ACS Sensors最新文献

{"title":"Crystalline Energy Funneling in Mixed-Ligand Zr-MOFs Drives Radical-Triggered ECL Amplification for Ultrasensitive Thrombin Sensing.","authors":"Ju-Zheng Wang,Yi-Xuan Li,Qiaoting Yang,Jérome Chauvin,Serge Cosnier,Xue-Ji Zhang,Dan Shan","doi":"10.1021/acssensors.5c02948","DOIUrl":"https://doi.org/10.1021/acssensors.5c02948","url":null,"abstract":"Harnessing crystalline architectures to direct exciton migration presents a promising avenue for electrochemiluminescence (ECL) signal amplification in biosensing. Herein, we report a structurally orchestrated ECL platform based on a mixed-ligand zirconium metal-organic framework (Zr-MOF), assembled from 1,3,6,8-tetrakis(p-benzoic acid)pyrene (TBAPy) and zinc tetrakis(4-carboxyphenyl)porphyrin (ZnTCPP). The nanoscale colocalization of donor-acceptor pairs within a crystalline lattice establishes an intraframework energy funneling pathway, enabling directional resonance energy transfer (RET) from TBAPy to ZnTCPP with an efficiency of up to 76.5%. Beyond RET, radical-triggered excitation involving TBAPy•- and superoxide (O2•-) further activates ZnTCPP-centered ECL emission, resulting in a 3-fold enhancement compared to single-ligand controls. By leveraging this synergistic amplification, an aptamer-gated, signal-off ECL biosensor was constructed for femtomolar-level thrombin detection (limit of detection: 0.47 fM) with exceptional selectivity. This work exemplifies a crystalline energy-programmed approach to coupling exciton dynamics with redox-active interfaces, offering a mechanistically traceable and highly sensitive platform for advanced bioanalytical applications.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"37 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SERS-Integrated Microneedles: Bridging Nanoplasmonics and Microsampling for Advanced Bioanalysis.","authors":"Dongchang Yang,Brian Youden,Naizhen Yu,Andrew Carrier,Runqing Jiang,Mark Servos,Ken Oakes,Xu Zhang","doi":"10.1021/acssensors.5c02335","DOIUrl":"https://doi.org/10.1021/acssensors.5c02335","url":null,"abstract":"Sensitive analytical techniques capable of in situ measurements in biological tissues with high selectivity and rapid response are essential for health monitoring, disease diagnosis, agriculture management, and food safety. However, conventional biological sampling is often invasive, expensive, and inconvenient. Microneedle (MN) technology offers a noninvasive, quick, and self-administered approach for in vivo sampling of extracellular fluids that are rich in biomarkers and metabolites indicative of health status. By integrating MNs with highly sensitive surface-enhanced Raman spectroscopy (SERS), the hybrid technique provides unprecedented convenience, user compliance, and analytical sensitivity for biomonitoring. The versatility of SERS-integrated MNs (SERS-MNs), along with their integration into portable, self-administered devices, makes them ideal for point-of-care testing. SERS-MNs can also be incorporated into wearable medical devices for real-time, long-term biochemical monitoring with high temporal resolution. This perspective explores the emerging applications of SERS-MNs by critically examining the key requirements in materials, structural design, and fabrication methods, while elucidating their underlying working principles. We further assess current challenges and highlight future opportunities, providing insights to advance their use in clinical diagnostics, precision agriculture, and food safety. This work offers a systematic discussion on the integration of SERS-MNs into wearable devices for long-term, real-time health monitoring, opening new possibilities to empower individuals in proactive health management.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"8 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BF2-Postmodified Cobalt-Porphyrin Covalent Organic Framework for High-Performance Specific Detection of NH3.","authors":"Qi Liu,Binghan Hou,Qiang Li,Taotao Su,Yu Li,Yuexing Zhang,Youzhi Xu","doi":"10.1021/acssensors.5c02512","DOIUrl":"https://doi.org/10.1021/acssensors.5c02512","url":null,"abstract":"The development of high-performance ammonia (NH3) sensors is critical for environmental and industrial safety; however, conventional chemiresistive materials face challenges in sensitivity and humidity interference. This work presents a covalent organic framework synthesized by Co-5,10,15, 20-tetrakis (4-aminophenyl) (CoTAPP) and 2,5-dihydroxy terephthalaldehyde (DTA) postmodified with electron-deficient BF2 groups (COF-CoDT-BF2) to address these limitations. First, the construction of donor-acceptor interfaces between cobalt porphyrin and BF2 groups enhances charge transport while modulating Co-site electron density for optimized NH3 adsorption. Moreover, BF2 groups serve as secondary active sites, synergistically strengthening the NH3 adsorption anchoring. Hydrophobic transformation via BF2 incorporation enables stable operation across 0-98% relative humidity, overcoming water competition effects that plague conventional chemiresistive gas sensors (CGSs). The optimized COF-CoDT-BF2-based CGSs achieve record sensitivity (722.3% ppm-1), sub-ppb detection limit (0.9 ppb), excellent environmental tolerance, and stability. Density functional theory calculations corroborate the dual adsorption charge-transfer mechanism, while in situ spectroscopic analyses reveal reversible NH3 adsorption dynamics. This molecular engineering strategy establishes a paradigm for designing multifunctional sensing materials, paving the way for intelligent gas monitoring systems in precision agriculture and food safety detection.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"32 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-Resolved Sweat Collection for Off-Body SERS Analysis: Bridging Wearability and Sensitivity","authors":"Yisong Yu, Xiaohui Fang, Zhenle Qin, Yang Li, Xinping Zhang","doi":"10.1021/acssensors.5c03029","DOIUrl":"https://doi.org/10.1021/acssensors.5c03029","url":null,"abstract":"Sweat carries a wealth of physiological information and is ideal for noninvasive health monitoring. Surface-enhanced Raman scattering (SERS) enables highly sensitive, multiplexed detection of sweat biomarkers, but its integration into wearable systems remains impractical due to the bulky nature of Raman spectrometers and laser sources. To address this limitation, we developed a wearable platform that focuses on in situ sweat collection and time-sequenced storage, enabling delayed, off-body high-sensitivity SERS detection. The system integrates a Janus microporous membrane with a wettability gradient, fabricated via femtosecond laser ablation and oxygen plasma etching, to achieve directional and continuous sweat collection from the skin. This is combined with a microfluidic chip containing burst valves that enable passive, time-sequenced sampling and storage of sweat over the course of exercise. For detection, a capillary-based SERS substrate was fabricated using a silver mirror reaction, achieving detection limits down to 1 mM for sodium lactate and urea. Characteristic peaks were clearly identified from human sweat samples. This work presents a feasible path for combining wearable sweat sensing with high-performance spectroscopic analysis, offering promising applications in personalized health monitoring and dynamic physiological assessment.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"56 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flat Plasmonic Biosensor with an On-Chip Metagrating-Integrated Laser.","authors":"Erik Strandberg,Mindaugas Juodėnas,Hana Šípová-Jungová,Mikael Käll","doi":"10.1021/acssensors.5c01997","DOIUrl":"https://doi.org/10.1021/acssensors.5c01997","url":null,"abstract":"Metasurfaces are emerging as a transformative platform in optics, offering compact and versatile alternatives to bulky traditional components. Here, we present a metasurface-enabled, on-chip surface plasmon resonance (SPR) biosensor that enables label-free biomolecular analysis in a miniaturized, chip-scale format. By integrating flat metaoptics together with semiconductor lasers, a collimated fan of light for angle-resolved SPR measurements can be emitted directly into a glass substrate, eliminating the need for conventional optics. As a proof of concept, we demonstrate a bulk refractive index sensitivity of 4.9 × 10-6 RIU, along with multiplexed detection of low-molecular-weight microRNA with limits of detection of 0.1 nM via direct sensing and 0.02 nM with antibody amplification. The scalability of metasurface fabrication, coupled with the low cost of semiconductor lasers, suggests this platform can be readily adapted for diverse sensing modalities and mass manufacture, potentially transforming SPR beyond its conventional, benchtop implementations.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"20 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemiluminescence at Functionalized Trapped Microbeads in Microfluidic Channels","authors":"Bixente Carre, Yumeng Ma, Neso Sojic, Laurent Thouin","doi":"10.1021/acssensors.5c02800","DOIUrl":"https://doi.org/10.1021/acssensors.5c02800","url":null,"abstract":"Electrochemiluminescence (ECL) is successfully combined with microbead-based immunoassays for quantification of a wide range of biomarkers. Herein, a microfluidic platform was developed to study the electrochemiluminescence (ECL) emission of a model microbead-based system under controlled flow conditions. The microbeads, functionalized with tris(2,2′-bipyridine)ruthenium(II) as luminophore, were entrapped by micropillars in a microfluidic channel and exposed to a circulating solution of tri<i>-n</i>-propylamine coreactant. The confined space of the microchannel combined with convective mass transport allowed the enhancement of the ECL signal emitted by the entrapped beads. Analysis of the light profiles from isolated beads showed that the performance of the heterogeneous ECL pathway was greatly influenced by the flow rate. Therefore, mass transport was found to be essential for tuning the ECL intensity of these systems, as it leads to a 4-fold increase in ECL intensity from diffusive to convective regimes. These results already highlight real opportunities for improving ECL immunoassays through novel flow-based strategies.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"112 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinspired Iontronic Gas Sensor for Selective CO2 Sensing via Reversible Lysine Carbamylation","authors":"Jiyuan Xue, Bingcheng Shen, Juan Wang, Juan Li, Hongran Zhao, Tong Zhang","doi":"10.1021/acssensors.5c01661","DOIUrl":"https://doi.org/10.1021/acssensors.5c01661","url":null,"abstract":"Carbon dioxide (CO₂) is ubiquitous in both natural and indoor atmospheres, playing a pivotal role in global climate regulation, air quality, and biological processes. However, their chemical inertness poses inherent challenges for developing compact, high-sensitivity detection platforms. In living organisms, CO₂ often modulates protein function through reversible carbamylation of lysine residues, illustrating a finely tuned molecular recognition mechanism. Inspired by this principle, we developed a bioinspired iontronic sensor by embedding lysine moieties into a cross-linked poly(ethylene glycol) diacrylate (PEGDA) hydrogel. Upon exposure to CO₂, the lysine ε-amino group forms transient carbamate adducts, inducing the electrostatic interaction, which disrupts Grotthuss-like conduction pathways and causes a distinct impedance increase. This lysine-based recognition enables high selectivity over interfering gases and operates reliably under ambient conditions. The resulting hydrogel sensor exhibits excellent linearity (<i>R</i>² &gt; 0.995) from 0 to 2000 ppm of CO₂, with a theoretical detection limit of ∼76 ppm, suitable for indoor and ambient atmospheric CO₂ monitoring at low concentrations. Furthermore, it maintains stable performance over at least 28 days of repeated measurements and shows negligible cross-sensitivity toward common interfering gases (e.g., H₂S, CH₄, and formaldehyde). By harnessing lysine–CO₂ carbamylation within an ion-conducting matrix, our approach provides a versatile, low-power platform for precise CO₂ sensing in applications ranging from indoor environmental evaluation to plant-level respiratory monitoring.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"22 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Composite Polyimide Foam-Based Sensors Dominated by the Piezoelectric Effect for Detecting Human Activity and Sounds","authors":"Lijun Ma, Yuanyuan Zhong, Yugen Wang, Pengfei He, Jun Fang, Jianwei Li","doi":"10.1021/acssensors.5c02340","DOIUrl":"https://doi.org/10.1021/acssensors.5c02340","url":null,"abstract":"Fluorine polyimide (FPI) materials have been attracting significant attention due to their potential application as an ideal substrate for flexible piezoelectric sensors. However, the limited piezoelectric output remains a challenge to be overcome. Herein, an effective method for the synthesis of isocyanate-based fluorine polyimide foam containing BaTiO₃ nanoparticles via a one-step foaming method is proposed. Notably, the prepared FPI foams show improved piezoelectric properties with output voltage of up to 31 V at a vibration frequency of 20 Hz under the pressure of 1–5 N. In addition, the fabricated FPI foam-based sensor exhibits high sensitivity (8.232 V/N), short response time (7 ms), and outstanding durability (10,000 cycles). Moreover, the prepared FPI foams retain excellent thermal insulation and thermal stability. Specifically, when the sample was exposed to a hot stage at 220 °C for 10 min, the upper surface temperature of the samples was maintained at about 95.6 °C. In addition, the FPI foam has the ability to recognize various types of natural acoustic signals, demonstrating excellent piezoelectric sensitivity. This study provides an effective solution for enhancing the piezoelectric properties of FPI materials, showing significant potential in expanding their applications in smart, wearable microelectronic devices.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"9 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Phase Spinel High-Entropy (FeCoNiCrMn)3O4 Synthesized Using Electrospinning Technique and Its Application in the Sensing of Trimethylamine Gas at Room Temperature.","authors":"Jie Huo,Bosen Zhang,Hongli Zhu,Huiyu Lu,Jiarui Qi,Xinyu Meng,Shuangming Wang,Jing Cao,Longlong Fan","doi":"10.1021/acssensors.5c02540","DOIUrl":"https://doi.org/10.1021/acssensors.5c02540","url":null,"abstract":"High-entropy engineering strategies have achieved success in enhancing energy storage and catalytic performances but are rarely reported to improve gas-sensing dynamics, especially for room-temperature gas sensing. Herein, single-phase spinel high-entropy oxide (FeCoNiCrMn)3O4 has been synthesized by electrospinning and authenticated by XRD Rietveld refinement simulation, configuration entropy calculation, and element mapping. For the first time, the as-prepared alkalized high-entropy oxide (FeCoNiCrMn)3O4 shows room-temperature trimethylamine gas-sensing properties, including superior sensing response (113%), high gas selectivity, fast response/recovery speed (11 s/28 s), as well as preferable repeatability and reliability toward 500 ppm of trimethylamine gas. Gas-sensing tests of comparative samples obtained by replacing and reducing metal ions validate that the synergistic effect by Fe, Co, Ni, Cr, and Mn ions enables (FeCoNiCrMn)3O4 to exhibit room-temperature trimethylamine gas sensing, while more lattice distortion, adsorbed oxygen, and oxygen vacancies generated by alkalization treatment further heighten trimethylamine gas adsorption and catalyze surface gas-sensing reactions. The coupling of high entropy and alkalization strategy opens up a new path for improving room-temperature gas sensing.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"477 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-Sensitive CH4-LITES Sensor Enabled by Low-Frequency Slingshot-Shaped Quartz Tuning Fork and Optical Enhancement.","authors":"Hanxu Ma,Shaoning Zheng,Runqiu Wang,Ying He,Yanjun Chen,Xiaorong Sun,Shunda Qiao,Yufei Ma","doi":"10.1021/acssensors.5c02573","DOIUrl":"https://doi.org/10.1021/acssensors.5c02573","url":null,"abstract":"This paper reports for the first time an ultrasensitive methane (CH4)-LITES sensor based on a low-frequency slingshot-shaped quartz tuning fork (QTF) and optical enhancement. The slingshot-shaped QTF serves as the core innovative component, featuring low resonant frequency (∼7.9 kHz), wide prong gap (>1000 μm), and slingshot-shaped curved transition structure, which significantly extends acoustic energy accumulation time, suppresses optical scattering noise, and optimizes stress distribution, thereby comprehensively enhancing sensing performance. Finite element simulation results demonstrate that, compared to a standard commercial QTF, the maximum temperature gradient and total surface charge of the slingshot-shaped QTF increased by factors of 3.53 and 2.68, respectively. Experimental validation shows that the signal-to-noise ratio (SNR) of the LITES system based on this slingshot-shaped QTF improved by 2.26 times compared to the system using a standard QTF. To further optimize the detection performance for CH4, a Raman fiber amplifier (RFA) was employed to enhance the power of the diode laser, while a multipass cell (MPC) with a dense spot pattern and an optical path length of approximately 80 m, along with a self-designed amplifier, were used to promote gas absorption and enhance signal gain, respectively. These three components work synergistically to effectively improve the sensor's detection capability by increasing excitation intensity, promoting gas absorption, and enhancing signal gain. In this configuration, the sensor's minimum detection limit (MDL) for CH4 was calculated to be 8.42 ppb, and the noise-equivalent normalized absorption coefficient (NNEA) was calculated as 1.38 × 10-9 cm-1·W·Hz-1/2. Allan deviation analysis indicated that at an averaging time of 350 s, the sensor's MDL was optimized to 0.72 ppb. This study provides a novel QTF structure with significant performance advantages and an optical enhancement strategy for highly sensitive CH4 gas detection, holding important application prospects in fields such as environmental monitoring and industrial safety.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"31 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}