South Asian Research Journal of Pharmaceutical Sciences最新文献

{"title":"Metformin Effects on Blood Levels of Myonectin in Polycystic Ovarian Women","authors":"Sh Allow, E. Sarhat","doi":"10.36346/sarjps.2023.v05i03.005","DOIUrl":"https://doi.org/10.36346/sarjps.2023.v05i03.005","url":null,"abstract":"Background: Polycystic ovary syndrome (PCOS) is a most prevalent endocrine diseases for females of childbearing age, and lead to an ovulatory infertility. It was shown that myonectin may be positively associated with insulin resistance parameters. Objectives: To evaluate serum myonectin levels and to determine the effects of metformin treatment on myonectin levels in patients with polycystic ovary syndrome. Patients and Methods: The Cross-Sectional Study carried out in the Department of Obstetrics and Gynecology Salahdeen general hospital in Tikrit city from 1st November 2022-30th January 2023. Patients diagnosed with PCOs depending based on the Rotterdam criteria. Participants were enrolled after all eligibility criteria were confirmed and informed consent completed. Sixty PCOS patients were selected as the PCOS group, while 30 healthy women matched for age with the PCOS patients were selected as the control group. Only 30 patients of them complete the follow up study and they agree to continue on metformin treatment during three months, the duration of the follow up. They take metformin 850 mg twice daily for three months and provide fasting blood samples on the second day of menstruation before and after treatment. The data collection done through: a designed closed and open-ended questionnaire, by using direct interviewing and Ultrasound examination, Laboratory examination. Myonectin, Luteinizing hormone (LH), Follicular Stimulating Hormone (FSH), and insulin were analysed by enzyme-linked immunosorbent assay (ELIZA) technique from Biomeriuex. Data were analyzed using SPSS for Windows 7. Results: The level of myonectin decreased significantly in PCOS patients compare to control group. The level of blood glucose, Insulin, and HOMA-IR, were increased significantly compared to the control. Serum LH levels were significantly higher, while the level of FSH were lowerin in women with PCOS than in controls. After metformin intake, all patients showed significant in decrease in gremlin concentration at p-values 0.05, but no significant difference (P>0.05) in myonectin level when compared to pre-treatment. Treatment resulted a significant decrease in in body mass index, Blood glucose, Insulin, HOMA-IR, testosterone and LH at p-values 0.05. However, the study found no significant difference (p > 0.05) in myonectin level between both groups in treated group with metformin compared with pre-treatment. Conclusion: Metformin testosterone and insulin resistance but can’t induce changes of myonectin level in patients with polycystic ovary syndrome.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122328345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin Effects on Plasminogen Activator Inhibitor-1 in Polycystic Ovarian Women","authors":"Maryam Taher Tawfeq, E. Sarhat","doi":"10.36346/sarjps.2023.v05i03.007","DOIUrl":"https://doi.org/10.36346/sarjps.2023.v05i03.007","url":null,"abstract":"Background: Polycystic ovary syndrome (PCOS) is a widespread complex endocrine disorder of women in the reproductive age group. Plasminogen activator inhibitor-1(PAI-1) has been shown to be associated with the regulation of inflammation and ovulation. Objectives: The aim of this study was to evaluate serum PAI-1 level and to determine the effects of metformin treatment on serum PAI-1 levels in patients with PCOS. Patients and Methods: This study was conducted on sixty women with PCOS, while 30 healthy women matched for age with the PCOS patients were selected as the control group, only 30 patients of them complete the follow up study and they agree to continue on metformin treatment during three months, the duration of the follow up. Study Design: A cross sectional study is done in Salah Al-Deen general hospital/gynecology and obstetrics department in Tikrit city from 1st November 2022-30th January 2023. Patients diagnosed with PCOs depending based on the Rotterdam criteria. Participants were enrolled after all eligibility criteria were confirmed and informed consent completed. The body mass index is determined before and after therapy. Homeostatic model assessment for insulin resistance is determined according to the following formula: (fasting insulin multiplied by fasting glucose) divided by 405. Fasting serum PAI-1 was measured by Enzyme-Linked Immunosorbent Assay method. Data were analyzed using SPSS for Windows 7. Results: Compared with the control group, the levels of PAI1, fasting blood glucose (FBG), Insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) While the levels of follicle stimulating hormone (FSH) were significantly decreased (P<0.05). In the PCOS group were significantly increased (P<0.05). Serum levels of testosterone in PCOS group was significantly increased (P<0.05). In PCOS women treated with metformin for three months, all patients showed significant in decrease in PAI1, and testosterone concentration at p-values 0.05, when compared to pre-treatment. Treatment resulted a significant decrease in in body mass index, Blood glucose, Insulin, HOMA-IR, and LH at p-values 0.05. Conclusion: Plasminogen activator inhibitor-1 level decreased significantly after 3 months of treatment with 850 mg per day with metformin in women with PCOS.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127699277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allium cepa and Beta Vulgaris Extracts and Their Synergistic Activity with Antifungal against Candida albicans","authors":"S. Ahmed","doi":"10.36346/sarjps.2023.v05i03.003","DOIUrl":"https://doi.org/10.36346/sarjps.2023.v05i03.003","url":null,"abstract":"Background: Due to their high mineral and vitamin content, beetroot and onions, which are frequently utilized as antibiotics, antioxidants, and nutrients, are generating growing interest in their potential medical applications. Objective: The current study's is to separate the active components from beetroot and onions and use them as antimicrobial agents. Materials and Methods: A mixture of beetroot and onion in varying ratios, as well as fungal and bacterial cultures, were created for testing. Various procedures, including hot water, were utilized to extract the active components. Results: According to the findings, hot alcohol was used to extract the components that were the most active. Depending on the concentration of the active ingredients in the extract solution, the extracts exhibit varying bioactivities. Conclusions: Extracts of beetroot and onions can be used to treat Candida albicans. Conclusions: The antifungals nystatin, miconazol, and clotremazol as well as beetroot and onion demonstrated the best efficacy against Candida albicans at 95/5, 50/50, and 75/25, respectively.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"153 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121045562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicinal and Nutritional Importance of Mushrooms","authors":"‏Qays M. Issa","doi":"10.36346/sarjps.2023.v05i03.002","DOIUrl":"https://doi.org/10.36346/sarjps.2023.v05i03.002","url":null,"abstract":"Mushrooms have been used as food for centuries because of their unique taste, in addition to their great nutritional value, as it was found that there are many nutritional and medical benefits due to human consumption of mushrooms, both wild and cultivated. Nutritionally, mushrooms are rich in proteins, carbohydrates and fibers and are also low in energy and fats. It also contains a large variety of nutrients and minerals such as potassium, copper and vitamins such as riboflavin, niacin and folate. Most types of mushrooms are an important source of active compounds with the potential for medicinal and therapeutic effects. Biologically of potential medical importance, as the results of studies showed that the bioactive components isolated from mushrooms have pharmacological effects such as antitumor, antioxidant, antiviral, cholesterol-lowering, as well as lowering blood sugar effects in patients. Consuming mushrooms or one of their products in our daily diet may provide many health benefits.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115033933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Scenario of Hydrogel as Drug Delivery System","authors":"S. Akhtar, G. Singh, S. Singh, Sunil Kumar, J. Malik","doi":"10.36346/sarjps.2023.v05i02.002","DOIUrl":"https://doi.org/10.36346/sarjps.2023.v05i02.002","url":null,"abstract":"Crosslinked polymer networks known as hydrogels are capable of absorbing large volumes of water liquids. Depending on whether the crosslink connections are chemical or physical, hydrogels can be categorised into two groups. Physical networks feature temporary junctions that result from either polymer chain entanglements or physical interactions like ionic contacts, hydrogen bonds, or hydrophobic interactions, as opposed to chemically crosslinked networks, which have permanent junctions. Swellable polymeric polymers called hydrogels have received a lot of attention as potential drug delivery system carriers. These biomaterials have drawn attention because of their unusual properties, such as swelling in aqueous media, sensitivity to pH and temperature, or sensitivity to other stimuli. Because they are made of biocompatible materials, hydrogels are known to protect drugs from the in vivo environment, particularly peptides and proteins. Moreover, these swelling polymers are useful as tissue-specific targetable carriers for bioactive medicines. This article provides a summary of the developments in hydrogel-based drug delivery that have captured the attention of the majority of researchers.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124972848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic and Mechanistic Approaches of Tridax procumbens Flavonoids for the Treatment of Pyrexia: Molecular Docking","authors":"Pradyumna Pal, S. Sushanth Kumar, J. Malik","doi":"10.36346/sarjps.2023.v05i02.001","DOIUrl":"https://doi.org/10.36346/sarjps.2023.v05i02.001","url":null,"abstract":"The perennial plant Tridax Procumbens is particularly intriguing, and its secondary metabolites, also known as T. procumbens flavonoids (TPFs), are well-known phytochemical agents due to their diverse medicinal uses, including their anti-inflammatory, anti-anemic, and anti-diabetic effects. The antipyretic potential of luteolin, a natural product isolated from the medicinal plant Tridax procumbens, was investigated for antipyretic action through molecular docking analyses with the target enzymes cyclooxygenase-2 (COX-2). The docking result of luteolin revealed that their docking scores was -7.24 kcal mol–1 and it can be predicted as good inhibitor of human COX2 receptor.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127819915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Novel Isoxazole Derivatives as Analgesic Agents by Using Eddy’s Hot Plate Method","authors":"S. S. Sangale, Priyanka S. Kale, Rachana B. Lamkane, Ganga S. Gore, Priyanka B. Parekar, Shivraj S. Shivpuje","doi":"10.36346/sarjps.2023.v05i01.002","DOIUrl":"https://doi.org/10.36346/sarjps.2023.v05i01.002","url":null,"abstract":"The Isoxazole ring system belongs to a much studied class of compound. In the last few decades, the chemistry of Isoxazoles and their fused heterocyclic derivatives have received considerable attention owing to their significant and effective biological activity. The present study aimed to design and synthesize novel derivatives of Isoxazole from 4-methoxy aniline gives N-(4-methoxyphenyl) acetamide which was hydrolysis with sodium hydroxide and treated aromatic aldehydes yields resultant compound N-(4-methoxyphenyl) 3-phenyl propanamide (BSM-IIIA-IIIJ). Title compound were synthesized and the structures of newly synthesized compounds were confirmed by IR, Mass and 1H-NMR spectroscopy. All the compounds synthesized were evaluated for their analgesic activity by using Eddy’s hot plate method. The compounds 5- (4-bromophenyl)-N-(4- methoxyphenyl) 4,5- dihydroisoxazole-3-amine (BSM-IIID) and 5- (4-chloro-3-nitrophenyl)-N-(4- methoxyphenyl) 4,5- dihydroisoxazole-3-amine (BSM-IIIF) were shown good analgesic activity and remaining compounds were shown poor analgesic activity.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123552074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Docking Interaction of Mycobacterium Tuberculosis Enoyl-Acp-Reductase Enzyme with Delamaind","authors":"K. Neha, J. Malik","doi":"10.36346/sarjps.2022.v04i05.001","DOIUrl":"https://doi.org/10.36346/sarjps.2022.v04i05.001","url":null,"abstract":"One of the eldest human diseases is tuberculosis (TB), for which there is molecular evidence dating back more than 17,000 years. Unfortunately, TB is still one of the top 10 infectious diseases that kill people worldwide, second only to HIV, despite advances in detection and treatment. The World Health Organization (WHO) claims that TB is an international pandemic. It is the main cause of death for those with HIV. In India, the fight against TB has largely been divided into three eras throughout its history: the early era, before the development of x-ray and chemotherapy; the post- independence era, when national TB control programmes were started and put into place; and the current era, when an ongoing WHO-assisted TB control programme is in place. Today's DOTS in India. A new anti-tuberculosis (TB) medication called delamanid, a nitroimidazo-oxazole derivative, has strong in-vitro and in- vivo antitubercular action against drug-susceptible and -resistant strains of Mycobacterium tuberculosis. With intention to propose the most probable mechanism of action of delamanid the docking based computational analysis has been performed against enyl ACP reductase (InhA) as targeted protein. The molecular docking of delamanid with enyl ACP reductase (InhA) showed binding energy (Kcal/mol) -10.86 having molecular interaction Lys165, Ala198, Phe149, Pro193, Met199, Glu219, Pro156, Met103 & Gly96. The concluding consequences of the existing research found out that the chosen molecule highly bounded with InhA thereby inhibiting the mycobacterial cell wall synthesis.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114537622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and Development of Terbutaline Sulphate Fast Mouth Dissolving Tablet","authors":"G. Singh, G. Singh, J. Malik","doi":"10.36346/sarjps.2022.v04i05.002","DOIUrl":"https://doi.org/10.36346/sarjps.2022.v04i05.002","url":null,"abstract":"Asthma is a chronic inflammatory disease that causes an associated increase in airway hyperreactivity leading to recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, especially at night and early in the morning. Terbutaline sulfate is a selective beta2 adrenergic agonist. It is highly selective for β2 adrenergic receptors and has a long-lasting effect. It is given for symptomatic relief of bronchospasm and obstructive airway disease. Terbutaline sulfate is effective when taken orally, subcutaneously, or by inhalation. Although effects are rapidly observed after inhalation, the use of inhaled sympathomimetic drugs is initially associated with possible tachyphylaxis of resistance to beta-agonists, cardiac arrhythmias due to β1-adrenergic receptor stimulation, and Freon propellants. Raised concerns about hypoxemia and arrhythmia due to fluorinated hydrocarbons in many patient groups, including the elderly, children, the mentally ill, and uncooperative or nauseous patients, have difficulty swallowing conventional dosage forms such as tablets. Swallowing conventional tablets is further hampered by conditions such as water unavailability, allergic reactions, and coughing fits. These problems can be overcome by developing rapidly disintegrating and dissolving tablet dosage forms for oral administration, as they dissolve in saliva and do not require water to be swallowed. When ingested, saliva serves to quickly dissolve the dosage form. A fast mouth dissolving tablet (FMDT) is an oral solid dosage form that dissolves rapidly when placed on the tongue, releasing a drug that dissolves or disperses in saliva and can be swallowed without the need for drinking water. Additionally, some of the saliva-soluble drugs from the mouth, throat, and esophagus are absorbed once saliva enters the stomach, increasing bioavailability by avoiding first-pass metabolism.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123393705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotics Sensitivity of Bacterial Strains Isolated From Cold Meat in Saudi Markets","authors":"Saif Al-Masabi, Abdullah F. Abdullah, F. Al-Sarraj","doi":"10.36346/sarjps.2022.v04i04.002","DOIUrl":"https://doi.org/10.36346/sarjps.2022.v04i04.002","url":null,"abstract":"The objective research works on cold and ready-to-eat meat products from local markets and how they are affected by external factors and the transmission of microorganisms to them and their reproduction despite their preservation, despite the preservation of these meats in consumers' refrigerators, and how some of these microbes are pathogenic or cause diseases by excreting toxins. The result of our research centers on displaying the total number of bacteria in all samples, identifying the strain contained in these ready-to-eat meats, and comparing them with the permissible limits imposed by most food and drug authorities in the world to preserve the safety of consumers. Also, we test the microbes' sensitivity to antibiotics. The types of bacteria were identified through approved protocols. The total count of bacteria was not in the range of the FDA limits rate, and we found some strains that should not be in the product as E. coli and Salmonella. spp. These strains can cause severe gastrointestinal tract diseases. The results of the Antibiotic test were positive. Only two of the 30 species we identified were resistant to all the antibiotics we used. They were S. aureus. The microbiological quality of cold meats in Jeddah, Saudi Arabia, is barely within the limits of the FDA. In terms of coliforms, Staphylococcus, and streptococci. So, all the food handlers should receive training to increase the level of hygiene in the supermarkets in Jeddah, Saudi Arabia.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"318 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125781392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}