中华流行病学杂志最新文献

{"title":"[Associations between dietary patterns and colorectal neoplasia in Chinese adults].","authors":"J H Luo, Z L He, C Y Luo, Y K Yan, Y Q Chen, X R Cheng, K Song, D Wu, M Dai, H D Chen","doi":"10.3760/cma.j.cn112338-20251210-00889","DOIUrl":"10.3760/cma.j.cn112338-20251210-00889","url":null,"abstract":"<p><p><b>Objective:</b> To identify dietary patterns among Chinese adults and examine their associations with colorectal neoplasia. <b>Methods:</b> Based on a national multicenter randomized controlled trial of colorectal cancer screening, 4 257 subjects who underwent colonoscopy and had complete dietary data were included. The intake frequencies of various types of food of the subjects were obtained through a food frequency questionnaire. The sociodemographic and lifestyle information of the subjects were obtained through a questionnaire survey. Factor analysis was used to extract dietary patterns, and multivariate logistic regression models were used to analyze the correlation between colorectal neoplasia and dietary patterns. <b>Results:</b> Three dietary patterns were extracted: the Healthy Balanced Pattern was characterized by the primary consumption of dairy products, fruits, whole grains, and eggs; the Vegetable-Refined Grain Pattern was characterized by the primary consumption of refined grains and vegetables; the High-Protein Meat Pattern was characterized by the primary consumption of red meat, white meat, and processed, salted, or smoked food. Multivariate logistic regression analysis showed that as the Healthy Balanced Pattern score increased from <i>Q</i>₁ to <i>Q</i>₄, the risk of non-advanced adenoma and advanced neoplasia both showed a decreasing trend (<i>P</i> for trend <0.001). For the Vegetable-Refined Grain Pattern, the risk of non-advanced adenoma in the <i>Q</i>₂-<i>Q</i>₃ groups was higher than that in the <i>Q</i>₁ group, but the linear trend test was not statistically significant; however, as the score levels of the Vegetable-Refined Grain Pattern increased from <i>Q</i>₁ to <i>Q</i>₄, the risk of advanced neoplasia significantly increased (<i>P</i> for trend < 0.001). As the score levels of the High-Protein Meat Pattern increased from <i>Q</i>₁ to <i>Q</i>₄, the risk of non-advanced adenoma and advanced neoplasia both showed an increasing trend (<i>P</i> for trend < 0.001). Subgroup analyses showed that sex and age showed significant interactions in the associations between the three dietary patterns and the risks of non-advanced adenoma and advanced neoplasia (<i>P</i> for interaction <0.05). <b>Conclusions:</b> Dietary patterns are associated with colorectal neoplasia. The Healthy Balanced Pattern is associated with reduced risk, whereas the Vegetable-Refined Grain Pattern and High-Protein Meat Pattern are associated with increased risk of colorectal neoplasia.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"47 6","pages":"1039-1045"},"PeriodicalIF":0.0,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Epidemiological characteristics of test-negative severe acute respiratory infections during the 2024-2025 surveillance years in Beijing].","authors":"Y Shen, D T Zhang, W X Shi, C N Ma, D Huo, P Yang, Q Y Wang, Z M Feng","doi":"10.3760/cma.j.cn112338-20260104-00004","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20260104-00004","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the epidemiological characteristics of cases with severe acute respiratory infection (SARI) in Beijing who tested negative for 22 common respiratory pathogens by nucleic acid testing, and to explore the potential pathogen spectrum using metagenomic next-generation sequencing (mNGS). <b>Methods:</b> Data were obtained from the Beijing Acute Respiratory Infectious Disease Surveillance Network. Hospitalized SARI cases from week 40 of 2024 to week 39 of 2025 were included. All cases were tested for 22 common respiratory pathogens using nucleic acid assays. Among those test-negative results, 50 specimens were randomly selected for mNGS analysis. Multivariable logistic regression was performed to identify factors associated with test-negative results. <b>Results:</b> A total of 7 202 SARI cases were included, of whom 4 212 (58.5%) tested negative for all 22 common respiratory pathogens. The proportion of negative results increased with age, with 32.9% (322/978) in children aged 0-5 years, 69.1% (972/1 407) in adults aged 18-59 years, and 65.0% (2 506/3 856) in those aged ≥60 years, the difference was statistically significant (all <i>P</i><0.001). Multivariable analysis showed that age was independently associated with negative results (18-59 years: a<i>OR</i>=4.62, 95%<i>CI</i>:3.85-5.55; ≥60 years: a<i>OR</i>=4.08, 95%<i>CI</i>:3.49-4.78). Upper respiratory samples were more likely to test negative. Among 48 valid mNGS samples, 32 pathogens were identified. At least one pathogen was detected in 44 cases (93.6%), and multiple infections were common (37 cases, 84.1%). Human herpesvirus 7 (20 cases) was most frequently detected, followed by <i>Stenotrophomonas maltophilia</i> (16 cases), Human herpesvirus (15 cases), and <i>Streptococcus pneumoniae</i> (12 cases). <b>Conclusions:</b> A high proportion of SARI cases in Beijing tested negative for common respiratory pathogens, and age played an important role. mNGS identified predominantly opportunistic pathogens and herpesviruses, and did not detect novel pathogens with clear respiratory significance. These findings indicate that the current SARI surveillance covers the most common respiratory pathogens.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"47 6","pages":"1114-1119"},"PeriodicalIF":0.0,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of the vaccination status and trends of the herpes zoster vaccine in Shandong Province from 2020 to 2024].","authors":"G J Luan, L Sun, S N Liu, Y Liu, W Guo, W Y Zhang, Y J Zhang","doi":"10.3760/cma.j.cn112338-20251009-00702","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20251009-00702","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the current status and changing trends of herpes zoster vaccination in Shandong Province from 2020 to 2024 and provide a reference for the prevention and control of herpes zoster in the population. <b>Methods:</b> The first dose of herpes zoster vaccine was collected from the Immunization Information System of Shandong Province from 2020 to 2024, and vaccination coverage was calculated based on population data. The temporal trend in vaccination coverage was analyzed using Joinpoint 5.3.0. <b>Results:</b> The vaccination coverage of the herpes zoster vaccine in Shandong Province showed an upward trend from 2021 to 2024 [average annual percentage change (AAPC)=46.48%, <i>P=</i>0.065], with the highest in 2023 (0.084%). The vaccination coverage of females was higher than that of males, but the growth rate of male vaccination coverage (AAPC=48.95%, <i>P</i>=0.057) was slightly higher than that of females (AAPC=45.11%, <i>P</i>=0.074). The vaccination coverage in regions with high gross domestic product (GDP) had a turning point in 2022, with rapid growth in 2021-2022 [annual percentage change (APC)=70.75%, <i>P</i>=0.028], and a flat growth rate in 2022-2024 (APC=4.91%, <i>P</i>=0.737), with the highest vaccination coverage in 2023 (0.094%). The growth rate of vaccination coverage in regions with medium GDP (AAPC=62.48%, <i>P</i>=0.039) and low GDP (AAPC=64.40%, <i>P</i>=0.040) was faster than that in regions with high GDP (AAPC=23.41%, <i>P</i>=0.037). The vaccination coverage was highest in the 50-59 age group, with the turning point in 2022. From 2021 to 2022, it increased rapidly (APC=128.03%, <i>P</i>=0.028), and from 2022 to 2024 (APC=5.68%, <i>P</i>=0.743), the growth rate tended to be flat. The growth trend in vaccination coverage in the 70-79 age group (AAPC=54.17%, <i>P</i>=0.024) and the 80- age group (AAPC=59.15%, <i>P</i>=0.028) was relatively fast. <b>Conclusions:</b> Herpes zoster vaccination coverage showed an upward trend in Shandong Province from 2020 to 2024, and vaccination coverage among the middle-aged population aged 50 to 69 has increased significantly. However, it is important to focus on increasing vaccination coverage in economically underdeveloped areas, among males, and older age groups.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"47 6","pages":"1099-1104"},"PeriodicalIF":0.0,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association between blood selenium level and depressive symptoms in older adults aged 65 years and above in 18 longevity areas in China].","authors":"Z H Xue, W Y Shi, Y Chen, Y L Qu, C Chen, X Meng, J Wang, W H Shi, J H Chen, Y M Wang, L L Wei, C H Jiang, Z Y Yin, P P Dong, Y Q Chen, F Y Long, Z H Li, X M Shi, C Mao, Y B Lyu","doi":"10.3760/cma.j.cn112338-20251229-00931","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20251229-00931","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the association between blood selenium (Se) level and depressive symptoms among the older adults aged ≥65 years in 18 longevity regions of China. <b>Methods:</b> Based on the 2021 China Healthy Ageing and Biomarkers Cohort Study, 5 278 participants were enrolled. In this study, inductively coupled plasma-mass spectrometry was used to measure blood Se levels, and the Patient Health Questionnaire-9 was used to assess depressive symptoms; a score of ≥10 was defined as indicative of depressive symptoms. Multivariable logistic regression models and restricted cubic spline (RCS) analyses were utilized to examine the association and dose-response relationship between blood Se levels and depressive symptoms. <b>Results:</b> The mean age of participants was (84.15±11.28) years old, and 55.2% were female. A total of 332 older adults with depressive symptoms were detected, with a detection rate of 6.3%. Compared with those without depressive symptoms, older adults with depressive symptoms have lower blood Se levels (<i>P<</i>0.001), which are (105.02±29.77) μg/L and (112.53±31.84) μg/L, respectively. Multivariate logistic regression results showed a negative association between blood Se levels and the risk of depressive symptoms. After adjusting for all covariates, for every 10 μg/L increase in blood Se levels, the risk of depressive symptoms decreased by 5% (<i>OR</i>=0.95, 95%<i>CI</i>: 0.91-0.99). Compared with the <i>Q</i>₁, the <i>OR</i>s (95%<i>CI</i>s) of blood Se in <i>Q</i>₂, <i>Q</i>₃, and <i>Q</i>₄ were 0.85 (0.63-1.15), 0.69 (0.49-0.95), and 0.67 (0.47-0.94), respectively. Furthermore, RCS analysis revealed a near-linear negative dose-response relationship between blood Se levels and the risk of depressive symptoms (<i>P</i> for linear =0.055). <b>Conclusion:</b> Blood Se level is significantly associated with decreased risk of depressive symptoms among older adults aged 65 and older in 18 longevity regions of China.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"47 6","pages":"1015-1022"},"PeriodicalIF":0.0,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis and projection of the disease burden of endometriosis and polycystic ovary syndrome-related infertility among women aged 15-49 years in China and globally from 1990 to 2021].","authors":"S Lu, P Zhang, H Qian, H M Li","doi":"10.3760/cma.j.cn112338-20250929-00691","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20250929-00691","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the burden of endometriosis (EMs)-related and polycystic ovary syndrome (PCOS)-related infertility among women aged 15-49 years in China and globally, and to project trends over the next 15 years. &lt;b&gt;Methods:&lt;/b&gt; Data were sourced from the 2021 Global Burden of Disease (GBD) database. Disease burden indicators, including the age-standardized prevalence rate (ASPR) and age-standardized years lived with disability rate (ASYR) for EMs- and PCOS-related infertility, were calculated and analyzed among women aged 15-49 years in China and globally. Linear regression models and Joinpoint regression analysis were used to further analyze the trend changes in disease burden in China and globally. The Bayesian age-period-cohort (BAPC) model was employed to predict disease trends over the next 15 years. &lt;b&gt;Results:&lt;/b&gt; From 1990 to 2021, ASPR and ASYR of EMs-related infertility among women aged 15-49 years in China and globally showed a declining trend. The ASPR of EMs-related infertility declined faster in China than globally, with an average annual percentage change (AAPC) of -1.42% in China and -0.95% globally. By 2021, the ASPR and ASYR for EMs-related infertility in Chinese women aged 15-49 years were lower than the global average and those of all sociodemographic index (SDI) regions. In 2021, the highest ASPR and ASYR were observed in Chinese women aged 40-44 years, while globally, the highest rates were in the 25-29 age group. From 1990 to 2021, the ASPR and ASYR of PCOS-related infertility among women aged 15-49 years showed an increasing trend in both China and globally. The increase in ASPR among Chinese women aged 15-49 years was significantly higher than the global average and that of all SDI regions, with an AAPC of 1.93% in China and 0.99% globally. In 2021, the highest ASPR for PCOS-related infertility in China was observed in women aged 25-29 years, while the fastest increases in ASPR and ASYR both globally and in China occurred in women aged 20-24 years. The BAPC model predicts that by 2036, the ASPR and ASYR of EMs-related infertility among women aged 15-49 years will decrease to 32.98 per 100 000 and 0.21 per 100 000 in China, and to 55.57 per 100 000 and 0.33 per 100 000 globally, respectively. In contrast, the ASPR and ASYR of PCOS-related infertility among women aged 15-49 years will increase to 620.39 per 100 000 and 3.46 per 100 000 in China, and to 774.34 per 100 000 and 4.45 per 100 000 globally, respectively. &lt;b&gt;Conclusions:&lt;/b&gt; The ASPR and ASYR for EMs-related infertility among women aged 15-49 years are declining in China and globally, with China's burden lower than the global average, and this trend is expected to continue over the next 15 years. In contrast, the ASPR and ASYR for PCOS-related infertility among women aged 15-49 years are increasing persistently, with a faster increase in China than globally and across all SDI regions. This indicates that PCOS has become a key priority for t","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"47 6","pages":"1091-1098"},"PeriodicalIF":0.0,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association between life behavior patterns and symptoms of anxiety and depression among adolescents in Jinan].","authors":"F F Yan, J Z Li, Y H Li, Y Li, L Yang","doi":"10.3760/cma.j.cn112338-20251217-00905","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20251217-00905","url":null,"abstract":"<p><p><b>Objective:</b> The purpose of this study is to understand the current situation of anxiety and depression among adolescents in Jinan, and to explore the relationship between their life behavior patterns and the two, so as to provide a scientific basis for formulating effective prevention and control strategies and measures to reduce the incidence of anxiety and depression among adolescents. <b>Methods:</b> The study adopted a stratified cluster sampling method to conduct a questionnaire survey among middle school students in Jinan from September to November 2023. Cluster analysis method was used to reveal the common characteristics of adolescents with anxiety, depression and both, and binary logistic regression was used to analyze the relationship between different demographic characteristics, different life behavior patterns and anxiety and depression. <b>Results:</b> A total of 13 171 middle school students were surveyed in this study, of which 25.78%, 15.88% and 13.09% were having anxious, depressed and experiencing both emotions, respectively. After controlling for other variables, female, students with <8 hours of sleep per day and internet addiction were more likely to experience anxiety, while ≤2 hours of video screen time per day was a protective factor for anxiety (<i>OR</i>=0.568, 95%<i>CI</i>: 0.512-0.632). In the depression group, the risk of depression among female students, urban students, students with <3 days of exercise per week, students with <8 hours of sleep per day, and students with internet addiction was 1.349, 1.140, 1.157, 2.962, and 4.977 times higher than that of the control group, respectively. Video screen time ≤2 hours per day was also a protective factor for depression (<i>OR</i>=0.528, 95%<i>CI</i>: 0.468-0.595). Furthermore, the risk of anxiety, depression and comorbidity of anxiety and depression among students in the high video screen time pattern was 2.368, 2.722 and 2.830 times higher than that in the high exercise frequency pattern, respectively. <b>Conclusions:</b> Female students, students with <8 hours of sleep per day and internet addiction were the common risk factors of anxiety and depression. Urban students and students with <3 days of exercise per week increased the risk of depression. High video screen time increased the risks of anxiety, depression, and their comorbidity, while video screen time ≤2 hours per day exerted a protective effect. It is recommended that prevention and control interventions among adolescents focus on reducing video screen time, increasing physical activity, and ensuring adequate sleep.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"47 6","pages":"1083-1090"},"PeriodicalIF":0.0,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Baseline characteristics of the West China Bone Health Cohort and analysis on the influencing factors of osteoporosis and fragility fracture risk].","authors":"J Y Zhou, X Y Zhao, T Liu, Y Q Zou, Y Qu, X F Ma, X Song, B W Lei, B Yang, D Zhang, M Y Xia, Y D Zhong, W Z Wang, L Sun, T Zhang, J Y Li, M Y Fan, B Zhang, X Jiang","doi":"10.3760/cma.j.cn112338-20251022-00747","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20251022-00747","url":null,"abstract":"<p><p><b>Objective:</b> To characterize the baseline features of the West China Bone Health Cohort and to identify major factors of osteoporosis and fragility fractures. <b>Methods:</b> A prospective epidemiological survey was conducted based on outpatients at West China Fourth Hospital of Sichuan University and community residents from Hongguang, Chengdu. Demographic characteristics, lifestyle factors, biochemical indicators, and imaging data were collected (etiological study). Medical records of inpatients admitted to the osteoporosis department of the same hospital between 2017 and 2024 were retrospectively analyzed (prognostic study). Descriptive analysis, univariate and multivariate logistic regression model were performed to explore risk factors of osteoporosis and fragility fractures. <b>Results:</b> A total of 3 918 participants was enrolled in the prospective survey, and 6 737 inpatients were included in the retrospective analysis. Multivariate logistic regression analysis showed that in the prospective survey, age (a<i>OR</i>=1.06, 95%<i>CI</i>: 1.05-1.08), female sex (a<i>OR</i>=10.76, 95%<i>CI</i>: 7.39-15.94), and smoking (former smoking: a<i>OR</i>=1.58, 95%<i>CI</i>: 1.02-2.45; current smoking: a<i>OR</i>=1.90, 95%<i>CI</i>: 1.21-2.97) were risk factors for osteoporosis, while BMI (a<i>OR</i>=0.87, 95%<i>CI</i>: 0.84-0.89) and education (a<i>OR</i>=0.80, 95%<i>CI</i>: 0.65-0.99) were protective factors. In the retrospective analysis, age (a<i>OR</i>=1.07, 95%<i>CI</i>: 1.06-1.08) and monocyte count (a<i>OR</i>=1.91, 95%<i>CI</i>: 1.03-3.54) were positively associated with the risk of fragility fracture, while lymphocyte count (a<i>OR</i>=0.83, 95%<i>CI</i>: 0.75-0.92) was negatively associated with the risk. <b>Conclusions:</b> Age, female sex, smoking, low BMI, and low educational attainment were the main factors associated with osteoporosis, whereas age and abnormal inflammatory markers were closely related to fragility fractures. These findings highlight the importance of early identification and intervention among high-risk populations.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"47 6","pages":"1076-1082"},"PeriodicalIF":0.0,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Identification and validation of plasma biomarkers for mild cognitive impairment based on mRNA N⁶-methyladenosine methylome analysis].","authors":"H Yan, X L Wang, S T Wei, Q M Huang, J Gao, P L Chen, Y X Zhang, W F Zhong, J Yang, H Chen, J H Xie, D Liu, Z H Li, C Mao","doi":"10.3760/cma.j.cn112338-20251110-00808","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20251110-00808","url":null,"abstract":"<p><p><b>Objective:</b> To identify and validate differential mRNA N⁶-methyladenosine (m⁶A) methylation sites associated with mild cognitive impairment (MCI), providing potential molecular evidence for its early prevention and intervention. <b>Methods:</b> A case-control study was conducted among older adults recruited from multiple community health centers in Shenzhen, including a pilot cohort (5 pairs) and a validation cohort (25 pairs). Single-based m⁶A quantitative polymerase chain reaction was used to quantify plasma mRNA m⁶A methylation levels. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed, followed by the construction of a protein-protein interaction network to identify hub genes. The differential methylation levels of key genes were validated in an expanded cohort. For normally distributed data, <i>t</i>-tests were used; for non-normal data, Mann-Whitney <i>U</i> or <i>χ</i>² tests were applied. Partial correlation analysis and Firth logistic regression were conducted to verify the associations further. <b>Results:</b> A total of 126 differential mRNA m⁶A methylation sites were identified, including 73 upregulated and 53 downregulated sites. Five hub genes (<i>ZFHX3</i>, <i>PARD3</i>, <i>ARHGEF2</i>, <i>GLB1</i>, and <i>LRIG3</i>) were selected, based on protein-protein interaction network topology. Validation experiments showed that the mRNA m⁶A methylation levels of these five genes were significantly higher in the MCI group than in healthy controls (all <i>P</i><0.001). After adjustment for potential confounders, partial correlation analysis revealed that the methylation levels of all five genes were negatively correlated with MMSE scores (<i>r</i>=-0.719- -0.426, all <i>P</i><0.05). Firth logistic regression confirmed that these genes were independently associated with MCI (<i>OR</i>=1.57-2.88, all <i>P</i><0.001). <b>Conclusion:</b> This study screened and verified a range of MCI-related differential m⁶A methylation sites, suggesting that abnormal m⁶A methylation of specific gene mRNAs may be associated with MCI, providing research clues for further exploration of the molecular mechanism of MCI and potential plasma molecular markers.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"47 6","pages":"1062-1068"},"PeriodicalIF":0.0,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress on the impact of the digital information environment on the health of children and adolescents].","authors":"K H Zhu, J Guo, Y Yang, Z Y Sun, Y J Wang, D L Shi, L Yang, Y Song","doi":"10.3760/cma.j.cn112338-20251029-00769","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20251029-00769","url":null,"abstract":"<p><p>The digital information environment has deeply integrated into the learning, living, and social scenarios of children and adolescents, and has had a profound impact on their physical and mental health. This article systematically reviews research from both domestic and international sources, clarifies the connotations and characteristics of the digital information environment, and analyzes its multi-dimensional impacts on the health of children and adolescents from four domains:physical health, mental health, cognitive function, and social adaptation. It also analyzes the internal mechanisms and key regulatory factors to provide a scientific basis for promoting the health of children and adolescents in the digital era.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"47 6","pages":"1183-1188"},"PeriodicalIF":0.0,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association between urinary nickel levels and impaired kidney function in older adults aged 65 years and above in 18 longevity areas in China].","authors":"Y D Wu, Y Q Chen, C Chen, L S Yang, J Wang, K Zhang, W H Shi, X Meng, Y Li, Z H Zhang, J H Chen, L Li, C W Fu, J H Zhou, Y B Lyu, X M Shi","doi":"10.3760/cma.j.cn112338-20251216-00902","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20251216-00902","url":null,"abstract":"<p><p><b>Objective:</b> To explore the association between urinary nickel levels and impaired renal function in older adults aged ≥65 years from 18 longevity regions of China. <b>Methods:</b> Based on the 2021 China Healthy Ageing and Biomarkers Cohort Study, 5 045 participants were enrolled. Venous blood and urine samples were collected to detect renal function-related indicators and urinary nickel. Impaired renal function was jointly determined by calculating the estimated glomerular filtration rate and urinary albumin-creatinine ratio, and urinary nickel levels were adjusted by urinary creatinine. To assess the relationship between urinary nickel levels and impaired kidney function, we used multivariate logistic regression. Restricted cubic splines were applied to examine the dose-response relationship, with additional subgroup analyses and interaction analyses performed. <b>Results:</b> The median age of participants was 83.40 years, 54.73% of whom were female, and the median urinary nickel level was 2.10 μg/L. Following adjustment for covariates in the multivariate logistic regression analysis, the comparison with the <i>Q</i>₁ revealed that the <i>Q</i>₄ group of urinary nickel had a 26% increased risk of impaired renal function (<i>OR</i>=1.26, 95%<i>CI</i>: 1.05-1.51). Dose-response analysis revealed a positive nonlinear association between urinary creatinine-adjusted urinary nickel and impaired renal function (all <i>P</i> for overall <0.05, nonlinear <i>P</i><0.05). Subgroup and interaction analyses indicated that the association between urinary nickel and impaired renal function was more significant in men, Han Chinese, and non-diabetic populations, with significant interaction effects (all <i>P</i><0.05). <b>Conclusion:</b> The risk of impaired renal function increases with elevated urinary nickel levels in older adults aged ≥65 years from 18 longevity areas of China.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"47 6","pages":"1023-1030"},"PeriodicalIF":0.0,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}