical looping combustion: Fuel-nitrogen transformation and model-aided gas purity optimization","authors":"Daofeng Mei, Anders Lyngfelt, Tobias Mattisson, Carl Linderholm","doi":"10.1016/j.cej.2025.161267","DOIUrl":"https://doi.org/10.1016/j.cej.2025.161267","url":null,"abstract":"Chemical looping combustion (CLC) is a carbon capture technology for heat, power and hydrogen production. This work focuses on fuel-nitrogen transformation in fuel reactor and its further conversion in oxy-polishing step of CLC system. A 100 kW CLC pilot equipped with an oxy-polishing chamber (called POC) was used to perform experiment study and a zero-dimensional reactor model combining elementary reaction kinetics was developed and used for oxy-polishing simulation and reaction path analyses. An ilmenite and a manganese ore called Sinaus were used as oxygen carriers, and a coal and a coal-biomass mixture are the fuels in the CLC tests. It was found that in the fuel reactor, part of the fuel-nitrogen was converted to NO and the rest remained as NH3 which was then oxidized to NO in the POC. The concentrations of HCN and NO2 were negligible in the fuel reactor and POC. According to the simulation, when the oxygen excess is too low it is difficult to reach 1150–1200 °C which are temperatures needed for oxidizing the unconverted fuel gases. In a reference case, a high conversion was reached when the overall oxygen ratio was above 1.03 and temperature above 925 °C. With a fuel reactor temperature of 950 °C, the oxygen demand needed could be up to around 8 %. Based on the model, optimal geometrical designs of the POC were proposed. With a gas residence time of 3 s in the POC, it was possible to decrease the content of impurities (O2, H2, CO, NO, CH4) to 3.3 %.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":"16 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microglial membrane-coated nanoparticles for ACSL4-siRNA delivery in Parkinson’s disease

IF 15.1 1区工程技术

Chemical Engineering Journal Pub Date : 2025-03-05 DOI: 10.1016/j.cej.2025.161251

Heyue Lu, Bo Zhang, Min Ge, Juncheng Yu, Fei Ju, Jie Sun, You Lang Zhou, Lei Wang, Zhongzheng Jia

{"title":"Microglial membrane-coated nanoparticles for ACSL4-siRNA delivery in Parkinson’s disease","authors":"Heyue Lu, Bo Zhang, Min Ge, Juncheng Yu, Fei Ju, Jie Sun, You Lang Zhou, Lei Wang, Zhongzheng Jia","doi":"10.1016/j.cej.2025.161251","DOIUrl":"https://doi.org/10.1016/j.cej.2025.161251","url":null,"abstract":"The loss of dopaminergic (DA) neurons in the substantia nigra was a core pathogenic mechanism of Parkinson’s disease (PD). Recent studies have highlighted ferroptosis as a major contributor to DA neuron degeneration, revealing a complex interplay between iron deposition and PD pathogenesis. In this study, we demonstrated that targeting ACSL4, a ferroptosis-inducing factor, significantly improved motor function in PD. We developed a GM@ACSL4-siRNA/NPs targeted delivery system based on microglial cell membranes (GM) and poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs). This system exhibited negligible biotoxicity, effective blood–brain barrier (BBB) traverse ability, and increased brain accumulation during treatment. Importantly, GM@ACSL4-siRNA/NPs led to marked improvements in motor and cognitive functions in the MPTP-induced PD mouse model compared to control treatment, with average time in platform quadrant 41.25 % vs 22.48 % in Morris water maze test, hanging time of 9.88 s vs 5.70 s in traction test, descent time of 7.59 s vs 12.57 s in vertical pole-climbing test and rotarod duration of 272.33 s vs 132.33 s in rotarod test. Furthermore, following treatment, we observed significant reductions in iron deposition in the substantia nigra, as well as decreased levels of ROS and the neuroinflammatory cytokines TNF-α, IL-6, and IL-1β, alongside a notable increase in TH-positive neurons in PD mice. Mechanistically, GM@ACSL4-siRNA/NPs was predominantly taken up by microglia, resulting in a significant reduction in ACSL4 expression in microglia. Both in vitro and in vivo studies confirmed that ACSL4 knockdown in microglia reduced the expression of neuroinflammatory factors primarily through the ferroptosis signaling pathway. In conclusion, our findings suggest that microglial membrane-coated nanomaterials offer a promising approach for specific targeting and precise drug delivery in PD, with ACSL4 emerging as a promising therapeutic target for PD","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":"15 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Energy and property trade-offs in nanocellulose production: High-pressure homogenization at different processing consistencies

IF 15.1 1区工程技术

Chemical Engineering Journal Pub Date : 2025-03-05 DOI: 10.1016/j.cej.2025.161257

Giovana Signori-Iamin, Roberto J. Aguado, Jean-Luc Putaux, Alexandre F. Santos, Wim Thielemans, Marc Delgado-Aguilar

{"title":"Energy and property trade-offs in nanocellulose production: High-pressure homogenization at different processing consistencies","authors":"Giovana Signori-Iamin, Roberto J. Aguado, Jean-Luc Putaux, Alexandre F. Santos, Wim Thielemans, Marc Delgado-Aguilar","doi":"10.1016/j.cej.2025.161257","DOIUrl":"https://doi.org/10.1016/j.cej.2025.161257","url":null,"abstract":"Cellulose nanofibers are gaining attention as innovative bio-based materials due to their remarkable surface area, versatility in functionalization, and superior mechanical properties, making them ideal for applications in papermaking, material engineering, and wastewater treatment. However, their production via fibrillation is both energy-intensive and expensive, creating barriers to large-scale adoption. This study explores how processing consistency influences energy and cost efficiency during the high-pressure homogenization of TEMPO-oxidized bleached eucalyptus kraft pulp. Results reveal that energy consumption initially depends on processing volume but later becomes constrained by viscosity. The optimal homogenization condition was not at the highest fiber content, where energy demand would be expected to be at its lowest, but at an intermediate consistency where viscosity allowed efficient equipment operation. Increasing processing consistency was observed to improve fibrillation efficiency and facilitate the transition from micro- to nanoscale structures by promoting shearing both between the fibers themselves and between the fibers and the equipment. Furthermore, the processing concentration significantly impacted the final nanofibers’ characteristics, particularly viscosity as a 0.5 wt% suspension, due to variations in fiber morphologies and network structures such as aspect ratios, entanglements, and bundles. A techno-economic analysis showed that while higher energy usage is required for some conditions, transportation cost savings can offset these expenditures, making intermediate consistencies the most economical choice depending on transport distances. Ultimately, this study emphasizes the importance of balancing cost efficiency and nanofiber quality to optimize production for diverse industrial applications.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":"53 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0