ACS Sensors最新文献_第5页

Amorphous Carbon-Loaded WO3 Nanosheet Arrays for ppb-Level NO2 Sensing with Improved Anti-Humidity Property

IF 8.2 1区化学

ACS Sensors Pub Date : 2025-03-18 DOI: 10.1021/acssensors.4c0370110.1021/acssensors.4c03701

Yichao Wang, Xi Li, Chuanxin Ge, Guiwu Liu, Guanjun Qiao and Mingsong Wang*,

引用次数: 0

Amorphous Carbon-Loaded WO3 Nanosheet Arrays for ppb-Level NO2 Sensing with Improved Anti-Humidity Property

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-03-18 DOI: 10.1021/acssensors.4c03701

Yichao Wang, Xi Li, Chuanxin Ge, Guiwu Liu, Guanjun Qiao, Mingsong Wang

引用次数: 0

Rapid Differentiation between Microplastic Particles Using Integrated Microwave Cytometry with 3D Electrodes

IF 8.2 1区化学

ACS Sensors Pub Date : 2025-03-18 DOI: 10.1021/acssensors.4c0326810.1021/acssensors.4c03268

Yagmur Ceren Alatas, Uzay Tefek, Sayedus Salehin, Hashim Alhmoud and M. Selim Hanay*,

{"title":"Rapid Differentiation between Microplastic Particles Using Integrated Microwave Cytometry with 3D Electrodes","authors":"Yagmur Ceren Alatas, Uzay Tefek, Sayedus Salehin, Hashim Alhmoud and M. Selim Hanay*, ","doi":"10.1021/acssensors.4c0326810.1021/acssensors.4c03268","DOIUrl":"https://doi.org/10.1021/acssensors.4c03268https://doi.org/10.1021/acssensors.4c03268","url":null,"abstract":"Rapid identification of microparticles in liquid is an important problem in environmental and biomedical applications such as microplastic detection in water sources and physiological fluids. Existing spectroscopic techniques are usually slow and not compatible with flow-through systems. Here we analyze single microparticles in the 10–24 μm range using a combination of two electronic sensors in the same microfluidic system: a microwave capacitive sensor and a resistive pulse sensor. Together, this integrated sensor system yields an electrical signature of the analyte particles for their differentiation. To simplify data analysis, 3D electrode arrangements were used instead of planar electrodes so that the generated signal is unaffected by the height of the particle in the microfluidic channel. With this platform, we were able to distinguish between polystyrene (PS) and polyethylene (PE) microparticles. We showcase the sensitivity and speed of this technique and discuss the implications for the future application of microwave cytometry technology in the environmental and biomedical fields.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"10 3","pages":"1729–1735 1729–1735"},"PeriodicalIF":8.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acssensors.4c03268","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantification and Mitigation of Site-Preferred Nonspecific Interactions in Single-Nanoparticle Biosensors

IF 8.2 1区化学

ACS Sensors Pub Date : 2025-03-17 DOI: 10.1021/acssensors.4c0357110.1021/acssensors.4c03571

Jiayi Jin, Liwei Wu, Yushi Gao and Guangzhong Ma*,

{"title":"Quantification and Mitigation of Site-Preferred Nonspecific Interactions in Single-Nanoparticle Biosensors","authors":"Jiayi Jin, Liwei Wu, Yushi Gao and Guangzhong Ma*, ","doi":"10.1021/acssensors.4c0357110.1021/acssensors.4c03571","DOIUrl":"https://doi.org/10.1021/acssensors.4c03571https://doi.org/10.1021/acssensors.4c03571","url":null,"abstract":"Understanding the origin and behavior of nonspecific interactions is essential for advancing biosensing technologies. In this study, we investigate nonspecific interactions between a functionalized single nanoparticle (NP) and a sensor surface. The NP, tethered by a single DNA molecule, exhibits flexible motion that allows it to interact with the surface. Using surface plasmon resonance microscopy (SPRM) with nanometer precision, we tracked the motion dynamics of the NP and revealed that nonspecific binding leads to repeated transient trapping at the surface. The NP shows a preference for interacting with a particular site, indicating site-preferred nonspecific interactions. This behavior mimics specific binding events, emphasizing the need to mitigate such effects in biosensors. By systematically varying NP size, ionic strength, solution viscosity, blocking agents, and applying external forces, we identified external force as the most effective factor in reducing such nonspecific interactions. We hope these insights can provide strategies for designing next-generation single-NP and single-molecule biosensors with minimal nonspecific signals, thereby enhancing detection reliability.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"10 3","pages":"2258–2265 2258–2265"},"PeriodicalIF":8.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantification and Mitigation of Site-Preferred Nonspecific Interactions in Single-Nanoparticle Biosensors

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-03-17 DOI: 10.1021/acssensors.4c03571

Jiayi Jin, Liwei Wu, Yushi Gao, Guangzhong Ma

{"title":"Quantification and Mitigation of Site-Preferred Nonspecific Interactions in Single-Nanoparticle Biosensors","authors":"Jiayi Jin, Liwei Wu, Yushi Gao, Guangzhong Ma","doi":"10.1021/acssensors.4c03571","DOIUrl":"https://doi.org/10.1021/acssensors.4c03571","url":null,"abstract":"Understanding the origin and behavior of nonspecific interactions is essential for advancing biosensing technologies. In this study, we investigate nonspecific interactions between a functionalized single nanoparticle (NP) and a sensor surface. The NP, tethered by a single DNA molecule, exhibits flexible motion that allows it to interact with the surface. Using surface plasmon resonance microscopy (SPRM) with nanometer precision, we tracked the motion dynamics of the NP and revealed that nonspecific binding leads to repeated transient trapping at the surface. The NP shows a preference for interacting with a particular site, indicating site-preferred nonspecific interactions. This behavior mimics specific binding events, emphasizing the need to mitigate such effects in biosensors. By systematically varying NP size, ionic strength, solution viscosity, blocking agents, and applying external forces, we identified external force as the most effective factor in reducing such nonspecific interactions. We hope these insights can provide strategies for designing next-generation single-NP and single-molecule biosensors with minimal nonspecific signals, thereby enhancing detection reliability.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"14 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143640234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iron-Supported Asymmetric Iontronic Pressure Sensors with High Sensitivity and Extended Linearity

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-03-16 DOI: 10.1021/acssensors.4c03443

Ke Ma, Senrong Ye, Gengzhe Shen, Baijun Li, Zijun Pan, Chenchen Bian, Zheng Liu, Chi Zhang, Haowei Kong, Haohan Wu, Yeqing Chen, Xin He

{"title":"Iron-Supported Asymmetric Iontronic Pressure Sensors with High Sensitivity and Extended Linearity","authors":"Ke Ma, Senrong Ye, Gengzhe Shen, Baijun Li, Zijun Pan, Chenchen Bian, Zheng Liu, Chi Zhang, Haowei Kong, Haohan Wu, Yeqing Chen, Xin He","doi":"10.1021/acssensors.4c03443","DOIUrl":"https://doi.org/10.1021/acssensors.4c03443","url":null,"abstract":"Iontronic pressure sensors (IPSs) are emerging as promising candidates for integration into wearable electronics and healthcare monitoring systems due to their high sensitivity and low power consumption. However, achieving high sensitivity across a broad linear pressure range remains a significant challenge. This study presents a novel IPS device with an asymmetric sandwich structure, which includes a three-dimensional electrode made of nickel manganese oxide/carbon nanotubes (NMO/CNT) and an embedded iron needles ionic dielectric layer. The proposed device demonstrates exceptional linearity over 1700 kPa, with a sensitivity exceeding 7700 kPa–1. It exhibits rapid response and recovery times in the millisecond range and maintains a consistent capacitive response over 15,000 loading–unloading cycles. Moreover, the device enables noncontact sensing in response to magnetic field variations, broadening its potential applications. The innovative IPS design effectively balances high sensitivity and a wide linear pressure range, rendering it suitable for various applications such as nonverbal communication aids and healthcare monitoring systems.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"13 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iron-Supported Asymmetric Iontronic Pressure Sensors with High Sensitivity and Extended Linearity

IF 8.2 1区化学

ACS Sensors Pub Date : 2025-03-16 DOI: 10.1021/acssensors.4c0344310.1021/acssensors.4c03443

Ke Ma, Senrong Ye, Gengzhe Shen, Baijun Li, Zijun Pan, Chenchen Bian, Zheng Liu, Chi Zhang, Haowei Kong, Haohan Wu, Yeqing Chen and Xin He*,

{"title":"Iron-Supported Asymmetric Iontronic Pressure Sensors with High Sensitivity and Extended Linearity","authors":"Ke Ma, Senrong Ye, Gengzhe Shen, Baijun Li, Zijun Pan, Chenchen Bian, Zheng Liu, Chi Zhang, Haowei Kong, Haohan Wu, Yeqing Chen and Xin He*, ","doi":"10.1021/acssensors.4c0344310.1021/acssensors.4c03443","DOIUrl":"https://doi.org/10.1021/acssensors.4c03443https://doi.org/10.1021/acssensors.4c03443","url":null,"abstract":"Iontronic pressure sensors (IPSs) are emerging as promising candidates for integration into wearable electronics and healthcare monitoring systems due to their high sensitivity and low power consumption. However, achieving high sensitivity across a broad linear pressure range remains a significant challenge. This study presents a novel IPS device with an asymmetric sandwich structure, which includes a three-dimensional electrode made of nickel manganese oxide/carbon nanotubes (NMO/CNT) and an embedded iron needles ionic dielectric layer. The proposed device demonstrates exceptional linearity over 1700 kPa, with a sensitivity exceeding 7700 kPa–1. It exhibits rapid response and recovery times in the millisecond range and maintains a consistent capacitive response over 15,000 loading–unloading cycles. Moreover, the device enables noncontact sensing in response to magnetic field variations, broadening its potential applications. The innovative IPS design effectively balances high sensitivity and a wide linear pressure range, rendering it suitable for various applications such as nonverbal communication aids and healthcare monitoring systems.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"10 3","pages":"2162–2172 2162–2172"},"PeriodicalIF":8.2,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143713830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustainable Electrochemical-Magnetic Biosensor Fabricated from Recycled Materials for Label-Free Detection of SARS-CoV-2 in Human Saliva

IF 8.2 1区化学

ACS Sensors Pub Date : 2025-03-14 DOI: 10.1021/acssensors.4c0317510.1021/acssensors.4c03175

Caio Lenon Chaves Carvalho, Steffane Q. Nascimento, Thiago Bertaglia, Luana C. I. Faria, Erika R. Manuli, Geovana M. Pereira, Welter Cantanhêde da Silva, Carlos M. Costa, Josu Fernández Maestu, Senentxu Lanceros-Méndez, Osvaldo N. Oliveira Jr., Ester C. Sabino and Frank N. Crespilho*,

{"title":"Sustainable Electrochemical-Magnetic Biosensor Fabricated from Recycled Materials for Label-Free Detection of SARS-CoV-2 in Human Saliva","authors":"Caio Lenon Chaves Carvalho, Steffane Q. Nascimento, Thiago Bertaglia, Luana C. I. Faria, Erika R. Manuli, Geovana M. Pereira, Welter Cantanhêde da Silva, Carlos M. Costa, Josu Fernández Maestu, Senentxu Lanceros-Méndez, Osvaldo N. Oliveira Jr., Ester C. Sabino and Frank N. Crespilho*, ","doi":"10.1021/acssensors.4c0317510.1021/acssensors.4c03175","DOIUrl":"https://doi.org/10.1021/acssensors.4c03175https://doi.org/10.1021/acssensors.4c03175","url":null,"abstract":"The COVID-19 pandemic has highlighted the critical need for scalable, rapid, and cost-effective diagnostic solutions, especially in resource-limited settings. In this study, we developed a sustainable magnetic electrochemical biosensor for the mass testing of SARS-CoV-2, emphasizing affordability, environmental impact reduction, and clinical applicability. By leveraging recycled materials from spent batteries and plastics, we achieved a circular economy-based fabrication process with a recyclability rate of 98.5%. The biosensor employs MnFe2O4 nanoparticles functionalized with anti-SARS-CoV-2 antibodies, integrated into a 3D-printed electrochemical device for decentralized testing. Advanced characterization confirmed the biosensor’s robust performance, including high sensitivity (LOD: 3.46 pg mL–1) and specificity, with results demonstrating a 95% correlation to RT-PCR gold standard testing. The cost of materials used per biosensor test is only USD 0.2, making it highly affordable and suitable for large-scale production using additive manufacturing. Key features include simple preparation, rapid response, and reusability, making it ideal for point-of-care diagnostics. Beyond COVID-19, this platform’s modularity allows for adaptation to other viral diseases, offering a versatile solution to global diagnostic challenges. This work highlights the potential of integrating electrochemical sensing with sustainable practices to address healthcare inequities and reduce environmental impact.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"10 3","pages":"1970–1985 1970–1985"},"PeriodicalIF":8.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acssensors.4c03175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustainable Electrochemical-Magnetic Biosensor Fabricated from Recycled Materials for Label-Free Detection of SARS-CoV-2 in Human Saliva

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-03-14 DOI: 10.1021/acssensors.4c03175

Caio Lenon Chaves Carvalho, Steffane Q. Nascimento, Thiago Bertaglia, Luana C. I. Faria, Erika R. Manuli, Geovana M. Pereira, Welter Cantanhêde da Silva, Carlos M. Costa, Josu Fernández Maestu, Senentxu Lanceros-Méndez, Osvaldo N. Oliveira, Jr., Ester C. Sabino, Frank N. Crespilho

{"title":"Sustainable Electrochemical-Magnetic Biosensor Fabricated from Recycled Materials for Label-Free Detection of SARS-CoV-2 in Human Saliva","authors":"Caio Lenon Chaves Carvalho, Steffane Q. Nascimento, Thiago Bertaglia, Luana C. I. Faria, Erika R. Manuli, Geovana M. Pereira, Welter Cantanhêde da Silva, Carlos M. Costa, Josu Fernández Maestu, Senentxu Lanceros-Méndez, Osvaldo N. Oliveira, Jr., Ester C. Sabino, Frank N. Crespilho","doi":"10.1021/acssensors.4c03175","DOIUrl":"https://doi.org/10.1021/acssensors.4c03175","url":null,"abstract":"The COVID-19 pandemic has highlighted the critical need for scalable, rapid, and cost-effective diagnostic solutions, especially in resource-limited settings. In this study, we developed a sustainable magnetic electrochemical biosensor for the mass testing of SARS-CoV-2, emphasizing affordability, environmental impact reduction, and clinical applicability. By leveraging recycled materials from spent batteries and plastics, we achieved a circular economy-based fabrication process with a recyclability rate of 98.5%. The biosensor employs MnFe2O4 nanoparticles functionalized with anti-SARS-CoV-2 antibodies, integrated into a 3D-printed electrochemical device for decentralized testing. Advanced characterization confirmed the biosensor’s robust performance, including high sensitivity (LOD: 3.46 pg mL–1) and specificity, with results demonstrating a 95% correlation to RT-PCR gold standard testing. The cost of materials used per biosensor test is only USD 0.2, making it highly affordable and suitable for large-scale production using additive manufacturing. Key features include simple preparation, rapid response, and reusability, making it ideal for point-of-care diagnostics. Beyond COVID-19, this platform’s modularity allows for adaptation to other viral diseases, offering a versatile solution to global diagnostic challenges. This work highlights the potential of integrating electrochemical sensing with sustainable practices to address healthcare inequities and reduce environmental impact.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"56 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-Molecule Detection via Pore Nanoconfinement of Covalent Organic Frameworks for Surface-Enhanced Raman Scattering

IF 8.9 1区化学

ACS Sensors Pub Date : 2025-03-13 DOI: 10.1021/acssensors.4c02391

Mengya Lv, Xiao Wu, Wen Wang, Dandan Han, Sheng Chen, Yifan Hu, Qidong Zhang, Qiyan Wang, Ronghan Wei

{"title":"Single-Molecule Detection via Pore Nanoconfinement of Covalent Organic Frameworks for Surface-Enhanced Raman Scattering","authors":"Mengya Lv, Xiao Wu, Wen Wang, Dandan Han, Sheng Chen, Yifan Hu, Qidong Zhang, Qiyan Wang, Ronghan Wei","doi":"10.1021/acssensors.4c02391","DOIUrl":"https://doi.org/10.1021/acssensors.4c02391","url":null,"abstract":"Surface-enhanced Raman scattering (SERS) offers significant advantages for single-molecule detection. However, stochastic molecular motion makes it challenging to consistently capture signals from single-molecule binding events, particularly in complex environments. Herein, we propose a novel SERS system via the pore nanoconfinement effect of covalent organic frameworks (COFs) to achieve reliable single-molecule detection. The self-assembled COF thin films on SERS metal substrates (Au/Ag) create a nanogap of 3 nm, allowing electric field enhancement. By precise tuning of the COF shell thickness, a molecular-scale pore volume is formed, effectively trapping individual molecules from molecular aggregates. Furthermore, the strong intermolecular forces within the COF pores significantly enhance the residence time of individual molecules, thereby increasing the probability of detecting single-molecule binding events. This innovative approach ensures consistent and reliable SERS single-molecule detection in complex mixtures, paving the way for advanced applications in biochemical sensing and diagnostics.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"5 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0