South Asian Research Journal of Pharmaceutical Sciences最新文献

{"title":"Development of a Transdermal Delivery System for Tacrine","authors":"Divakar Kanakagiri, A. Chettupalli","doi":"10.36346/sarjps.2022.v04i01.002","DOIUrl":"https://doi.org/10.36346/sarjps.2022.v04i01.002","url":null,"abstract":"Tacrine has several mechanisms of action. The putative primary mechanism of action of tacrine for Alzheimer's disease is reversible inhibition of acetylcholinesterase (AChE), which thus slows the breakdown of the chemical messenger acetylcholine (ACh) in the brain. Tacrine also inhibits butyrylcholinesterase activity. In accumulation, tacrine blocks sodium and potassium channels. Tacrine also acts as a histamine N-methyltransferase inhibitor. This study was carried out to develop matrix based transdermal patches containing Tacrine to overcome the first pass metabolism and to reduce frequency of dosing compared to oral route. . Matrix type of transdermal patches was developed by using Methocel K4M, Methocel K15M, Methocel K100M and Xanthan gum polymers. Transdermal patches were prepared by employing solvent casting method. Drug excipients compatibility studies were carried out by using FTIR, and it was observed that there were no interactions. Formulations were prepared with the varying concentrations polymers ranging from F1-F16, and all the formulations were evaluated for various physical parameters Physical appearance, Flatness, Weight variation, Thickness, Folding endurance, Drug content, Moisture uptake, Moisture content and Swelling study and all the results were found to be within the pharmacopeial limits, invitro drug release studies by using dialysis membrane. Among all the 16 Tacrine transdermal patches formulations F5 formulations which contain Methocel K15M 100 mg had shown 97.61% % cumulative drug release within 12 hours.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133445286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rice-A Review of Nutritional and Medicinal Aspect Mentioned in Ayurveda","authors":"Padma Lochan Naik, M. Kotecha, S. Nathani, B. S. Rathore","doi":"10.36346/sarjps.2022.v04i01.001","DOIUrl":"https://doi.org/10.36346/sarjps.2022.v04i01.001","url":null,"abstract":"Rice not only an essential food but also a source of protein. Ancient Ayurvedic Acharyas described Raktashali red rice as a nutritive food and medicine. Rice is the second most used cereals in the world next to wheat. Ayurveda have attributed some medicinal properties too in addition to main stay as food. According to Ayurveda rice has the ability to alleviate or subdue Tridoshas (humors) – Vata, Pitta and Kapha -whose imbalance causes various types of diseases within the body. Different groups of rice have different effect on human body as they have different inherent properties. From being used as a diet for sick it has been used as a wholesome and rice is considered as best food in some diseases mentioned in different Ayurveda text.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128994784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant and Antibacterial Effect of Vitis labrusca, Vitis vinifera and Vitis vinifera Seeds Extract","authors":" Sakina S. Saadwi, A. Ammar, Riham J. Kushaiba, Surror A. Harakat, Khairi A. Alennabi","doi":"10.36346/sarjps.2021.v03i02.003","DOIUrl":"https://doi.org/10.36346/sarjps.2021.v03i02.003","url":null,"abstract":"Grape seeds extract has therapeutic values including antimicrobial activity, antioxidant effect, wound healing and prevention of cardiovascular diseases. This study aimed to evaluate and compare antibacterial activity of different species of grape seed) Vitis labrusca, Vitis vinifera and Vitis vinifera( against some bacterial strains (Staphylococcus aureus, Streptococcus pneumonia, Acinetobacter Calcoaceticus, Klebsiella pneumoniae and Escherichia coli). Determine antioxidant effect of grape seed extracts (qualitatively). Antibacterial effects was performed using agar cup cut diffusion method for all bacterial species, followed by using minimum inhibitory concentration MIC for the species showed to be inhibited by grape seeds extracts. Antioxidant assay was done using DPPH scavenging test, methanolic solution of each grape seeds was spotted on TLC paper, sprayed with 0.2 % methanolic solution of diphenyl picryl hydrazyl (DPPH) reagent. Vitamin C was used as positive control. From the results, all grape species didn’t have any effect on K. pneumonia and E. coli, red and black grape seeds showed the highest inhibition zone (20 mm) on Staph. Aureus agar plate, green grape had the highest effect on Sterp. Pneumonia agar plate (20 mm). The lowest effect was for the red grape seeds extract (13 mm) on Acinetobacter calciaceticus. In general the three grape seeds extract had effect on Staph. aureus, Sterp. pneumonia and Acinetobacter calciaceticus. The red and black grape seed extract was effective against Sterp. pneumonia strain at MIC values of 7.8 mg/mL and black grape seeds extract had MIC at 7.8 mg/mL on Staph. aureus. However, the test for MIC of seeds extracts for the rest of bacterial species ranged between 15.62 and 87.5 mg/mL. The result showed that black grape seeds extract had the largest spot change in color indicating strong antioxidant effect. The lowest effect was by red grape seeds. From this result black grape showed to be the best grape seeds extract among the three chosen species in its antibacterial and antioxidant efficacy.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128709082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and in Vitro Evaluation: Once-Daily Sustained Release Matrix Tablets of Propranolol","authors":" Rashmi Shivaji Tambare, Minal Chaudhari, S. Kakade","doi":"10.36346/sarjps.2021.v03i02.002","DOIUrl":"https://doi.org/10.36346/sarjps.2021.v03i02.002","url":null,"abstract":"The objective of the present study was to develop once-daily sustained-release matrix tablets of propranolol used in the treatment of hypertension, angina pectoris, and many other cardiovascular disorders. The constrained mixture experimental design was used to prepare systematic model formulations, which were composed of Eudragit RSPO and different viscosity grades of HPMC (Methocel E50 and Methocel K15M CR). The matrix tablets were prepared by direct compression process. The prepared tablets were evaluated for various physico-chemical parameters. In vitro release profile was check for 24 hrs to evaluate the SR matrix tablet of propranolol. Increase in Eudragit RSPO and HPMC concentrations or increase in viscosity grades of HPMC polymers (Methocel E50 and Methocel K15M CR) resulted in a significant decrease in propranolol release. Administration of propranolol in a sustained release dosage would be more desirable for antihypertensive effects by maintaining the plasma concentrations of the drug well above the therapeutic concentration. From in vitro dissolution profile, Batch F4 was prepared with blend of Eudragit RSPO (80 mg), Methocel E50 (60 mg) and Methocel K15M CR (80 mg) where drug release was about 98.11%.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114070321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Assessement of the Severity of Knee Osteoarthritis in the University of Benin Teaching Hospital","authors":"J. Idiake, Lauretta Efienokwu Lawrence, A. W. Udezi, S. Usifoh, M. I. Agun","doi":"10.36346/sarjps.2021.v03i02.001","DOIUrl":"https://doi.org/10.36346/sarjps.2021.v03i02.001","url":null,"abstract":"Osteoarthritis is the most common arthritis affecting millions of people worldwide. Knee osteoarthritis calls for serious medical concern as severe cases/advance stages can impair mobility and lead to a poor quality of life. The objective is to assess the severity of knee osteoarthritis and to determine its association with demographic data. This descriptive consecutive study assesses the severity of osteoarthritis by the use of a questionnaire administered to patients visiting the Orthopedic and Rheumatology Departments of the Hospital. Data collected were entered into Microsoft excel and exported into the statistical package for social science which was used to assess the association between sociodemographic data and severity of the disease. P-value less than 0.05 was interpreted to be statistically significant. Only 209 patients were included in the study and the severe, very severe and extremely severe cases accounted for 17.6%, 23.7%, and 44.0% of the cases respectively. Females accounted for 69.9% of the study participants and they also had more severe cases than males. Sex, advanced age, a high body mass index and co-morbid disease condition (Hypertension) were highly associated with the severity of osteoarthritis (p-value <0.05). The majority of the cases of osteoarthritis were either very severe or extremely severe and these cases were mostly reported by females, older patients, overweight or obese patients and those that have hypertension as a co-morbid condition.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122922514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Gut Microbiota on Diabetes Mellitus","authors":"M. Mubeen","doi":"10.36346/SARJPS.2020.V02I06.002","DOIUrl":"https://doi.org/10.36346/SARJPS.2020.V02I06.002","url":null,"abstract":"Gut microbiota (GMB) occupy the body at birth with the newborn swallowing microbacteria from the birth canal, and evolve with aging. Bacteria make up most of the gut microorganisms and up to 60% of the dry fecal mass. The GMB is consist of of ~100 trillion bacteria, 10-fold the number of cells in the human body. The collective genome of these bacteria (microbiome) is 150-fold larger than the human genome. Whereas, the preservation of normal microbiota is encouraged by lower modulatory levels of controlling T cells secreting IL-10 and transforming growth factor beta (TGFβ), which decrease inflammation [22]. In addition, the mutualistic reaction to be related to a variability of regulatory T-cells subsets in a real-life gut flora, inclusive of symbiotic, commensal with the probable to become pathogenic, and pathogenic microorganisms. In that complicated situation, Bacteroidetes species reduce intestinal inflammation and promote regulatory T cells induction. However, these replies support the preservation of self-tolerance, and suggest a key role of probiotics in preserving a healthier intestinal microbiota.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121359383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial Properties of Rosemary (Rosmarinus Officinalis)","authors":"Abdulrahman Kloy, J. Ahmad, Umar Yusuf, M. Muhammad","doi":"10.36346/sarjps.2020.v02i01.002","DOIUrl":"https://doi.org/10.36346/sarjps.2020.v02i01.002","url":null,"abstract":"Medicinal herbs have long been used as traditional medicine to treat infectious diseases. The increasing use of synthetic antibiotics today has led to an increase in resistant strains and high side effects. In this regard, every year many researchers from this huge plant source are sending a range of secondary compounds to the consumer market for the treatment of human diseases. Therefore, the identification of herbs with antimicrobial effects can help to produce new drugs with a broad spectrum of effects. This study, based on scientific references, describes information on the antimicrobial effects of rosemary.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127433671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Prevalence of Road Traffic Accident and it’s Associated Factors in Chuko Town, Southern Ethiopia","authors":"Kaleab Tesfaye Tegegne","doi":"10.36346/sarjps.2019.v01i03.003","DOIUrl":"https://doi.org/10.36346/sarjps.2019.v01i03.003","url":null,"abstract":"Background: A road traffic accident is an incident on a way or street open to public traffic, resulting in one or more persons being killed or injured, and involving at least one moving vehicle..Ethiopia, a developing country in Africa, has witnessed a number of the most risky roads in the world and has followed to overtake a determined road spreading out guiding principle in the past 15 years. Objective: To assess the prevalence and associated factors of Road Traffic Accidents in Chuko town, Sidama zone, Southern Ethiopia from March 27 to April 4, 2009 E.C. Method: Community based cross sectional study was done in Chuko Town with a total sample size of 422 from March 27 to April 4, 2009 E.C. The quantitative data was checked, edited, and entered to SPSS software version 20. The study employed logistic regression and chi-square analysis models. Data from qualitative was analyzed manually then triangulated with the quantitative one. The result is presented using descriptive statistics using tables, graphs and charts. Result: A total of 422 respondents participated in our study with 100% respondent rate. Among them, 244 (57.8%) were male and the rest 178 (42.2%) were female. Among the participants recruited on data collection, 99(23.5%) of them had previous history of RTA. Concerning the causes of RTA, 141(33.4%) majority of them were caused by poor road condition followed by 119(28.2%) by over speed. The results from FGDs and interviews showed that the Town has traffic flow and motor bikes were most common causes of the accident. It also revealed that the Road and Traffic Office had worked on public education even if it‟s not enough. Conclusion and Recommendation: The study found out that RTA is big problem of the Town and the Town is experiencing it. The most common cause of RTA is poor road condition and Motor Bikes are most commonly involved in the accident. Legalizing Motor Bikes, public meeting and improving the road condition are among the recommendations given to various groups.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121231574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Intention and Practice of VCT and Infant Feeding in The Context of HIV/AIDS among Lactating Mothers in Dilla University Referal Hospital, Southern Ethiopia","authors":"Kaleab Tesfaye Tegegne","doi":"10.36346/sarjps.2019.v01i03.002","DOIUrl":"https://doi.org/10.36346/sarjps.2019.v01i03.002","url":null,"abstract":"Background: Mother-to-child transmission of HIV is the most significant route of HIV infection in children and by far the largest source of HIV infection in children below the age of 15 years. Objectives: the aim of this study was to assess current practices and future intention of lactating mothers on VCT and infant feeding in relation to prevention of MTCT of HIV in DURH. Methods: Institutional based cross sectional quantitative survey was conducted from February, 1 to February 1","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114283451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Prevalence of Trauma Cases Visited At Emergency OPD in Dilla University Referal Hospital from April 20, 2008–May 20, 2008 E.C","authors":"Kaleab Tesfaye Tegegne","doi":"10.36346/sarjps.2019.v01i03.001","DOIUrl":"https://doi.org/10.36346/sarjps.2019.v01i03.001","url":null,"abstract":"Background: Injuries and violence pose a major public health and developmental problem globally. Each year over 5 million people around the world die as a result of injury. Injuries are ranked among the leading cause of death and disability particularly in low income and middle income countries where they are growing insignificance, largely as a consequences of epidemiologic, demographic and socioeconomic transitions. Moreover, it is in these very setting that the vital statistics and routine health information are often seriously lacking. Objective: The objective of this study was to assess the prevalence of trauma cases visited at emergency OPD of DURTH and to describe the magnitude and pattern of injury. Methods: Health institutional based cross sectional study was conducted at emergency OPD from APRIL 20, 2008-MAY 20, 2008 E.C and the data was collected using questionnaires by using convenience sampling technique. All injury cases come to EOPD was studied. A questioner was used to collect the data and the data entered to computer and was analysed by using SPSS version 20. Ethical clearance was obtained from Rift valley University Hawassa campus before the study conducted and the hospital management. Result: 128 patients were visited EOPD of DURH during the study period. The commonest mechanism of injury was RTA, 42(32.8%), followed by falling related injury and cut by sharp instruments, 22(17.2%), 20(15.6%) respectively. More males had RTA, cut and falling related injuries compared to females. The commonest outcomes which resulted in severe injuries were RTA, stab and falling related injuries. Conclusion: The magnitude of injury in the hospital was considerably high. Appropriate prevention strategies should be designed and implemented against RTA, falling related injury and cut by sharp instruments.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116950535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}