Bioelectrochemistry最新文献_第2页

Bioluminescence-based electrochemical sensor for dual-mode direct hydrocarbon detection in saline water utilizing Photobacterium leiognathi and d-luciferin-modified au-SPE 利用光杆菌和d-荧光素修饰的au-SPE进行盐水中碳氢化合物双模直接检测的生物发光电化学传感器

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-08-01 Epub Date: 2026-01-24 DOI: 10.1016/j.bioelechem.2026.109233

Arash Rasti , Muhamad Afiq Aziz , Zaira Zaman Chowdhury , Sook Mei Khor

{"title":"Bioluminescence-based electrochemical sensor for dual-mode direct hydrocarbon detection in saline water utilizing Photobacterium leiognathi and d-luciferin-modified au-SPE","authors":"Arash Rasti , Muhamad Afiq Aziz , Zaira Zaman Chowdhury , Sook Mei Khor","doi":"10.1016/j.bioelechem.2026.109233","DOIUrl":"10.1016/j.bioelechem.2026.109233","url":null,"abstract":"<div><div>Early detection of hydrocarbon pollution in saline ecosystems faces challenges due to their complexity and the limitations of current detection methods. Salinity, temperature variations, the presence of other organic matter, and weathering processes hinder the effectiveness of traditional techniques, while the cost and complexity of some advanced detection technologies limit their widespread application. In this study, a gold screen-printed electrode (Au-SPE) modified with d-luciferin was developed to monitor the metabolic response of <em>Photobacterium leiognathi</em> to hexane and aromatic hydrocarbons in saline water and seawater. The sensor works by capturing adenosine triphosphate (ATP)-dependent electron release associated with bacterial bioluminescence, which varies according to the type of hydrocarbon. D-luciferin was immobilized on the Au-SPE via a self-assembled monolayer using ethylenediamine and EDC/NHS coupling to create a biocompatible interface. CV analysis revealed time-dependent shifts of anodic and cathodic peaks from −0.5 V to +0.5 V. The presence of aromatic hydrocarbons increased both bioluminescence light emission and current, indicating metabolic stimulation. In contrast, hexane suppressed bioluminescence and decreased current, indicating metabolic inhibition. These distinct responses enable rapid and selective differentiation between different types of hydrocarbons. The developed biosensor exhibits strong potential for real-time monitoring of oil contamination and assessing water quality in saline ecosystems.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"170 ","pages":"Article 109233"},"PeriodicalIF":4.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resourceful utilization of Bougainvillea horticultural waste for synchronous degradation and power generation in MFCs 九重葛园艺废弃物在mfc同步降解和发电中的资源化利用

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-08-01 Epub Date: 2026-01-24 DOI: 10.1016/j.bioelechem.2026.109237

Yeling Zhou, Yicheng Wu, Bingjun Shu, Feipeng Xu

{"title":"Resourceful utilization of Bougainvillea horticultural waste for synchronous degradation and power generation in MFCs","authors":"Yeling Zhou, Yicheng Wu, Bingjun Shu, Feipeng Xu","doi":"10.1016/j.bioelechem.2026.109237","DOIUrl":"10.1016/j.bioelechem.2026.109237","url":null,"abstract":"<div><div>The disposal of horticultural waste derived from <em>Bougainvillea</em> species poses substantial environmental challenges in coastal cities of southeastern China. This study innovatively employs <em>Bougainvillea</em> horticultural waste (BHW) as the main substrate in microbial fuel cells (MFCs) for simultaneous organic degradation and bioenergy recovery, with an acid-pretreated BHW-fed MFC (MFC-ABG) included for comparison. Results indicated that the untreated BHW-fed MFC (MFC-BG) achieved a peak voltage of 0.401 V and sustained operation for 19 days, coupled with 78.7% polysaccharide removal. Metagenomics showed that MFC-BG significantly enriched electroactive <em>Geobacter</em> (29.39%) and hydrolytic <em>Proteiniphilum</em> (2.69%), driving lignocellulose decomposition through oxidative auxiliary enzymes (AA4/AA6). Comparatively, MFC-ABG achieved an enhanced voltage of 0.706 V and a high polysaccharide reduction efficiency of 85.6%, benefits attributable to acid-induced substrate solubilization and glycoside hydrolase (GH)-dominated enzymatic shifts. Although microbial community diversity declined in both MFC systems, MFC-BG retained a higher species richness (MFC-BG: Sobs = 28,209; MFC-ABG: Sobs = 25,746), reflecting the adaptive resilience of the associated microbial community. This study confirms BHW as a viable feedstock for MFCs and clarifies the microbial mechanisms underlying the synergistic coupling of substrate degradation and electron transfer</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"170 ","pages":"Article 109237"},"PeriodicalIF":4.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering the redox signature and reactivity of wines with differential pulse voltammetry 用差分脉冲伏安法破译葡萄酒的氧化还原特征和反应性。

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-08-01 Epub Date: 2026-02-03 DOI: 10.1016/j.bioelechem.2026.109239

Alice L. Dauphin, Samuel Guilbault, Stéphane Arbault

{"title":"Deciphering the redox signature and reactivity of wines with differential pulse voltammetry","authors":"Alice L. Dauphin, Samuel Guilbault, Stéphane Arbault","doi":"10.1016/j.bioelechem.2026.109239","DOIUrl":"10.1016/j.bioelechem.2026.109239","url":null,"abstract":"<div><div>Phenolic compounds, including polyphenols and tannins, contribute to the sensory characteristics of wines and help protect them against oxidation through their reductive properties. Linear or cyclic voltammetry methods were previously reported to monitor specific wine phenolic compounds and decipher on their antioxidant activity. Pulsed voltammetry methods improve selectivity and accuracy and recently raised further interest for wine studies. We report the use of differential pulse voltammetry-DPV to characterize each wine redox profile and reactivity. Without any prior solution preparation, DPV analysis in wine provides curves displaying several oxidation peaks assigned to families of reductive phenolic acids or anthocyanins, flavonoids and tannins. Wine redox profiles vary as a function of their color, winemaking process, grape variety, vintage, etc. DPV and cyclic voltammetry-CV allowed further to study wines when changing their composition in caffeic and gallic acids, demonstrating the reactivity between phenolic species. Finally, the oxidation of a red wine under air and oxygen-saturated conditions was monitored by colorimetric and DPV analyses, directly showing the correlation between color browning, decrease of reductive ability and dissolved oxygen level. This work demonstrates the effectiveness of DPV in directly deciphering the oxidation-reduction processes occurring during winemaking and wine ageing.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"170 ","pages":"Article 109239"},"PeriodicalIF":4.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146136935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cu-enhanced microbiological corrosion resistance of CoNiV medium-entropy alloy cu增强CoNiV中熵合金的耐微生物腐蚀性能。

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-08-01 Epub Date: 2026-01-23 DOI: 10.1016/j.bioelechem.2026.109232

Zihao Wang , Xiaobao Zhou , Zuchuan Zhang , Lin Liu , Cong Li , Boxin Wei , Tangqing Wu

{"title":"Cu-enhanced microbiological corrosion resistance of CoNiV medium-entropy alloy","authors":"Zihao Wang , Xiaobao Zhou , Zuchuan Zhang , Lin Liu , Cong Li , Boxin Wei , Tangqing Wu","doi":"10.1016/j.bioelechem.2026.109232","DOIUrl":"10.1016/j.bioelechem.2026.109232","url":null,"abstract":"<div><div>Microbiologically influenced corrosion (MIC) critically compromises the integrity of metal structures. This study investigates the effect of copper on the MIC behavior of CoNiV–Cu<sub><em>x</em></sub> medium-entropy alloys (MEAs) in <em>Desulfovibrio vulgaris</em> environments. In sterile medium, increasing Cu reduced the combined film and charge transfer resistance, whereas in inoculated medium, the trend reversed. After 360 h, CoNiV–Cu<sub>10</sub> MEA formed a protective oxide layer (<em>δ</em><sub>eff</sub> = 0.912 nm), three times thicker than CoNiV MEA. The corrosion current and passivation current were significantly lower in Cu-rich alloys under MIC. The apparently adverse effect of Cu in sterile conditions was associated with modifications in passive film defect chemistry and charge-transfer processes, whereas under MIC conditions, Cu addition enhanced passive film stability, suppressed microbial adhesion, and improved MIC resistance. These findings provide insight for designing Cu-alloyed MEAs with superior performance in MIC environments.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"170 ","pages":"Article 109232"},"PeriodicalIF":4.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146058377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced microalgae-based microbial fuel cell performance using single-chamber photocatalyst air-cathode modification 利用单室光触媒空气阴极改性提高微藻微生物燃料电池性能

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-08-01 Epub Date: 2026-01-02 DOI: 10.1016/j.bioelechem.2026.109215

Hnin Thandar Myint , Yuka Yokoi , Lulu'atul Hamidatu Ulya , Chairat Treesubsuntorn , Yordkhuan Tachapermpon

{"title":"Enhanced microalgae-based microbial fuel cell performance using single-chamber photocatalyst air-cathode modification","authors":"Hnin Thandar Myint , Yuka Yokoi , Lulu'atul Hamidatu Ulya , Chairat Treesubsuntorn , Yordkhuan Tachapermpon","doi":"10.1016/j.bioelechem.2026.109215","DOIUrl":"10.1016/j.bioelechem.2026.109215","url":null,"abstract":"<div><div>To address the global challenges of fossil fuel depletion and climate change, attention has turned to alternative energy sources. Photosynthetic microalgae-based microbial fuel cells (AMFC) have emerged as a promising solution, utilizing bacteria to convert organic matter into energy. This study explores the improvement of electricity generation using single-chamber microalgae-based microbial fuel cells with a modified graphite-photocatalyst air cathode. Modified graphite air cathode using graphite-photocatalyst (TiO<sub>2</sub> and MnO<sub>2</sub>) was observed to enhance greater power production. The electricity produced by the AMFC system using a 25% TiO<sub>2</sub>-graphite mixture was the best potential air cathode, generating up to 5.56 ± 0.32 mW/m<sup>2</sup>. The higher power density is also obtained using the fabrication of a photocatalyst air cathode. The fabricated air cathode electrocatalyst can play a reasonable cost material for the enriched energy recovery in the AMFC and/or other such electrochemical devices. This study also investigates the power generation performance of algal microbial fuel cells under three electrical configurations: series, parallel, and mixed connection. Parallel connection showed the greatest power density of 23.82 ± 3.72 mW/m<sup>2</sup> among them. However, mixed configuration provided balanced performance, with moderate voltage, current, and power density. From these results, connection type plays an important role in optimizing AMFC performance for specific applications.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"170 ","pages":"Article 109215"},"PeriodicalIF":4.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel label-free electrochemical aptamer sensor based on base mismatch and strand displacement for detection of kanamycin 基于碱基错配和链位移的新型无标记电化学适体传感器检测卡那霉素。

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-08-01 Epub Date: 2026-02-07 DOI: 10.1016/j.bioelechem.2026.109246

Hua Ma , Xia Gu , Hao Yang , Qiuyan Lan , Dandan Wang , Yu Huang , Yanru Fan

{"title":"A novel label-free electrochemical aptamer sensor based on base mismatch and strand displacement for detection of kanamycin","authors":"Hua Ma , Xia Gu , Hao Yang , Qiuyan Lan , Dandan Wang , Yu Huang , Yanru Fan","doi":"10.1016/j.bioelechem.2026.109246","DOIUrl":"10.1016/j.bioelechem.2026.109246","url":null,"abstract":"<div><div>Misuse of kanamycin in animal husbandry has led to serious food safety issues. In this study, a label-free electrochemical aptasensor based on the base mismatch and strand displacement was developed for detection of kanamycin residue in agricultural products. A novel ferrocene-naphthalimide derivative was employed as the electroactive indicator. The effects of complementary DNA (cDNA) probe length, position and number of mismatched bases in aptamer-cDNA duplex on the performance of displacement-based aptasensor were systematically investigated. The experimental results were in well accordance with the molecular simulation results. Under optimal conditions, the aptasensor exhibited good reproducibility, stability, selectivity, and a wide linear range of 1.0 × 10<sup>−10</sup>–1.0 × 10<sup>−4</sup> g/mL, with a LOD of 1.1 × 10<sup>−11</sup> g/mL (S/N = 3). The proposed aptasensor was used to detect kanamycin residues in milk and chicken liver. Satisfactory recoveries and relative standard deviations indicated that the aptasensor was competent for detection of kanamycin residues in agricultural products.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"170 ","pages":"Article 109246"},"PeriodicalIF":4.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146155504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An anti-fouling multifunctional interface enables hierarchical validation and ultrasensitive electrochemical detection of Coxsackievirus A6 specific nucleic acids 一个防污多功能接口，使分层验证和超灵敏的电化学检测柯萨奇病毒A6特异性核酸

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-08-01 Epub Date: 2026-01-26 DOI: 10.1016/j.bioelechem.2026.109242

Shiwei Chen , Xunda Zhou , Wenting Xia , Zhiyi Liu , Chunyu Liu , Ying Huang , Nicole Jaffrezic-Renault , Liang Hu , Yanming Dong , Zhenzhong Guo

{"title":"An anti-fouling multifunctional interface enables hierarchical validation and ultrasensitive electrochemical detection of Coxsackievirus A6 specific nucleic acids","authors":"Shiwei Chen , Xunda Zhou , Wenting Xia , Zhiyi Liu , Chunyu Liu , Ying Huang , Nicole Jaffrezic-Renault , Liang Hu , Yanming Dong , Zhenzhong Guo","doi":"10.1016/j.bioelechem.2026.109242","DOIUrl":"10.1016/j.bioelechem.2026.109242","url":null,"abstract":"<div><div>Coxsackievirus A6 (CVA6) has emerged as the dominant etiological agent of hand, foot and mouth disease worldwide. At present, neither specific antivirals nor effective vaccines are available, creating an urgent need for rapid, low-cost in vitro diagnostics that can interrupt transmission. This study developed an electrochemical biosensor based on a “screening-validation” strategy. It utilizes a MoS<sub>2</sub>/MWCNT/AgNPs three-dimensional highly conductive network as the substrate, tightly anchored with p(NIPAm-<em>co</em>-SBMA) microgel to form a “protective-conductive” synergistic interface. The capture probe is immobilized via Ag<img>S bonds, achieving three integrated functions: signal amplification, anti-contamination, and specific recognition. The detection process occurs in two stages: First, the target nucleic acid sequence generates steric hindrance signals through direct hybridization, enabling rapid initial screening within the 1 fM-100 pM range; For significant initial responses, the <em>Cb</em>Ago protein system is introduced to specifically cleave target PCR products under guide DNA direction. The resulting short-chain products trigger secondary cleavage of surface probes on the electrode, enabling sequence-specific validation. This reduces the detection limit to 26.5 aM, with a linear range spanning 100 aM-10 pM. This layered strategy significantly enhances detection specificity and reliability, establishing a new paradigm for precise viral nucleic acid detection.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"170 ","pages":"Article 109242"},"PeriodicalIF":4.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From data to diagnosis: A comprehensive review of machine learning-driven wearable sensors in healthcare 从数据到诊断：医疗保健中机器学习驱动的可穿戴传感器的全面回顾

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-08-01 Epub Date: 2026-01-12 DOI: 10.1016/j.bioelechem.2026.109228

Meiting Zhao , Rui Liu , Shuang Jin , Binqiao Ren , Qiang Zhang

{"title":"From data to diagnosis: A comprehensive review of machine learning-driven wearable sensors in healthcare","authors":"Meiting Zhao , Rui Liu , Shuang Jin , Binqiao Ren , Qiang Zhang","doi":"10.1016/j.bioelechem.2026.109228","DOIUrl":"10.1016/j.bioelechem.2026.109228","url":null,"abstract":"<div><div>The integration of machine learning (ML) with advanced wearable sensor technologies is revolutionizing healthcare by enabling real-time, intelligent monitoring of physiological parameters such as electrocardiogram (ECG), blood glucose, and respiratory patterns. This review systematically examines the transformative potential of ML-driven biosensors across three core domains: health monitoring, early disease detection, and precision medicine. Key technological advancements—including self-optimizing sensor networks, explainable AI (XAI) architectures, and edge-computing-enabled miniaturized devices—are critically evaluated. Despite rapid progress, the translation of these technologies into clinical practice faces significant challenges, such as data standardization, algorithmic interpretability, privacy concerns, and regulatory hurdles. This paper also discusses emerging trends, including federated learning, quantum machine learning, and neural interfaces, which hold promise for overcoming these barriers. By addressing these challenges and leveraging ongoing interdisciplinary collaborations, ML-enhanced wearable systems are poised to redefine personalized medicine and proactive healthcare delivery on a global scale.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"170 ","pages":"Article 109228"},"PeriodicalIF":4.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145974509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of synthesis temperature of eggshell-derived hydroxyapatite on biofilm formation and microbial fuel cell performance 蛋壳羟基磷灰石合成温度对生物膜形成和微生物燃料电池性能的影响

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-08-01 Epub Date: 2026-01-22 DOI: 10.1016/j.bioelechem.2026.109235

Vasumathi K. , Chin-Tsan Wang

{"title":"Influence of synthesis temperature of eggshell-derived hydroxyapatite on biofilm formation and microbial fuel cell performance","authors":"Vasumathi K. , Chin-Tsan Wang","doi":"10.1016/j.bioelechem.2026.109235","DOIUrl":"10.1016/j.bioelechem.2026.109235","url":null,"abstract":"<div><div>Microbial fuel cells (MFCs) enable simultaneous wastewater treatment and bioelectricity generation, but their performance is often constrained by poor bacterial adhesion and slow anode electron transfer. Hydroxyapatite (HA) can address these limitations; however, most studies rely on commercial HA and rarely examine biowaste-derived sources or synthesis-route effects. In this study, eggshell-derived HA was synthesized via room-temperature precipitation (CHP) and hydrothermal treatment at 250 °C for 3 h (CHH), then blended with carbon to fabricate composite anodes. Dual-chamber MFCs inoculated with <em>Shewanella putrefaciens</em> were evaluated using electrochemical analyses (CV, EIS, polarization) and biofilm characterization (CFU counts, crystal violet staining, SEM). CHH achieved a peak power density of 0.164 W m<sup>−2</sup>, approximately 167% higher than bare carbon and 23–33% higher than carbon and CHP. CHP exhibited slightly lower peak power but superior sustained output over a wider current-density range, attributed to its low-crystallinity structure and rapid early colonization. The results demonstrate that HA nanostructure, governed by synthesis route, directly influences biofilm formation and electron transfer. Overall, eggshell-derived HA anodes significantly enhance MFC performance, establishing a clear synthesis–nanostructure–biofilm–performance relationship.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"170 ","pages":"Article 109235"},"PeriodicalIF":4.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Nernst slope within the Association–Induction Hypothesis framework 联想-归纳假设框架内的能思特斜率

IF 4.5 2区化学

Bioelectrochemistry Pub Date : 2026-08-01 Epub Date: 2026-01-22 DOI: 10.1016/j.bioelechem.2026.109236

Anh L. Duong , Keito Kaida , Kaito Goto , Iori Kojima , Bernard Delalande , Hirohisa Tamagawa

{"title":"The Nernst slope within the Association–Induction Hypothesis framework","authors":"Anh L. Duong , Keito Kaida , Kaito Goto , Iori Kojima , Bernard Delalande , Hirohisa Tamagawa","doi":"10.1016/j.bioelechem.2026.109236","DOIUrl":"10.1016/j.bioelechem.2026.109236","url":null,"abstract":"<div><div>The Goldman–Hodgkin–Katz (GHK) equation provides a quantitative description of the membrane potential, a quantity commonly ascribed to passive and active ion movements through channels and pumps in the plasma membrane. Consequently, the membrane potential is frequently viewed as a hallmark of living cells. In physiology, the Nernst equation is often treated as a simplified version of the GHK equation. The factor <span><math><mrow><mo>−</mo><mi>e</mi><mi>ψ</mi><mo>/</mo><mi>z</mi><mi>k</mi><mi>T</mi></mrow></math></span> (<span><math><mi>z</mi></math></span>: ion valency; <span><math><mi>ψ</mi></math></span>: membrane potential), termed the Nernst slope, serves as a key marker of the Nernst equation’s applicability and of cellular viability. Yet, nonliving systems can also develop potentials that exhibit the same characteristic slope, indicating that the Nernst slope is not necessarily a product of biological activity. An older, largely disregarded physiological model, the Association–Induction Hypothesis (AIH), explains membrane potential generation purely in terms of ion adsorption–desorption phenomena. Within the AIH framework, membrane potentials do not arise from ionic fluxes across the membrane but from equilibria that obey the law of mass action. In this study, we derive the Nernst slope using the AIH framework. This result suggests that the membrane potential may primarily reflect mass-action-determined equilibria rather than active physiological mechanisms.</div></div>","PeriodicalId":252,"journal":{"name":"Bioelectrochemistry","volume":"170 ","pages":"Article 109236"},"PeriodicalIF":4.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0