H. Ittrich, O. Bruns, A. Bartelt, K. Peldschus, M. Kaul, G. Adam, J. Heeren
{"title":"体内磁共振成像的脂蛋白分布和代谢使用spio标记脂蛋白在3T","authors":"H. Ittrich, O. Bruns, A. Bartelt, K. Peldschus, M. Kaul, G. Adam, J. Heeren","doi":"10.1109/IWMPI.2013.6528361","DOIUrl":null,"url":null,"abstract":"TRL-NS is a potent MR contrast agent with comparable properties to TRL. Dynamic in-vivo MR measurements after application of TRL-NS showed a two phase SNR change with a rapid exponential SNR decrease in order of vena cava, aorta, portal vein followed by a protracted SNR recovery in all vessels. Liver and BAT showed an exponential SNR decline (rΔ0394;SNRliver= -0.60 ±0.14 (p<;0.01); rΔSNRBAT = -0.74±0.13 (p<;0.01)) indicating high metabolism, that was confirmed with radioactive measurements. Skeletal muscle (rΔSNR= -0.08±0.18), myocardium (rΔSNR= -0.10±0.15) and WAT (rΔSNR= -0.05±0.11) showed a non-significant decline trend in contrast to significant uptake measured by y-counting. Brain showed no significant SNR changes in correlation to radioisotope counting. Corresponding to MR imaging histology and electron microscopy confirmed a predominantly accumulation of TRL-NS in liver and brown adipose tissue.","PeriodicalId":267566,"journal":{"name":"2013 International Workshop on Magnetic Particle Imaging (IWMPI)","volume":"37 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2013-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"In-vivo MR imaging of lipoprotein distribution and metabolism using spio-labeled lipoproteins at 3T\",\"authors\":\"H. Ittrich, O. Bruns, A. Bartelt, K. Peldschus, M. Kaul, G. Adam, J. Heeren\",\"doi\":\"10.1109/IWMPI.2013.6528361\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"TRL-NS is a potent MR contrast agent with comparable properties to TRL. Dynamic in-vivo MR measurements after application of TRL-NS showed a two phase SNR change with a rapid exponential SNR decrease in order of vena cava, aorta, portal vein followed by a protracted SNR recovery in all vessels. Liver and BAT showed an exponential SNR decline (rΔ0394;SNRliver= -0.60 ±0.14 (p<;0.01); rΔSNRBAT = -0.74±0.13 (p<;0.01)) indicating high metabolism, that was confirmed with radioactive measurements. Skeletal muscle (rΔSNR= -0.08±0.18), myocardium (rΔSNR= -0.10±0.15) and WAT (rΔSNR= -0.05±0.11) showed a non-significant decline trend in contrast to significant uptake measured by y-counting. Brain showed no significant SNR changes in correlation to radioisotope counting. Corresponding to MR imaging histology and electron microscopy confirmed a predominantly accumulation of TRL-NS in liver and brown adipose tissue.\",\"PeriodicalId\":267566,\"journal\":{\"name\":\"2013 International Workshop on Magnetic Particle Imaging (IWMPI)\",\"volume\":\"37 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-03-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2013 International Workshop on Magnetic Particle Imaging (IWMPI)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/IWMPI.2013.6528361\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2013 International Workshop on Magnetic Particle Imaging (IWMPI)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/IWMPI.2013.6528361","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
In-vivo MR imaging of lipoprotein distribution and metabolism using spio-labeled lipoproteins at 3T
TRL-NS is a potent MR contrast agent with comparable properties to TRL. Dynamic in-vivo MR measurements after application of TRL-NS showed a two phase SNR change with a rapid exponential SNR decrease in order of vena cava, aorta, portal vein followed by a protracted SNR recovery in all vessels. Liver and BAT showed an exponential SNR decline (rΔ0394;SNRliver= -0.60 ±0.14 (p<;0.01); rΔSNRBAT = -0.74±0.13 (p<;0.01)) indicating high metabolism, that was confirmed with radioactive measurements. Skeletal muscle (rΔSNR= -0.08±0.18), myocardium (rΔSNR= -0.10±0.15) and WAT (rΔSNR= -0.05±0.11) showed a non-significant decline trend in contrast to significant uptake measured by y-counting. Brain showed no significant SNR changes in correlation to radioisotope counting. Corresponding to MR imaging histology and electron microscopy confirmed a predominantly accumulation of TRL-NS in liver and brown adipose tissue.
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