中华流行病学杂志最新文献

{"title":"[Pangenome analysis on plasmids carried by hypervirulent <i>Klebsiella pneumoniae</i>].","authors":"X M Wu, Z P Li, J Huang, Y H Wang, X Lu, B Kan, J L Zhao","doi":"10.3760/cma.j.cn112338-20241026-00663","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20241026-00663","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the pangenome, pan drug resistance genes, pan virulence genes, pan replicons, and others of the plasmids carried by hypervirulent <i>Klebsiella pneumoniae</i> (hvKP) in the world and their evolutionary trends over time, and provide evidence for more comprehensive understanding of the evolution of genetic diversity, drug resistance genes, and virulence genes of the plasmids. <b>Methods:</b> From the National Center for Biotechnology Information database, a total 1 738 plasmids were screened from 524 strains with completed genome sequences in 2 136 strains of hvKP carrying plasmids. Through pangenome, pan drug resistance gene, and pan-virulence gene composition and functional analyses, the curves of pangenome size and new gene size against plasmid isolation time were established, revealing the diversity of the plasmid pangenome and its evolutionary patterns. <b>Results:</b> The homologous genes, homologous drug resistance genes, homologous virulence genes, and replicons of the plasmids carried by hvKP comprised of 12 906, 149, 107 and 89 types, respectively. The fitting curves for the number of new genes, new drug resistance genes and new replicons increased with the increase of plasmids in an open state, while the curve for novel virulence genes was in a closed state. A obvious increase in new drug resistance genes was observed during 2018-2019. Among the newly added drug resistance genes during 2021-2023, beside those conferring aminoglycoside resistance, they were mainly new subtypes conferring carbapenem resistance. <b>Conclusions:</b> The pangenome of plasmids carried by hvKP exhibited high diversity, with the plasmid pan genes, pan drug resistance genes, and pan replicon types gradually expanding, while the pan virulence genes remains stable. The increase in novel drug resistance genes in specific years and the emergence of new carbapenem-resistant gene subtypes during 2021-2023 suggested the need for strengthened drug resistance surveillance and prevention efforts, with particular attention to carbapenem resistance.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"46 3","pages":"506-513"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Progress and scientific significance of life course study in elderly cohort].","authors":"M Liu, Y He","doi":"10.3760/cma.j.cn112338-20241114-00726","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20241114-00726","url":null,"abstract":"<p><p>Population ageing is rapid in China, so it is urgent to address this problem. Providing equitable, accessible, systematic and continuous health care services in life course and conducing life course study in elderly cohort can facilitate the construction of a life-course health care system for ageing. At present, there are limited prospective cohort studies of the elderly population in China, especially the oldest-old and centenarians, indicating that it is still necessary to establish and integrate cohorts of the elderly population to conduct epidemiological studies of the life course of the elderly. This special issue focuses on the topic of healthy ageing to discuss the future development of the health management of the elderly population in Beijing from different aspects and the potential risk factors affecting the health of the elderly, analyse the key influencing factors that can reduce all-cause and cardiovascular diseases mortalities, provide evidence support for the development of healthy ageing strategies, prevention of chronic diseases in the elderly and the construction of an ageing health care system in China.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"46 3","pages":"361-365"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Epidemiological characteristics of enteritis due to norovirus in Guizhou Province, 2016-2023].","authors":"P S Yang, J Y Yang, H Huang, C Yu, G H Yao","doi":"10.3760/cma.j.cn112338-20240722-00446","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240722-00446","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To understand the incidence and epidemiological characteristics of enteritis due to norovirus infection in Guizhou Province from 2016 to 2023, and provide reference for the prevention and control of enteritis caused by norovirus. &lt;b&gt;Methods:&lt;/b&gt; The data were from National Notifiable Infectious Disease Reporting System of China Information System for Disease Control and Prevention. To collect the data of other infectious diarrhea cards in Guizhou from 2016 to 2023, which were annotated as enteritis due to norovirus and food-borne disease surveillance sentinel report in Guizhou, which were positive for norovirus detection. The data of cluster/outbreaks were from the Public Health Emergency Event Surveillance System and the field investigation reports of CDC at all levels. Descriptive epidemiological method was used to describe the characteristics of its three-dimension distribution, epidemic situation and pathogen spectrum. R 4.2.2 software was used for statistical analysis. &lt;b&gt;Results:&lt;/b&gt; A total of 2 340 cases of enteritis due to norovirus were reported in Guizhou Province during this period, with an average annual reported incidence of 0.79/100 000, and the incidence showed an upward trend (trend &lt;i&gt;χ&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt;=1 723.80, &lt;i&gt;P&lt;/i&gt;&lt;0.001). The high incidence season is from October to March (winter and spring). The male to female ratio of the cases was 1.39∶1 (1 362∶978). A total 1 382 cases occurred in age group under 5 years old (59.06%) and 1 249 cases occurred in children living scatteredly (53.38%). The average annual reported incidence in 6 prefectures (muniipality)(1.15/100 000 in Qiandongnan Miao and Dong Autonomous Prefecture, 1.08/100 000 in Guiyang, 1.07/100 000 in Liupanshui, 1.06/100 000 in Qianxinan Buyi and Miao Autonomous Prefecture, 0.91/100 000 in Qiannan Buyi and Miao Autonomous Prefecture and 0.89/100 000 in Tongren) in Guizhou Province was higher than provincial level, and the affected areas gradually expanded from southeastern counties (districts) to western and northern counties (districts). The average annual reported incidence rate was higher in urban area (1.12/100 000) than in rural area (0.39/100 000). A total of 31 cluster/outbreaks of enteritis due to norovirus were reported, in which 83.87% (26/31) occurred in child care settings, primary and secondary schools, in which 74.19% (23/31) were caused by human-to-human transmission. In the 2 340 cases, 2 147 were laboratory diagnosed (91.75%), and 193 were clinically diagnosed (8.25%). In the laboratory diagnosed cases, 2 026 (94.36%) were caused by single norovirus infection and 121 (5.64 %) were caused by mixed infection. &lt;b&gt;Conclusions:&lt;/b&gt; On the whole, the incidence of enteritis due to norovirus in Guizhou Province was on the rise from 2016 to 2023, and winter and spring were the high incidence seasons. Effective prevention and control measures should be taken for key populations, key regions and key places, and multi-channel and multi-","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"46 3","pages":"423-429"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Study of construction of index system for evaluation of response capanility for public health risk in mass gathering].","authors":"F Ding, K Qu, Q Wang, L M Jin","doi":"10.3760/cma.j.cn112338-20240914-00576","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240914-00576","url":null,"abstract":"<p><p><b>Objective:</b> To construct an index system for the systematic evalaution of response capabiity for public health risk in mass gathgering and improvemet of preparedness and level of public health risk response. <b>Methods:</b> Based on the theory of health emergency management and the public health practice to support domestic and international mass events, the theoretical framework was constructed. Authoritative experts in relevant fields were invited to conduct multiple rounds of expert consultation for the construction of an evaluation index system, with Delphi method. <b>Results:</b> In this study, 12 authoritative experts in relevant professional fields were selected to participate in the survey, with an expert response rate of 100.0% and an average authority coefficient of 0.89. The final Kendall's <i>W</i> coefficient was 0.408 for the second-level indicators, and 0.416 for the third-level indicators (all <i>P</i><0.001). Finally, an evaluation index system consisting of 4 first-level indicators (surveillance, risk assessment, laboratory support and response), 15 second-level indicators, and 75 third-level indicators was constructed. <b>Conclusion:</b> The evaluation index system constructed in this study can provide a reference for evaluation of the response capability for the public health risk in mass gathering.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"46 3","pages":"527-532"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis on adverse treatment outcome of rifampicin-resistant tuberculosis patients and influencing factors in 9 provinces in China, 2017-2021].","authors":"H J Sun, X Q Liu, W Su, T Li, Y L Zhao, W Chen","doi":"10.3760/cma.j.cn112338-20240702-00394","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240702-00394","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the incidence of adverse treatment outcome of rifampicin-resistant tuberculosis (RR-TB) patients and influencing factors in 9 provinces in China. <b>Methods:</b> The information about the basic characteristics, diagnosis and treatment of RR-TB patients registered from January 1, 2017 to December 31, 2021 in 9 provinces (Beijing, Jilin, Shanghai, Jiangsu, Zhejiang, Hubei, Henan, Yunnan and Guizhou) were collected from the tuberculosis information management sub-system of China Disease Control and Prevention Information System for a descriptive analysis, and the influencing factors of adverse treatment outcome were identified by binary logistic regression analysis. <b>Results:</b> In 18 204 RR-TB patients in this study a total of 6 852 had adverse treatment outcomes (37.64%). Treatment failure occurred in 1 031 patients, 1 272 patients died, 2 284 patients were lost to follow-up, and 2 265 patients were not evaluated. The results of multivariate logistic regression analysis showed that being man (a<i>OR</i>=1.54, 95%<i>CI</i>: 1.43-1.66), age ≥65 years (a<i>OR</i>=2.42, 95%<i>CI</i>: 2.20-2.67), being from other ethnic groups (a<i>OR</i>=1.18, 95%<i>CI</i>: 1.03-1.35), being farmer (a<i>OR</i>=1.22, 95%<i>CI</i>: 1.13-1.32), being retired with honours or being retired (a<i>OR</i>=1.16, 95%<i>CI</i>: 1.00-1.35) and being floating population (a<i>OR</i>=1.23, 95%<i>CI</i>: 1.13-1.34), re-treatment (a<i>OR</i>=1.33, 95%<i>CI</i>: 1.24-1.42), long-term treatment therapy (a<i>OR</i>=3.26, 95%<i>CI</i>: 2.52-4.23), living in central provinces (a<i>OR</i>=2.76, 95%<i>CI</i>: 2.55-2.99), living in western provinces (a<i>OR</i>=2.31, 95%<i>CI</i>: 2.08-2.57) were the influencing factors for adverse treatment outcome of RR-TB. <b>Conclusions:</b> The incidence of adverse outcomes in RR-TB patients in 9 provinces in China was higher from 2017 to 2021. There were many influencing factors associated with adverse treatment outcome in RR-TB patients, especially the area specific factors. The national tuberculosis control program should strengthen the follow-up and treatment management of RR-TB in men, the elderly, floating population, people in central and western provinces and other key groups, actively promote the short-term treatment program and improve the allocation of medical resources to reduce the influencing for adverse treatment outcomes in RR-TB patient.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"46 2","pages":"188-195"},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association between dietary choline intake trajectories and cognitive function in middle-aged and older population].","authors":"Y B Liu, W W Du, Q Y Cao, H J Wang, C Su, Y N He, J G Ji, J Li, X F Jia","doi":"10.3760/cma.j.cn112338-20240906-00559","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240906-00559","url":null,"abstract":"<p><p><b>Objective:</b> To identify the trajectories of dietary choline intake in middle-aged and older population, and to analyze its longitudinal association with cognitive function. <b>Methods:</b> Subjects aged 55 to 79 years with at least two rounds of completed population economics, lifestyle, disease history, cognitive function, dietary assessments and physical measurements in 1997-2018 and those with at least three rounds of dietary measures in 1991-2015 were selected from the China Health and Nutrition Survey. Dietary survey was conducted using three consecutive 24-hour dietary recalls combined with a weighing inventory at the household level. Cognitive assessment was performed using part of the Telephone Interview for Cognitive Status Scale. Group-based univariate trajectory modeling was used to identify trajectory of choline intake, and three-level linear mixed-effects models or three-level logistic mixed-effects models was employed to analyze the relationship between trajectory groups and cognitive function. Subgroup analyses were conducted by gender and age at baseline. <b>Results:</b> Four trajectories of dietary choline intake were identified in the whole population, named as low-intake-stable group (61.0%), medium-intake-stable group (23.9%), medium-intake-slowly-declined group (11.2%), and high-intake-stable group (3.9%). Three trajectories were identified for each subgroup. Low-intake-stable group accounted for more than 60% in total population as well as each subgroup, especially in women and 55-59 years group. After adjusting for covariates, global cognitive scores were 0.54 (95%<i>CI</i>: 0.26-0.82), 0.77 (95%<i>CI</i>: 0.36-1.18), and 0.85 (95%<i>CI</i>: 0.21-1.48) points higher in medium-intake-stable, medium-intake- slowly-declined and high-intake-stable groups in the whole population, respectively, compared with the low-intake-stable group. The likelihoods of cognitive decline were 18.4% (<i>OR</i>=0.816,95%<i>CI</i>: 0.709-0.939), 17.6% (<i>OR</i>=0.824, 95%<i>CI</i>: 0.680-0.998), 24.4% (<i>OR</i>=0.756, 95%<i>CI</i>: 0.589-0.970) and 22.4% (<i>OR</i>=0.776,95%<i>CI</i>: 0.623-0.968) lower in medium-intake-stable group of dietary choline in the whole population, medium-intake-stable group in males, medium-intake-slightly-increased group in females and medium-intake-slowly-increased group in 55-59 years at baseline than in low-intake-stable group, respectively. <b>Conclusions:</b> Dietary choline intake is generally lower in the Chinese population aged 55-79 years. Long-term lower choline intake has a negative impact on cognitive function in middle-aged and older adults and may increase the risk of cognitive decline. The increment in the consumption of choline-enriched foods should be recommended.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"46 2","pages":"210-217"},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Development of an evaluation indicator system for access to cancer screening services: a Delphi study].","authors":"X Wang, A Y Mao, X Y Zhou, P Dong, Y J Li, S Y Cai, Y J Wu, H Y Huang, G X Liu, W H Xu, J M Qin, W Q Chen, J F Shi","doi":"10.3760/cma.j.cn112338-20240622-00367","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240622-00367","url":null,"abstract":"<p><p><b>Objective:</b> To present an evaluation indicator system for access to cancer screening services. <b>Methods:</b> The evaluation indicator pool was constructed through a scoping review. The theoretical framework was constructed based on the multi-source indicators, and the qualitative expert consultation method was employed to form the initial version of the three-level evaluation indicator system. Delphi expert consultation method was conducted in two rounds to evaluate the relevance, importance, and availability of the proposed evaluation indicator system. The expert positive coefficient, authority coefficient, coordination degree of expert opinions, and concentration of expert opinions were subjected to analysis. Subsequently, the three-level evaluation indicator system for access to cancer screening services was adjusted and determined based on the boundary value method and the open opinions of experts. Finally, the combination weight method was employed to determine the weight. <b>Results:</b> The initial version of the indicator system comprised 3 primary (first-level) indicators, 11 secondary (second-level) indicators, and 46 tertiary (third-level) indicators. Delphi expert consultation was conducted for the initial version, and 17 experts ultimately completed it, exhibiting a positive coefficient of 100% and an authority coefficient of 0.87. In comparison to the initial round of consultation, Kendall's W coefficient ranges (0.15-0.43, all <i>P</i><0.05) of relevance, importance, and availability scores for each tertiary indicator in the second round exhibited an improvement. The analysis of the importance dimension indicates that expert opinions are also more concentrated, as evidenced by an increase of 8.5% and 7.0% in the proportion of the tertiary indicators with an arithmetic mean above 8 and a full mark ratio above 0.5, respectively. The final evaluation indicator system comprises three primary indicators, with the weights of structure evaluation, process evaluation, and outcome evaluation being 0.338, 0.378, and 0.285, respectively. It also comprises 11 secondary indicators and 45 tertiary indicators. <b>Conclusions:</b> The evaluation indicator system developed in this article can be an effective evaluation tool for quantitative comparison of access to cancer screening services across different populations, cancer types, and before and after intervention. Furthermore, it is recommended that the system undergo continuous optimization concerning its application.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"46 2","pages":"307-315"},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Prevalence of common chronic diseases and related factors in HIV-infected persons in Henan Province, 2023].","authors":"Z Y Chen, Q X Zhao, X Yang, M Deng, S X Zhao, C L Liu, M J Hou, Z H Zhang, Q Li, Y Sun","doi":"10.3760/cma.j.cn112338-20240626-00375","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240626-00375","url":null,"abstract":"<p><p><b>Objective:</b> To understand the prevalence and related factors of three common chronic diseases, hyperlipidemia, hypertension and diabetes in HIV-infected persons. <b>Methods:</b> As of December 2023, HIV-infected persons >15 years old who are receiving antiviral therapy (ART) and follow-up in Henan Province were selected as the study objects. Questionnaires, physical examinations, and blood samples were collected to collect demographic information, ART, body weight, blood lipids, blood pressure, and blood sugar of HIV-infected persons. The logistic regression model was used to analyze the related factors of hyperlipidemia, hypertension and diabetes. <b>Results:</b> Among 4 023 HIV-infected patients, the prevalence rates of hyperlipidemia, hypertension, and diabetes were 64.47% (2 594/4 023), 16.80% (676/4 023), and 10.54% (424/4 023), respectively. Multivariate analysis showed that hyperlipidemia was positively associated with ≥40 years of age, overweight and obesity, two nucleoside reverse transcriptase inhibitors (NRTIs) + proteasome inhibitors (PIs) regimen and two NRTIs+ integrase inhibitor regimen, and negatively associated with low body weight. Hypertension was positively correlated with the age group ≥40 years old, family history of cardiovascular and cerebrovascular diseases, overweight and obesity, ART time ≥0.5 years, and negatively correlated with low body weight. Diabetes was positively associated with age group ≥40 years, family history of cardiovascular and cerebrovascular disease, overweight and obesity, and negatively associated with the use of two NRTIs+PIs treatment regimens. <b>Conclusions:</b> In 2023, the prevalence of hyperlipidemia, hypertension, and diabetes among HIV-infected people in Henan Province was relatively high, and the risk of common chronic diseases among those ≥40 years old, overweight and obese, and those with a family history of cardiovascular and cerebrovascular diseases was also relatively high. It is recommended to strengthen the prevention and management of common chronic diseases among HIV-infected people.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"46 2","pages":"258-263"},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A survey on the cognition of mpox expertise among relevant clinicians in China].","authors":"Z W Chen, W Q Zhu, Y L Wu, S Q Liang, X L Yue, J Li, J H Zhang, X D Gong","doi":"10.3760/cma.j.cn112338-20240719-00439","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240719-00439","url":null,"abstract":"<p><p><b>Objective:</b> To investigate and evaluate the correct cognition and influencing factors of mpox expertise among relevant Chinese clinicians and to provide a reference for prevention and control. <b>Methods:</b> A cross-sectional survey was conducted among clinicians in relevant departments using a structured questionnaire compiled by ourselves through a non-random network recruitment method. The content includes demography, clinical specialties, and characteristics of medical institutions, and 37 questions to evaluate the professional cognition of mpox etiology, clinical characteristics, transmission, prevention, and control. Using the modified Bloom's cutoff point to determine the correct answer is greater than or equal to 26 entitled correct cognition. A logistic regression model was used to analyze the factors influencing the correct cognition rate. <b>Results:</b> A total of 4 332 clinicians in 23 provinces (autonomous regions, municipality) in China were investigated by online questionnaires and 4 276 effective questionnaires were collected, with an effective rate of 98.71%. The mean age of the respondents was (39.46±9.54) years old, 61.18% were female. The overall correct cognition rate of mpox expertise was 62.04% (95%<i>CI</i>: 60.59%-63.50%), the correct cognition rates of mpox etiology, clinical characteristics, transmission, prevention and control were 48.25% (95%<i>CI</i>: 46.68%-49.82%), 78.66% (95%<i>CI</i>: 77.38%-79.95%), 68.56% (95%<i>CI</i>: 67.10%-70.02%), respectively. Multivariate logistic regression analysis showed that the relevant factors affecting the overall correct cognition of mpox expertise among Chinese clinicians included gender (female: <i>OR</i>=1.54, 95%<i>CI</i>: 1.31-1.80), region (eastern region: <i>OR</i>=1.46, 95%<i>CI</i>: 1.18-1.79; midwestern region: <i>OR</i>=1.24, 95%<i>CI</i>: 1.04-1.49), professional title (deputy senior: <i>OR</i>=1.43, 95%<i>CI</i>:1.16-1.76; senior: <i>OR</i>=1.72, 95%<i>CI</i>:1.30-2.28), the clinical field (the clinical fields of dermatology and venereal diseases: <i>OR</i>=1.78, 95%<i>CI</i>: 1.42-2.23). <b>Conclusions:</b> The overall correct cognition rate of mpox expertise among relevant Chinese clinicians was low. It was essential to conduct mpox knowledge training for clinicians in males, northeast regions, junior professional title and the clinical fields other than dermatology and venereal diseases to improve their correct cognition rates and epidemic prevention and control ability.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"46 2","pages":"239-244"},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Epidemiological characteristics of hand, foot and mouth disease among people aged 6 and over in Guangzhou, 2010-2023].","authors":"S Y Zhong, H Wang, Q Zeng, Q L Wu, L Luo, X Zhang, Z B Zhang","doi":"10.3760/cma.j.cn112338-20240729-00465","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240729-00465","url":null,"abstract":"<p><p><b>Objective:</b> The purpose of this study was to analyze the epidemiological characteristics of hand, foot, and mouth disease (HFMD) among individuals aged 6 years and above in Guangzhou from 2010 to 2023, with the intention that a scientific basis be provided for effective prevention and control measures in older age groups. <b>Methods:</b> Data on HFMD incidence among individuals aged 6 years and above in Guangzhou from 2010 to 2023 were collected and analyzed. Descriptive epidemiological methods were used to analyze the distributions and pathogen components of HFMD cases in Guangzhou residents aged 6 years and above. Spatial autocorrelation analysis and Getis-Ord <i>Gi</i>* analysis were conducted to identify the spatial clustering patterns of HFMD at the street town level. <b>Results:</b> From 2010 to 2023, the gender ratio of HFMD cases in persons aged 6 and above was 1.49∶1 in Guangzhou. The average annual incidence rate of HFMD among individuals aged 6 years and above in Guangzhou was 25.75 per 100 000. Furthermore, the reported incidence rate indicated an increased tendency. The annual incidence showed a bimodal distribution, with the main peak occurring from May to July and the secondary peak from September to October. HFMD incidence rates vary by townships, with hotspots clustered in urban and urban-rural regions. The dominant pathogen shifts from year to year. Enterovirus 71 (EV71) was the prevalent strain in 2010, followed by other enteroviruses and Coxsackievirus (CV)-A16 from 2011 to 2016. Since 2017, CV-A6 has steadily become the major pathogen. <b>Conclusions:</b> The incidence of HFMD cases among individuals aged 6 years and above in Guangzhou increased generally from 2010 to 2023, with hotspots localized in urban and urban-rural areas. The pathogen composition altered dramatically, with the proportion of EV71 dropping overall, while CV-A6 eventually became the dominating strain. Therefore, it is imperative to focus on the prevention and control of HFMD in this age group, especially by strengthening measures in areas with high prevalence.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"46 2","pages":"196-203"},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}