ACS Sensors最新文献

{"title":"Ti3C2Tx Aerogel-Based Wearable Humidity Sensors with Low Hysteresis and High Linearity for Expiratory Comfort Management","authors":"Yanan Xiao, Qi Pu, Xiaoteng Jia, Tianyi Gu, Yong Liu, Peng Sun, Fangmeng Liu, Geyu Lu","doi":"10.1021/acssensors.4c02338","DOIUrl":"https://doi.org/10.1021/acssensors.4c02338","url":null,"abstract":"Wearable and flexible humidity sensors hold great promise for expiratory comfort management. However, the high hysteresis and poor detection linearity restrict the immediate and accurate detection of humidity. Herein, we have prepared Ti₃C₂T_<i>x</i> MXene/chitosan/polyvinylidene difluoride aerogels with a controllable hydrophobic/hydrophilic surface to regulate the catch/escape behavior of H₂O molecules. The MXene aerogel-based humidity sensor demonstrates low hysteresis (3.2% relative humidity) and a high linear relationship (<i>R</i>² = 0.99). Integrated with a control circuit, an expiratory humidity monitoring system is constructed for nasal comfort management as a humidity switch. The exhaled breath humidity can be automatically regulated during dry exhalation conditions. This wearable humidity sensor enables the real-time monitoring and intelligent control of nasal exhaled humidity. This work represents a new avenue for improving breathing comfort and preventing respiratory diseases.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"54 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal–Organic Frameworks (MOFs)-Based Piezoelectric-Colorimetric Hybrid Sensor for Monitoring Green Leaf Volatiles","authors":"Laxmi Raj Jaishi, Wei Ding, Rick A. Kittelson, Francis Tsow, Xiaojun Xian","doi":"10.1021/acssensors.4c02016","DOIUrl":"https://doi.org/10.1021/acssensors.4c02016","url":null,"abstract":"Green leaf volatiles (GLVs) are organic compounds emitted by plants in response to insect attacks, offering early detection potential. Current GLV detection methods like gas chromatography–mass spectroscopy (GC-MS) are costly and complex and lack real-time monitoring capability. There is an unmet need for affordable and portable sensors with high sensitivity to monitor GLVs in real time. In this study, we developed a novel sensor capable of capturing piezoelectric and colorimetric signals for the sensitive and selective detection of 1-hexanol, a well-known green leaf volatile. We used a piezoelectric micro quartz tuning fork (MQTF) as the multifunctional transducer. The MQTF’s two prongs were coated with a metal–organic framework (MOF)-thymol blue hybrid sensing material, enabling detection through both color change and resonating frequency shift upon 1-hexanol binding. MOFs offer a high surface area and tunable pore size, which enhance sensor sensitivity and selectivity. The sensor’s frequency shift indicates mass change due to 1-hexanol binding to MOFs, while the colorimetric sensing signal relies on thymol blue’s reaction with 1-hexanol. Our test results demonstrate the sensor’s ability to detect 1-hexanol from 62.5 ppb to 250 ppm with high sensitivity and selectivity when the colorimetric and piezoelectric sensing signals are integrated. Due to its compact size, affordability, easy fabrication, wide detection range, and high sensitivity and selectivity, this colorimetric-piezoelectric sensor could serve as an effective tool for early detection of insect herbivore attacks and timely crop protection strategies.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"191 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142713165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transparent TiO2/MoO3 Heterojunction-Based Photovoltaic Self-Powered Triethylamine Gas Sensor with IoT-Enabled Smartphone Interface","authors":"Rahul Suresh Ghuge, Sreelakshmi Madhavanunni Rekha, Hajeesh Kumar Vikraman, Surya Velappa Jayaraman, Mangalampalli S R N Kiran, S Venkataprasad Bhat, Yuvaraj Sivalingam","doi":"10.1021/acssensors.4c02110","DOIUrl":"https://doi.org/10.1021/acssensors.4c02110","url":null,"abstract":"Conventional gas sensors encounter a significant obstacle in terms of power consumption, making them unsuitable for integration with the next generation of smartphones, wireless platforms, and the Internet of Things (IoT). Energy-efficient gas sensors, particularly self-powered gas sensors, can effectively tackle this problem. The researchers are making significant strides in advancing photovoltaic self-powered gas sensors by employing diverse materials and their compositions. Unfortunately, several of these sensors seem complex in fabrication and mainly target oxidizing species detection. To address these issues, we have successfully employed a transparent, cost-efficient solution processed bilayer TiO₂/MoO₃ heterojunction-based photovoltaic self-powered gas sensor with superior VOC sensing capabilities, marking a significant milestone in this field. The scanning Kelvin probe (SKP) measurement reveals the remarkable change in contact potential difference (−23 mV/kPa) of the TiO₂/MoO₃ bilayered film after UV light exposure in a triethylamine (TEA) atmosphere, indicating the highest reactivity between TEA molecules and TiO₂/MoO₃. Under photovoltaic mode, the sensor further demonstrates exceptional sensitivity (∼2.35 × 10^–3 ppm^–1) to TEA compared to other studied VOCs, with an admirable limit of detection (22 ppm) and signal-to-noise ratio (1540). Additionally, the sensor shows the ability to recognize TEA and estimate its composition in a binary mixture of VOCs from a similar class. The strongest affinity of TiO₂/MoO₃ toward the TEA molecule, the lowest covalent bond energy, and the highest electron-donating nature of TEA may be mainly attributed to the highest adsorption between TiO₂/MoO₃ and TEA. We further demonstrate the practical applicability of the TEA sensor with a prototype device connected to a smartphone via the IoT, enabling continuous surveillance of TEA.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"10 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Present and Future of Emerging Catalysts in Gas Sensors for Breath Analysis","authors":"Jong Won Baek, Euichul Shin, Jinho Lee, Dong-Ha Kim, Seon-Jin Choi, Il-Doo Kim","doi":"10.1021/acssensors.4c02464","DOIUrl":"https://doi.org/10.1021/acssensors.4c02464","url":null,"abstract":"To rationalize the noninvasive disease diagnosis by breath analysis, developing a high-performance gas sensor with exceptional sensitivity and selectivity is important to detect trace biomarkers in complex exhaled breath under harsh conditions. Among the various technological innovations, catalyst design and synthesis techniques are the foremost challenges, because gas sensing properties are predominantly determined by surface chemical reactions governed by catalytic activities. Conventional nanoparticle-based catalysts, with their simple structural features, have technical limitations in achieving the requirement for accurate breath analysis. Innovative strategies have been pursued to synthesize unconventional catalyst types with enhanced catalytic capabilities. This Perspective provides a comprehensive overview of recent advancements in catalyst technology for chemiresistive-type gas sensors used in breath analysis. It discusses various emerging catalysts, such as doping catalysts, single-atom catalysts (SACs), bimetallic alloy catalysts, high-entropy alloy (HEA) catalysts, exsolution catalysts, and catalytic filter membranes, along with their unique chemical activation mechanisms that enhance gas sensing properties for detecting target biomarkers in exhaled breath. The review also explores novel strategies for catalyst design, including computational prediction, advanced synthesis techniques, and the integration of sensor arrays with artificial intelligence (AI) to improve diagnostic reliability. By highlighting the crucial role of these emerging catalysts, this review provides valuable insights into the catalytic, synthetic, and analytical aspects that are essential for advancing breath analysis technology.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"98 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142713168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complexation Behavior and Clinical Assessment of Isomeric Calcium Ionophores of ETH 1001 in Polymeric Ion-Selective Membranes","authors":"Yupu Zhang, Junyu Zhou, Tianbao Yang, Xue Li, Ye Zhang, Zejian Huang, Gabriel J. Mattos, Nikolai Yu Tiuftiakov, Yaotian Wu, Jinxu Gao, Yu Qin, Eric Bakker","doi":"10.1021/acssensors.4c01907","DOIUrl":"https://doi.org/10.1021/acssensors.4c01907","url":null,"abstract":"Calcium ions are crucial in numerous physiological processes, and their precise measurement is important for many clinical diagnostics and therapeutic interventions. Traditional detection methods, such as atomic absorption spectroscopy, cannot meet clinical requirements, as they measure total calcium instead of the clinically relevant ionized form (Ca²⁺). Ion-selective electrodes (ISEs) provide a convenient, accurate, and specific method for Ca²⁺ determination. Here, two isomeric calcium ionophores (<i>R</i>,<i>R</i>)-calcium ionophore I, also known as ETH 1001, and (<i>R</i>,<i>S</i>)-calcium ionophore I are synthesized and characterized for the analysis of whole blood samples with the Eaglenos blood gas analyzer (model: EG-i30) equipped with test cartridges containing screen-printed electrodes. (<i>R</i>,<i>R</i>)-Calcium ionophore I demonstrated excellent precision in whole blood samples, achieving an average bias of −2.2% compared with the available gold standard. On the other hand, the (<i>R</i>,<i>S</i>) isomer was not satisfactory, exhibiting a bias of up to −20%. Ion transfer voltammetry at thin membrane films gave information about the complex stoichiometry, complex formation constants, and ion selectivity for the two isomeric ionophores. A stoichiometry of the Ca²⁺-ionophore complex was confirmed to be 1:2 for both ionophores, while the (<i>R</i>,<i>R</i>) isomer gave 3.4 orders of magnitude larger complex formation constants and a modestly higher selectivity. While these data are valuable, the poor performance of membranes containing the (<i>R</i>,<i>S</i>) isomer is not directly apparent from the fundamental binding characteristics. It may be caused by interference from lipophilic blood sample components and/or surface adsorption processes, suggesting that routine selectivity characterizations of membranes containing selective ionophores are insufficient to assess their usefulness in clinical applications.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"65 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142713170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graphene-Enhanced Refreshable Metasurface Expands Analytes of THz Label-Free Sensing and Achieves Picogram Limit of Detection.","authors":"Youxin Chen, Qingkang Wang, Kaiyu Wu","doi":"10.1021/acssensors.4c02077","DOIUrl":"https://doi.org/10.1021/acssensors.4c02077","url":null,"abstract":"<p><p>THz sensing offers unique advantages including strong penetrability, low photon energy, and specific recognition of biomolecules and chemicals. However, current label-free THz sensors all operate below 1 THz, severely limiting applications as many drugs and chemicals vibrate at higher THz frequencies. Moreover, the THz detection of analytes at picogram levels is challenging. Here, a modern graphene-enhanced THz metasurface label-free sensor is presented. Its tunable resonance from ∼1.8 to 2.6 THz matches the fingerprint resonant frequencies of various analytes not currently detectable by label-free THz sensing. Quantitative detection of trace 1,3-DNB (absorbing at ∼2.52 THz) is first achieved with a maximum reflectance sensitivity of ∼10% pmol^-1 and a detection limit of 42 pg. The sensor can also be refreshed, minimizing cost and being more environmentally friendly. Our strategy expands application scenarios of label-free THz sensing, enhancing its potential in fields such as the pharmaceutical industry, environmental monitoring, and security.</p>","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorescent Chemosensors in the Creation of a Commercially Available Continuous Glucose Monitor","authors":"Anthony W. Czarnik, Tony D. James","doi":"10.1021/acssensors.4c02403","DOIUrl":"https://doi.org/10.1021/acssensors.4c02403","url":null,"abstract":"Fully automated insulin delivery (i.e., an artificial pancreas) would revolutionize diabetes disease management, minimize negative secondary disease outcomes, and simultaneously reduce health care costs and system burdens. Continuous glucose monitoring (CGM) is an essential aspect of the artificial pancreas. Abiotic fluorescent chemosensors play a key role in generating long-lived CGM sensors for this purpose. In this Perspective, we detail our initial discoveries of chemosensors for saccharides, as well as the development and advancement of bis((<i>o</i>-aminomethylphenyl)boronic acid)anthracene-based sensors for commercial use. While a few companies have sought to bring a copolymerized diboronic acid CGM sensor to the market, Senseonics is the only one, to date, to have done so. In this case, the system has been approved in the U.S. and Europe to provide accurate CGM for up to 365 days with a single sensor and can be integrated directly with an insulin pump, bringing an artificial pancreas one step closer to realization.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"24 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultralow Potential Cathodic Electrochemiluminescence Aptasensor for Detection of Kanamycin Using Copper Nanoribbons as Coreaction Accelerator.","authors":"Fangfang Chen, Lan Luo, Jixiang Liu, Yukun Xing, Xinya Yang, Yumiao Xue, Xiangyuan Ouyang","doi":"10.1021/acssensors.4c01638","DOIUrl":"10.1021/acssensors.4c01638","url":null,"abstract":"<p><p>An ultralow cathodic potential electrochemiluminescence (ECL) aptasensor was designed, employing DNA nanoribbon template self-assembly copper nanoclusters (DNR-CuNCs) as a novel coreaction accelerator within the luminol-H₂O₂ system for the sensitive detection of kanamycin (KANA). Mechanistic investigations revealed that the DNR-CuNCs preferred to generate highly active hydroxyl radicals by facilitating the reduction of the coreactant H₂O₂ under neutral pH conditions, consequently enhancing cathodic luminescence. By the strong π-π stacking effect of KANA aptamer and graphene as a signal modulation switch, DNR-CuNCs were displaced from the electrode surface due to the affinity of KANA and its aptamer, resulting in the inhibition of the luminol-H₂O₂ system and a decrease in the ECL signal. Under optimal experiments, the aptasensor demonstrated exceptional sensitivity in detecting KANA within the concentration range from 1 × 10^-2 to 5 × 10⁵ pg/mL, with the detection limit as low as 0.18 fg/mL. This innovative strategy provided a novel approach to designing effective ECL emitters for monitoring food safety.</p>","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":" ","pages":"5906-5914"},"PeriodicalIF":8.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142491075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Label-Free Single-Cell Cancer Classification from the Spatial Distribution of Adhesion Contact Kinetics.","authors":"Balint Beres, Kinga Dora Kovacs, Nicolett Kanyo, Beatrix Peter, Inna Szekacs, Robert Horvath","doi":"10.1021/acssensors.4c01139","DOIUrl":"10.1021/acssensors.4c01139","url":null,"abstract":"<p><p>There is an increasing need for simple-to-use, noninvasive, and rapid tools to identify and separate various cell types or subtypes at the single-cell level with sufficient throughput. Often, the selection of cells based on their direct biological activity would be advantageous. These steps are critical in immune therapy, regenerative medicine, cancer diagnostics, and effective treatment. Today, live cell selection procedures incorporate some kind of biomolecular labeling or other invasive measures, which may impact cellular functionality or cause damage to the cells. In this study, we first introduce a highly accurate single-cell segmentation methodology by combining the high spatial resolution of a phase-contrast microscope with the adhesion kinetic recording capability of a resonant waveguide grating (RWG) biosensor. We present a classification workflow that incorporates the semiautomatic separation and classification of single cells from the measurement data captured by an RWG-based biosensor for adhesion kinetics data and a phase-contrast microscope for highly accurate spatial resolution. The methodology was tested with one healthy and six cancer cell types recorded with two functionalized coatings. The data set contains over 5000 single-cell samples for each surface and over 12,000 samples in total. We compare and evaluate the classification using these two types of surfaces (fibronectin and noncoated) with different segmentation strategies and measurement timespans applied to our classifiers. The overall classification performance reached nearly 95% with the best models showing that our proof-of-concept methodology could be adapted for real-life automatic diagnostics use cases. The label-free measurement technique has no impact on cellular functionality, directly measures cellular activity, and can be easily tuned to a specific application by varying the sensor coating. These features make it suitable for applications requiring further processing of selected cells.</p>","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":" ","pages":"5815-5827"},"PeriodicalIF":8.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141854131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Performance Triboelectric Nanogenerator Based on Silk Fibroin-MXene Composite Film for Diagnosing Insomnia Symptoms.","authors":"Xueqiang Tan, Zuyi Huang, Lu Chang, Hairun Pei, Zongchao Jia, Jimin Zheng","doi":"10.1021/acssensors.4c00852","DOIUrl":"10.1021/acssensors.4c00852","url":null,"abstract":"<p><p>In this study, we developed a flexible, biocompatible, and high-output electrical performance triboelectric nanogenerator (TENG) employing a silk fibroin (SF)-MXene composite film (SF-MXene-F) and a PDMS film as the friction layer. The inclusion of MXene in the SF film increased its surface charge density, presenting a practical approach to designing high-performance SF composite film-based TENGs. At a MXene content of 40%, our SF-MXene composite film-based TENG (SF-MXene-FTENG) achieved optimal output electrical performance, featuring a maximum open-circuit voltage (Voc) of 418 V, a maximum short-circuit current (Isc) of 11.6 μA, and a maximum output power density of 9.92 W/m². The Voc and power densities of the SF-MXene-FTENG surpassed previously reported optimal values for SF-based TENGs by 1.6 and 3.8 times, respectively. Furthermore, leveraging the exceptional biocompatibility and light shading performance of TENGs, we designed a wearable smart TENG eye mask capable of diagnosing insomnia symptoms and monitoring sleep quality in real time. The SF-MXene-FTENG holds promising application potential as a wearable electronic device for diagnosing sleep-related diseases.</p>","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":" ","pages":"5782-5791"},"PeriodicalIF":8.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}