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2013 International Workshop on Magnetic Particle Imaging (IWMPI)最新文献

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Magnetic particle spectroscopy of magnetite-polyethylene nanocomposite films: A novel sample for MPI tracer design 磁铁矿-聚乙烯纳米复合膜的磁粒子光谱:一种用于MPI示踪剂设计的新样品
2013 International Workshop on Magnetic Particle Imaging (IWMPI) Pub Date : 2013-03-23 DOI: 10.1109/IWMPI.2013.6528379
L. Bauer, M. Pablico-Lansigan, R. Deissler, M. Martens, R. Brown, A. Samia, M. Griswold
{"title":"Magnetic particle spectroscopy of magnetite-polyethylene nanocomposite films: A novel sample for MPI tracer design","authors":"L. Bauer, M. Pablico-Lansigan, R. Deissler, M. Martens, R. Brown, A. Samia, M. Griswold","doi":"10.1109/IWMPI.2013.6528379","DOIUrl":"https://doi.org/10.1109/IWMPI.2013.6528379","url":null,"abstract":"Several harmonic spectra are plotted in Figure 2. An important result is the comparison of free particles embedded in agar and films (Figure 2c). The particles embedded in the films are “frozen” in place, while those in agar, unless bound within the matrix, should still have some freedom to rotate. Particles in both should have identical Neel relaxation times, as that is dependent only on the structure of the iron core and not local environment, provided magnetic interactions can be excluded. A calculation of the Neel relaxation time yields values in the range of 0.12-171 microseconds (for crystal anisotropies in the range of 11-21kJ/m3). The Brownian relaxation time for the films is assumed to be infinite, such that relaxation is only possible through the Neel mechanism. However, the Brownian relaxation times for particles in agar are long enough that relaxation is also assumed to be dominated by the Neel mechanism. While Brownian relaxation may play a role in explaining the signal difference, it is likely due to magnetic interactions between neighboring particles that steepen the magnetization curve. Figure 2c demonstrates that a low interparticle distance generally results in a higher signal. In samples with high local concentrations (such as the films presented here, or samples that exhibit significant aggregation), the average distance between two particles is small enough that dipole-dipole interactions must be considered. Such interactions are one possible explanation for the performance of Feridex IV and Resovist.","PeriodicalId":267566,"journal":{"name":"2013 International Workshop on Magnetic Particle Imaging (IWMPI)","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130912082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Towards multidimensional x-space magnetic particle imaging for improved resolution 面向提高分辨率的多维x空间磁粒子成像
2013 International Workshop on Magnetic Particle Imaging (IWMPI) Pub Date : 2013-03-23 DOI: 10.1109/IWMPI.2013.6528389
Kuan Lu, B. Zheng, J. Konkle, E. Saritas, P. Goodwill, S. Conolly
{"title":"Towards multidimensional x-space magnetic particle imaging for improved resolution","authors":"Kuan Lu, B. Zheng, J. Konkle, E. Saritas, P. Goodwill, S. Conolly","doi":"10.1109/IWMPI.2013.6528389","DOIUrl":"https://doi.org/10.1109/IWMPI.2013.6528389","url":null,"abstract":"In this work,a method to achieve higher, more isotropic resolution for x-space MPI through analyzing various FFP trajectories and developing multidimensional transmit/receive hardware was presented. However, many parameters remain to be optimized for this technique, including the various tradeoffs between pFOV coverage, scanning speed, and resolution. Additional hardware challenges include precise control of the FFP through controlling the phase of the transmit fields and compensating for received particle signal based the anisotropic sensitivity profiles of the transmit and receive coils.","PeriodicalId":267566,"journal":{"name":"2013 International Workshop on Magnetic Particle Imaging (IWMPI)","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132581581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
A 7 T/M 3D X-space MPI mouse and rat scanner 一台7t /M 3D x空间MPI小鼠和大鼠扫描仪
2013 International Workshop on Magnetic Particle Imaging (IWMPI) Pub Date : 2013-03-23 DOI: 10.1109/IWMPI.2013.6528387
P. Goodwill, L. Croft, J. Konkle, Kuan Lu, E. Saritas, B. Zheng, S. Conolly
{"title":"A 7 T/M 3D X-space MPI mouse and rat scanner","authors":"P. Goodwill, L. Croft, J. Konkle, Kuan Lu, E. Saritas, B. Zheng, S. Conolly","doi":"10.1109/IWMPI.2013.6528387","DOIUrl":"https://doi.org/10.1109/IWMPI.2013.6528387","url":null,"abstract":"This prototype system has already produced high quality images with spatial resolutions very similar to the theoretically predicted resolution across mouse and rat sized FOVs. We have imaged both plastic and biological imaging phantoms, as well as ex vivo mice (not shown). Some early images are shown below in Fig. 1b-c. Imaging times are comparable to micro-MRI: full mouse and rat images (up to 12 cm × 5 cm × 5 cm) require between 2-5 minutes per image.","PeriodicalId":267566,"journal":{"name":"2013 International Workshop on Magnetic Particle Imaging (IWMPI)","volume":"136 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122146375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
In vivo measurement of local biomarker concentrations 体内局部生物标志物浓度的测量
2013 International Workshop on Magnetic Particle Imaging (IWMPI) Pub Date : 2013-03-23 DOI: 10.1109/IWMPI.2013.6528364
Xiaojuan Zhang, D. Reeves, I. Perreard, W. Kett, K. Griswold, B. Gimi, J. Weaver
{"title":"In vivo measurement of local biomarker concentrations","authors":"Xiaojuan Zhang, D. Reeves, I. Perreard, W. Kett, K. Griswold, B. Gimi, J. Weaver","doi":"10.1109/IWMPI.2013.6528364","DOIUrl":"https://doi.org/10.1109/IWMPI.2013.6528364","url":null,"abstract":"The reaction has been explored in vitro in solution and the results for a DNA target are provided in Fig. 2. The 24 base pair DNA target can be found with 100 pM sensitivity. Shorter 20 base pair DNA target molecules bound the NPs together with less affinity so the sensitivity is only 2 nM. DNA molecules with incorrect sequencing produced no change in the MSB signal. Thrombin can also be measured with 4 nM sensitivity and streptavidin with 150 pM sensitivity. These proof of concept experiments demonstrate that the method is feasible for hormone concentrations.","PeriodicalId":267566,"journal":{"name":"2013 International Workshop on Magnetic Particle Imaging (IWMPI)","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123904082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Use of red blood cells as new strategy to avoid the rapid clearance of SPIOs nanoparticles 利用红细胞作为避免SPIOs纳米颗粒快速清除的新策略
2013 International Workshop on Magnetic Particle Imaging (IWMPI) Pub Date : 2013-03-23 DOI: 10.1109/IWMPI.2013.6528327
A. Antonelli, C. Sfara, E. Manuali, S. Salamida, M. Magnani
{"title":"Use of red blood cells as new strategy to avoid the rapid clearance of SPIOs nanoparticles","authors":"A. Antonelli, C. Sfara, E. Manuali, S. Salamida, M. Magnani","doi":"10.1109/IWMPI.2013.6528327","DOIUrl":"https://doi.org/10.1109/IWMPI.2013.6528327","url":null,"abstract":"The advantage of SPIO-loaded RBCs is that they are stable constructs able to survive for a number of days without being eliminated and with a lifespan comparable to that of untreated RBCs. The potential of RBCs loaded with SPIO nanoparticles has been previously investigated as a tracer material for magnetic particle imaging (MPI), a new quantitative medical imaging modality recently introduced by Philips showing that it is possible to detect a beat heart in mice. These data make SPIO-loaded RBCs ideally suited to increase the in vivo circulation of SPIO contrast agents as longer blood half-time tracer materials improving diagnostic imaging procedures, such as angiography analysis of patients with cardiovascular diseases and therapeutic interventions with long-term monitoring, since up to now the time window for data acquisition is limited to the first pass due to very short lifespan of iron oxide nanoparticles.","PeriodicalId":267566,"journal":{"name":"2013 International Workshop on Magnetic Particle Imaging (IWMPI)","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127961558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Solid state MPI: Imaging of iron oxide nanoparticles embedded in polyurethane 固态MPI:氧化铁纳米颗粒嵌入聚氨酯的成像
2013 International Workshop on Magnetic Particle Imaging (IWMPI) Pub Date : 2013-03-23 DOI: 10.1109/IWMPI.2013.6528348
J. Rahmer, H. Rahn, F. Henrich, Stefan Odenbach, Bernhard Gleich, J. Borgert
{"title":"Solid state MPI: Imaging of iron oxide nanoparticles embedded in polyurethane","authors":"J. Rahmer, H. Rahn, F. Henrich, Stefan Odenbach, Bernhard Gleich, J. Borgert","doi":"10.1109/IWMPI.2013.6528348","DOIUrl":"https://doi.org/10.1109/IWMPI.2013.6528348","url":null,"abstract":"MPI of particles embedded in solid materials is feasible. For improved image quality, particles with better MPI performance should be used for incorporation, so that the iron concentration can be reduced. Solid state materials could be used for calibration phantoms or fiducial markers.","PeriodicalId":267566,"journal":{"name":"2013 International Workshop on Magnetic Particle Imaging (IWMPI)","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120948029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Control of a hybrid filter topology for the reduction of high frequency harmonics 用于降低高频谐波的混合滤波器拓扑控制
2013 International Workshop on Magnetic Particle Imaging (IWMPI) Pub Date : 2013-03-23 DOI: 10.1109/IWMPI.2013.6528328
J. Bergmann, K. Hoffmann, B. Gleich, O. Woywode
{"title":"Control of a hybrid filter topology for the reduction of high frequency harmonics","authors":"J. Bergmann, K. Hoffmann, B. Gleich, O. Woywode","doi":"10.1109/IWMPI.2013.6528328","DOIUrl":"https://doi.org/10.1109/IWMPI.2013.6528328","url":null,"abstract":"The Digital Chain is realized as an adaptive finite impulse response filter (FIR). FIR filters with the order of N consist of (N-1) time delay elements, adder and filter coefficients w(n). Based on the measured harmonics in the voltage of ZLoad the filter coefficients are adjusted using the Filtered x Least Mean Square (FxLMS) algorithm [2]. The FxLMS is a stochastic gradient descent method producing the least mean squares of the detected harmonics by updating the filter coefficients with the given formula: w(n +1) = w(n) + μe(n)x(n).","PeriodicalId":267566,"journal":{"name":"2013 International Workshop on Magnetic Particle Imaging (IWMPI)","volume":"38 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116337370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new approach to the fabrication of tracer particles for MPI 一种制备MPI示踪粒子的新方法
2013 International Workshop on Magnetic Particle Imaging (IWMPI) Pub Date : 2013-03-23 DOI: 10.1109/IWMPI.2013.6528366
J. Jacobsohn, Mahmoud Reza Rahbar Azad, F. Biebl, A. Meyer, H. Oepen
{"title":"A new approach to the fabrication of tracer particles for MPI","authors":"J. Jacobsohn, Mahmoud Reza Rahbar Azad, F. Biebl, A. Meyer, H. Oepen","doi":"10.1109/IWMPI.2013.6528366","DOIUrl":"https://doi.org/10.1109/IWMPI.2013.6528366","url":null,"abstract":"Magnetic Particle Imaging (MPI) relies on superparamagnetic iron oxide particles (SPIO) as tracer particles. SPIOs have diameters of only a few nanometers and a low saturation magnetization, which severely limits the obtainable signal in MPI. This was already recognized by B. Gleich and J. Weizenecker in their first presentation of the MPI concept [1]. In order to solve this problem research has been focused on multicore nanoparticles [2] and on SPIOs with larger core diameters [3].","PeriodicalId":267566,"journal":{"name":"2013 International Workshop on Magnetic Particle Imaging (IWMPI)","volume":"71 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125978418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In-vivo MR imaging of lipoprotein distribution and metabolism using spio-labeled lipoproteins at 3T 体内磁共振成像的脂蛋白分布和代谢使用spio标记脂蛋白在3T
2013 International Workshop on Magnetic Particle Imaging (IWMPI) Pub Date : 2013-03-23 DOI: 10.1109/IWMPI.2013.6528361
H. Ittrich, O. Bruns, A. Bartelt, K. Peldschus, M. Kaul, G. Adam, J. Heeren
{"title":"In-vivo MR imaging of lipoprotein distribution and metabolism using spio-labeled lipoproteins at 3T","authors":"H. Ittrich, O. Bruns, A. Bartelt, K. Peldschus, M. Kaul, G. Adam, J. Heeren","doi":"10.1109/IWMPI.2013.6528361","DOIUrl":"https://doi.org/10.1109/IWMPI.2013.6528361","url":null,"abstract":"TRL-NS is a potent MR contrast agent with comparable properties to TRL. Dynamic in-vivo MR measurements after application of TRL-NS showed a two phase SNR change with a rapid exponential SNR decrease in order of vena cava, aorta, portal vein followed by a protracted SNR recovery in all vessels. Liver and BAT showed an exponential SNR decline (rΔ0394;SNRliver= -0.60 ±0.14 (p<;0.01); rΔSNRBAT = -0.74±0.13 (p<;0.01)) indicating high metabolism, that was confirmed with radioactive measurements. Skeletal muscle (rΔSNR= -0.08±0.18), myocardium (rΔSNR= -0.10±0.15) and WAT (rΔSNR= -0.05±0.11) showed a non-significant decline trend in contrast to significant uptake measured by y-counting. Brain showed no significant SNR changes in correlation to radioisotope counting. Corresponding to MR imaging histology and electron microscopy confirmed a predominantly accumulation of TRL-NS in liver and brown adipose tissue.","PeriodicalId":267566,"journal":{"name":"2013 International Workshop on Magnetic Particle Imaging (IWMPI)","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130431293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fast continuous motion of the field of view in magnetic particle imaging 磁粒子成像中视场的快速连续运动
2013 International Workshop on Magnetic Particle Imaging (IWMPI) Pub Date : 2013-03-23 DOI: 10.1109/IWMPI.2013.6528353
J. Rahmer, B. Gleich, J. Weizenecker, A. Halkola, C. Bontus, J. Schmidt, I. Schmale, O. Woywode, T. Buzug, J. Borgert
{"title":"Fast continuous motion of the field of view in magnetic particle imaging","authors":"J. Rahmer, B. Gleich, J. Weizenecker, A. Halkola, C. Bontus, J. Schmidt, I. Schmale, O. Woywode, T. Buzug, J. Borgert","doi":"10.1109/IWMPI.2013.6528353","DOIUrl":"https://doi.org/10.1109/IWMPI.2013.6528353","url":null,"abstract":"When shifting the FOV during imaging, artifacts arise when the shift per volume encoding time is larger than the resolution. Up to shift velocities of about 1 m/s, these can be removed by compensating the system function for the rapid translation. Fast continuous FOV shifts may be used to rapidly steer a single imaging volume to a region of interest or to achieve large spatial coverage by repeatedly sweeping the FOV through a volume of interest.","PeriodicalId":267566,"journal":{"name":"2013 International Workshop on Magnetic Particle Imaging (IWMPI)","volume":"130 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133094425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
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