South Asian Research Journal of Pharmaceutical Sciences最新文献

{"title":"Comparison of the Sensitivity of Sterility Tests Based on the Analysis of 2x2 Contingency Tables","authors":"Stanislav V. Yefimov","doi":"10.36346/sarjps.2022.v04i04.001","DOIUrl":"https://doi.org/10.36346/sarjps.2022.v04i04.001","url":null,"abstract":"The work is devoted to statistical methods for determining the comparative sensitivity of sterility analyzers with a binary scale: 1/0, +/-. The paper considers both traditional statistical test methods namely the direct binomial test, the McNemar test, and the new, highly sensitive Yefimov Method, and Pearson-Yefimov statistical test. First, the comparative effectiveness of statistical methods for assessing the sensitivity of testers is demonstrated on a specially developed model system (the Test Bench), and then on real experimental data. The data were obtained during the validation of a new tester and a new method for analyzing samples for sterility. The new method is compared with the old one, the certified method. The sensitivity of both new and old methods (testers) was already determined earlier by a direct non-statistical method, which allowed us to compare the results of the two approaches. The factors influencing the efficiency of statistical tests are revealed and described.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"57 8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127576536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quorum Sensing and its Correlation with Virulence Factors","authors":"F. N. Jaafar, Majid Ahmed AL-Bayati, H. Musafer, M. Azeez, Zahraa Kareem Raheem","doi":"10.36346/sarjps.2022.v04i03.003","DOIUrl":"https://doi.org/10.36346/sarjps.2022.v04i03.003","url":null,"abstract":"Quorum sensing (QS) is cell to cell signaling mechanism that enables bacteria collectively control gene expression in response to their population density, or it is bacterial communicate with one another using chemical signals. There are three types of signaling molecules: Acyl-homoserinelactonase (AHLs), Auto-inducer peptides (AIPs) and Autoinducer-2 (AI-2). Q.S was first observed and described in bioluminescence bacterium V.fischeri.In V. fischeri, several kinds of quorum sensing system were identified. At first, lux system was found and regulates the luciferase operon and light production. LuxIwas isolated as an AHL synthase while LuxR was isolated as a transcriptional activator of the luciferase operon. At low cell density, LuxOrepresses LitR, which is a positive regulator of the expression of LuxR. Quorum quenching (QQ) refers to the mechanism by which bacterial communication can be interrupted, or it is the process of preventing QS by disrupting the signaling.The first major QS-disrupting strategy that has been studied is the interference with the detection of the AIs and the second one is the inactivation/degradations of the signal molecules.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132644183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Fibrinogen Level and Platelets Parameters among Vaccinated Healthy Individuals with COVID-19 Vaccine at Shendi Town","authors":"Eslam Mohammed Yousef Ahmed, M. Ali, Lana Jamal Abubaker, G. M. Mahjaf, Hamza Hassan, M. Hamad","doi":"10.36346/sarjps.2022.v04i03.004","DOIUrl":"https://doi.org/10.36346/sarjps.2022.v04i03.004","url":null,"abstract":"Background: Covid-19 vaccine is an immunization method used to reduce coronavirus incidence but lately caused life-threatening events such as thrombosis with thrombocytopenia syndrome. Methods: This is a case-control study conducted at Shendi town to evaluate platelet parameters and fibrinogen levels in vaccinated healthy individuals With Covid-19 vaccines between Augusts to November 2021. A total of (100) vaccinated healthy individual With the Covid-19 vaccine was enrolled in the study as test groups, compared with (50) healthy volunteers as a control group. Venous blood samples were transferred into Trisodium citrate and EDTA anticoagulant. Data was collected using a questionnaire and the (SPSS) version (22) program was used for data analysis. Results: The study revealed that the vaccinated healthy individuals were; (50%) male and (50%) female. The platelets parameter and fibrinogen indicated the mean values of platelets count, mean platelets volume, platelets distribution width, platelet crit, and fibrinogen, in Janssen vaccine groups, were (251.14 109L), (8.39 fl), (15.6), (0.203%), and (158 mgdl) respectively. The results study revealed the mean of PLT, MPV, PDW, PCT, and Fibrinogen, in Astrazeneca vaccine groups, were (272.08 109L), (8.13fl), (15.56), (0.2211%), (159 mg/dl) respectively. Also explained the mean of PLT, MPV, PDW, PCT and Fibrinogen, in Astrazeneca vaccine groups were (272.08 109L), (8.13fl), (15.56), (0.2211%), (159 mgdl) respectively and in Janssen vaccine groups the mean values of PLT, MPV, PDW, PCT, Fibrinogen were ( 251.14 109L), (8.39fl), (15.63), (0.2034%), (158 mgdl) respectively. Conclusions: Covid-19 vaccines are responsible for significant changes in fibrinogen level in both AstraZeneca and Janssen vaccine groups.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133691303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levels of Interleukin-6,17, Complement and Dopamine in Infected Women with Toxoplasmosis","authors":"Talib Wseen Hussein, K. Mohammed, Mohammed Abdul Salam","doi":"10.36346/sarjps.2022.v04i03.002","DOIUrl":"https://doi.org/10.36346/sarjps.2022.v04i03.002","url":null,"abstract":"The study was carried out to detection of Toxoplasma gondii in (135) women patients with repeated abortion with age ranged 18-43 years who attended two teaching hospitals in Baghdad. The diagnosis is done by Immunochromatography and ELISA methods. a blood samples was taken from each patients as well as other(30)healthy control matching in age. The study included measurement the concentration of Interleukin-6, Interleukin-17, Dopamine and Complement in sera of patients and control .The result indicated presence the of anti-Toxoplasma IgG in 26 cases a, Anti-toxoplasma IgM in 14 cases and 10 in both out of 135 cases of aborted women with Toxoplasma in immunochromatography methods while the level of IgM 1.57 IU/ml and IgG 142.73. Also, the result indicated significant increasing levels of IL-6 and IL-17, Complement and Dopamine in patients sera in comparison with healthy control.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114291980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical Screening and Learning and Memory Activity of Cucurbita pepo against Ethanol Induced Cognitive Impairment in Rodents by Using 8-ARM Radial Maze [8-ARM]","authors":"K. Lakshmi, A. Sowmya, Bathina Vara Lakshmi, Tejavathu Vijaya Lakshmi, Bhukya Ratna Madhuri, Peddarapu Sandhyarani, P. Supriya, Pilli Anusha, Shaik Sabeeha","doi":"10.36346/sarjps.2022.v04i03.001","DOIUrl":"https://doi.org/10.36346/sarjps.2022.v04i03.001","url":null,"abstract":"The present study was undertaken to investigate the learning and memory enhancing activity of Cucurbita pepo seed extract in rats by using the ethanol induced cognitive impairment and its effects were examined by using 8-radial arm maze (8-RAM) test. For radial arm maze test all groups showed significantly (P value is< 0.0001& < 0.001) decreased in the time taken to reach the paired arm and number of entries in baited arm and non-baited arm as compared to ethanol inducing group. Therefore seed extracts of Cucurbita pepo exhibited significantly learning and memory activity in Alzheimer’s disease.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127429702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Analysis of a Multi-Component Injection Solution Containing Folic Acid, Tryptophan, Niacin, and Thiamine by HPLC","authors":"Stanislav V. Yefimov","doi":"10.36346/sarjps.2022.v04i02.004","DOIUrl":"https://doi.org/10.36346/sarjps.2022.v04i02.004","url":null,"abstract":"We were tasked with testing a multicomponent aqueous solution for injection used in veterinary medicine. The composition of the solution included the following components: folic acid, tryptophan, nicotinic acid, thiamine hydrochloride, ascorbic acid, sodium acetate, and benzyl alcohol. The composition indicates that the drug is intended to stimulate the vital activity of the body. It was required to determine the activity and stability of four components: folic acid, tryptophan, nicotinic acid, and thiamine hydrochloride. The complexity of the simultaneous determination of these components was that they differ greatly in their acid-base properties and solubility in water. We managed to solve the problem using an Agilent HPLC/DAD/MS instrument and selected the parameters to determine all four components together reliably and accurately or each separately by one method.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128817195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dithymoquinone Prevents Preeclampsia and Conserves Foetal Health: A Perspective Study","authors":"M. Hamad","doi":"10.36346/sarjps.2022.v04i02.003","DOIUrl":"https://doi.org/10.36346/sarjps.2022.v04i02.003","url":null,"abstract":"Dithymoquinone is a poorly studied carbonyl polymer of thymoquinone component of black cumin seeds. It suppresses release of histamines and improves clearance of cortisol in the liver and maintains the strength of placental aryl hydrocarbon receptors. Furthermore, we hypothesized that the low percentage of it in black seeds and its slow reduction make it safe for both the mother and her foetus. As many studies suggest, high levels of both histamine and cortisol are associated with preeclampsia, miscarriage, still birth and preterm delivery. We hypothesized that administration of dithymoquinone during pregnancy will prevent pregnancy complications, certainly preeclampsia and maintain the foetus’s life. Experimental research is required to know more about the role of dithymoquinone in maternal and foetal health.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124425527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Synthesis and Characterization of Libyan Propolis Nanoparticles and its Biological Activity","authors":"S. Saadawi, Rokaya Amara, H. N. Mughrbi, Bushra M. Dakhil, R. M. E. Moslemany, Khadija O. Turkman, Masarra A. Daraweel, K. Alennabi, R. Alghazeer","doi":"10.36346/sarjps.2022.v04i02.002","DOIUrl":"https://doi.org/10.36346/sarjps.2022.v04i02.002","url":null,"abstract":"The ever-increasing demand for natural products and biotechnology, derived from bees and ultra-modernization of various analytical devices, has facilitated the rational and planned development of biotechnology products with a focus on human health to treat chronic and neglected diseases. This study aimed to prepare, characterize and examine the stability and evaluation of the antioxidant and the antibacterial activity of Libyan propolis. Propolis Nanoparticles PNP were prepared using particle size reduction, then Transmission Electron Microscope (TEM) at a magnification of X 25000, was used for accurate evaluation of the size distribution of NPs. Three different concentration (10, 5, 2.5 mg/ml) of propolis and nano-propolis powder were tested for their 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. The quantitative antioxidant activity test results using UV Spectrophotometer absorbance at 517 nm. The antibacterial activities of propolis and prepared nano propolis at different concentrations (10, 5 and 2.5mg/ml) were tested on bacterial strain, Klebsiella, human mouth, skin, and surface bacteria using cup cut diffusion method. The findings exhibited that the prepared propolis Nanoparticles (PNPs) were generally non-spherical with a size 100-200 nm. The PNP was a nano-sized particle around 316 nm in diameter. Zeta potential of PNP showed a negative surface charge value (− 48 mV) which was sufficiently high to avoid NPs aggregation. This value represents a stable and dispersed suspension of NPs and disables the tendency of aggregations in a short in period of time. Poly dispersity index (PdI) of synthetized PNP was used as a measurement of the size distribution. PdI values for PrNP were generally uniform with PdI 0.3 indicating monodispersity of the prepared systems. The propolis and PNPs displayed good antioxidant activity with inhibition percentage (77%, 46% and 18%) for propolis and (82%, 66% and 37%) for PNPs. Propolis nanoparticles showed to have more antibacterial effect compared to propolis. Libyan propolis nanoparticles has shown to be potential candidates as antioxidant and antibacterial agent.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129036425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Energy Drinks Consumption on Physical Performance Beneficial and Adverse Impact on Health","authors":"Sara Chaudhry, Sabeeha Iqbal, Mahjbeen Abdul Kareem, Ayesha Amanat, J. Fatima","doi":"10.36346/sarjps.2022.v04i02.001","DOIUrl":"https://doi.org/10.36346/sarjps.2022.v04i02.001","url":null,"abstract":"Consumption of energy drinks has been increasing dramatically in the last two decades, particularly amongst adolescents and young adults. Energy drinks are aggressively marketed with the claim that these products give an energy boost to improve physical and cognitive performance. Energy drinks have several adverse health effects. The prevalence of Energy Drinks usage in this group ranges from 52% to 68%, whilst in adults is estimated at 32%. The compositions of energy drinks vary widely. Caffeine content can range from 75 to 240 mg, whereas the average taurine quantity is 342.28 mg/100 mL. Caffeine and taurine in doses 3–6 mg/kg and 1–6 g, respectively, appear to be the main ergogenic elements. It is concluded that although energy drink may have beneficial and adverse effects on physical performance, these products also have possible detrimental health consequences. Energy-drink usage is higher among males and those with higher monthly expenditure. A high proportion of students are ignorant to the main constituents and side effect of energy drinks.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132541266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One Step Extraction Method, Sample Preparation Procedure for HPLC/MS Analysis of Altrenogest Sesame Oil Solutions [Extraction of altrenogest from sesame oil with acetonitrile, HPLC/MS]","authors":"Stanislav V. Yefimov, P.B.F. Gil","doi":"10.36346/sarjps.2022.v04i01.003","DOIUrl":"https://doi.org/10.36346/sarjps.2022.v04i01.003","url":null,"abstract":"The extraction of altrenogest with acetonitrile from sesame oil is not an easy task due to the formation of a stable emulsion. The problem of extracting more than 99% of altrenogest from sesame oil with acetonitrile was solved. The optimal ratio of extractant to extractor was established. This approach allowed for a quantitative analysis of altrenogest in sesame oil solutions by HPLC/MS. A generalization of the proposed approach to cases of altrenogest extraction from stable emulsions was discussed.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127959147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}