ACS Sensors最新文献

{"title":"A Self-Powered Thermogalvanic Hydrogel Dressing for In Situ Wound Monitoring and Enhanced Healing.","authors":"Chunjing Wang, Ruixin Wei, Changchang Lu, Yu Niu, Xinyue Jia, Xiaojing Cui, Zhou Li, Qingzhen Yang, Shengbo Sang, Hulin Zhang","doi":"10.1021/acssensors.6c03280","DOIUrl":"https://doi.org/10.1021/acssensors.6c03280","url":null,"abstract":"<p><p>Wound management critically requires the synergistic integration of real-time monitoring and precise intervention. Current electrical stimulation dressings suffer from external power dependence, poor air permeability, restricted customizability, and decoupled monitoring and treatment. Herein, this study presents a self-powered, breathable porous thermogalvanic hydrogel dressing, which employs a poly(vinyl alcohol)/poly(ethylene glycol) diacrylate double-network matrix loaded with the [Fe(CN)6]3-/4- redox couple and is endowed with personalized wound-matching capability by DLP-based 3D printing. By coupling the thermogalvanic and active piezoresistive effects, the dressing achieves real-time monitoring of wound temperature and deformation, along with additional functionality for wound exudate detection and pH visualization. Furthermore, the dressing provides biomimetic electrical stimulation without exogenous drugs or external power, enabling closed-loop monitoring and treatment. Integrated with a deep learning algorithm, the dressing delivers 96.5% wound severity classification accuracy and accelerates wound healing in mice, reaching 98.09% closure on day 14. This work offers a new paradigm for precise personalized wound management with potential for clinical translation.</p>","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Performance MEMS Gas Sensors Utilizing an N-CQD/NiCo2O4 Composite for H2S Detection and Concentration Regression Prediction","authors":"Ruilong Ma,Youlin Gu,Zhenyu Liu,Zhencheng Liu,Wenhao Wu,Fanhao Meng,Xiaoyan Peng","doi":"10.1021/acssensors.6c02912","DOIUrl":"https://doi.org/10.1021/acssensors.6c02912","url":null,"abstract":"Abstract Hydrogen sulfide (H2S) poses significant risks in industrial settings due to its high toxicity and flammability, making its efficient detection crucial for operational safety. In this study, high-performance MEMS gas sensors based on a nitrogen-doped carbon quantum dot/nickel cobaltite (N-CQD/NiCo2O4) nanocomposite were developed, achieving highly sensitive H2S detection. Characterization techniques such as XRD, XPS, SEM, and TEM confirmed the successful loading of N-CQDs onto the NiCo2O4 surface, leading to an increase in oxygen vacancy concentration. The sensor with NCQD/NCO-2 exhibited excellent H2S selectivity, good repeatability, and long-term stability over 40 days. At low-temperature heating, the response to 1000 ppm H2S was enhanced by a factor of 6.84, with a theoretical detection limit of 9.42 ppb. Beyond the material-level enhancement, this work integrates N-CQD-mediated surface/interfacial activation, a low-temperature-heated MEMS sensor array, and a lightweight temporal regression model for H2S quantification. The DCG-Net model achieved accurate concentration prediction with an R2 value of 0.9902 and was successfully deployed, offering a compact material–device–algorithm solution for intelligent H2S monitoring.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"21 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149091859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-Complexation Synthesis of Responsive Polymer Nanoparticles Functionalized with Kinetically Inert Europium(III) Complexes for Bicarbonate Sensing","authors":"Magnus Christian Wied,Kirill Mamonov,Thomas Just Sørensen","doi":"10.1021/acssensors.6c02152","DOIUrl":"https://doi.org/10.1021/acssensors.6c02152","url":null,"abstract":"Abstract Engineering nanomaterials to perform a specific function requires control of the complex chemistry involved in the formation of the nanomaterial and thus control of the resulting architecture. Here, we explored the sequence of steps required to make responsive nanoparticles (NPs), nanooptodes, for bicarbonate sensing. The sensor action is based on lanthanide-centered interactions and lanthanide luminescence, which, in addition to providing the sensing action, informs on the NP architecture. Two NP-forming reactions were tested, but only the synthesis pathway where amphiphilic components were used reproducibly provided functional nanooptodes with a responsive lanthanide complex placed at the nanoparticle–solution interface. This protocol creates nanooptodes with a shelf life of years and an explainable response to bicarbonate. The lanthanide luminescence provides real-time feedback on the NP structure, ensuring reliability and reproducibility across sensing applications.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"8 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149092139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HCCO Nanoreactor-Integrated Electrochemical Paper-Based Analytical Device for Anti-EBNA1 IgA Detection toward Nasopharyngeal Carcinoma Screening","authors":"Yuanyuan Li,Wanxin Cao,Fangjun Chen,Yan Zhu,Yi Duan,Jiping Li,Yourong Duan","doi":"10.1021/acssensors.6c03368","DOIUrl":"https://doi.org/10.1021/acssensors.6c03368","url":null,"abstract":"Abstract Serological detection of anti-Epstein–Barr virus nuclear antigen 1 immunoglobulin A (anti-EBNA1 IgA) is clinically relevant to nasopharyngeal carcinoma screening, but conventional immunoassays rely on centralized instrumentation and multistep procedures. Here, we developed a disposable origami electrochemical paper-based analytical device integrating hollow C@CuO–CeO2 nanoreactors (HCCO-ePAD) for label-free anti-EBNA1 IgA detection. HCCO was designed as a multifunctional sensing interface in which the hollow carbon framework supports charge and mass transport, Cu-containing domains provide an intrinsic cathodic redox response, and surface carboxyl functionalization enables covalent EBNA1 immobilization. Binding of anti-EBNA1 IgA to surface-bound EBNA1 formed a poorly conductive immunocomplex that restricted interfacial electron transfer, producing a concentration-dependent decrease in the differential pulse voltammetric current. Under optimized conditions, the HCCO-ePAD showed a linear response from 0.1 to 500 ng mL–1, with a detection limit of 0.029 ng mL–1, together with good selectivity, repeatability, reproducibility, and storage stability. Preliminary evaluation using serum samples from 15 patients with nasopharyngeal carcinoma and 15 healthy controls yielded an area under the receiver operating characteristic curve of 0.969 (95% confidence interval, 0.918–1.000). The HCCO-ePAD results were further compared with those obtained using a commercial enzyme-linked immunosorbent assay (ELISA). This work demonstrates an intrinsic-redox nanoreactor interface that integrates electrochemical transduction and bioreceptor immobilization within a disposable origami paper platform for decentralized serological analysis.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"12 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149091860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensor-Integrated Organ-on-a-Chip Platforms: Advances in Drug Evaluation and Disease Modeling","authors":"Zhaofeng Huang,Yaohui Zhang,Feiyang Li,Yunxiao Li,Zhiwei Xue,Mengya Chen,Junfei Li,Wei Li,Yule Zhang,Lulu Zheng,Songlin Zhuang","doi":"10.1021/acssensors.6c00932","DOIUrl":"https://doi.org/10.1021/acssensors.6c00932","url":null,"abstract":"Abstract Organ-on-a-chip (OoC) platforms have made remarkable progress in simulating the physiological complexity of human tissues, and provide advanced in vitro models for drug development. These platforms offer superior physiological relevance over conventional cell culture and animal models and thus enhance preclinical drug testing. However, a key challenge is how to align the dynamics of these systems with analytical methods. The wide use of static endpoint assays can restrict the depth of obtainable mechanistic data, and often capture correlative results rather than the basic kinetic processes of a drug effect. This review probes into the premise that functional combination of sensors for real-time non-terminal detection is a critical trend for strengthening the analytical capability of OoC technology. Herein, this perspective is illustrated by systematically examining recent applications in drug toxicity evaluation and disease modeling. The discussion highlights how the focus of sensor-integrated platforms is shifting from physiological endpoint replication to dynamic mechanistic inquiry. These systems enable the continuous detection of key cellular and environmental indices, and thus provide high-resolution temporal data and a more detailed view of pharmacological responses. Finally, the current technological landscape, remaining challenges, and future outlook are summarized, positing that a further integration of sensing technologies is the key to exposing the full potential of OoCs for mechanistic and predictive drug assessment.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"5 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149091862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Self-Unlocking Biocatalytic Cascade Enabled by a Laccase-Entrapping Metal–Organic Framework for Point-of-Care Detection of Alkaline Phosphatase","authors":"Rui Gao,Xiaoxue Kou,Weiyu Ye,Yizhang Li,Jing Li,Siming Huang,Hao Wang,Fang Zhu,Guosheng Chen,Gangfeng Ouyang","doi":"10.1021/acssensors.6c02560","DOIUrl":"https://doi.org/10.1021/acssensors.6c02560","url":null,"abstract":"Abstract The point-of-care testing (POCT) for alkaline phosphatase (ALP), a critical biomarker for hepatobiliary diseases, bone disorders, and specific malignancies, remains analytically challenging due to signal interference from complex biological matrices. Herein, we report the development of a laccase-entrapping zeolitic imidazolate framework-8 nanoprobe (LAC@ZIF-8) that enables a self-unlocking biocatalytic cascade (SUBC) for the selective colorimetric detection of ALP. The SUBC mechanism proceeds via three discrete steps: (1) ALP-catalyzed hydrolysis of disodium phenyl phosphate yields phenol and inorganic phosphate (Pi); (2) Pi induces the structural collapse of the ZIF-8 scaffold via competitive coordination, thereby, releasing the encapsulated LAC which is otherwise sterically locked by intact ZIF-8 with a narrow microporous aperture (ca. 3.4 Å) and inaccessible to consequent bioreaction; (3) the cogenerated phenol is subsequently oxidized by the released LAC in the presence of 4-aminoantipyrine to generate a quantifiable red quinoneimine chromophore. By requiring the concerted presence of both Pi and phenol, the dual products of ALP catalysis, this LAC@ZIF-8-mediated SUBC design effectively suppresses false-positive signals originating from endogenous phosphate-containing compounds or phenolic interferents. This biosensor exhibits exceptional specificity for ALP activity, demonstrating negligible cross-reactivity with common ionic species (K+, Na+, Ca2+, CO32–), glucose, amino acids, proteins, phosphate-containing compounds, and endogenous phenols. The assay achieves a linear dynamic range of 0.5–50 U/L with a detection limit of 0.43 U/L. Furthermore, a smartphone-coupled POCT hydrogel kit was developed, facilitating on-site, instrument-free visual detection of ALP activity and its inhibitor Na3VO4. This work presents a generalized strategy for the design of highly specific biosensors through the integration of metal–organic framework (MOF)-gated selectivity with biocatalytic signal amplification.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"176 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149091870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why Do I Reject So Many?","authors":"","doi":"10.1021/acssensors.6c04626","DOIUrl":"https://doi.org/10.1021/acssensors.6c04626","url":null,"abstract":"","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149100928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Programming of CRISPR Diagnostics: From Target Recognition to Field Deployment","authors":"Hengyu Wang,Meiyou Chen,Qiurun He,Zuohao Wu,Junjie Zheng,Xiaoyi He,Ling Deng,Xuhu Mao,Yong Sheng","doi":"10.1021/acssensors.6c02636","DOIUrl":"https://doi.org/10.1021/acssensors.6c02636","url":null,"abstract":"Abstract Rapid and accurate diagnostics are essential for controlling emerging infectious diseases and antimicrobial resistance, yet CRISPR assays with exceptional analytical sensitivity often remain difficult to translate into deployable tests. Existing reviews have commonly organized CRISPR diagnostics by Cas effector, biosensor format, or application, offering limited guidance on how design decisions interact across complete workflows or why promising systems remain at the proof-of-concept stage. We introduce an integrated framework that connects five coupled design layers with five levels of translational evidence. The design layers comprise guide RNA engineering, signal amplification circuits, molecular adaptors, computational design support, and specimen and intended-use implementation. The evidence levels progress from purified-target characterization and spiked-matrix testing to retrospective specimen evaluation, prospective integrated-workflow evaluation, and intended-use operation by target users supported by controls, usability assessment, real-time stability, manufacturing consistency, cost per valid result, and claim-specific regulatory preparation. This dual framework shows how improvements at one layer can shift the dominant bottleneck to another. For example, preamplification can lower the analytical limit of detection while increasing contamination risk and workflow burden, whereas guide designs that improve sequence discrimination may reduce cognate-target activation. The framework supports bottleneck-guided selection of effectors, signal-gain strategies, adaptors, computational tools, and multiplexing formats according to target type and abundance, specimen matrix, intended decision, target users, and deployment setting. High analytical sensitivity or single-nucleotide discrimination under controlled conditions does not establish clinical utility unless such performance improves classification at the intended decision threshold within the complete workflow. Translation requires standardized benchmarking, matrix-aware validation, appropriate controls, stability and manufacturability assessment, prospective intended-use studies, and economic evaluation suited to the intended claim and setting. This framework shifts the evaluation of CRISPR diagnostics from isolated analytical performance toward evidence-based workflow co-design.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"36 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149091864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self‑Powered All‑Fiber Hydrogen Sensor via Whispering Gallery Mode Microcavity and Built‑in Electric Field Synergy","authors":"Ying Liu,Zhibo Li,Jie Mao,Yuansheng Yin,Wanjun Li,Liang Huang,Shuang Shang,Jianle Huang,Yiyang Qin,Daotong You,Minghui Du,Tuan Guo","doi":"10.1021/acssensors.6c03580","DOIUrl":"https://doi.org/10.1021/acssensors.6c03580","url":null,"abstract":"Abstract Fiber‑optic hydrogen sensors offer intrinsic safety and remote operation, yet their application is constrained by expensive spectrometers and complex demodulation. Here, we present a self-powered all‑fiber hydrogen sensor (SAHS) that integrates optical excitation, electrical readout and gas detection on a single fiber tip, enabling remote and room‑temperature sensing at zero bias. By constructing a whispering gallery mode (WGM)-enhanced lateral ZnO/PEDOT:PSS n–p heterojunction on the fiber tip, we achieve synergy between the localized optical field and the built‑in electric field. The WGM microcavity confines and recycles incident light, markedly enhancing light-matter interaction and photogeneration on the tiny fiber tip. Meanwhile, the lateral built‑in field efficiently dissociates the photogenerated carriers, producing a substantial photocurrent without any external voltage. The self‑powered sensor exhibits outstanding room‑temperature H2 detection under 380 nm light excitation upon Pd functionalization, with a detection limit of ∼19 ppm and response/recovery times of 30 s and 7 s, respectively. This light‑activated, electrically‑read‑out architecture eliminates costly optical demodulation equipment, offering a low‑cost, user‑friendly and intrinsically safe solution for advanced hydrogen energy monitoring.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"48 6 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149091863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Atom Nanozyme Integrated Double-Clasp Transition Probe-Driven CRISPR/Cas12a Cascade for Preamplification-Free Detection of Non-Nucleic Acid Targets","authors":"Jianle Wang,Qiuyun Tian,Yuling Li,Yaqi Qin,Xiaorong Xiong,Shijia Ding,Wenchun Xu,Meiying Shen,Changjin Liu","doi":"10.1021/acssensors.6c02981","DOIUrl":"https://doi.org/10.1021/acssensors.6c02981","url":null,"abstract":"Abstract CRISPR/Cas12a diagnostics have greatly advanced nucleic acid testing, yet their extension to non-nucleic acid targets remains constrained by the intricate preamplification process and by inefficient signal transduction. Herein, we present a non-nucleic acid detection platform that integrates a CRISPR/Cas12a positive-feedback cascade with a single-atom nanozyme. In this strategy, cleavage of the designed double-clasp transition probe (DCTP) activates additional Cas12a ribonucleoprotein (RNP) complexes, enabling cascade signal amplification without a preamplification treatment. Meanwhile, the created single-atom Pt-engineered PdCeB nanozyme (Pt1/PdCeB SAN) functions as an efficient electrochemiluminescence (ECL) nanolabel in the luminol/O2 system, converting dissolved oxygen (O2) into reactive oxygen species (ROS) to produce a robust ECL response without an external coreactant. Using human epidermal growth factor receptor 2 (HER2) as a clinically relevant non-nucleic acid target, the DCTP-driven Cas12a positive-feedback system shortened the cleavage time from 33 min in the conventional Cas12a system to 18 min and achieved a wide linear range from 10–3 to 104 ng/mL, with a low detection limit of 0.513 pg/mL. Furthermore, preliminary analysis of 31 clinical serum samples supported the feasibility of the strategy for quantitative serum HER2 (sHER2) determination, although validation in larger independent cohorts is required.","PeriodicalId":24,"journal":{"name":"ACS Sensors","volume":"16 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149092069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}