South Asian Research Journal of Pharmaceutical Sciences最新文献

{"title":"Diuretic Activity of Water Fraction of Avocado (Persea Americana Mill.) Leaves Extract in Rat","authors":"Mohammad Kanedi, Akhmad Rokiban, Alfiati Peni Dafita","doi":"10.36346/sarjps.2024.v06i03.004","DOIUrl":"https://doi.org/10.36346/sarjps.2024.v06i03.004","url":null,"abstract":"Currently available diuretics are not completely free from side effects such as electrolyte imbalance and metabolic alterations. Avocado (Persea americana Mill.) contained many type of bioactive substances that related to diuretics. This study aimed to reveal and verify the effect of water fraction of avocado leaves extract against output of rat urine. Three different doses of leaf extract of avocado prepared i.e., 91.125mg/kg BW, 182.25 mg/kg BW and 364.5 mg/kg BW. The urinary parameters assessed were the urine volume hourly for 6 hours, urine color density and urine pH. The results showed water fraction of avocado at the dose of 182.25 and 364.5 mg/kg significantly increase urine volume in comparison to the negative control. Urine color density scores varied but did not have a dependent manner that follows the dose levels of diuretics given. However all treatments showed no statistical difference in the urine pH. Thus, it can be conclude that the water fraction of avocado leaves extract potentially for diuretic herb without make significant changes on pH.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":" 28","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141128858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Human Leukocyte Antigen in Susceptibility to Migraine in Patients","authors":"Israa Mohammad Abd AL-Khaliq","doi":"10.36346/sarjps.2024.v06i03.002","DOIUrl":"https://doi.org/10.36346/sarjps.2024.v06i03.002","url":null,"abstract":"Migraine affects more than one billion individuals each year across the world, and is one of the most common neurologic disorders, with a high prevalence and morbidity, especially among young adults and females. Migraine is associated with a wide range of comorbidities, which range from stress and sleep disturbances to suicide. The complex and largely unclear mechanisms of migraine development have resulted in the proposal of various social and biological risk factors, such as hormonal imbalances, genetic and epigenetic influences, as well as cardiovascular, neurological, and autoimmune diseases. Experimental findings suggest an involvement of neuroinflammatory mechanisms in the pathophysiology of migraine. Specifically, preclinical models of migraine have emphasized the role of neuroinflammation following the activation of the trigeminal pathway at several peripheral and central sites including dural vessels, the trigeminal ganglion, and the trigeminal nucleus caudalis. The evidence of an induction of inflammatory events in migraine pathophysiological mechanisms has prompted researchers to investigate the human leukocyte antigen (HLA) phenotypes as well as cytokine genetic polymorphisms in order to verify their potential relationship with migraine risk and severity. Furthermore, the role of neuroinflammation in migraine seems to be supported by evidence of an increase in pro-inflammatory cytokines, both ictally and interictally, together with the prevalence of Th1 lymphocytes and a reduction in regulatory lymphocyte subsets in peripheral blood of migraineurs. Cytokine profiles of cluster headache (CH) patients and those of tension-type headache patients further suggest an immunological dysregulation in the pathophysiology of these primary headaches, although evidence is weaker than for migraine.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":" 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141128959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Review Article on Herbal Cosmetics","authors":"Harshada S. Deshmukh, Vishal B. Babar, Prajkta S. Jagtap, Rupendra V. Doshi, Shivarti V. Deokate, Ashwini V. Todkari, Amrata S. Mantri, Priyanka B. Parekar, Shivraj S. Shivpuje","doi":"10.36346/sarjps.2024.v06i03.003","DOIUrl":"https://doi.org/10.36346/sarjps.2024.v06i03.003","url":null,"abstract":"Nowadays, Herbal cosmetic is growing rapidly as most women prefer natural products rather than chemicals products for their personal care. Herbal cosmetic contains natural nutrients to improve and provide consumers satisfaction due to relatively fewer side effects compared to synthetic cosmetics. The herbal Cosmetics have been the first choice of the customers, for being more potent, easily available and thought to be less side effective. These were used for food, medicine, or cosmetics. Flower, leaf, fruit, root, bark, inner stem, wood, beans, rhizome, endosperm, bulb, seed or whole plant are used to produce bioactive ingredients Herbal cosmetic are the beauty products, which having a physiological activities, such as smoothening, appearance, enhancing and conditioning properties, because of Herbal excipients. The bioactive components from botanicals contains vitamins, alkaloids, proteins, and terpenoid which serve as cosmetics for caring of body and it’s body part. The Herbal cosmetic contains herbal shampoo, herbal hair conditioner, herbal soap, herbal face wash etc. That’s are used to improve skin appearance. Used in skin care and used in hair herbal cosmetic products avoid the adverse effects such as itching, burning or irritation the skin. Cosmeceuticals is the fastest growing segment of the personal care products these are cosmetic preparations which contain biologically active principles or ingredients of plant origin. In recent years there is an increased demand for the use of herbs in cosmetics due to their mild action and less toxic in nature and they are found to be more effective.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":" 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141128983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study the Physiological and Biochemical Effects of Berberine Extract on Nonalcoholic Fatty Liver Disease (NAFLD) in Male Rabbits","authors":"H.H.K. Al-Shukri, Areej Gh Al-Charak, R. Abd, Tiba H. Salih, Noora H. Ali, Haneen H. Ghazi, Dunia M. Al-Rubaie, Mohammad H. Mohsen","doi":"10.36346/sarjps.2024.v06i03.001","DOIUrl":"https://doi.org/10.36346/sarjps.2024.v06i03.001","url":null,"abstract":"Nonalcoholic fatty liver disease (NAFLD) is a prevalent global health issue, characterized by hepatic steatosis and associated with metabolic comorbidities such as obesity, diabetes, and dyslipidemia. Berberine (BBR), an isoquinoline alkaloid, has emerged as a potential therapeutic agent for NAFLD. In this research, we evaluated the effects of BBR on NAFLD management and its associated complications. Our analysis included three groups involving 10 rabbits induced NAFLD by administration cholesterol rich diet, 10 rabbits administrated high rich diet with fats and cholesterol, and 10 rabbits with normal fed as control group. BBR demonstrated significant improvements in liver function biochemical markers (ALT, AST, GGT), lipid indices (TC, TG, LDL-C, HDL-C), and physiological parameters such as insulin sensitivity (HOMA-IR) and body mass index (BMI). Importantly, BBR exhibited a favorable safety profile, with minimal gastrointestinal adverse events reported. These findings highlight BBR potential as an adjunct therapy for NAFLD. However, further well-designed clinical trials involving human subjects are warranted to validate its efficacy and safety.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"6 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141014482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relation among Vitamin B12 and B9 in Hypothyroidism in Iraqi Patients","authors":"Mohammed Liwaa Abdulateef, Nihad N. Hilal, Mohammed M. Abdul-Aziz","doi":"10.36346/sarjps.2023.v05i06.005","DOIUrl":"https://doi.org/10.36346/sarjps.2023.v05i06.005","url":null,"abstract":"Background: The thyroid gland constitutes an integral component of the endocrine system, exerting regulatory control over numerous vital physiological processes through the synthesis and release of specific hormones. Hypothyroidism is a disorder in which the thyroid gland fails to produce enough thyroid hormone to maintain normal physiological function. The prevalence of hypothyroidism varies substantially worldwide and is more common in populations with a relatively high iodine intake or severe iodine deficiency, Hashimoto's thyroiditis, inflammation of the thyroid, congenital hypothyroidism, hypothyroidism that is present from birth, iodine deficiency or excess, as well as diseases of the pituitary gland or hypothalamus, are the most frequent causes of hypothyroidism. Objective: The study aims to investigate the relationship between some vitamins and hypothyroidism in Iraqi patients. Subjects and Methods: This is a case-control study, manipulated from the first of March to the end May of 2023, 90 samples aged (18-70) years old, from Baghdad City, were selected and divided them into two groups. The first group consists of 60 people infected with hypothyroidism. The second group (control group) consists of 30 apparently healthy people. Blood samples were assessed for serum vitamin B12, and vitamin B9 using enzyme linked immunosorbent assay technique. Results: The study showed that the level of vitamin B12 and folate B9 in hypothyroidism patients significantly lower compared to control group (p value < 0.001). Conclusion: Patients with hypothyroidism had noticeably low levels of vitamin B12 and folate B9, indicating that this may be involved in the etiology of hypothyroidism.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"53 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139268187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NSAID-Induced Tubulo-Interstical Nephritis, Case Report","authors":"Gabriela Alcalá Ramos, Paola Alcalá Ramos, M. Ramos","doi":"10.36346/sarjps.2023.v05i06.004","DOIUrl":"https://doi.org/10.36346/sarjps.2023.v05i06.004","url":null,"abstract":"We present a clinical case of acute renal failure due to acute tubulo-interstitial nephritis induced by NSAIDS without presenting the classic triad (fever, rash and eosinophilia), the withdrawal of the drug did not resolve renal failure, but had an excellent response to corticosteroid therapy until normalization of renal function.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"11 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139277620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Wet Cupping Therapy on Reducing Pain in Patients with Low Back Pain in Bonto Bangun Work Area","authors":"S. Safruddin, Khairul Mukrimin, Hariyanti Haris Asri","doi":"10.36346/sarjps.2023.v05i06.003","DOIUrl":"https://doi.org/10.36346/sarjps.2023.v05i06.003","url":null,"abstract":"Data from Public Health Center Bonto Bangun Bulukumba found that there were 93 patients experiencing LBP complaints from 2020, while in 2021 there were 71 patients and in 2022 from January to March there were 37 patients. Judging from the prevalence, from 2020-2022 it has indeed decreased but not yet resolved perfectly. Cupping therapy is a therapy recommended by the Prophet in which blood is extracted using a cup and a suction cup in the skin area which is incised 1 cm wide and 4 mm deep, so that it penetrates the epidermal layer of the skin, and because of the difference in pressure, the blood is pulled out of the peripheral blood vessels as much as 50-300 ml in 5 minutes and will cause a red or black rash. This series of therapies will eventually lead to healing as predicted by the Prophet Muhammad in his hadith with the permission of Allah ta'ala Research Objectives: To know the effect of wet cupping therapy on reducing pain in sufferers of Low Back Pain in the working area of Bonto Bangun, Bulukumba. The research design is true experimental. The sample is 16 people in the treatment group, and 16 people in the control group. The sampling technique is Simple Random sampling. The research was carried out in July 2022 in Bonto Bangun District, Bulukumba Regency. The results of the study are the pain scale before carrying out wet cupping therapy in the treatment group with a scale of 4.50 and the control group with a scale of 5.50. There was a difference in the pain scale after carrying out wet cupping therapy, namely in the treatment group it was 3.00 while in the control group it was 6.00. The results of the mean withney test obtained a value of p = 0.01 (smaller than the value of a = 0.05). There is a significant difference in pain scale between before and after doing wet cupping therapy. It is better for agencies to carry out routine wet cupping therapy programs and facilitate more LBP patients.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139277253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potent Effect of Plant Mediated Zinc Oxide Nanoparticles on Pathogenic Bacteria","authors":"I. Alzamily","doi":"10.36346/sarjps.2023.v05i06.002","DOIUrl":"https://doi.org/10.36346/sarjps.2023.v05i06.002","url":null,"abstract":"ZnO NPs are metal oxide nanoparticles that offer novel biomedical uses ranging from diagnosis to treatment. UV-VIS utilized to analyze nanoparticles derived from Trifolium pratense flower extracts to be able gain knowledge concerning the optical features of produced ZnO nanoparticles. Aggregation of smaller nanoparticles confirmed via SEM images. FT-IR test verified ZnO NPs-bacterial cell wall polypeptide and glycogen binding. Nanoparticles' shape was determined using plant extract and confirmed using (XRD) analysis. antibacterial efficacy of ZnO NPs was obvious on all species of bacteria that studied, the most effective of it was on gram ve – than gram ve+.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139279831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation Asprosin Level in Polycystic Ovary Syndrome and Its Association with Fetuin a and Some Biochemical Parameter","authors":"Balasim J Mahmmoed, N. Hilal, E. Sarhat","doi":"10.36346/sarjps.2023.v05i04.011","DOIUrl":"https://doi.org/10.36346/sarjps.2023.v05i04.011","url":null,"abstract":"An ovarian cyst is a common hormonal condition that affects women of reproductive age and affects the ovaries. Although the precise an etiology is unknown, environmental and genetic variables may play a role in the condition's genesis. Among the most significant symptoms are irregular menstruation, excessive hair growth, and acne. Early diagnosis is crucial since it can help control symptoms and possibly save chronic medical conditions from developing. The aim of this study was to evaluate the levels and relation of asprosin in patients of polycystic ovary syndrome. the relationship between asprosin with fetuin a and some parameter biochemical such as fasting blood sugar, insulin, cholesterol and triglyceride in woman patient’s polycystic ovary syndrome. Ninety females were recruited into the study; 60 patients (females) aged between (15-45) years were taken and women that diagnosed with the Polycystic ovaries, by gynecological specialist. The result was a disruption in the hormones responsible for ovulation, such as LH, FSH, as well as an increase in the protein asprosin and fetuin a. On the other hand, 30 people as a control group of (females) were taken and their ages were also and were not infected with polycystic ovary syndrome. Laboratory tests were conducted for both groups to determine the level of asprosin, fetuin a, fasting blood sugar, insulin, total cholesterol and triglyceride. the study conducted a asprosin analysis for patents and a control group. When comparing the results were statistically no significant at P. value =0.115. Also conducted a Fetuin an analysis. When comparing the results of these two groups of patients and healthy controls, the results were statistically highly significant at P. value =0.0002.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127112566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Vitamin D in Patients with Type 2 Diabetes Mellites","authors":"Hussam Sahib Ahmed, N. N. Hilal, Mohamed Ghalib Zakari","doi":"10.36346/sarjps.2023.v05i04.010","DOIUrl":"https://doi.org/10.36346/sarjps.2023.v05i04.010","url":null,"abstract":"Background: Type 2 diabetes mellitus is a chronic metabolic condition caused by either a reduction in insulin secretion and/or effect. It affects more than 90% of all diabetic patients. Diabetes is a complex illness that is brought on by a number of genetic and environmental (diet and lifestyle) risk factors working together. On average, one person dies from diabetes-related complications every eight seconds throughout the world. Also, according to a recent International Diabetic Federation (IDF) survey, 537 million persons aged 20-79 years are now living with diabetes worldwide. It is expected to increase to 783 million (12.2%) by 2045. Furthermore, 240 million individuals globally have undiagnosed diabetes. Therefore, there is a rising interest in studying the possible therapeutic value of fat-soluble micronutrients like vitamin D for preventing or controlling type 2 diabetes mellitus. Aim of Study: The present study was designed to evaluate levels of vitamin D in patients with type 2 diabetes mellitus. Patients and Methods: To achieve this aim, in a case-control study conducted in Diyala governorate at Baqubah Teaching Hospital and Balad Ruz General Hospital from first of January to the end of March 2023, the study included 60 patients with type 2 diabetes mellitus (30 males and 30 females). On the other hand, 30 people as a control group of both sexes (15 males and 15 females) were taken, and the ages of the two groups ranged between 30 and 65 years. The information about patients in this study was retrieved from the patients themselves through a direct interview with them, according to a prepared questionnaire. In the present study, blood samples were collected from each participant for estimation of vitamin D by (ELISA), HbA1c by (Cobas), lipid profile by (colorimetric methods) and calculated BMI. Results: The mean ± Standard Deviation (SD) of vitamin D levels for the type 2 diabetes group were (11.16± 2.18) ng /ml, with a highly significant decrease (p < 0.001) when compared with control group (20.73± 3.64) ng /ml. The mean ± SD of HbA1c level for the type 2 diabetes group was (8.88± 1.86) %, with a highly significant increase (p < 0.001) when compared with control (5.59 0.45) %. The mean ± SD of cholesterol, TG, and LDL-C levels for the type 2 diabetes group were (161.48± 21.70) mg/dl, (203.40± 8.16) mg/dl and (81.15± 21.62) mg/dl, respectively, with a highly significant increase (p < 0.001) when compared with the control group (105.77± 12.50) mg/dl, (191.73± 8.70) mg/dl, and (22.96± 13.38) mg/dl, respectively. The mean ± SD of HDL-C levels for the type 2 diabetes group was (39.66± 2.52) mg/dl and control (44.46± 4.82) mg/dl, with a highly significant decrease when compared with the control group. The mean ± SD of BMI for the type 2 diabetes group was (27.20± 4.25) and control (26.66± 2.30), respectively, with no significant difference (p < 0.05) when comparing the two groups. Conclusion: The current study concluded that Vitamin D levels ","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114341627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}