Aquatic Toxicology最新文献

{"title":"Effect of antibiotics on diverse aquatic plants in aquatic ecosystems","authors":"Yiting Li,&nbsp;Yani Zhang,&nbsp;Dongyao Wang,&nbsp;Jiamei Zhao,&nbsp;Huan Yu,&nbsp;Yun Chen,&nbsp;Jiqiang Yang","doi":"10.1016/j.aquatox.2025.107289","DOIUrl":"10.1016/j.aquatox.2025.107289","url":null,"abstract":"<div><div>The widespread presence of antibiotics in aquatic ecosystems, mainly due to their use in medicine and veterinary practices, poses a significant environmental challenge. Aquatic plants play a vital role in maintaining ecosystem stability, but their responses to antibiotics vary by species, influenced by differences in their traits and interactions with environmental factors. However, the specific ways antibiotics affect these plants remain poorly understood. In this study, we conducted a meta-analysis of 167 peer-reviewed studies to investigate the mechanisms of antibiotic uptake and their effects on different types of aquatic plants-submerged, emergent, and floating. Our analysis shows that antibiotics, particularly common ones like sulfonamides, tetracyclines, and quinolones, impact aquatic plants through multiple pathways. Submerged and floating plants often face widespread, direct exposure, resulting in “full-coverage” impacts, while emergent plants experience mixed exposure patterns, affecting both submerged and aerial parts and leading to “partial-coverage” impacts. These findings provide a foundation for phytoremediation strategies, enabling the rational selection and management of aquatic plant types to mitigate antibiotic pollution. Our study underscores the ecological risks posed by antibiotic contamination in aquatic ecosystems and offers a theoretical framework for developing effective restoration strategies.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"281 ","pages":"Article 107289"},"PeriodicalIF":4.1,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative stress dynamics in Hyalella azteca under sub-chronic exposure to naturally aged polypropylene microplastics","authors":"Caio César Achiles Prado ,&nbsp;Lucas Gonçalves Queiroz ,&nbsp;Teresa Cristina Brazil de Paiva ,&nbsp;Marcelo Pompêo ,&nbsp;Rômulo Ando ,&nbsp;Bárbara Rani-Borges","doi":"10.1016/j.aquatox.2025.107303","DOIUrl":"10.1016/j.aquatox.2025.107303","url":null,"abstract":"<div><div>Microplastics (MPs) pollution has revealed a serious environmental issue, demonstrating chronic consequences for the affected environments and organisms. Although these plastic particles, pristine and aged, can circulate in different environmental matrices, their actual impacts on aquatic ecosystems are still under investigation. Here, we studied the toxicity of naturally aged secondary polypropylene (PP) MPs after constant exposure to ultraviolet radiation (26 µm) to the freshwater amphipod <em>Hyalella azteca</em>. The concentrations tested were 135, 1350, and 13,500 items/L. <em>H. azteca</em> was investigated for mortality and changes in enzyme markers after 7 and 14 days of exposure followed by a further 7 days of depuration. The results show that mortality was only significant at the highest concentration tested. The concentration of 13,500 items induced oxidative stress after 7 days of exposure only at the MDA levels and CAT activity, while the concentrations of 1350 and 13,500 items/L induced oxidative stress in all tested markers (SOD, CAT, GST and MDA after 14 days. After 7 days of depuration, the levels of biochemical damage were reduced, demonstrating the ability of the species to recover as they are isolated from this pollutant.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"281 ","pages":"Article 107303"},"PeriodicalIF":4.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting mito-target interactions for per-and poly-fluoroalkyl compounds: Mapping mitochondrial toxicity on zebrafish voltage-dependent anion channel 2","authors":"Michael González-Durruthy,&nbsp;Amit K. Halder,&nbsp;Ana S. Moura,&nbsp;M. Natalia D.S. Cordeiro","doi":"10.1016/j.aquatox.2025.107302","DOIUrl":"10.1016/j.aquatox.2025.107302","url":null,"abstract":"<div><div>Effective and reliable prediction for ecotoxicity, especially when affecting different levels of trophic chains, including humans, is increasingly gaining even more prominence as ecosystems face new threats and challenges, as that posed by the per- and poly-fluoroalkyl substances (PFAS). Toxicological prediction of PFAS in aquatic organisms, such as zebrafish, can be efficiently achieved through computational ecotoxicological approaches which are fully aligned with the state-of-the-art of new approach methodologies (NAMs) and current regulatory recommendations. Specifically in this work, the PFAS toxicodynamics interaction on the zebrafish mitochondrial voltage-dependent anion channel (zfVDAC2) was evaluated, mimicking <em>in silico</em> the PFAS bioaccumulation in low-concentration by integrating structure-based virtual screening (SB-VS) and predictive quantitative structure-activity(mitotoxicity) relationship (QSAR) methodologies (e.g., 2D/3D-QSAR) to address mechanistic aspects of PFAS toxicity. The best ranked PFAS pose docked in zfVDAC2 exhibits a ΔG-binding affinity higher than the ATP, i.e., the native substrate of the zfVDAC2 channel, with prevalence of van der Waal interactions, followed by fluorine (F)-halogen-bonds and finally hydrogen-bonds interactions. Mitochondrial ATP-transport blocking is thus suggested to be linked with local-flexibility perturbations in the zfVDAC2. Similarly, the obtained 2D/3D- QSAR models point out the packing density index as the most significant PFAS molecular descriptor to induce toxicity in the zfVDAC2, and mainly involving van der Waal interactions. The predictive and statistical performance of these models further indicate its NAM relevance regarding PFAS risk assessment while highlighting its interoperability and extrapolation capability for the ecotoxicological evaluation of other families of compounds.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"281 ","pages":"Article 107302"},"PeriodicalIF":4.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmentally relevant concentrations lithium exposure induces neurotoxicity in yellowstripe goby (Mugilogobius chulae): Responses of BDNF/AKT/FoxOs in regulating glutamate excitotoxicity and mitochondrial function","authors":"Weibo Gong ,&nbsp;Yufei Zhao ,&nbsp;Huiyu Zhang,&nbsp;Chunni Duan,&nbsp;Yuanyuan Xiao,&nbsp;Yimeng Wang,&nbsp;Chao Wang,&nbsp;Xiangping Nie","doi":"10.1016/j.aquatox.2025.107294","DOIUrl":"10.1016/j.aquatox.2025.107294","url":null,"abstract":"<div><div>The wide application of lithium in green energy and clinical psychiatry results in ubiquitous occurrence of lithium in aquatic environments. However, researches on the toxicity of lithium are largely confined to acute and/or high-dose scenarios, with insufficient data on its impacts on non-target organisms at environmental levels. The present study investigated the neurotoxicological effects of environmentally relevant concentrations of lithium exposure on yellowstripe goby (<em>Mugilogobius chulae</em>) and the related molecular response mechanisms. The results showed that lithium exposure significantly inhibited the expression of the target protein GSK-3β in the brain of <em>M. chulae</em>, and induced a series of harmful events including oxidative stress, glutamate accumulation, and even behavioral alteration. The organism mitigated the excitotoxic effects of glutamate accumulation by down-regulating ionotropic glutamate receptors. At the same time, the organism met the energy supply and alleviated oxidative stress by altering mitochondrial function. Notably, the stress regulators FoxOs and sestrins both modulated synaptic sensitivities to enhance the neural signaling and altered the energy metabolism pattern to alleviate energy crisis, all of which were important for maintaining neuronal survival and organismal homeostasis. In conclusion, lithium exposure induced glutamate excitability and led to a series of toxic events. Meanwhile, FoxOs played an important role in neural signaling and homeostatic regulation of energy metabolism in brain. This study furthered the comprehension of the neurotoxic impacts of lithium on aquatic organisms, elucidated the associated molecular mechanisms, and underscored the environmental risks posed by increasing lithium contamination.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"281 ","pages":"Article 107294"},"PeriodicalIF":4.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First insights into aliphatic and polycyclic aromatic hydrocarbons (PAHs) in hawksbill turtle (Eretmochelys imbricata) eggs from Persian Gulf, Iran","authors":"Sara Pouyande,&nbsp;Alireza Riyahi Bakhtiari,&nbsp;Seyed Mahmoud Ghasempouri","doi":"10.1016/j.aquatox.2025.107287","DOIUrl":"10.1016/j.aquatox.2025.107287","url":null,"abstract":"<div><div>Petroleum pollution in marine ecosystems has raised great concern for both marine organisms and human health. The Persian Gulf, as a significant hotspot of petroleum pollution, is a crucial nesting area for hawksbill turtles (<em>Eretmochelys imbricata</em>) worldwide. In this work concentration level, source, and compositional profiles of polycyclic aromatic hydrocarbons (PAHs) and normal alkanes (<em>n</em>-alkanes) were analyzed in the yolk, albumen, and shell of hawksbill turtle eggs collected from 3 nests on the Persian Gulf coast of Iran. Twenty-eight PAHs and 19 <em>n</em>-alkanes were detected in samples. The highest levels of ƩPAHs and Ʃ<em>n</em>-alkanes were found in yolk samples compared to the albumen and shell, possibly due to the high lipid content and lengthy duration of yolk formation. Comparable levels of pollutants were found in eggshells, indicating the potential for turtle eggshells to accumulate organic pollutants. The source of PAHs and <em>n</em>-alkanes in all samples primarily indicates petrogenic, suggesting extensive oil-producing activities and petroleum pollution in the Persian Gulf. Inter-nest variations in levels and profiles of PAHs and <em>n</em>-alkanes were observed in the eggs from the 3 nests, which might be related to the turtle's diets and migration patterns. Although this study provides the first monitoring data on organic pollutants for sea turtles in the Persian Gulf, more complementary researches are required in terms of monitoring petroleum biomarkers in foraging grounds, maternal blood, and their eggs in this region.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"281 ","pages":"Article 107287"},"PeriodicalIF":4.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polar cod early life stage exposure to potential oil spills in the Arctic","authors":"Frode B. Vikebø ,&nbsp;Raymond Nepstad ,&nbsp;Mateusz Matuszak ,&nbsp;Edel S.U. Rikardsen ,&nbsp;Benjamin J. Laurel ,&nbsp;Sonnich Meier ,&nbsp;Elena Eriksen ,&nbsp;Johannes Röhrs ,&nbsp;Kai H. Christensen ,&nbsp;Malgorzata Smieszek-Rice ,&nbsp;Alf Håkon Hoel ,&nbsp;Mats Huserbråten","doi":"10.1016/j.aquatox.2025.107293","DOIUrl":"10.1016/j.aquatox.2025.107293","url":null,"abstract":"<div><div>Arctic amplification of climate change is causing sea ice to retreat at unprecedented rates, potentially opening up large vulnerable Arctic areas for oil and gas exploration and new shipping routes. This rapid warming marginalizes sympagic species habitats making them more sensitive to other anthropogenic pressures. Here, we assess potential impacts of hypothetic oil spills from the northernmost licensed oil field Wisting and additional neighbouring spill sites in areas currently not open to oil exploitation on the key ice-associated Arctic fish species polar cod (<em>Boreogadus saida</em>). We do this by developing and running combined data-driven models for the ocean, oil spill dispersal and fate, and the early life stages of polar cod. Sea ice and the Polar Front act as natural barriers limiting the exchange of polar cod eggs and larvae and oil spill between Atlantic and Polar Water. However, both barriers vary seasonally so that the sea ice retreats and the Polar Front weakens towards summer causing significant increases in oil exposure to early life stages of polar cod under varying oil spill scenarios investigated here. Previous literature emphasizes that fall feeding conditions must be sufficient for juvenile polar cod to allocate lipids and survive their first winter. Here, we show that less than half the exposed individuals experience these suitable feeding conditions in the fall. The seasonal exposure intensity suggests a need for petroleum regulations with temporal and spatial limitations varying through the year. However, even with these seasonal dynamic regulations in place, climate change induced by the use of fossil fuel will likely reduce these natural barriers through continued sea ice retreat and a weakening of the Polar Front thereby reducing their barrier effects. Risk assessments of anthropogenic impacts on key Arctic ecosystem components in the vicinity of the ice edge zone and the Polar Front will therefore have to be updated to account for these major changes.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"281 ","pages":"Article 107293"},"PeriodicalIF":4.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined toxicity of microplastic fibers and dibutyl phthalate on algae: Synergistic or antagonistic?","authors":"Le Liang ,&nbsp;Yangyang Liang ,&nbsp;Min Su ,&nbsp;Zhe Wang ,&nbsp;Zhendong Zhou ,&nbsp;Xiaotao Zhou ,&nbsp;Zhongguan Jiang","doi":"10.1016/j.aquatox.2025.107290","DOIUrl":"10.1016/j.aquatox.2025.107290","url":null,"abstract":"<div><div>Plastics, combined with plasticizers, have been widely utilized worldwide. Microplastic fibers (MPFs) and dibutyl phthalate (DBP) account for the most predominant microplastics and plasticizers detected in freshwater ecosystem, with their joint toxicity being limited studied. In this study, we employed freshwater algae (<em>Chlorella vulgaris</em>) as toxicity test model organism to assess their growth, photosynthesis, metabolism, and oxidative response when exposing to different concentrations of polypropylene MPFs and the co-exposure of DBP. In addition, the toxic interaction between MPFs and DBP was assessed by combining the integrated toxicity value (Integrated Biomarker Response version 2, IBRv2) and the mixture toxicity index (Effect Addition Index, EAI). Our results demonstrated significant toxic effects of MPFs and DBP on <em>C. vulgaris</em>, and highlighted their dynamic interactions with <em>C. vulgaris</em>. Specifically, when combining with DBP, MPFs with high concentrations exhibited significantly increase in algae growth inhibition, photosynthetic pigment contents (Chl-a, Chl-b, and carotenoids), protein contents, and oxidative enzymes (SOD, CAT, and MDA). In terms of integrated toxicity values, higher IBRv2 values were recorded by the combined exposure of MPFs and DBP in contrast with the sole exposure groups, indicating that the combined exposure caused more severe damage to photosynthesis, oxidation and metabolism. In addition, our study recorded synergistic combined toxicity when MPFs were in high concentrations, whereas antagonistic combined toxicity when MPFs were in low concentrations. Our study highlights the MPFs concentration-dependent combined toxicity (synergistic or antagonistic) when exposing to microplastics and plasticizers in freshwater ecosystems.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"281 ","pages":"Article 107290"},"PeriodicalIF":4.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to complex mixtures of urban sediments containing Tyre and Road Wear Particles (TRWPs) increases the germ-line mutation rate in Chironomus riparius","authors":"Lorenzo Rigano ,&nbsp;Markus Schmitz ,&nbsp;Volker Linnemann ,&nbsp;Martin Krauss ,&nbsp;Henner Hollert ,&nbsp;Markus Pfenninger","doi":"10.1016/j.aquatox.2025.107292","DOIUrl":"10.1016/j.aquatox.2025.107292","url":null,"abstract":"<div><div>Tyre and road wear particles (TRWPs) are a significant yet often underestimated source of environmental pollution, contributing to the accumulation of microplastics and a complex mixture of contaminants in both terrestrial and aquatic ecosystems. Despite their prevalence, the long-term evolutionary effects of TRWPs, beyond their immediate toxicity, remain largely unknown. In this study, we assessed mutagenicity in the non-biting midge <em>Chironomus riparius</em>, upon exposure to urban sediment collected from a runoff sedimentation basin. To assess the extent of mutagenic effects over multiple generations, we combined the urban sediment exposure model with short-term mutation accumulation lines (MALs) and subsequent whole genome sequencing (WGS). The study was conducted over five generations, with urban sediment concentrations of 0.5 % and 10 %. Our results reveal that the exposure to urban sediment significantly increases mutation rates compared to control groups by 50 %, independent of concentration (0.5 % and 10 %). To infer potential causal processes, we conducted a comparative analysis using known mutational spectra from previous studies. This comparison showed that the mutation profiles induced by urban sediment clearly clustered with those caused by Benzo[a]Pyrene (BaP), a known Polycyclic Aromatic Hydrocarbon (PAH). A comprehensive chemical characterization of the sediment confirmed a considerable impact of road runoff and traffic-related contamination, including PAHs of primarily petrogenic origin. This suggests that PAH-like compounds present in urban sediments may play a significant role in the observed mutagenic effects. Our study shows that urban sediments influence mutation rates and alter mutational spectra in exposed organisms, potentially compromising genomic stability and shaping evolutionary trajectories. These genetic changes can have profound long-term effects on population dynamics and ecosystem health, underlining the importance of understanding the evolutionary consequences of environmental pollution. Additionally, we show that comparatively analysing of mutational spectra may provide valuable insights into mutational processes.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"281 ","pages":"Article 107292"},"PeriodicalIF":4.1,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute cardiorespiratory effects of 6PPD-quinone on juvenile rainbow trout (Oncorhynchus mykiss) and arctic char (Salvelinus alpinus)","authors":"Summer J. Selinger ,&nbsp;David Montgomery ,&nbsp;Steve Wiseman ,&nbsp;Markus Hecker ,&nbsp;Lynn Weber ,&nbsp;Markus Brinkmann ,&nbsp;David Janz","doi":"10.1016/j.aquatox.2025.107288","DOIUrl":"10.1016/j.aquatox.2025.107288","url":null,"abstract":"<div><div>N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPD-quinone) is an environmental transformation product of the widely used rubber tire antioxidant, 6PPD. Found in stormwater runoff, 6PPD-quinone has been reported to cause acute lethality at ≤1 μg/L in salmonids like coho salmon, rainbow trout, and brook trout. Conversely, other species such as Arctic char and brown trout are insensitive, even when exposed to significantly greater concentrations (3.8–50 μg/L). Sensitive species exhibit symptoms such as gasping, spiraling, increased ventilation, and loss of equilibrium, suggesting a possible impact on cardiorespiratory physiology. This study investigated sublethal 6PPD-quinone toxicities, focusing on cardiovascular and metabolic effects in two salmonids of varying sensitivity: a sensitive species, rainbow trout (<em>Oncorhynchus mykiss)</em> and a tolerant species, Arctic char (<em>Salvelinus alpinus</em>). Fish were exposed to measured concentrations of 0.59 or 7.15 μg/L 6PPD-quinone, respectively, in respirometry chambers for 48 h to assess temporal changes in resting oxygen consumption compared to unexposed controls. Following exposure, cardiac ultrasound and electrocardiography characterized cardiac function <em>in vivo,</em> while blood gas analysis examined blood composition changes. In both species, changes in resting oxygen consumption were observed. In rainbow trout only, a decrease in end systolic volume and an increase in passive ventricular filling, cardiac output, and PR interval length were observed, indicating cardiac stimulation. Cardiorespiratory symptoms observed following rainbow trout exposure might partly be driven by a significant increase in methemoglobin, resulting in an impaired ability to oxygenate tissues. This study is the first to examine the effects of 6PPD-quinone exposure on the cardiorespiratory system of salmonid fishes and provides information invaluable to a better understanding of the mechanism of 6PPD-quinone toxicity.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"280 ","pages":"Article 107288"},"PeriodicalIF":4.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modelling the size distribution and bioaccumulation of gold nanoparticles under mixture exposure","authors":"Yao Li ,&nbsp;Xiangrui Wang ,&nbsp;Dingyuan Liang ,&nbsp;Xiaoli Zhao ,&nbsp;Zhaomin Dong ,&nbsp;Yingchen Bai ,&nbsp;Wen-Xiong Wang ,&nbsp;Willie J.G.M. Peijnenburg ,&nbsp;Ying Wang ,&nbsp;Wenhong Fan","doi":"10.1016/j.aquatox.2025.107286","DOIUrl":"10.1016/j.aquatox.2025.107286","url":null,"abstract":"<div><div>To assess the bioaccumulation and toxicity of nanoparticles (NPs), analyzing and modelling the relationship between the size distribution of NPs in organisms and the exposure particle size distribution represents an important challenge. Previous studies mostly focused on the NPs with single size. However, the size distribution of NPs is wide and variable in the natural environment. There is a lack of research on the NPs with mixed sizes. This study investigated the size distribution of three gold (Au) NPs with different sizes and their mixtures within a ciliate <em>Tetrahymena thermophila</em> under the same number concentration of particles. Results revealed that smaller particles tended to aggregate and bioaccumulate more in cells. Using expectation–maximization algorithm, a particle size distribution model of NPs in cells was established. This model effectively simulated the size distribution of NPs with mixed sizes in cells, demonstrating high accuracy with a mean absolute error of &lt; 0.001, a root mean squared error of &lt; 0.001, and a correlation coefficient exceeding 0.98. Experimental results further verified that the model reliably predicted the size distribution of NPs with mixed sizes in cells, and smaller particles accounted for a larger proportion of the size distribution and bioaccumulation. These results demonstrated the importance of particle size and size distribution of NPs in their environmental effects. Models developed here can provide guidance for future evaluation of the environmental risks of NPs mixtures.</div></div>","PeriodicalId":248,"journal":{"name":"Aquatic Toxicology","volume":"280 ","pages":"Article 107286"},"PeriodicalIF":4.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}