Biosensors and Bioelectronics: X最新文献_第10页

Current state of the art on implantable sensors for continuous post-EVAR surveillance of abdominal aortic aneurysms: A comprehensive review 腹主动脉瘤evar后持续监测植入式传感器的研究现状：综述

IF 10.61

Biosensors and Bioelectronics: X Pub Date : 2025-10-01 Epub Date: 2025-06-12 DOI: 10.1016/j.biosx.2025.100645

G. Saroglia , S. Marocco , S. Nicoloso , S. Diana , M. Tozzi , I. Stefanini

{"title":"Current state of the art on implantable sensors for continuous post-EVAR surveillance of abdominal aortic aneurysms: A comprehensive review","authors":"G. Saroglia , S. Marocco , S. Nicoloso , S. Diana , M. Tozzi , I. Stefanini","doi":"10.1016/j.biosx.2025.100645","DOIUrl":"10.1016/j.biosx.2025.100645","url":null,"abstract":"<div><div>Post-endovascular aneurysm repair (EVAR) surveillance currently relies on routine imaging techniques such as computed tomography angiography and magnetic resonance angiography, which expose patients to radiation, nephrotoxic contrast agents, and place logistical burdens on healthcare systems. This review critically examines the potential of implantable sensors, particularly pressure-monitoring systems, to provide continuous, minimally invasive post-EVAR surveillance. We present an overview of the biological and biomechanical rationale for monitoring aneurysm sac pressurization, analyze existing sensor technologies including EndoSure® and ImPressure®, and discuss technical challenges such as wireless telemetry, biocompatibility, signal attenuation, and power management. Regulatory milestones and alignment with ESVS and SVS surveillance guidelines are reviewed, along with the current evidence gap between pressure trends and clinical outcomes such as reintervention or rupture. While technical feasibility has been demonstrated in controlled settings, no studies to date have shown that pressure monitoring improves long-term outcomes or guides decision-making independently of imaging. The limitations of pressure-based monitoring are discussed alongside emerging sensor designs that integrate pressure, morphological, and biochemical sensing. This review concludes that implantable pressure sensors remain investigational tools whose clinical adoption will depend on future trials demonstrating diagnostic accuracy, patient acceptability, cost-effectiveness, and outcome benefit.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"26 ","pages":"Article 100645"},"PeriodicalIF":10.61,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144290716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A simple MOF-based nanosensor for bisphenol A detection: in vitro application in supernatant of human endothelial cell models 用于双酚A检测的简单mof纳米传感器：在人内皮细胞模型上清液中的体外应用

IF 10.61

Biosensors and Bioelectronics: X Pub Date : 2025-10-01 Epub Date: 2025-08-06 DOI: 10.1016/j.biosx.2025.100666

Lorena Garcia-Rodrigo , Cristina Tortolini , Araceli González-Cortés , Ilenia Ventura , Silvia Migliaccio , Elisabetta Ferretti , Riccarda Antiochia

{"title":"A simple MOF-based nanosensor for bisphenol A detection: in vitro application in supernatant of human endothelial cell models","authors":"Lorena Garcia-Rodrigo , Cristina Tortolini , Araceli González-Cortés , Ilenia Ventura , Silvia Migliaccio , Elisabetta Ferretti , Riccarda Antiochia","doi":"10.1016/j.biosx.2025.100666","DOIUrl":"10.1016/j.biosx.2025.100666","url":null,"abstract":"<div><div>This work describes a simple electrochemical nanosensor for bisphenol A (BPA) detection based on an iron metal organic framework (MIL-100(Fe)) immobilized onto a commercial multiwalled carbon nanotubes (MWCNTs)/gold nanoparticles (AuNPs) modified graphite screen printed electrode (GSPE). The electrochemical platform has been characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and SEM-EDX analysis. The resulting MIL-100(Fe)/AuNPs_MWCNTs/GSPE platform exhibited competitive analytical performances, including a wide dynamic range (0.1–100 μM), and a low detection limit (20 nM). Additionally, the proposed sensor demonstrated excellent selectivity, enabling accurate BPA detection in the presence of potential interferences. Lastly, the sensor has been successfully tested for <em>in vitro</em> BPA detection in the supernatant samples of human endothelial cellular models, Human Umbilical Vein Endothelial Cells (HUVECs) and Human Aortic Endothelial Cells (HAECs), exposed to BPA. These findings highlight the potential of the proposed nanosensor for the detection of BPA in supernatant cell fluids of individuals exposed to BPA at different concentrations and incubation times.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"26 ","pages":"Article 100666"},"PeriodicalIF":10.61,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A wireless reader for detecting frequency shift of passive sensors 一种用于检测无源传感器频移的无线读取器

IF 10.61

Biosensors and Bioelectronics: X Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI: 10.1016/j.biosx.2025.100668

Fariborz Mirlou , Emine Bardakci , Taher Abbasiasl , Levent Beker

{"title":"A wireless reader for detecting frequency shift of passive sensors","authors":"Fariborz Mirlou , Emine Bardakci , Taher Abbasiasl , Levent Beker","doi":"10.1016/j.biosx.2025.100668","DOIUrl":"10.1016/j.biosx.2025.100668","url":null,"abstract":"<div><div>A body area sensor network (bodyNET) consists of wearable and implantable sensors to monitor human physiological signals. While passive disposable, chip-free, and batteryless sensors have been widely studied, benchtop equipment is still required for data collection, limiting usage to laboratory settings. Efficient integration of passive wearable and implantable sensors with dedicated compact readout circuitry is crucial for enabling data acquisition outside controlled laboratory environments. Here, we present a miniaturized, flexible wireless reader (WiRe) designed for frequency-shifting passive sensors, which also incorporates power harvesting capability. WiRe is compatible with a wide variety of passive sensors, offering a versatile platform for diverse medical applications. We deployed WiRe across various passive sensor platforms to track frequency shifts associated with biological signals. Our results show that WiRe uniquely combines power harvesting with a flexible, portable readout interface, enabling effective and non-invasive detection of even minor frequency shifts in a frequency sweep range of 1–8 MHz with 100 kHz resolution for both in vitro and in vivo experiments.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"26 ","pages":"Article 100668"},"PeriodicalIF":10.61,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced analysis of fully-printed organic transistors platform for multi-ion detection in sweat 汗液中多离子检测全印刷有机晶体管平台的先进分析

IF 10.61

Biosensors and Bioelectronics: X Pub Date : 2025-10-01 Epub Date: 2025-07-25 DOI: 10.1016/j.biosx.2025.100661

Silvia Demuru , Jaemin Kim , Ilya Kiselev , Guillaume Joël Jeanneret-Grosjean , Brince Paul Kunnel , Min Liu , Xi Chen , Mathieu Saubade , Celine Lafaye , Shih-Chii Liu , Danick Briand

引用次数: 0

Computational modeling of the effects of biofouling and foreign body response on continuous glucose monitors 生物污垢和异物反应对连续血糖监测仪影响的计算模型

IF 10.61

Biosensors and Bioelectronics: X Pub Date : 2025-10-01 Epub Date: 2025-08-21 DOI: 10.1016/j.biosx.2025.100676

John R. Aggas

{"title":"Computational modeling of the effects of biofouling and foreign body response on continuous glucose monitors","authors":"John R. Aggas","doi":"10.1016/j.biosx.2025.100676","DOIUrl":"10.1016/j.biosx.2025.100676","url":null,"abstract":"<div><div>Biofouling and eventual foreign body response are critical issues limiting the long-term performance of implantable continuous glucose monitors (CGMs). The implant is subjected to reduced blood flow in situ governed by the inflammatory response, resulting in decreased access to glucose and a decrease in sensor sensitivity (drift). In this work, a computational model of an amperometric 2<sup>nd</sup> generation enzymatic glucose sensor is examined that incorporates the time-dependent changes in the interstitial environment due to the foreign body response (FBR). Appropriate physics are applied with respect to glucose transport from tissue, temporal foreign body response, enzyme kinetics, and measured electrochemical current. The resultant sensor performance is modeled against publicly available clinical data over a 14-day wear time, using test cases of an idealized implant that is not subjected to FBR, fibrous encapsulation with neovascularization, and fibrous encapsulation without neovascularization. The resultant sensitivity, lag-time, and sensor performance are compared against the reference clinical data. Results demonstrate that <em>in silico</em> modeling has utility in predicting <em>in vivo</em> performance, offering a vital tool for sensor design and pre-clinical optimization.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"26 ","pages":"Article 100676"},"PeriodicalIF":10.61,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticle-enabled portable biosensors for early detection and monitoring of non-communicable diseases: A focus on diabetes, cardiovascular, and cancer diagnostics 用于非传染性疾病早期检测和监测的纳米颗粒便携式生物传感器：重点关注糖尿病、心血管和癌症诊断

IF 10.61

Biosensors and Bioelectronics: X Pub Date : 2025-10-01 Epub Date: 2025-08-24 DOI: 10.1016/j.biosx.2025.100675

Anjali Upadhaya , Joynath Pegu , Yengkhom Disco Singh , Senpon Ngomle

{"title":"Nanoparticle-enabled portable biosensors for early detection and monitoring of non-communicable diseases: A focus on diabetes, cardiovascular, and cancer diagnostics","authors":"Anjali Upadhaya , Joynath Pegu , Yengkhom Disco Singh , Senpon Ngomle","doi":"10.1016/j.biosx.2025.100675","DOIUrl":"10.1016/j.biosx.2025.100675","url":null,"abstract":"<div><div>The increasing global prevalence of non-communicable diseases (NCDs) such as diabetes, cardiovascular disorders, and cancer poses a significant challenge to healthcare systems, particularly in low resource settings. Improving patient outcomes requires early and accurate diagnosis, but existing diagnostic approaches frequently depend on invasive procedures and centralized labs, which limits their timeliness and accessibility. This review emphasizes the increasing importance of the nanoparticle-based portable biosensors as a pioneering strategy for these diagnostic issues. These emerging biosensing platforms provide a great combination of miniaturization, sensitivity, and instant detection, which are especially promising in point-of-care and personalized healthcare. Great advances in biosensor platforms in terms of detection of biomarkers had been made by inclusion of nanomaterials in these devices, showing potential for non-invasive and rapid disease monitoring at low-cost impact. It provides a comprehensive understanding of how nanotechnology-driven biosensors are reshaping the future of diagnostics for chronic diseases. In order to demonstrate how these systems might facilitate early intervention, ongoing monitoring, and wider access to healthcare, this paper compiles current advancements. Therefore, portable biosensors that use nanotechnology can contribute to quicker, simpler, and more accessible illness diagnosis, which will improve patient care everywhere.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"26 ","pages":"Article 100675"},"PeriodicalIF":10.61,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical immunosensors targeting hormonal biomarkers for polycystic ovary syndrome: Recent advances and analytical bottlenecks 针对多囊卵巢综合征激素生物标志物的电化学免疫传感器：最新进展和分析瓶颈

IF 10.61

Biosensors and Bioelectronics: X Pub Date : 2025-10-01 Epub Date: 2025-07-05 DOI: 10.1016/j.biosx.2025.100657

Aniket Nandi , Samuel W. Gillespie , S. Nick Ice , Divyanshi Thakur , Yash Kumar Gaur , Kamal Singh , Kalicharan Sharma

{"title":"Electrochemical immunosensors targeting hormonal biomarkers for polycystic ovary syndrome: Recent advances and analytical bottlenecks","authors":"Aniket Nandi , Samuel W. Gillespie , S. Nick Ice , Divyanshi Thakur , Yash Kumar Gaur , Kamal Singh , Kalicharan Sharma","doi":"10.1016/j.biosx.2025.100657","DOIUrl":"10.1016/j.biosx.2025.100657","url":null,"abstract":"<div><div>Polycystic Ovary Syndrome (PCOS) is a multifactorial endocrine disorder affecting up to 13 % of women of reproductive age, with nearly 70 % remaining undiagnosed due to the limitations of conventional diagnostic methods. These traditional approaches, based on imaging, hormonal assays, and symptom evaluation, are often delayed, nonspecific, and unsuitable for large-scale screening. Recent advances in electrochemical biosensors targeting hormonal biomarkers such as Anti-Müllerian Hormone (AMH), Sex Hormone-Binding Globulin (SHBG), and Follicle-Stimulating Hormone (FSH) offer a promising alternative for rapid, sensitive, and cost-effective PCOS diagnosis. This review critically evaluates electrochemical biosensor technologies developed in last five years for the detection of PCOS, discussing material choices, electrode fabrication strategies, signal transduction techniques (EIS, DPV, CV), and their analytical performance. Key limitations in analytical design, clinical validation, and commercialization are identified, including challenges with multiplexed detection, stability in real biological matrices, and scalability. Finally, solution strategies and future research directions are proposed to bridge the gap between laboratory innovation and real-world point-of-care diagnostic tools for PCOS.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"26 ","pages":"Article 100657"},"PeriodicalIF":10.61,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MoS2-Si3N4-based SPR biosensor for the detection of malaria at different stages: A theoretical insight 基于mos2 - si3n4的SPR生物传感器在不同阶段检测疟疾：一个理论见解

IF 10.61

Biosensors and Bioelectronics: X Pub Date : 2025-10-01 Epub Date: 2025-06-25 DOI: 10.1016/j.biosx.2025.100655

Talia Tene , Marco Guevara , Isaías Caicedo , Jose Luis Granizo Jara , Myrian Borja , Lala Gahramanli , Cristian Vacacela Gomez , Stefano Bellucci

{"title":"MoS2-Si3N4-based SPR biosensor for the detection of malaria at different stages: A theoretical insight","authors":"Talia Tene , Marco Guevara , Isaías Caicedo , Jose Luis Granizo Jara , Myrian Borja , Lala Gahramanli , Cristian Vacacela Gomez , Stefano Bellucci","doi":"10.1016/j.biosx.2025.100655","DOIUrl":"10.1016/j.biosx.2025.100655","url":null,"abstract":"<div><div>The accurate differentiation of malaria stages is essential for effective treatment and epidemiological control. This work presents a theoretical analysis of a multilayer surface plasmon resonance (SPR) biosensor for malaria stage detection based on refractive index variations of infected red blood cells. The sensor combines silver, silicon nitride (Si<sub>3</sub>N<sub>4</sub>), monolayer molybdenum disulfide (MoS<sub>2</sub>), and thiol-functionalized single-stranded DNA (ssDNA) on a BK7 prism. Using the transfer matrix method (TMM), we evaluate the sensor performance across Ring, Trophozoite, and Schizont stages through sensitivity, full width at half maximum (FWHM), quality factor (QF), detection accuracy (DA), limit of detection (LoD), and comprehensive sensitivity factor (CSF). The optimized configuration achieves angular sensitivities of 318.2 (Ring), 268.9 (Trophozoite), and 244.8 (Schizont) °/RIU, demonstrating clear stage discrimination and competitive performance compared to reported multilayer SPR sensors. The layered architecture was designed with experimentally accessible materials and configurations, supporting future translation to stage-specific diagnostic platforms.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"26 ","pages":"Article 100655"},"PeriodicalIF":10.61,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

WGM Sensors for future diagnostics: small molecules to whole organisms 用于未来诊断的WGM传感器：从小分子到整个生物体

IF 10.61

Biosensors and Bioelectronics: X Pub Date : 2025-10-01 Epub Date: 2025-08-07 DOI: 10.1016/j.biosx.2025.100671

Wilhelm Eugen Andreas Krames , Defne Ilayda Dayi , Lars Kaiser , Oliver Riester , Michael Himmelhaus , René Csuk , Hans-Peter Deigner

{"title":"WGM Sensors for future diagnostics: small molecules to whole organisms","authors":"Wilhelm Eugen Andreas Krames , Defne Ilayda Dayi , Lars Kaiser , Oliver Riester , Michael Himmelhaus , René Csuk , Hans-Peter Deigner","doi":"10.1016/j.biosx.2025.100671","DOIUrl":"10.1016/j.biosx.2025.100671","url":null,"abstract":"<div><div>In a world facing constant challenges from diseases and pathogens, rapid diagnosis is crucial. Whispering gallery mode (WGM) resonators present an advanced sensor technology suitable for the detection of various analytes. Like surface plasmon resonance (SPR), they offer highly sensitive and selective measurements, ideal for medical diagnostics. Traditional WGM resonators, however, are immobilized on surfaces near optical couplers, making their production complex and costly. Nevertheless, a more recent approach employs polystyrene microspheres localized to cavities in fluidic chips as resonators, simplifying preparation and functionalization and displaying enhanced performance. Here, we assess the applicability of those sensors to different analyte sizes, ranging from small molecules (<1000 Da) to whole organisms. By employing different detection strategies, we confirm the applicability of the WGM sensors for detecting a wide range of targets.</div><div>The study focuses on <em>L. pneumophila</em>, TEM-1 beta-lactamase, aztreonam, and meropenem as representatives of these three major groups. We show that the detection was successful for all chosen analytes, while small molecules required additional signal amplification through a sandwich approach. Results of the analysis of the protein measurements showed an LOD of 0.09 μM and an LOQ of 0.28 μM with a R<sup>2</sup> greater than 0.99. Additionally, a comparative measurement demonstrates that the WGM is more sensitive than the widely used gold standard SPR (LOD 0.34 μM; LOQ 1.12 μM). Taken together, our work demonstrates the applicability of the WGM sensors to pathogen detection, protein quantification or small molecule analysis with an improved sensitivity compared to current gold standard methods.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"26 ","pages":"Article 100671"},"PeriodicalIF":10.61,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144842006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and fabrication of smartphone based single paper lateral flow assay for early detection of PCOS biomarker 基于智能手机的PCOS生物标志物早期检测单纸侧流法的设计与制作

IF 10.61

Biosensors and Bioelectronics: X Pub Date : 2025-10-01 Epub Date: 2025-08-07 DOI: 10.1016/j.biosx.2025.100672

Aniket Nandi , Yash Kumar Gaur , Divyanshi Thakur , Ekta Daweshar , Kalicharan Sharma

{"title":"Design and fabrication of smartphone based single paper lateral flow assay for early detection of PCOS biomarker","authors":"Aniket Nandi , Yash Kumar Gaur , Divyanshi Thakur , Ekta Daweshar , Kalicharan Sharma","doi":"10.1016/j.biosx.2025.100672","DOIUrl":"10.1016/j.biosx.2025.100672","url":null,"abstract":"<div><div>Polycystic Ovary Syndrome (PCOS) is a multifactorial endocrine disorder with significant diagnostic challenges, especially in early stages. Current diagnostic methods are often complex, time-consuming, and dependent on laboratory-based infrastructure. This study presents the design and fabrication of a smartphone-assisted paper-based lateral flow assay (LFA) for the early detection of PCOS via the quantification of sex hormone-binding globulin (SHBG), a promising metabolic biomarker. Fluorescent nitrogen-doped carbon dots (CDs) were synthesized using a microwave-assisted method and conjugated with anti-SHBG antibodies via EDC/NHS chemistry. The LFA strips were constructed using Whatman filter paper, and hydrophobic barriers were drawn using permanent marker ink. A portable device equipped with a 365 nm UV LED and a smartphone camera enabled fluorescence detection. Recombinant SHBG antigen samples in phosphate-buffered saline (PBS) were tested across a concentration range of 80–4000 ng/mL. The system exhibited a strong linear response (R<sup>2</sup> = 0.9677) between SHBG concentration and fluorescence intensity, with a calculated limit of detection (LOD) and limit of quantification (LOQ) of 2.68 ng/mL and 19.93 ng/mL, respectively. The analytical range of 80–4000 ng/mL corresponds to 0.8–42.1 nmol/L, covers the clinical diagnostic threshold of SHBG (<36 nmol/L). These results demonstrate the feasibility of a low-cost, point-of-care diagnostic tool for early PCOS screening. Further validation with clinical samples is necessary for real-world deployment.</div></div>","PeriodicalId":260,"journal":{"name":"Biosensors and Bioelectronics: X","volume":"26 ","pages":"Article 100672"},"PeriodicalIF":10.61,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144829637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0