Biosensors and Bioelectronics: X最新文献_第9页

Integrating voltammetry and substrate-enhanced luminescence for noninvasive glucose sensing 集成伏安法和底物增强发光的无创葡萄糖传感

IF 10.61

Biosensors and Bioelectronics: X Pub Date : 2025-02-07 DOI: 10.1016/j.biosx.2025.100591

Gabriel López-Peña , Ana Pallarés Vilar , Aida Jaafar , Silvia Simón-Fuente , Antonio Arranz , Maria Ribagorda , Miguel Manso-Silván , Emma Martín Rodríguez

{"title":"Integrating voltammetry and substrate-enhanced luminescence for noninvasive glucose sensing","authors":"Gabriel López-Peña , Ana Pallarés Vilar , Aida Jaafar , Silvia Simón-Fuente , Antonio Arranz , Maria Ribagorda , Miguel Manso-Silván , Emma Martín Rodríguez","doi":"10.1016/j.biosx.2025.100591","DOIUrl":"10.1016/j.biosx.2025.100591","url":null,"abstract":"<div><div>This study presents a novel noninvasive and enzyme-free dual sensor based on porous silicon (PSi) for the detection of D-glucose through tear fluid analysis. The sensor incorporates NaGdF<sub>4</sub>:20% Yb<sup>3+</sup>, 2% Er<sup>3+</sup> nanoparticles (YbEr-NPs) immobilized on a PSi substrate functionalized with a phenylboronic ester molecule. The YbEr-NPs enable luminescence-based sensing, exploiting the sensitivity of Er<sup>3+</sup> ions to the OH vibrational groups present in D-glucose. Electrodes fabricated on a PSi substrate allow for voltammetric analysis, providing a second detection method. The voltammetric sensor achieved a limit of detection (LoD) of 20 mg/dL in the range of 20–200 mg/dL, which is suitable for detecting D-glucose concentrations in the tear fluid of diabetic patients. The luminescence-based sensor, utilizing the red-to-green emission ratio of YbEr-NPs, reached a LoD of 140 mg/dL in the range of 10–70 mg/dL, covering the hyperglycemic range. The interaction between the YbEr-NPs and the PSi substrate led to the appearance of new emission bands and increased intensity, attributed to surface defects acting as an additional excitation source. The 556 nm emission band showed a strong dependence on the D-glucose concentration, improving the LoD to 110 mg/dL. This provides a novel strategy for D-glucose detection based on the effect of the molecule on the interaction between the Rare-earth-doped nanoparticles and the PSi substrate. This triple-sensing approach offers a promising solution for noninvasive glucose monitoring, enabling detection in both the hypoglycemic and hyperglycemic ranges.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"23 ","pages":"Article 100591"},"PeriodicalIF":10.61,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An electrolyte-gated transistor for the monitoring of a CRISPR/Cas activity 一种用于监测CRISPR/Cas活性的电解门控晶体管

IF 10.61

Biosensors and Bioelectronics: X Pub Date : 2025-02-06 DOI: 10.1016/j.biosx.2025.100590

Pierre Guermonprez , Le Tu Anh , Louis Renaud , Pierre Nioche , Eric Krejci , Aurélie Alleaume-Butaux , Nicolas Battaglini , Vu Thi Thu , Sébastien Sanaur , Benoît Piro

{"title":"An electrolyte-gated transistor for the monitoring of a CRISPR/Cas activity","authors":"Pierre Guermonprez , Le Tu Anh , Louis Renaud , Pierre Nioche , Eric Krejci , Aurélie Alleaume-Butaux , Nicolas Battaglini , Vu Thi Thu , Sébastien Sanaur , Benoît Piro","doi":"10.1016/j.biosx.2025.100590","DOIUrl":"10.1016/j.biosx.2025.100590","url":null,"abstract":"<div><div>Detection of Ribonucleic acids (RNA) is a critical step in the identification of viral or bacterial infections in humans and animals. Reverse transcriptase-polymerase chain reaction (RT-PCR) remains the gold standard, but clustered regularly interspaced short palindromic repeats linked to a Cas endoribonuclease particle (CRISPR/Cas) have recently revolutionized the recognition step of two RNAs, i.e. the CRISPR-RNA (crRNA) and the target, providing a much better selectivity compared to the naked hybridization on which RT-PCR is based. Here, we combine the high efficiency of the CRISPR/Cas13a system with the transduction and amplification capabilities of an electrolyte-gated graphene field-effect transistor (EGGFET) for the detection of specific RNA sequences. In these devices, fabricated on flexible plastic substrates, the active material (reduced graphene oxide, rGO) is deposited by printing and then functionalized with Au nanoparticles decorated with polyU RNA reporter strands. In this system, the CRISPR/Cas13a complex acts as a catalyst: in the presence of a specific RNA target sequence, the enzymatic function is activated and the polyU RNA reporter strands are cleaved from the Au nanoparticles, inducing a loss of negative charges on the rGO layer. This phenomenon leads to measurable changes in the transfer curve of the transistors. These sensors were tested for the detection of a SARS-CoV-2 RNA sequence and showed a linear response in the range of 10<sup>−7</sup> - 10<sup>2</sup> ng μL<sup>−1</sup> with an estimated limit of detection of 10 fM. This work is an important milestone in the development of the next generation of point-of-care RNA sensors.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"23 ","pages":"Article 100590"},"PeriodicalIF":10.61,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SpAi: A machine-learning supported experimental workflow for high-throughput spheroid production and analysis SpAi：一个支持机器学习的实验工作流，用于高通量球体生产和分析

IF 10.61

Biosensors and Bioelectronics: X Pub Date : 2025-01-31 DOI: 10.1016/j.biosx.2025.100588

Nedim Hacıosmanoğlu , Murat Alp Güngen , Eylul Gulsen Yilmaz , Emre Ece , Alphan Uzun , Arda Taşcan , Burak M. Görmüş , Ismail Eş , Fatih Inci

{"title":"SpAi: A machine-learning supported experimental workflow for high-throughput spheroid production and analysis","authors":"Nedim Hacıosmanoğlu , Murat Alp Güngen , Eylul Gulsen Yilmaz , Emre Ece , Alphan Uzun , Arda Taşcan , Burak M. Görmüş , Ismail Eş , Fatih Inci","doi":"10.1016/j.biosx.2025.100588","DOIUrl":"10.1016/j.biosx.2025.100588","url":null,"abstract":"<div><div>Three-dimensional (3D) cell cultures, especially spheroids, provide a physiologically accurate model for cancer research in comparison to conventional two-dimensional (2D) cultures. Nevertheless, the difficulties in producing and analyzing spheroids have impeded their extensive use in high-throughput screening—a critical process for drug discovery. This study presents a simplified process for the effective creation and examination of spheroids using a 3D-printed mold casted polydimethylsiloxane (PDMS) microwells. The utilization of our specially constructed mold facilitated the creation of consistent spheroids, which were subsequently exposed to doxorubicin for the purpose of anticancer medication treatment. We herein improved spheroid analysis by including a convolutional neural network (CNN) model, specifically U-Net, into a graphical user interface (GUI). This integration allows for automated detection and measurement of spheroid size from microscope pictures. The performance of this system surpassed that of conventional image analysis methods in terms of both accuracy and efficiency. The implemented workflow offers a scalable and cost-efficient platform for conducting high-throughput drug screening, which has the potential to enhance the success rates of cancer therapies in clinical trials.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"23 ","pages":"Article 100588"},"PeriodicalIF":10.61,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revolutionizing cervical cancer diagnostics: A shift from traditional techniques to biosensors 宫颈癌诊断的革命：从传统技术到生物传感器的转变

IF 10.61

Biosensors and Bioelectronics: X Pub Date : 2025-01-31 DOI: 10.1016/j.biosx.2025.100587

Ubaid Mushtaq Naikoo , Roberto Pilloton , Humaira Farooqi , Jagriti Narang

{"title":"Revolutionizing cervical cancer diagnostics: A shift from traditional techniques to biosensors","authors":"Ubaid Mushtaq Naikoo , Roberto Pilloton , Humaira Farooqi , Jagriti Narang","doi":"10.1016/j.biosx.2025.100587","DOIUrl":"10.1016/j.biosx.2025.100587","url":null,"abstract":"<div><div>Cervical cancer is the most important contributor to ailment and death among females universally, highlighting the urgent need for effective diagnostic tools. Traditional diagnostic techniques, such as Pap smears and HPV testing, though effective, suffer from limitations including invasiveness, variable sensitivity, and dependence on clinical infrastructure. This review explores the transformative potential of biosensors as a non-invasive, cost-effective, and sensitive alternative for cervical cancer diagnostics. Comprehensive analysis of current biosensor technologies, emphasizing their mechanisms, advantages, and potential to overcome the drawbacks of conventional methods. Furthermore, the review discusses recent advancements in biosensor design, including integrating nanomaterials and point-of-care systems, which enhance their diagnostic accuracy and accessibility. Key challenges in the clinical translation of biosensors are also addressed, along with potential solutions and future research directions. By highlighting the shift from traditional techniques to biosensors, this review underscores the promise of these innovative tools in improving early detection and patient outcomes in cervical cancer care.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"23 ","pages":"Article 100587"},"PeriodicalIF":10.61,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143259670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface plasmon resonance biosensors for SARS-CoV-2 sensing: The role of silicon nitride and graphene 表面等离子共振生物传感器对SARS-CoV-2的传感：氮化硅和石墨烯的作用

IF 10.61

Biosensors and Bioelectronics: X Pub Date : 2025-01-29 DOI: 10.1016/j.biosx.2025.100586

Talia Tene , Diana Coello-Fiallos , Myrian Borja , Narcisa Sánchez , Fabián Londo , Cristian Vacacela Gomez , Stefano Bellucci

引用次数: 0

Fluorescent probes to track complex membrane blebbing 荧光探针跟踪复杂膜泡

IF 10.61

Biosensors and Bioelectronics: X Pub Date : 2025-01-27 DOI: 10.1016/j.biosx.2025.100584

Juan L. Cortes-Muñoz , Johan-Moritz Kux , Pablo J. Sáez , Arturo Jiménez-Sánchez

{"title":"Fluorescent probes to track complex membrane blebbing","authors":"Juan L. Cortes-Muñoz , Johan-Moritz Kux , Pablo J. Sáez , Arturo Jiménez-Sánchez","doi":"10.1016/j.biosx.2025.100584","DOIUrl":"10.1016/j.biosx.2025.100584","url":null,"abstract":"<div><div>Cellular blebbing, pivotal in processes such as apoptosis, cytokinesis, and migration, involves dynamic interactions between the actomyosin network and microtubules. However, existing probes inadequately capture these simultaneous interactions, limiting our ability to study blebbing mechanisms. We present <strong>AztecBleb</strong> probes (<strong>AztecBleb</strong><sup><strong>DAPI</strong></sup>, <strong>AztecBleb</strong><sup><strong>GFP</strong></sup>, <strong>AztecBleb</strong><sup><strong>TxR</strong></sup>, <strong>AztecBleb</strong><sup><strong>Cy5</strong></sup>), novel fluorescent reporters designed to selectively target and monitor blebbing in real-time. These probes incorporate a pregnenolone-based scaffold as a hydrophobic core derived from abiraterone acetate, facilitating precise localization to blebs and microtubules without disrupting cellular function. Through persistent staining of cell blebs, these photostable and biocompatible probes enable continuous monitoring of blebbing and microtubule dynamics during cellular migration. Our approach provides new insights into the coordination of bleb formation and cytoskeletal remodeling, offering a unique tool for studying motility-driven cellular behaviors.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"23 ","pages":"Article 100584"},"PeriodicalIF":10.61,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143161324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced glucose sensing via nanoparticles-modified extended gates: A novel approach to electric double layer modulation and signal amplification in field effect transistors for improved detection sensitivity 通过纳米粒子修饰的扩展门增强葡萄糖传感：电场效应晶体管中双电层调制和信号放大的新方法，以提高检测灵敏度

IF 10.61

Biosensors and Bioelectronics: X Pub Date : 2025-01-20 DOI: 10.1016/j.biosx.2025.100576

Sheng-Chun Hung, Yi-Hua Lee

{"title":"Enhanced glucose sensing via nanoparticles-modified extended gates: A novel approach to electric double layer modulation and signal amplification in field effect transistors for improved detection sensitivity","authors":"Sheng-Chun Hung, Yi-Hua Lee","doi":"10.1016/j.biosx.2025.100576","DOIUrl":"10.1016/j.biosx.2025.100576","url":null,"abstract":"<div><div>This study presents an innovative glucose sensing platform that harnesses the enhanced electrocatalytic properties of planar electric double layer (EDL) structures in conjunction with extended gate field effect transistors (EGFETs). By integrating specific nanoparticles onto the sensor surface, this platform achieves substantial improvements in glucose detection sensitivity and overall performance. The materials employed in this research include Ni nanowires combined with graphene films, CuO nanoparticles incorporated into carbon nanostructures, and gold nanoparticles affixed to ZnO nanostructures. These nanomaterials exhibit remarkable catalytic activity, while the localized electric field effect generated by the electric double layer significantly amplifies the signal, thereby enhancing sensitivity. Experimental findings reveal notable enhancements in both sensitivity and detection limits compared to conventional glucose sensors, underscoring the potential of this platform for effective glucose monitoring. Specifically, the Ni nanowire-graphene film sensor recorded a sensitivity of 3102.7 μA mM⁻<sup>1</sup> cm⁻<sup>2</sup> with a detection limit of 51 nM. The CuO nanoparticle-carbon nanostructure sensor achieved a sensitivity of 2206.25 μA mM⁻<sup>1</sup> cm⁻<sup>2</sup> and a detection limit of 39 nM, while the gold nanoparticle-ZnO nanostructure sensor demonstrated a sensitivity of 811.8 μA mM⁻<sup>1</sup> cm⁻<sup>2</sup> with a detection limit of 59 nM.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"23 ","pages":"Article 100576"},"PeriodicalIF":10.61,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143161323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive review of Interferometric Reflectance Imaging Sensor as a sensitive detection platform and its application areas 综述了干涉反射成像传感器作为一种灵敏的检测平台及其应用领域

IF 10.61

Biosensors and Bioelectronics: X Pub Date : 2025-01-07 DOI: 10.1016/j.biosx.2025.100574

Monireh Bakhshpour-Yucel , Nese Lortlar Unlu , Elif Seymour , Adil Denizli

{"title":"A comprehensive review of Interferometric Reflectance Imaging Sensor as a sensitive detection platform and its application areas","authors":"Monireh Bakhshpour-Yucel , Nese Lortlar Unlu , Elif Seymour , Adil Denizli","doi":"10.1016/j.biosx.2025.100574","DOIUrl":"10.1016/j.biosx.2025.100574","url":null,"abstract":"<div><div>The Interferometric Reflectance Imaging Sensor (IRIS) technology represents a significant advancement in biosensing, providing a label-free, selective, sensitive, and high-throughput platform for detecting molecular interactions. This review explores the underlying principles, instrumentation, and diverse applications of IRIS, with a focus on its efficacy for real-time monitoring of DNA-protein and protein-protein interactions, as well as virus detection. IRIS can measure DNA hybridization kinetics and identify pathogens without labeling, highlighting its versatility and reliability in biomedical research and diagnostics. IRIS achieves enhanced sensitivity and specificity by leveraging spectral reflectivity as a transduction mechanism and employing a 3D polymeric surface chemistry for bioreceptor immobilization. The review underscores IRIS's potential to revolutionize clinical diagnostics, biomolecular screening, and the study of biomolecular binding affinities, establishing it as a powerful tool for future research and medical applications.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"22 ","pages":"Article 100574"},"PeriodicalIF":10.61,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Personal glucose meter-based portable method for creatine kinase assay 基于个人血糖仪的便携式肌酸激酶测定方法

IF 10.61

Biosensors and Bioelectronics: X Pub Date : 2025-01-07 DOI: 10.1016/j.biosx.2025.100575

Jinhwan Lee , Yejin Oh , Hyoyong Kim, Sangmo Lee, Hyun Gyu Park

{"title":"Personal glucose meter-based portable method for creatine kinase assay","authors":"Jinhwan Lee , Yejin Oh , Hyoyong Kim, Sangmo Lee, Hyun Gyu Park","doi":"10.1016/j.biosx.2025.100575","DOIUrl":"10.1016/j.biosx.2025.100575","url":null,"abstract":"<div><div>We herein developed a simple and label-free method to detect the creatine kinase (CK) activity by employing a personal glucose meter (PGM) as a detection device. This method relies on the target-induced consumption of glucose by the cascade enzymatic reaction (CER) promoted by the combined activities of CK and hexokinase (HK). The target CK first catalyzes the phosphorylation of adenosine 5′-diphosphate (ADP) to adenosine 5′-triphosphate (ATP) using creatine phosphate (CP) as a phosphate donor. HK then phosphorylates glucose into glucose-6-phosphate by converting the produced ATP back to ADP, which could enter another cycle of the CER to further phosphorylate glucose in a sample. As a consequence, the glucose level would decrease depending on the CK activity, which could be very conveniently detected using a PGM. With this unique design principle, we successfully determined the CK activity down to 0.0147 U/mL with high specificity against various non-target enzymes. We also verified that the developed strategy can reliably detect CK activity in heterogeneous human blood, ensuring its robust utility in various clinical applications. This user-friendly method enables point-of care detection of CK, offering a practical tool for monitoring muscle health. By allowing simultaneous tracking of CK and glucose levels with the same PGM device, this approach is particularly beneficial for diabetes mellitus (DM) patients, empowering them to proactively manage their health and reduce the risk of muscle-related complications.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"22 ","pages":"Article 100575"},"PeriodicalIF":10.61,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fiber-tip photonic crystal for real-time referenced biosensing in serum 用于血清实时参考生物传感的光纤尖端光子晶体

IF 10.61

Biosensors and Bioelectronics: X Pub Date : 2024-12-27 DOI: 10.1016/j.biosx.2024.100573

Mathias Dolci , Paco Dreverman , Mildred S. Cano-Velázquez , Arthur L. Hendriks , Emiel Veth , P.J. van Veldhoven , Andrea Fiore , Peter Zijlstra

{"title":"Fiber-tip photonic crystal for real-time referenced biosensing in serum","authors":"Mathias Dolci , Paco Dreverman , Mildred S. Cano-Velázquez , Arthur L. Hendriks , Emiel Veth , P.J. van Veldhoven , Andrea Fiore , Peter Zijlstra","doi":"10.1016/j.biosx.2024.100573","DOIUrl":"10.1016/j.biosx.2024.100573","url":null,"abstract":"<div><div>Fiber optic sensors have become increasingly well-established due to the many advantages they provide such as immunity to electromagnetic interference, multiplexing capabilities, and remote sensing. The coupling of light with a transducer at the tip of the optical fiber enables the detection of physical and biological parameters. 2D photonic crystals (PhC) can be designed to feature guided-mode resonances (GMR) characterized by a strong electric field at the PhC surface, providing a suitable tool for the detection of local refractive index variations (e.g. biomolecule adsorption). Here, we demonstrate the use of a PhC transferred to the tip of a single-mode fiber for biosensing. The control of surface chemistry provides a sensitive platform for the molecular recognition of antibody biomarkers. By integrating the fiber in a continuous flow platform, the real-time detection of anti-IgG in undiluted serum was achieved, with a limit of detection down to 60 pM. Moreover, the use of a reference channel is demonstrated to correct for signal drifts in real-time due to changes in bulk refractive index. These referenced fiber-tip PhC biosensors may pave the way for fluidic integrated systems in environmental, industrial, and healthcare applications, and open up the possibility of biosensing in the human body by integrating them into catheters.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"22 ","pages":"Article 100573"},"PeriodicalIF":10.61,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0