ACS Sensors最新文献_第5页

Noise-Limited Nanophotonic Sensing: Fundamental Fluctuations Setting the Detection Floor 噪声限制纳米光子传感：基本波动设置检测底限

IF 8.9 1区化学

ACS Sensors Pub Date : 2026-10-12 DOI: 10.1021/acssensors.6c03568

Muhammad Ali Butt,Bartosz Janaszek,Xavier Mateos,B. Imran Akca

{"title":"Noise-Limited Nanophotonic Sensing: Fundamental Fluctuations Setting the Detection Floor","authors":"Muhammad Ali Butt,Bartosz Janaszek,Xavier Mateos,B. Imran Akca","doi":"10.1021/acssensors.6c03568","DOIUrl":"https://doi.org/10.1021/acssensors.6c03568","url":null,"abstract":"Nanophotonic sensing has traditionally been driven by maximizing optical sensitivity through stronger field confinement and higher quality factors. However, as devices approach regimes of extreme light-matter interaction, detection performance is increasingly limited not by signal strength but by fluctuations. This review presents a unified framework for noise-limited detection in nanophotonic sensors, spanning intrinsic thermodynamic noise, stochastic fluctuations at sensing interfaces, instrumental noise, and environmental perturbations. We highlight how these contributions set practical limits that depend on mode volume, material properties, analyte concentration, and measurement bandwidth. We further argue that conventional metrics based on sensitivity and quality factor are insufficient to describe detection capability and instead require noise-aware figures of merit. Finally, we discuss design strategies, including mode engineering, differential architectures, and system-level co-design, as pathways toward reducing noise and approaching fundamental limits. This perspective establishes a framework for developing nanophotonic sensors that operate with metrological precision.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"53 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149152030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polarization-Multiplexed Bloch Surface Wave Sensing of Single-Strand DNA Growth 单链DNA生长的极化多路斑点表面波传感

IF 8.9 1区化学

ACS Sensors Pub Date : 2026-10-12 DOI: 10.1021/acssensors.6c01248

Jonathan Barolak,Erika Mogni,Giovanni Pellegrini,Jorge Gil-Rostra,Francisco Yubero,Michele Celebrano,Marco Finazzi,Katharina Schmidt,Stefan Fossati,Jakub Dostálek,Paolo Biagioni

{"title":"Polarization-Multiplexed Bloch Surface Wave Sensing of Single-Strand DNA Growth","authors":"Jonathan Barolak,Erika Mogni,Giovanni Pellegrini,Jorge Gil-Rostra,Francisco Yubero,Michele Celebrano,Marco Finazzi,Katharina Schmidt,Stefan Fossati,Jakub Dostálek,Paolo Biagioni","doi":"10.1021/acssensors.6c01248","DOIUrl":"https://doi.org/10.1021/acssensors.6c01248","url":null,"abstract":"Refractometric biosensing is a vital label-free tool for the real-time detection and interaction analysis of biological and chemical substances. Nanophotonic platforms like surface plasmon resonance (SPR) have played a critical role in providing refractometric sensing capabilities for clinical diagnostics and environmental monitoring. However, traditional systems operating in a single-polarization state cannot fully characterize optical properties such as birefringence, which is crucial to resolve many complex biological interactions. Although Bloch surface wave (BSW) sensors can support both transverse electric (TE) and transverse magnetic (TM) modes, a key capability SPR lacks, they have historically been implemented in single-mode configurations. In this paper, we present a polarization-multiplexed BSW refractometric sensing system, simultaneously tracking the resonant wavelength shifts of both TE and TM BSW modes through time. Our technique was applied to investigate single-strand DNA growth during rolling circle amplification (RCA). To accurately recover the time-dependent birefringence, capturing dynamics of the DNA growth and orientation of its chains, we implemented a two-stage modeling approach based on the transfer matrix method (TMM). First, we utilized a wavelength-dependent surface sensitivity model, confining refractive index changes to the immediate layer above the crystal, to distinguish isotropic background dynamics from birefringent signals. Following the onset of RCA, we transitioned to a model that accounted for the vertical growth of the DNA layers in time. By fitting this model to the TE and TM resonant shifts, we monitor the growth rate of the single-strand DNA layer, as well as the refractive index along the two polarization components. Our findings demonstrate the platform’s ability to resolve the structural evolution of complex biomolecular interactions associated with conformational changes.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"2 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149152032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental Methods for CRISPR Enzyme Assays with Fluorescence Readout 荧光检测CRISPR酶的实验方法

IF 8.9 1区化学

ACS Sensors Pub Date : 2026-10-12 DOI: 10.1021/acssensors.6c02175

Qi Jiang,Alexandre S Avaro,Hyunjun Bae,Angelina Sorensen,Juan G Santiago

{"title":"Experimental Methods for CRISPR Enzyme Assays with Fluorescence Readout","authors":"Qi Jiang,Alexandre S Avaro,Hyunjun Bae,Angelina Sorensen,Juan G Santiago","doi":"10.1021/acssensors.6c02175","DOIUrl":"https://doi.org/10.1021/acssensors.6c02175","url":null,"abstract":"Fluorescence-based CRISPR diagnostic assays have become a popular platform for nucleic acid detection due to their programmability, configurability, specificity, and compatibility with standard laboratory equipment. However, reported enzymatic kinetic rates and limits of detection for CRISPR trans-cleavage assays vary by several orders of magnitude across the literature. This variation in performance parameters is coupled with, and exacerbated by, inconsistent calibration, incomplete correction of measurement biases, and nonstandardized or incomplete data analysis procedures. We present an experimental protocol and quantitative analysis framework for fluorescence-based enzyme assays using routine laboratory instrumentation, including thermocyclers and fluorescence microplate readers. Building on previous studies of CRISPR enzyme kinetics and fluorescence calibration, we describe procedures for flat-field and background correction; comprehensive fluorescence calibration, including correction for the inner filter effect; quantification and implications of reporter degradation; extraction of Michaelis–Menten kinetic parameters; and determination of assay's limits of detection. We provide step-by-step experimental guidelines and open-source Python implementations for each stage of the workflow. Using representative Cas12 trans-cleavage datasets, we demonstrate that explicit fluorescence calibration and correction procedures substantially reduce systematic bias in measured kinetic rates and improve consistency between experiments. Our framework aims to establish standardized practices for quantitative fluorescence-based CRISPR assays and provides researchers with practical tools for reproducible kinetic characterization and rational assay design.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"9 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149152033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Miniaturized, Multilayer Structured Vertical Flow Paper Device Enabled One-Step, Multiplex, Spontaneous Detection of Biomarkers in Microliter Blood for Disease Screening 一种小型化、多层结构的垂直流动纸装置，能够一步、多重、自发地检测微升血液中的生物标志物，用于疾病筛查

IF 8.9 1区化学

ACS Sensors Pub Date : 2026-10-12 DOI: 10.1021/acssensors.6c01051

Zichen Wang,Zixuan Ren,Xuanxu Nan,Lingyi Xu,Li Yang,Yue Cui

{"title":"A Miniaturized, Multilayer Structured Vertical Flow Paper Device Enabled One-Step, Multiplex, Spontaneous Detection of Biomarkers in Microliter Blood for Disease Screening","authors":"Zichen Wang,Zixuan Ren,Xuanxu Nan,Lingyi Xu,Li Yang,Yue Cui","doi":"10.1021/acssensors.6c01051","DOIUrl":"https://doi.org/10.1021/acssensors.6c01051","url":null,"abstract":"Developing a miniaturized, portable device for multiplexed detection of a library of protein biomarkers from microliter blood sample is critical for early disease screening in many scenarios, such as home healthcare and emergency care. However, major challenges remain, including multiplexed detection without cross-interference, system-level miniaturization, reliable flow manipulation, and simple user operation. Here, we present a miniaturized, multilayer structured vertical flow paper device that enables one-step, multiplexed, spontaneous detection of biomarkers in microliter blood for screening of heart disease, kidney disease, and inflammation. The device is designed with a multilayer membrane structure that integrates 3D-printed glass fiber membranes, wax-printed nitrocellulose membranes, and cellulose absorption membranes, enabling autonomous wicking of the sample through the device while concurrently distributing the sample into multiple equal parts and executing the sandwich immunoassay and washing steps. Simultaneous quantification of 12 biomarkers is achieved, and clinical performance is validated using clinical samples from patients with acute myocardial infarction (AMI), acute kidney disease (AKD), or sepsis. The device requires about 60 μL of sample, delivers results in 15 min, and is also compact (12.5 cm3). Overall, this platform provides a novel and universal strategy for miniaturized multiplexed immunoassays for rapid clinical screening.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"11 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149152035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differentiable End-to-End Sensor Array Optimization for Electronic Nose via Local Self-Attention 基于局部自关注的可微端到端电子鼻传感器阵列优化

IF 8.9 1区化学

ACS Sensors Pub Date : 2026-10-10 DOI: 10.1021/acssensors.6c00607

Zhiyuan Qu,Chen Su,Lu Zhang,Tao Du,Xiyang Liu,Weiwei Wu,Taoping Liu

{"title":"Differentiable End-to-End Sensor Array Optimization for Electronic Nose via Local Self-Attention","authors":"Zhiyuan Qu,Chen Su,Lu Zhang,Tao Du,Xiyang Liu,Weiwei Wu,Taoping Liu","doi":"10.1021/acssensors.6c00607","DOIUrl":"https://doi.org/10.1021/acssensors.6c00607","url":null,"abstract":"Abstract Electronic noses (e-noses) based on cross-selective gas sensors often suffer from severe redundancy, which degrades odor analysis accuracy and impedes practical deployment. Here, we introduce a fully deep-learning-based sensor array optimization (SAO) framework that learns an optimal subset of sensor array through an end-to-end differentiable manner. Unlike conventional step-by-step workflows, which separate feature extraction, feature selection, sensor selection, and model training, our method jointly optimizes the sensor selection strategy, feature extractor, and task-specific network, enabling global collaborative optimization. Core to the framework is a local self-attention mechanism that infers sensor-wise importance while preserving the temporal structure of individual sensor responses, together with a tanhshrink-based gating function that drives redundant channels exactly to zero without requiring explicit sparsity regularization. Experiments on a 13-channel polyaniline sensor array exposed to six volatile organic compounds show that the proposed method achieves an accuracy of 91.18 ± 0.55% using only four sensors, reducing the number of sensors by nearly 70% while outperforming conventional approaches. These results demonstrate that the differentiable SAO can improve both efficiency and accuracy in practical e-nose applications.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"29 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Centrifugal Microfluidic Soil-to-DNA Preparation for the Portable Detection of Phytophthora infestans Using a CRISPR/Cas12a-Based Quantum Dot Fluorescent Lateral Flow Assay 利用基于CRISPR/ cas12的量子点荧光横向流动实验制备土壤转dna便携式检测疫霉菌的离心微流控制备

IF 8.9 1区化学

ACS Sensors Pub Date : 2026-10-10 DOI: 10.1021/acssensors.6c01885

Cifu Xu,Liudong Cao,Sicheng Li,Wenshuai Ye,Jiangnan Zhao,Xuankun Li,Shiqi Luo,Liqun Zhang,Gang Liu,Fang Gao,Yan Wang

{"title":"Centrifugal Microfluidic Soil-to-DNA Preparation for the Portable Detection of\u0000 Phytophthora infestans\u0000 Using a CRISPR/Cas12a-Based Quantum Dot Fluorescent Lateral Flow Assay","authors":"Cifu Xu,Liudong Cao,Sicheng Li,Wenshuai Ye,Jiangnan Zhao,Xuankun Li,Shiqi Luo,Liqun Zhang,Gang Liu,Fang Gao,Yan Wang","doi":"10.1021/acssensors.6c01885","DOIUrl":"https://doi.org/10.1021/acssensors.6c01885","url":null,"abstract":"Abstract Portable detection of soil-borne pathogens is constrained by laborious soil sample preparation and nucleic acid extraction. Here, we report a centrifugal Soil-on-a-Disc (SoaD) microfluidic chip for rapid soil-to-DNA preparation with automated on-chip clarification and DNA purification, combined with a CRISPR/Cas12a-based quantum dot (QD) fluorescent lateral flow assay (LFA) and smartphone-based fluorescence analysis for the portable detection of Phytophthora infestans (P. infestans). The seven-layer PMMA disc integrates cascaded 5 and 0.8 μm membranes for stepwise particle filtration, together with a silica membrane and active puncture valves for sequential DNA capture, washing, and elution under centrifugal control. The SoaD chip reduced the turbidity of soil suspensions significantly from 12,980 NTU to below the detection limit (∼0 NTU), yielding a clarified sample matrix for downstream DNA extraction, and completed DNA extraction within 20 min. Compared with a commercial soil DNA kit, the relative total DNA recovery efficiency for P. infestans-spiked soils was 94.9 ± 3.3%. Coupled with downstream recombinase polymerase amplification and smartphone-assisted fluorescence readout, the system achieved a limit of detection of 0.135 ng/μL for PiNW-derived RPA products and detected P. infestans in soils spiked at levels as low as 1 spore/g. As a secondary validation of extraction compatibility, 16S rRNA/ITS amplicon sequencing showed that chip-prepared DNA yielded bacterial and fungal community profiles highly consistent with those obtained using the commercial soil DNA kit (r = 0.996/0.923). This work advances portable CRISPR-based sensing toward complex soil samples and provides a field-oriented strategy for molecular surveillance of soil-borne plant diseases.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"36 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated Multimodal Fusion Network and Multispectral Sensing Photoelectrochemical Platform for Sweat Glucose Monitoring 汗液葡萄糖监测的集成多模态融合网络和多光谱传感光电化学平台

IF 8.9 1区化学

ACS Sensors Pub Date : 2026-10-10 DOI: 10.1021/acssensors.6c03011

Ziyue Ju,Han Xu,Ruichan Lv,Yitong Chen,Yue Zhang,Jun Lin,Zhiguo Xia

{"title":"Integrated Multimodal Fusion Network and Multispectral Sensing Photoelectrochemical Platform for Sweat Glucose Monitoring","authors":"Ziyue Ju,Han Xu,Ruichan Lv,Yitong Chen,Yue Zhang,Jun Lin,Zhiguo Xia","doi":"10.1021/acssensors.6c03011","DOIUrl":"https://doi.org/10.1021/acssensors.6c03011","url":null,"abstract":"Abstract Sweat glucose detection offers the advantages of being painless, noninvasive, and suitable for continuous monitoring, showing broad application prospects in diabetes management. However, a single sweat glucose detection method cannot meet the requirements of multiscenario applications. To address this challenge, we developed a multimodal sweat glucose sensing platform integrating a type-II heterojunction with rare-earth nanoparticles (RENPs), which achieves an ultralow limit of detection (LOD) and a wide linear range while enabling robust adaptation to diverse scenarios. First, a photoelectrochemical sensing strategy was developed based on a Co(OH)2/Co3O4@Ag (CCA) type-II heterojunction, in which the surface plasmon resonance (SPR) effect of Ag nanoparticles lowered the LOD from 1.85 μM to 0.312 μM while maintaining a broad linear detection range of 0.001–13.776 mM. Second, a portable fluorescence quenching–recovery system was constructed based on the inner filter effect between RENPs and CCA, overcoming the corrosion and safety limitations inherent to alkaline electrolytes. To resolve spectral overlap issues at low concentrations, a dual-branch deep learning model was further designed to jointly process dual-modal fluorescence and absorption spectra, achieving 99.25% accuracy within the range of 10 μM–2 mM. Collectively, the integrated “RENPs–CCA–AI” strategy systematically addresses key challenges in sensitivity, detection range, wearable compatibility, and analytical accuracy, offering a systematic pathway toward noninvasive, continuous, and precise health monitoring.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"229 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid Isothermal Detection of Heavy Metals via Transcription-Factor-Gated DNA Strand Synthesis 通过转录因子门控DNA链合成快速等温检测重金属

IF 8.9 1区化学

ACS Sensors Pub Date : 2026-10-10 DOI: 10.1021/acssensors.6c02342

Padric M. Garden,Alexander A. Green

{"title":"Rapid Isothermal Detection of Heavy Metals via Transcription-Factor-Gated DNA Strand Synthesis","authors":"Padric M. Garden,Alexander A. Green","doi":"10.1021/acssensors.6c02342","DOIUrl":"https://doi.org/10.1021/acssensors.6c02342","url":null,"abstract":"Abstract Conventional methods for monitoring toxic heavy metals typically require sophisticated laboratory instrumentation and leave a critical gap for rapid, on-site detection. Herein we present Transcription-factor-Occluded Nick Extension or TONE, a rapid, isothermal biosensing platform for heavy metal detection that exploits allosteric transcription factor (aTF) regulation to gate DNA strand-displacement amplification. In this approach, operator sequences modified with deoxyinosine (dI) substitutions are employed. When bound by an aTF, the dI sites are shielded from cleavage by endonuclease V. Upon exposure to target heavy metals, the aTF dissociates, permitting the enzyme to nick the DNA and trigger a strand-displacement reaction. The amplified DNA is then detected via an instrument-free lateral flow assay, delivering a visual readout within 25 min at room temperature. We demonstrate the utility of TONE using the TetR aTF and further adapt the assay for copper and lead detection through the transcription factors CsoR and CadC, respectively, reliably detecting concentrations as low as 40 and 80 nM, respectively. TONE offers a sensitive, instrument-free assay that operates at room temperature, with the potential for field deployment, for use in environmental monitoring and other applications requiring rapid heavy metal analysis.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"31 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CRISPR/Cas13a-Based Nucleic Acid-Functionalized Discrete Floating-Gate Field-Effect Transistor for Amplification-Free Rapid Nipah Virus Detection 基于CRISPR/ cas13的核酸功能化离散浮门场效应晶体管无扩增快速检测尼帕病毒

IF 8.9 1区化学

ACS Sensors Pub Date : 2026-10-10 DOI: 10.1021/acssensors.6c02218

Zijin Tong,Zhen Huang,Jia Liu,Junhua Su,Qilong Zhao,Renlong Zhu,Renjie Xiong,Wenke Xie,Rui Xiao

{"title":"CRISPR/Cas13a-Based Nucleic Acid-Functionalized Discrete Floating-Gate Field-Effect Transistor for Amplification-Free Rapid Nipah Virus Detection","authors":"Zijin Tong,Zhen Huang,Jia Liu,Junhua Su,Qilong Zhao,Renlong Zhu,Renjie Xiong,Wenke Xie,Rui Xiao","doi":"10.1021/acssensors.6c02218","DOIUrl":"https://doi.org/10.1021/acssensors.6c02218","url":null,"abstract":"Abstract Nipah virus (NiV) is a highly lethal zoonotic pathogen, and existing rapid diagnostic tools are scarce and reliant on nucleic acid amplification. In this study, we designed and fabricated a thin-film field-effect transistor with an IGZO channel and, for the first time, combined a discrete AuNP floating gate with the CRISPR/Cas13a system to achieve amplification-free detection of NiV. A pair of partially complementary nucleic acid reporter probes was used to attach AuNPs onto the channel, forming a nucleic acid-functionalized discrete floating gate. Under positive gate voltage, the AuNPs electrostatically induce mirror charges in the IGZO channel, amplifying the sensing signal. Additionally, the electrons can be injected from AuNPs into the channel via the Fowler–Nordheim tunneling effect under negative gate voltage, as a potential complementary sensing mechanism. The AuNPs are immobilized via nucleic acid strands, ensuring good biocompatibility. CrRNA was designed and the CRISPR system was optimized for compatibility with the FET, achieving amplification-free detection of NiV standards down to 10° copies/μL within 10 min. This study not only provides a reliable and rapid detection tool for NiV but also establishes a biosensing framework applicable to other pathogens.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"14 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incomplete Desorption-Induced Irreversible Response Property: The Intrinsic Challenge for Detection of Aliphatic Ketone Vapors by Co3O4. 不完全解吸诱导的不可逆响应性质：Co3O4检测脂肪酮蒸气的内在挑战。

IF 10.9 1区化学

ACS Sensors Pub Date : 2026-10-09 DOI: 10.1021/acssensors.6c02861

Sihao Zhi, Liang Zhao, Hongda Zhang, Sen Liu, Haiyan Zhang, Tong Zhang

{"title":"Incomplete Desorption-Induced Irreversible Response Property: The Intrinsic Challenge for Detection of Aliphatic Ketone Vapors by Co3O4.","authors":"Sihao Zhi, Liang Zhao, Hongda Zhang, Sen Liu, Haiyan Zhang, Tong Zhang","doi":"10.1021/acssensors.6c02861","DOIUrl":"https://doi.org/10.1021/acssensors.6c02861","url":null,"abstract":"<p><p>Aliphatic ketones are widely used as solvents in industries because of their favorable solvency, while their inherent toxicity and flammability pose significant health and safety risks. However, the development of high-precision gas sensors for detecting aliphatic ketones remains significantly challenged by the indistinct reaction mechanism. Herein, Co3O4 with activating lattice oxygen (Co3O4-ALO) was prepared by a Mn2+-assisted hydrothermal method. The activation of lattice oxygen facilitates the formation of oxygen vacancies to drive surface redox, enabling a reversible and reproducible sensing response toward acetone. However, exposure to other aliphatic ketones resulted in incomplete recovery and progressive response attenuation during repeated measurements. Characterization of a series of Co3O4-ALO sensors (as prepared, after testing, and after regeneration) revealed that reaction intermediates or products were not completely desorbed from the sensor surface, and irreversible structural changes occurred during the ketone detection process. These findings demonstrate that the reversibility of Co3O4-ALO arises from the competition between surface redox reactions and the irreversible accumulation of oxidation intermediates accompanied by structural degradation. This study establishes the reason for the trade-off in sensing performance for detection of aliphatic ketone vapors by Co3O4 materials, providing vital theoretical guidelines for designing next-generation, highly reversible, and anti-poisoning gas sensors.</p>","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0