ACS Sensors最新文献

{"title":"Oxygen Vacancy Mediated-Bismuth Molybdate/Graphitic Carbon Nitride Type II Heterojunction Chemiresistor for Efficient NH3 Detection at Room Temperature","authors":"Kaidi Wu, Xinzhu Qiu, Yifan Luo, Chao Zhang","doi":"10.1021/acssensors.4c02307","DOIUrl":"https://doi.org/10.1021/acssensors.4c02307","url":null,"abstract":"Metal oxide-based chemiresistive gas sensors are expected to play a significant role in assessing human health and evaluating food spoilage. However, the high operating temperature, insufficient limit of detection (LOD), and long response/recovery time restrict their broad application. Herein, 3D Bi₂MoO₆/2D Eg-C₃N₄ heterocomposites are developed for advanced NH₃ gas sensors with RT operational mode. Utilizing the synergetic engineering of micro-nanostructure, surface oxygen vacancies, and well-defined Type II n–n heterojunctions, BMOCN3 demonstrated superior NH₃ sensing properties at 23 °C, including the high response (S = 13.6 at 10 ppm), fast response/recovery speed (8/30 s), excellent selectivity, and low LOD (166 ppb). Based on the experimental, DFT, and MD studies, the improved sensing performance can be ascribed to accelerated charge transfer, superior redox capacity, and improved adsorption/desorption kinetics. Moreover, the practical application in rapid exhaled NH₃ biomarker detection of the as-fabricated gas sensor was preliminarily verified. This work highlights that the novel synergetic engineering can effectively modulate the electronic structure and charge transfer, offering a rational solution for room temperature chemiresistive gas sensors.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"19 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142763046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Field Deployment of a ppb-Level SO2/NO2 Dual-Gas Sensor System for Agricultural Early Fire Identification","authors":"Gangyun Guan, Qiang Wu, Anqi Liu, Mingquan Pi, Fang Song, Jie Zheng, Yiding Wang, Yu Zhang, Xue Bai, Chuantao Zheng","doi":"10.1021/acssensors.4c02405","DOIUrl":"https://doi.org/10.1021/acssensors.4c02405","url":null,"abstract":"Sulfur dioxide (SO₂) and nitrogen dioxide (NO₂) are chemical indicators of crop straw combustion as well as significant atmospheric pollutants. It is challenging to promptly detect natural “wildfires” during agricultural production, which often lead to uncontrollable and substantial economic losses. Moreover, both “wildfires” and artificial “straw burning” practices pose severe threats to the ecological environment and human health. Consequently, developing sensors capable of rapid and high-precision quantitative analysis of SO₂/NO₂ is essential and urgent for detecting early fires in agricultural activities. Here, we demonstrate an incoherent broadband cavity-enhanced absorption spectroscopy (IBBCEAS) sensing system utilizing a 366 nm ultraviolet light emitting diode, designed for real-time, high-precision monitoring of SO₂ and NO₂ and is used for early fire detection validation. The optical resonant cavity is constructed within a 60 mm cage system mechanical structure, achieving a maximum optical path length of nearly 2 km with a length of ∼460 mm. The output light carrying information about the species and concentration of the analyte molecules is coupled into the miniaturized grating spectrometer via a fiber, and continuous spectral fitting and concentration inversion are performed on the computer. We propose a spectral analysis and concentration inversion model based on an improved particle swarm optimization-support vector machine (IPSO-SVM) algorithm. By discrimination of the absorption spectral characteristics of SO₂/NO₂, we achieve superior prediction accuracy. Experimental results indicate that the detection limits of SO₂ and NO₂ under the optimized averaging time are 77.5 parts per billion by volume (ppbv) and 0.037 ppbv, respectively. The field deployment of the sensor in scenarios such as continuous outdoor air pollution monitoring, in situ combustion feature identification, and early fire mobile detection has demonstrated the superior reliability and sensitivity of this sensor system.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"116 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142760096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intelligent DNA Nanosystem for Broad-Spectrum Oncological Typing and Therapy","authors":"Lina Zhu, Yuxi Zhang, Jiani Ding, Wenjuan Xin, Gao-Chao Fan, Zhi-Ling Song, Peisen Zhang, Xiliang Luo","doi":"10.1021/acssensors.4c02246","DOIUrl":"https://doi.org/10.1021/acssensors.4c02246","url":null,"abstract":"The occurrence of multiple primary cancers in individual patients underscores the need for diagnostic and therapeutic techniques with augmented cancer-targeting selectivity and broad-spectrum antitumor effects. To address this, we develop a quadruple-input-triggered <u>O</u>R-<u>A</u>ND-<u>A</u>ND logic gated oncological nanosystem (OAA). This system employs four cancer-related markers (EpCAM, MUC1, APE1, and miR-21) to generate three distinct fluorescence signals, enabling precise differentiation of various cancer cell lines (MCF-7, HepG2, and HeLa) from normal cells (MCF-10A). Additionally, the OAA system integrates photodynamic therapy (PDT) and gene silencing strategies, allowing selective activation of Ce6 release, miR-21 gene silencing, and VEGFR2 mRNA gene silencing through the OR-AND-AND logic gating mechanism in a cancer-specific manner. This synergetic therapeutic approach induces significant apoptosis in multiple cancer cell lines while sparing normal cells, demonstrating improved cancer-targeting specificity and broad-spectrum versatility. This intelligent platform precisely types and treats diverse cancer cells, powering the future exploration of advanced diagnostic and therapeutic strategies to combat highly heterogeneous diseases.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"13 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142760094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the Chemical Structure of a Self-Assembled Monolayer on the Gas-Sensing Behavior of SnO2 Nanowires","authors":"Hyoungwon Park, Jae-Hun Kim","doi":"10.1021/acssensors.4c02105","DOIUrl":"https://doi.org/10.1021/acssensors.4c02105","url":null,"abstract":"In this study, detailed investigations of the selective sensing capability of semiconducting metal oxide (SMO)-based gas sensors with self-assembled monolayer (SAM) functionalization were conducted. The selective gas-sensing behavior was improved by employing a simple and straightforward postmodification technique using functional SAM molecules. The chemical structure of the SAM molecules promoted interaction between the gas and SAM molecules, providing a gas selective sensing of SnO₂ nanowires (NWs). In addition, a bundle of SnO₂ NWs provided a large surface area that could act as a sensing site. SAM functionalization was confirmed by infrared spectroscopy and thermogravimetric analysis, and the selective gas-sensing behaviors were investigated under different sensing conditions. With variations in the chemical structures of the SAM molecules, the selective gas-sensing behaviors also changed as the corresponding intermolecular interaction forces were different. This integration of selective gas sensing and passivation of a sensing surface provides a straightforward approach for the preferred gas sensing of SnO₂ NWs. Furthermore, owing to the universal binding characteristics of SAM molecules to the metal oxide surface, this approach can be expanded to other SMO-based gas-sensing platforms.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"12 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into Selective Sensitivity of In2O3-CuO Heterojunction Nanocrystals to CH4 over CO and H2: Experiments and First-Principles Calculations","authors":"Shuai Nie, Jing Li, Yunxia He, Xitao Yin","doi":"10.1021/acssensors.4c01435","DOIUrl":"https://doi.org/10.1021/acssensors.4c01435","url":null,"abstract":"Metal oxide semiconductor gas sensors have demonstrated exceptional potential in gas detection due to their high sensitivity, rapid response time, and impressive selectivity for identifying various sorts of gases. However, selectively distinguishing CH₄ from those of CO and H₂ remains a significant challenge. This difficulty primarily stems from the weakly reducing nature of CH₄, which results in a low adsorption response and makes it prone to interference from stronger reducing gases in the surroundings. Herein, we synthesized In₂O₃-<i>x</i>CuO nanocomposites using a hydrothermal method to explore their gas sensing properties toward CH₄, CO, and H₂. Characterization tests confirmed the successful preparation of In₂O₃-<i>x</i>CuO nanocomposites with different In:Cu molar ratios and the formation of a p-n heterojunction. The gas sensing test results indicated that the In₂O₃-2.1CuO nanocomposites calcined at 500 °C and measured at 350 °C displayed a p-type response for CH₄ and an n-type response for CO and H₂, allowing for accurate differentiation of CH₄ from CO and H₂. Moreover, the In₂O₃-2.1CuO sensor also showed excellent stability and reproducibility across all three gases. First-principles calculations revealed distinct changes in the electronic structure of the In₂O₃-CuO heterojunction upon adsorption of CH₄, CO, and H₂, a finding that aligns with empirical evidence. The gas selectivity mechanism was effectively explained by variations in the energy band gap, driven by electrical behavior during the adsorption process. This work suggests a promising approach for developing selective gas sensors capable of detecting weakly reducing gases.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"69 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultradense Electrochemical Chip and Machine Learning for High-Throughput, Accurate Anticancer Drug Screening","authors":"Daniel S. Doretto, Paula C. R. Corsato, Christian O. Silva, James C. Pessoa, Luis C. S. Vieira, William R. de Araújo, Flávio M. Shimizu, Maria H. O. Piazzetta, Angelo L. Gobbi, Iris R. S. Ribeiro, Renato S. Lima","doi":"10.1021/acssensors.4c02298","DOIUrl":"https://doi.org/10.1021/acssensors.4c02298","url":null,"abstract":"Despite the potentialities of electrochemical sensors, these devices still encounter challenges in devising high-throughput and accurate drug susceptibility testing. The lack of platforms for providing these analyses over the preclinical trials of drug candidates remains a significant barrier to developing medicines. In this way, ultradense electrochemical chips are combined with machine learning (ML) to enable high-throughput, user-friendly, and accurate determination of the viability of 2D tumor cells (breast and colorectal) aiming at drug susceptibility assays. The effect of doxorubicin (anticancer drug model) was assessed through cell detachment electrochemical assays by interrogating Ru(NH₃)₆³⁺ with square wave voltammetry (SWV). This positive probe is presumed to imply sensitive monitoring of the on-sensor cellular death because of its electrostatic preconcentration in the so-called nanogap zone between the electrode surface and adherent cells. High-throughput assays were obtained by merging fast individual SWV measurements (9 s) with the ability of chips to yield analyses of Ru(NH₃)₆³⁺ in series. The approach’s applicability was demonstrated across two analysis formats, drop-casting and microfluidic assays. One should also mention that fitting a multivariate descriptor from selected input data via ML proved to be essential to providing accurate determinations (98 to 104%) of cell viability and half-maximal lethal concentration of the drug. The achieved results underscore the potential of the method in steering electrochemical sensors toward enabling high-throughput drug screening in practical applications.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"259 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142742707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Janus Wettable Mask with Integrated Ratiometric Fluorescent Probe for Comfortable Exhaled H2S Gas Sensing","authors":"Shuxin Zhang, Jing Wang, Yu-jia Zeng, Tailin Xu","doi":"10.1021/acssensors.4c02228","DOIUrl":"https://doi.org/10.1021/acssensors.4c02228","url":null,"abstract":"The exhaled H₂S gas is considered a promising noninvasive, rapid biomarker for diagnosing oral health and respiratory diseases. However, there is an urgent need in the healthcare industry for a sensitive, accurate, low-cost, and comfortable wearable breath sensor for H₂S detection. Herein, a Janus wettable mask was developed by integrating the ratiometric fluorescent probes and asymmetric wettable fabric into the interior of the mask, for the comfortable and visual detection of H₂S. The Janus wettable mask with unidirectional biofluid transport capabilities can quickly transfer liquids from the hydrophobic side to the hydrophilic side, ensuring the dryness of the face during prolonged mask wear. The fluorescent color change from red to blue on the mask sensor can be observed by the naked eye under ultraviolet light, which enables evaluation of the H₂S gas concentration within a linear range of 1–100 ppb, and a low detection limit of 0.8 ppb. On-body experiments confirmed that the mask accurately detects exhaled H₂S gas and effectively captures the dynamic variations in H₂S gas levels at different times of the day. This study provides new insights into developing user-friendly wearable sensors and offers innovative solutions for reducing the burden on healthcare systems.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"6 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142742682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biogel Library-Accelerated Discovery of All-Natural Bioelectronics.","authors":"Qiankun Zeng, Ning Tang, Guoyue Shi, Min Zhang","doi":"10.1021/acssensors.4c02297","DOIUrl":"https://doi.org/10.1021/acssensors.4c02297","url":null,"abstract":"<p><p>Biogels prepared from natural biopolymers are ideal candidates for constructing bioelectronics from the perspective of commercialization and environmental sustainability. However, discovering all-natural biogels that meet specific properties, such as mechanical properties, optical transparency, and stability, remains challenging. Here, our study introduces a revolutionary biogel library, a novel resource that significantly accelerates the discovery and application of suitable all-natural biogel materials for bioelectronics. Utilizing a high-throughput screening system designed with a frontend/backend development strategy, this biogel library facilitates the swift screening and customization of biogels, tailored to meet specific performance criteria. Along with demonstrating applications in soft bioelectronics and printed bioelectronics, this research also thoroughly investigates the recyclability and environmental impacts of biogels, setting a foundation for their use in sustainable, closed-loop ecological systems. This pioneering approach serves not only to foster the departure from petrochemical-derived polymers but also to bolster the advancement of environmentally responsible bioelectronics.</p>","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142737746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional Optical Sensor for the Comprehensive Detection of Zinc Ions in Cardiovascular Disease","authors":"Fangkun Yang, Ning Huangfu, Jiaxi Shen, Jiajun Ying, Hengyi Mao, Yongfang Yin, Pengpeng Su, Ruochi Zhao, Xiao Chen, Hailiang Zhu, Wenming He, Hanbin Cui, Kai Wang","doi":"10.1021/acssensors.4c02672","DOIUrl":"https://doi.org/10.1021/acssensors.4c02672","url":null,"abstract":"Cardiovascular diseases (CVDs) are a major global health concern, highlighting the need for effective diagnostic tools. Zinc ions (Zn²⁺) play a role in CVDs, but their detection is challenging. This study presents a multifunctional optical sensor, <b>HD-Zn</b>, designed to detect Zn²⁺ in relation to CVDs. We developed a novel fluorescence probe, <b>HD-Zn</b>, by conjugating <i>N,N</i>-di(2-picolyl)ethylenediamine (DPEN) to HD via an amide bond, which results in fluorescence quenching due to photoinduced electron transfer (PeT). Adding Zn²⁺ significantly increased fluorescence intensity in the near-infrared region (NIR-I). The probe showed a linear response to varying Zn²⁺ concentrations, with a detection limit of 9.8 nM, appropriate for physiological conditions. Fluorescence imaging in RAW264.7 macrophages indicated lower intracellular Zn²⁺ levels in foam cells compared to healthy cells, linked to CVDsprogression. <i>In vivo</i> imaging in mouse models showed decreased fluorescence intensity in the aorta with disease progression. Our findings confirm that <b>HD-Zn</b> is a reliable tool for measuring Zn²⁺ levels in plaques and demonstrate its biosafety for detecting Zn²⁺ in serum and urine, offering potential for clinical applications in CVDs diagnosis and monitoring.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"129 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Approach for Biosensor-Based Imaging of Cysteine Levels in Ischemeic Heart Disease: Insights from Preclinical Models and Human Samples","authors":"Fangkun Yang, Jie Cao, Xiaoxue Jia, Hailiang Zhu, Jieli Zhou, Zhaocheng Liu, Hanbin Cui, Kai Wang","doi":"10.1021/acssensors.4c02643","DOIUrl":"https://doi.org/10.1021/acssensors.4c02643","url":null,"abstract":"Cardiovascular diseases (CVDs) pose a serious threat to human health, with atherosclerosis being a leading cause of heart disease and stroke. Elevated cysteine (Cys) levels have been closely linked to an increased risk of cardiovascular diseases, underscoring its significance in cardiovascular health. However, current detection methods for cysteine in serum and atherosclerotic plaques present challenges in sensitivity, specificity, dynamic monitoring, and invasiveness. The development of more sensitive, specific, and noninvasive assays is needed to enable accurate monitoring of cysteine levels. This study introduces the development and characterization of <b>Cys-NPs</b>, a sensitive and selective tool for imaging cysteine in foam cells and atherosclerotic mice. Encapsulation of the <b>HD-probe</b> using DSPE-PEG to obtain <b>Cys-NPs</b> effectively reduced interference from glutathione (GSH), leading to successful preparation and validation of <b>Cys-NPs</b>’s nanoscale structure. At the same time, <b>Cys-NPs</b> was able to use the differences in Hcy and Cys concentrations in vivo to better assess Cys levels in vivo. In vitro and in vivo studies demonstrated <b>Cys-NPs</b>’s effective imaging of cysteine in foam cells and atherosclerotic mice, highlighting its potential for noninvasive assessment of cysteine levels in ischemic heart disease research and clinical practice.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"19 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}