{"title":"原甘黄酮类化合物治疗发热的机理研究:分子对接","authors":"Pradyumna Pal, S. Sushanth Kumar, J. Malik","doi":"10.36346/sarjps.2023.v05i02.001","DOIUrl":null,"url":null,"abstract":"The perennial plant Tridax Procumbens is particularly intriguing, and its secondary metabolites, also known as T. procumbens flavonoids (TPFs), are well-known phytochemical agents due to their diverse medicinal uses, including their anti-inflammatory, anti-anemic, and anti-diabetic effects. The antipyretic potential of luteolin, a natural product isolated from the medicinal plant Tridax procumbens, was investigated for antipyretic action through molecular docking analyses with the target enzymes cyclooxygenase-2 (COX-2). The docking result of luteolin revealed that their docking scores was -7.24 kcal mol–1 and it can be predicted as good inhibitor of human COX2 receptor.","PeriodicalId":244449,"journal":{"name":"South Asian Research Journal of Pharmaceutical Sciences","volume":"35 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Therapeutic and Mechanistic Approaches of Tridax procumbens Flavonoids for the Treatment of Pyrexia: Molecular Docking\",\"authors\":\"Pradyumna Pal, S. Sushanth Kumar, J. Malik\",\"doi\":\"10.36346/sarjps.2023.v05i02.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The perennial plant Tridax Procumbens is particularly intriguing, and its secondary metabolites, also known as T. procumbens flavonoids (TPFs), are well-known phytochemical agents due to their diverse medicinal uses, including their anti-inflammatory, anti-anemic, and anti-diabetic effects. The antipyretic potential of luteolin, a natural product isolated from the medicinal plant Tridax procumbens, was investigated for antipyretic action through molecular docking analyses with the target enzymes cyclooxygenase-2 (COX-2). The docking result of luteolin revealed that their docking scores was -7.24 kcal mol–1 and it can be predicted as good inhibitor of human COX2 receptor.\",\"PeriodicalId\":244449,\"journal\":{\"name\":\"South Asian Research Journal of Pharmaceutical Sciences\",\"volume\":\"35 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-03-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"South Asian Research Journal of Pharmaceutical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.36346/sarjps.2023.v05i02.001\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"South Asian Research Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36346/sarjps.2023.v05i02.001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Therapeutic and Mechanistic Approaches of Tridax procumbens Flavonoids for the Treatment of Pyrexia: Molecular Docking
The perennial plant Tridax Procumbens is particularly intriguing, and its secondary metabolites, also known as T. procumbens flavonoids (TPFs), are well-known phytochemical agents due to their diverse medicinal uses, including their anti-inflammatory, anti-anemic, and anti-diabetic effects. The antipyretic potential of luteolin, a natural product isolated from the medicinal plant Tridax procumbens, was investigated for antipyretic action through molecular docking analyses with the target enzymes cyclooxygenase-2 (COX-2). The docking result of luteolin revealed that their docking scores was -7.24 kcal mol–1 and it can be predicted as good inhibitor of human COX2 receptor.
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