Bioelectrochemistry最新文献_第4页

Molecular structure-dependent bioelectrochemical decolorization of azo dyes 偶氮染料的分子结构依赖性生物电化学脱色

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-08-01 Epub Date: 2026-01-19 DOI: 10.1016/j.bioelechem.2026.109229

Hou-Yun Yang , Xiang Geng , Zhi-Dao Quan , Li Yu , Xian-Huai Huang , Wei-Hua Li , Tong-Zhan Xue , Yang Mu

{"title":"Molecular structure-dependent bioelectrochemical decolorization of azo dyes","authors":"Hou-Yun Yang , Xiang Geng , Zhi-Dao Quan , Li Yu , Xian-Huai Huang , Wei-Hua Li , Tong-Zhan Xue , Yang Mu","doi":"10.1016/j.bioelechem.2026.109229","DOIUrl":"10.1016/j.bioelechem.2026.109229","url":null,"abstract":"<div><div>Azo dyes, containing one or more azo bonds (–N=N–), are widely used but pose environmental and health risks due to their toxicity and resistance to degradation. Bioelectrochemical systems (BESs) offer a potential approach for their reductive degradation, yet the role of molecular structure in degradation remains unclear. In this study, nine representative azo dyes were examined to access how substituent type and position affect degradation kinetics and electron transfer under controlled cathodic potentials in BESs. Electron-withdrawing substituents (e.g., –SO<sub>3</sub><sup>−</sup>, –NO<sub>2</sub>) and o−/m- substitution enhanced azo bond cleavage, while p-substitution or steric hindered degradation. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) revealed that higher reduction currents and lower charge-transfer resistance correlated with faster degradation. Quantitative structure-activity relationship (QSAR) analysis identified that the –N=N– group and other molecular features such as atom count, are key determinants of azo dyes removal. Experimental and theoretical calculations showed that molecular structure regulates the electron transfer efficiency from electrode to dye by affecting the electron density and steric hindrance of the azo bond, thereby determining degradation kinetics. This study deepened the influence of the molecular structure on azo dyes bioelectrochemical removal, and provided optimized guidance for the treatment of wastewater containing azo dyes by BESs.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"170 ","pages":"Article 109229"},"PeriodicalIF":4.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered LaBi₃O₆ nanosheet interface enabling robust and ultrasensitive detection of carcinoembryonic antigen 经过改造的LaBi₃O₆纳米片接口，能够对癌胚抗原进行稳健和超灵敏的检测

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-08-01 Epub Date: 2026-02-07 DOI: 10.1016/j.bioelechem.2026.109245

Chengyi Lu , Minjie Yang , Peiwu Chen , Hongyi Zhang , Shi Tang , Ling Zha , Ying Huang , Dong Sun , Ruizhuo Ouyang , Yuqin Jiang , Yuqing Miao , Baolin Liu

{"title":"Engineered LaBi₃O₆ nanosheet interface enabling robust and ultrasensitive detection of carcinoembryonic antigen","authors":"Chengyi Lu , Minjie Yang , Peiwu Chen , Hongyi Zhang , Shi Tang , Ling Zha , Ying Huang , Dong Sun , Ruizhuo Ouyang , Yuqin Jiang , Yuqing Miao , Baolin Liu","doi":"10.1016/j.bioelechem.2026.109245","DOIUrl":"10.1016/j.bioelechem.2026.109245","url":null,"abstract":"<div><div>Cancer early detection demands highly sensitive, cost-effective, and reliable sensing platforms. Herein, we report the synthesis of lanthanum bismuth oxide nanosheets (LaBi<sub>3</sub>O<sub>6</sub> NSs) via a simple sol–gel method and their innovative application in constructing a label-free electrochemical immunosensor for the detection of carcinoembryonic antigen (CEA). The LaBi<sub>3</sub>O<sub>6</sub> NSs serve as an excellent matrix offering a large specific surface area, high conductivity, and rich active sites, significantly enhancing electron transfer and biomolecular immobilization. The fabricated immunosensor demonstrates outstanding analytical performance: a wide linear range from 0.1 to 1000 ng mL<sup>−1</sup>, an ultra-low detection limit of 56.2 pg mL<sup>−1</sup>, and high selectivity against common interferents. It also exhibits remarkable reproducibility (RSD < 5%) and stability (retaining 90% activity after 15 days). Practical applicability was confirmed through successful CEA detection in human serum samples, with recovery rates of 98.8–101.2% and excellent agreement with standard methods. This work not only presents a novel bismuth-based nanomaterial for biosensing but also provides a robust, eco-friendly, and highly efficient strategy for clinical cancer biomarker detection. The proposed platform holds great promise for point-of-care diagnostics and opens new avenues for the development of next-generation electrochemical immunosensors.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"170 ","pages":"Article 109245"},"PeriodicalIF":4.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146170110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving the efficiency of tumor treating fields delivery in tumor cell proliferation inhibition through conductive electrodes 导电电极抑制肿瘤细胞增殖，提高肿瘤治疗电场传递效率。

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-08-01 Epub Date: 2026-02-01 DOI: 10.1016/j.bioelechem.2026.109244

Yuchen Tang , Hongbo Su , Chunxiao Chen , Kaida Liu , Xing Li

{"title":"Improving the efficiency of tumor treating fields delivery in tumor cell proliferation inhibition through conductive electrodes","authors":"Yuchen Tang , Hongbo Su , Chunxiao Chen , Kaida Liu , Xing Li","doi":"10.1016/j.bioelechem.2026.109244","DOIUrl":"10.1016/j.bioelechem.2026.109244","url":null,"abstract":"<div><div>In current clinical practice, Tumor Treating Fields (TTFields) are delivered through insulated ceramic electrode arrays via capacitive coupling, which limits the efficiency of electric field energy transfer. In this study, we propose a new TTFields delivery mode based on conductive electrodes, termed conductive TTFields (Ce-TTFields), to enhance energy delivery efficiency. Electromagnetic-field and lumped-circuit analysis was conducted to understand the underlying mechanisms of TTFields delivery and proposed the novel Ce-TTFields concept. We designed and fabricated a Ce-TTFields culture dish and conducted electromagnetic simulations, in vitro electric-field measurements, and U-87 glioma cell proliferation assays to validate this novel concept. Simulation and test experimental results demonstrate that Ce-TTFields produce stronger electric field intensities in the cell culture and the simulated human brain model compared with conventional insulated electrodes under the same driving voltage. U-87 glioma cell proliferation assays consistently confirmed that the U-87 glioma inhibition efficiency is enhanced by Ce-TTFields, indicating significantly improved energy-delivery efficiency. These findings suggest that Ce-TTFields may help optimize TTFields treatment protocols and offer a promising direction for developing more efficient, lightweight, and cost-effective TTFields therapeutic systems.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"170 ","pages":"Article 109244"},"PeriodicalIF":4.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biofilm inhibition and microbial corrosion protection of carbon steel by a green surfactant based novel ZnO nanofluid 基于绿色表面活性剂的新型ZnO纳米流体对碳钢的生物膜抑制和微生物腐蚀保护。

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-08-01 Epub Date: 2026-02-02 DOI: 10.1016/j.bioelechem.2026.109240

Lata Pasupulety , Mohamed I. Zaki , Lakshmi A.N.

{"title":"Biofilm inhibition and microbial corrosion protection of carbon steel by a green surfactant based novel ZnO nanofluid","authors":"Lata Pasupulety , Mohamed I. Zaki , Lakshmi A.N.","doi":"10.1016/j.bioelechem.2026.109240","DOIUrl":"10.1016/j.bioelechem.2026.109240","url":null,"abstract":"<div><div>A stable nanofluid containing ZnO nanoparticles (ZnO NPs) and a plant-based surfactant, soapnut, was synthesized and its composite nature established by thermogravimetry, Fourier-transform infrared spectroscopy, scanning electron microscopy, and energy dispersive X-ray (EDX) analyses. Its effectiveness as a microbially induced corrosion (MIC) inhibitor was investigated. Gravimetric and electrochemical techniques-potentiodynamic polarisation and electrochemical impedance spectroscopy, revealed a reduction in corrosion rates (from 31.63 to 1.17 mils/year), achieving an inhibition efficiency of up to 97% at a low nanofluid concentration of 4 vol%. Both the components- ZnO NPs and the soapnut extract (SN) exhibited pronounced bactericidal activity, leading to effective suppression of biofilm formation, as confirmed by biofilm inhibition assays (78%) and confocal laser scanning microscopy imaging. The amphiphilic nature of SN, together with the high surface availability of ZnO NPs, enhanced inhibitor adsorption on the metal surface which was supported by adsorption studies and surface analyses- field-emission scanning electron microscopy coupled with EDX. In the synthesized composite, SN acting as a ligand, prevented aggregation of ZnO NPs and thereby improved surface coverage and stability. Overall, the synergistic interaction between SN and ZnO NPs produced an environmentally benign nanofluid with strong potential for mitigating MIC in petrochemical pipeline systems.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"170 ","pages":"Article 109240"},"PeriodicalIF":4.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146136969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RNA aptamer-modified gold-plated carbon fiber microelectrodes for selective dopamine sensing RNA适体修饰的镀金碳纤维微电极选择性多巴胺传感。

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-08-01 Epub Date: 2026-01-14 DOI: 10.1016/j.bioelechem.2026.109225

Christian Meinert Bache , Michael E.J. López Mujica , Stepan Shipovskov , Andrew Ewing , Elena E. Ferapontova

{"title":"RNA aptamer-modified gold-plated carbon fiber microelectrodes for selective dopamine sensing","authors":"Christian Meinert Bache , Michael E.J. López Mujica , Stepan Shipovskov , Andrew Ewing , Elena E. Ferapontova","doi":"10.1016/j.bioelechem.2026.109225","DOIUrl":"10.1016/j.bioelechem.2026.109225","url":null,"abstract":"<div><div>Specific electroanalysis of neurotransmitters in the brain, bloodstream, cerebrospinal fluid (CSF), or at the cellular level critically depends on the availability of miniaturized electrodes for aptasensing. Yet, with electrode miniaturization, sensitivity of analysis and limits of detection (LOD) can be compromised. Here, we adapted the RNA-aptamer-based macroelectrode assay for dopamine to the microelectrode format, by using gold-plated carbon fiber microelectrodes (CFE), modified via thiol chemistry with cysteamine and an RNA aptamer, for specific dopamine detection. The sensitivity of analysis with gold-plated cylindrical microelectrodes improved 90-fold, to 9.75 μA μM<sup>−1</sup> cm<sup>−2</sup> (at +0.100 V) vs. 108 nA μM<sup>−1</sup> cm<sup>−2</sup> (at optimal +0.185 V) shown with gold disk macroelectrodes, with LOD being 60 and 100 nM, in PBS and in artificial CSF, respectively. Yet, epinephrine interfered at 0.1 V. At 0.05 V, the sensitivity dropped to 4.62 μA μM<sup>−1</sup> cm<sup>−2</sup> but the RNA-aptamer/cysteamine-modified CFEs demonstrated excellent selectivity for dopamine over epinephrine, norepinephrine, L-DOPA, DOPAC, and uric and ascorbic acids. These findings suggest a straightforward strategy for constructing biospecific aptamer-based microelectrodes. However, in matrices more complex than CSF, such as serum, dopamine oxidation was inhibited. Therefore, effective monitoring of dopamine levels in blood using aptamer microelectrodes will likely require the use of protective membranes.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"170 ","pages":"Article 109225"},"PeriodicalIF":4.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146008106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A dual-signal electrochemical aptasensor based on rGO@MoS2-Fc nanozyme for sensitive detection of low-density lipoprotein 基于rGO@MoS2-Fc纳米酶的双信号电化学感应传感器用于低密度脂蛋白的灵敏检测

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-06-01 Epub Date: 2025-12-24 DOI: 10.1016/j.bioelechem.2025.109206

Zhide Zhou , Haimei Li , Xiaohua Deng , Yuxuan Shi , Jiahang Huang , Yu Zhou , Xiaohong Tan , Jintao Liang , Guiyin Li

{"title":"A dual-signal electrochemical aptasensor based on rGO@MoS2-Fc nanozyme for sensitive detection of low-density lipoprotein","authors":"Zhide Zhou , Haimei Li , Xiaohua Deng , Yuxuan Shi , Jiahang Huang , Yu Zhou , Xiaohong Tan , Jintao Liang , Guiyin Li","doi":"10.1016/j.bioelechem.2025.109206","DOIUrl":"10.1016/j.bioelechem.2025.109206","url":null,"abstract":"<div><div>Cardiovascular disease (CVD) is the leading cause of death worldwide, particularly in the developing countries. Low-density lipoprotein (LDL), a critical biomarker for the early detection and intervention of CVD, provides valuable diagnostic and prognostic information for CVD. Herein, we developed a dual-signal electrochemical aptasensor for LDL detection based on a peroxidase-like nanozyme composed of reduced graphene oxide@molybdenum disulfide-ferrocenecarboxylic acid (rGO@MoS<sub>2</sub>-Fc). In the process of electrochemical testing, rGO@MoS<sub>2</sub>-Fc achieved the synergistic amplification of electrochemical signals both an enhanced Fc oxidation current detected by differential pulse voltammetry (DPV), and an increased hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) decomposition current via amperometric current-time (i-t) analysis. The DPV signal, corresponding to Fc oxidation, exhibited a logarithmic linear response over a broad LDL concentration ranged from 0.001 to 100.0 μg/mL, with a limit of detection (LOD) as low as 0.91 ng/mL. Meanwhile, the i-t signal, arising from H<sub>2</sub>O<sub>2</sub> decomposition, displayed a linear range of 1.0 to 80.0 μg/mL and an LOD of 0.80 μg/mL. This dual-signal strategy exhibited good selectivity, reproducibility, stability and self-calibration capability. Analysis of human serum samples showed that the proposed strategy is expected to be a powerful method for early-stage CVD diagnosis and clinical management.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"169 ","pages":"Article 109206"},"PeriodicalIF":4.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145836795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly sensitive detection of HER2 DNA based on enzyme-free target-triggered biped DNA walker combined with ARGET ATRP 基于无酶靶触发双足DNA行走器联合ARGET ATRP的HER2 DNA高灵敏度检测。

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-06-01 Epub Date: 2025-12-13 DOI: 10.1016/j.bioelechem.2025.109196

Xiaohui Zhai, Xiaohua He, Fengzhi Li, Yaping Zhang, Huaixia Yang, Yanju Liu

{"title":"Highly sensitive detection of HER2 DNA based on enzyme-free target-triggered biped DNA walker combined with ARGET ATRP","authors":"Xiaohui Zhai, Xiaohua He, Fengzhi Li, Yaping Zhang, Huaixia Yang, Yanju Liu","doi":"10.1016/j.bioelechem.2025.109196","DOIUrl":"10.1016/j.bioelechem.2025.109196","url":null,"abstract":"<div><div>Breast cancer (BC) is one of the most common cancers in women and a major global health challenge. Human epidermal growth factor receptor 2 (HER2) an important biomarker of BC, and its early detection is of great significance for the early diagnosis and treatment of BC patients. Here, a bipedal DNA walker was synthesized using an enzyme-free target-triggered catalytic hairpin assembly (CHA) strategy that is straightforward. And then an electrochemical DNA nanobiosensor for the ultrasensitive detection of HER2 was constructed based on the bipedal DNA walker and activators regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP), an electron-transfer regeneration catalyst with signal-amplifying effects. While moving, DNA walker operates without enzymatic involvement, consequently escaping enzymatic degradation in unfavorable environmental settings. The ARGET ATRP reaction introduces a large number of polymers into the sensing system, thus amplifying the signal. Notably, the method has a low detection limit of 0.04 pM and a wide detection range of 10<sup>−1</sup> pM to 10<sup>2</sup> nM. In addition, the biped DNA walker biosensor showed high selectivity and good reproducibility. More importantly, this strategy can be used for the detection of HER2 in human serum, proving its high practical value in biological analysis.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"169 ","pages":"Article 109196"},"PeriodicalIF":4.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145766675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functionalized laser-induced graphene enabled ultrasensitive electroimmunoassay for rapid hepatitis B virus detection 功能化激光诱导石墨烯超灵敏电免疫分析法用于乙型肝炎病毒的快速检测

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-06-01 Epub Date: 2025-11-22 DOI: 10.1016/j.bioelechem.2025.109179

Akkapol Suea-Ngam , Tidawan Ngamyoo , Orawon Chailapakul , Nadnudda Rodthongkum , Pisit Tangkijvanich , Pumidech Puthongkham

{"title":"Functionalized laser-induced graphene enabled ultrasensitive electroimmunoassay for rapid hepatitis B virus detection","authors":"Akkapol Suea-Ngam , Tidawan Ngamyoo , Orawon Chailapakul , Nadnudda Rodthongkum , Pisit Tangkijvanich , Pumidech Puthongkham","doi":"10.1016/j.bioelechem.2025.109179","DOIUrl":"10.1016/j.bioelechem.2025.109179","url":null,"abstract":"<div><div>Hepatitis B virus (HBV) infection remains a major global health challenge, necessitating the development of rapid, sensitive, and cost-effective diagnostics for disease and public health management. Herein, a high-performance electrochemical immunosensor for the ultratrace detection of hepatitis B surface antigen (HBsAg) is presented, leveraging laser-induced graphene (LIG) to address critical limitations of conventional diagnostics. A facile CO<sub>2</sub> laser process fabricates a porous, three-electrode graphene sensor on polyimide, which is subsequently functionalized via electrochemical oxidation to introduce carboxylic groups for covalent antibody immobilization. The assay operates on the steric-hindrance principle, where immunocomplex formation impedes redox probe diffusion, quantifiable via square wave voltammetry. The platform demonstrates exceptional analytical performance: a wide linear range (1 × 10<sup>−4</sup> to 1 × 10<sup>1</sup> ng mL<sup>−1</sup>), an ultra-low detection limit of 0.04 pg mL<sup>−1</sup> in buffer, and robust functionality in human serum with detection limit of 0.18 pg mL<sup>−1</sup>. It also exhibits outstanding selectivity against viral interferents and strong storage stability over 30 days. Combining laboratory-level sensitivity with point-of-care practicality, this biosensor offers a promising tool for early HBV screening, particularly in resource-limited settings.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"169 ","pages":"Article 109179"},"PeriodicalIF":4.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145616677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The journey toward microbial photo-electrochemical biosensors: harnessing photosynthetic organisms for next-generation environmental sensing 迈向微生物光电化学生物传感器之旅：利用光合生物进行下一代环境传感。

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-06-01 Epub Date: 2025-12-22 DOI: 10.1016/j.bioelechem.2025.109205

Rosa Maria Matteucci , Elisabetta Fanizza , Matteo Grattieri

{"title":"The journey toward microbial photo-electrochemical biosensors: harnessing photosynthetic organisms for next-generation environmental sensing","authors":"Rosa Maria Matteucci , Elisabetta Fanizza , Matteo Grattieri","doi":"10.1016/j.bioelechem.2025.109205","DOIUrl":"10.1016/j.bioelechem.2025.109205","url":null,"abstract":"<div><div>The urgent need for cost-effective and reliable environmental monitoring systems has sparked interest in developing innovative biosensing platforms. Among these, microbial photoelectrochemical biosensors, which leverage the unique properties of photosynthetic microorganisms, have emerged as promising tools for environmental analysis. This perspective examines recent advances in microbial photoelectrochemical biosensor technology, focusing on the fundamental mechanisms of photosynthetic organisms and their integration with materials science. The current limitations in the implementation of microbial photoelectrochemical biosensors will be discussed, highlighting emerging solutions through nanomaterial integration and exploring how these biological systems can be engineered to detect environmental pollutants. Accordingly, a roadmap to transform these biological systems into practical environmental monitoring tools is presented, paving the way to unprecedented opportunities for the development of sustainable, sensitive, and targeted microbial biosensing platforms for real-world pollutant detection. To fully utilize the promise of these next-generation biosensing platforms, future research should concentrate on enhancing signal transduction and its stability over time, optimizing biointerface engineering, and encouraging interdisciplinary collaboration.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"169 ","pages":"Article 109205"},"PeriodicalIF":4.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145861379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facile integration of NiO nanoflowers and Ketjen Black as a robust electrochemical aptasensing platform for tramadol detection in human biofluids NiO纳米花与Ketjen Black的快速集成作为人体生物体液中曲马多检测的强大电化学适体感应平台。

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-06-01 Epub Date: 2025-12-15 DOI: 10.1016/j.bioelechem.2025.109199

Seyed Ali Akbar Sajadi, Zeynab Khorablou

{"title":"Facile integration of NiO nanoflowers and Ketjen Black as a robust electrochemical aptasensing platform for tramadol detection in human biofluids","authors":"Seyed Ali Akbar Sajadi, Zeynab Khorablou","doi":"10.1016/j.bioelechem.2025.109199","DOIUrl":"10.1016/j.bioelechem.2025.109199","url":null,"abstract":"<div><div>Given the high potential for abuse and significant toxicological risks of tramadol (TRM), accurate monitoring of this opioid in human biofluids is of critical medico-legal importance. Despite substantial progress in analytical technologies, few biosensing platforms successfully combine high selectivity, operational simplicity, and clinical applicability. Herein, we report a novel electrochemical aptasensor based on differential pulse voltammetry (DPV), constructed using a hybrid nanocomposite of Ketjen Black (KB) and structurally disrupted nickel oxide nanoflowers (NiO NFs). The synergistic integration of conductive KB and defect-rich NiO nanostructures provides a robust matrix for stable aptamer immobilization and efficient signal amplification. The proposed aptasensor exhibited an exceptionally broad linear range (10 pM–750 nM) with an ultra-low limit of detection of 37 pM. It maintained excellent performance in complex biological matrices, including human serum, urine and saliva, offering high recovery rates and negligible cross-reactivity with structurally related opioids. Importantly, the fabrication strategy aligns with the principles of green analytical chemistry, utilizing microliter-scale reagent volumes, avoiding hazardous chemicals, and enabling a one-pot, scalable process. Collectively, these combined features underscore the platform's practical utility and ecological soundness, making it highly promising for real-time TRM detection in both clinical diagnostics and forensic investigations.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"169 ","pages":"Article 109199"},"PeriodicalIF":4.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145779722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0