{"title":"Cosmetics’ Safety: Gray Areas with Darker Inside-Mini Review","authors":"Abdul Kader Mohiuddin","doi":"10.36346/sarjps.2019.v01i02.002","DOIUrl":"https://doi.org/10.36346/sarjps.2019.v01i02.002","url":null,"abstract":"Cosmetic items contain a wide scope of chemicals to which we are exposed every day. All cosmetics were separated into 3 classifications: rinse-off items (shower gel, shampoo, toothpaste, liquid soap, private soap, shaving foam) leave-on items (body cream, face cream, hand cream, antiperspirant, sunscreen, post-shaving astringent) and make-up ones (lipstick, lip-balm, foundation, nail polish).The utilization of a significant number of these substances is permitted inside specific limits, because of their toxicity at higher concentrations. Other significant viewpoints ought to be considered as, for example, the likelihood of long-term effects. In the light of the continuous and close nature of the contact on skin and mucosa with these items, it is significant that they don't contain conceivably perilous substances. Additionally, the everyday use and continuous exposition of people to a wide scope of personal consideration items and to various types of chemicals, got from a few sources, may cause the alleged \"cocktail effect\" because of the synergistic interaction of various substances and, likewise, the \"added substance effect\" in light of the nearness of a similar ingredient in numerous items. Actually, every one of the ingredients utilized in cosmetic items meet certain regulatory prerequisites. Notwithstanding, the utilization of numerous substances is permitted inside specific limits, because of their toxicity at higher concentrations.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"129 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121526123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Arts and Science of Athletic Performance- Short Communication","authors":"Abdul Kader Mohiuddin","doi":"10.36346/sarjps.2019.v01i02.003","DOIUrl":"https://doi.org/10.36346/sarjps.2019.v01i02.003","url":null,"abstract":"Athletes utilize numerous strategies to reduce body weight or body fat and to increase stamina prior to competition. Personalized nutrition in athletic populations aims to optimize health, body composition, and exercise performance by targeting dietary recommendations to an individual's genetic profile. Additionally, athletes’ nutritional requirements may vary widely depending on sport, position, timing of season, and training vs rest day. Bodily hydration during sporting activity is one of the best indicators of health in athletes and can be a limiting factor for sport performance. Treatment for athletes is primarily to increase energy availability and often requires a team approach including a sport physician, sports dietitian, physiologist, and psychologist. Maximizing athletic performance is a passion that athletes, coaches, athlete support professionals, and sports scientists share. A thorough understanding of the basics of all aspects of human physiology and the ability of the body to adapt to the environmental stress of exercise training is the foundation we use to explain the incredible athletic and sport performances that are commonplace in today’s world.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125069283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Affordability Issues Of Biotech Drugs In Low- And Middle-Income Countries (Lmics)- Short Communication","authors":"Abdul Kader Mohiuddin","doi":"10.36346/sarjps.2019.v01i02.001","DOIUrl":"https://doi.org/10.36346/sarjps.2019.v01i02.001","url":null,"abstract":"As indicated by World Bank publication Disease Control Priorities: Improving Health and Reducing Poverty (third edition, 2017), about 20% all out health use universally originated from out-of-pocket payments in 2014. The equivalent was about 40% all out health use for low-income countries, 56% for lower-middle-income countries, and 30% for upper-middle-income countries (WHO, 2016). 33% of the world's populace needs opportune access to quality-guaranteed medicines while assessments demonstrate that in any event 10% of medicine in low-and middle-income countries (LMICs) are substandard or distorted, costing roughly US$ 31 billion every year (Global Health, 2018). Shockingly, 80% of worldwide cardiovascular passings happen in LMICs which is (halfway) because of the absence of access to healthcare including talented HR, equipped offices and medicines (Global status report on noncommunicable diseases, WHO, 2010). Cost of drugs, antibodies, and diagnostics is a noteworthy weight in LMICs round the globe. Cost of biotech drugs are much higher because of surprising expense caused by the pharmaceutical organizations for clinical preliminary. Biotech drugs have totally changed the administration of a few diseases, including malignant growth and immune system diseases. Albeit essential yet their affordability is as yet a consuming issue, particularly in LMICs.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126894666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Supplements and Enhancement Drugs: Athletes Torment Themselves with Potential Risks- Mini Review","authors":"Abdul Kader Mohiuddin","doi":"10.36346/sarjps.2019.v01i02.004","DOIUrl":"https://doi.org/10.36346/sarjps.2019.v01i02.004","url":null,"abstract":"An individual's dietary and supplement strategies can influence markedly their physical performance. Issues related to knowledge of nutrition and dietary supplementation (DS) are understudied in professional athletes. Supplements nowadays are used with the aim of improve body composition, of which the origins are multiplex in structure. Many approaches to improve the response to resistance training are the use of pre-/post-/in between workout nutritional interventions; with beverages garnering significant interest. The health benefits and risks of dietary supplement use are controversial as there is no visible immediate benefits observed. Sports nutrition recommendations for endurance exercise however remains a complex issue with often opposing views and advice by various health care professionals. Many athletes, at all levels of competition, place great emphasis on the use of dietary supplements, but of all the factors that determine athletic performance, supplements can play only a very small role. Compared with factors such as talent, training, tactics, and motivation, nutrition has a small effect on performance, and supplements can be no more than a minor part of the athlete’s nutrition strategy.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"23 1-2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133072013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medicinal and Therapeutic Value of Sesbania grandiflora","authors":"Abdul Kader Mohiuddin, Abdul Kader Mohiuddin","doi":"10.36346/sarjps.2019.v01i01.003","DOIUrl":"https://doi.org/10.36346/sarjps.2019.v01i01.003","url":null,"abstract":"There are around 60 global species belonging to the genus Sesbania which are commonly found to be grown in Africa, Australia, and Asia. The leaves of Sesbania grandiflora have been used in local traditional medicine since ancient times. Major chemical constituents are alkaloids, flavonoids, glycosides, tannin, anthraquinone, steroid, pholobatannins, and terpenoids. Isovestitol, medicarpin, sativan (isoflavonoids) and betulinic acid (tannin substance) are the major constituents responsible for antibacterial and antifungal, antioxidant, anti-urolithiatic, anticonvulsant and anxiolytic, and hepatoprotective properties. Also, the plant extract contains alkaloids, phenolics, tannins, triterpenoids, and sterols. All parts of S. grandiflora are used in traditional medicine and phytochemical investigations have been conducted on extracts of the leaves, seeds and roots of S. grandiflora to provide scientific validation of its properties.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130945174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pharmacological activities of pyridazines and pyridazinone Derivatives: A Review on biologically active scaffold","authors":"A. ., Md. Tauquir Alam, M. Asif","doi":"10.36346/sarjps.2019.v01i01.004","DOIUrl":"https://doi.org/10.36346/sarjps.2019.v01i01.004","url":null,"abstract":"Pyridazine and pyridazinone derivatives compounds are biologically important compounds. Pyridazinone has carbonyl group on third carbon on pyridazine ring. Pyridazine and pyridazinone is a wonder nucleus because their derivatives give amost all types of biological activities such as such as analgesic, antiinflammatory, antimicrobial, antisecretory, antiulcer, antidepressants, neuroleptics, anxiolytics, sedative, hypnotic, tranquillizer, anticonvulsant, antiplatelet, antithrombotics, anticancer, antihistamine, cardiotonics, vasodilatators, antiarrhythmics, antidiabetic, antihypertensive, antitubercular and various other types of activities. These compounds are synthesized with the aim of novel agents those possess interesting biological activities. The present review has been focused on the pyridazine and pyridazinone derivatives with potential pharmacologica activities.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"182 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124597118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Method Development of Simultaneous Estimation of Domperidone and Esomeprazole Using Spectrophotometry","authors":"G. Manoharan","doi":"10.36346/sarjps.2019.v01i01.001","DOIUrl":"https://doi.org/10.36346/sarjps.2019.v01i01.001","url":null,"abstract":"A novel, simple, sensitive and rapid spectrophotometric method has been developed for simultaneous estimation of Domperidone and Esomeprazole. The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths, 267 nm and 300 nm, λmax of Domperidone and Esomeprazole respectively. Beer’s law was obeyed in the concentration range of 10-50 μg/ml for Domperidone for Esomeprazole 5-25 μg/ml. The method was found to be precise, accurate, and specific. The proposed method was successfully applied to estimation of Domperidone and Esomeprazole in combined tablets form with good accuracy and precision. The suggested methods were validated according to International Conference of Harmonization (ICH) guidelines and the results revealed that; they were precise and reproducible. All the obtained results were statistically compared with those of the reported method, where there was no significant difference.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124785309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Brachytherapy Doses and Late Rectal and Bladder Toxicities for Cervical Cancer Patients: A Case Study of a Radiotherapy Centre in Zambia","authors":"Ernest Chanda, G. Azangwe, O. Bwanga","doi":"10.36346/sarjps.2019.v01i01.005","DOIUrl":"https://doi.org/10.36346/sarjps.2019.v01i01.005","url":null,"abstract":"The purpose of this study was to analyse the International Commission of Radiation Unit (ICRU) point doses delivered to the urinary bladder and rectum with ultrasound based intracavitary brachytherapy and to evaluate late toxicity relative to the equivalent total doses delivered in 2 gray per fraction of equivalent dose (EQD2) for bladder and rectum using point based methods of reporting. This study was conducted using a quantitative retrospective research design which looked at three hundred and thirty three women who received external beam radiation therapy (EBRT) + brachytherapy (BT) between 2009 to 2013. The patients were aged 25 years and above the median age was 48. The median follow-up was 24 months and 58% of patients received 50 Gray in 25 fractions with 24 Gray in 3 fractions of BT and 42% received 46 Gray in 23 fractions to the pelvis with 26 Gray in 4 fractions of BT. BT was delivered with ring and tandem applicators. The results showed no correlation between late toxicity for rectum and total EQD2 to ICRU rectal points rs =0.1. For bladder the null hypothesis that there was no association between EQD2 and late toxicity grade for bladder was rejected and the alternative hypothesis that there was association between EDQ2 and late toxicity grade for bladder accepted, rs= 0.013. The mean rectal and urinary bladder doses at ICRU points were 59.8 % (4.5 Gy) and 62% (4.6 Gy) which was below the ICRU 38 recommended dose of lower than 80% of maximum dose to the rectum and bladder of the prescribed dose to point A.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122368164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy of Anti-inflammatory Potential of Hydroethanolic Fruit extract of Ziziphus jujube","authors":"Jyoti Pethari, R. Saxena","doi":"10.36346/sarjps.2023.v05i02.003","DOIUrl":"https://doi.org/10.36346/sarjps.2023.v05i02.003","url":null,"abstract":"Every third person in the world has an inflammatory condition, which can strike at any stage of life. Inflammation is a fairly prevalent disease. Inflammation can be treated in a variety of ways. There are many medications on the market that are connected to the allopathic medical system. Herbal medications have a higher market value since they have fewer adverse effects and are less harmful. Due to their excellent nutritional and health benefits, the fruits of the Ziziphus jujuba tree, also known as jujube, red dates, or Chinese dates, are consumed as food both fresh and dried around the world. The pharmacological properties of jujube fruits, including their anticancer, anti-inflammatory, antiobesity, immunostimulating, antioxidant, hepatoprotective, gastrointestinal protective, and suppression of foam cell formation in macrophages, have been shed some light by recent phytochemical investigations. The goal of the current study was to evaluate Ziziphus jujube hydroethanolic extract's anti-inflammatory potential.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130788680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}