中华流行病学杂志最新文献

{"title":"[Statistical design and application of clinical trials with small sample sizes for rare diseases].","authors":"Y Gao, Z H Zhong, M Y Lu, F Chen","doi":"10.3760/cma.j.cn112338-20240705-00401","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240705-00401","url":null,"abstract":"<p><p>Due to the limited number of cases, conducting large-scale clinical trials for rare diseases is challenging. This review introduces several small sample statistical designs tailored for rare diseases, including crossover design, <i>n</i>-of-1 design, randomized placebo-phase design, randomized withdrawal design, group sequential design, and adaptive design. It discusses the advantages, disadvantages, and application scenarios of these designs. Additionally, it explores the benefits of Bayes decision-making in clinical trials for rare diseases. The aim is to provide a reference for designing and implementing small sample clinical trials for rare diseases.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"45 12","pages":"1700-1704"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Epidemiological characteristics and trend of mortality on hand, foot and mouth disease in China, 2008-2022].","authors":"F Gao, B C Tang, X L Jiang, S Y Yin, Z R Chang, Y Qin, Y Li, Z J Li","doi":"10.3760/cma.j.cn112338-20231125-00317","DOIUrl":"10.3760/cma.j.cn112338-20231125-00317","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the nationwide epidemiological characteristics and trend of hand, foot and mouth disease (HFMD) fatal cases from 2008 to 2022 and provide evidence for the prevention and control of HFMD. <b>Methods:</b> The information on HFMD fatal cases during 2008 to 2022 was collected from the National Notifiable Disease Surveillance Reporting System of China. Data of the epidemiological characteristics was analyzed by R 4.2.2 software and the changing trends for the case fatality rates, mortality rates and their age-adjusted rates were analyzed by Joinpoint 4.9.10 software. <b>Results:</b> From 2008 to 2022, a total of 3 704 fatal HFMD cases were reported in China. The fatal cases were primarily observed in children aged <3 years (83.42%, 3 090/3 704). The male and female gender ratio was 1.82 ∶1 (2 389 ∶1 315). Regarding the age-adjusted case fatality rates over time, there was a rapid increase from 2008 to 2010 [annual percentage change (APC) =41.97%, <i>P</i><0.05]. From 2010 to 2016, a steady decline was observed (APC=-28.57%, <i>P</i><0.05), and the decline accelerated (APC=-39.66%, <i>P</i><0.05) from 2016 to 2022. Since 2020, less than 10 fatal cases were reported annually nationwide. Among the 2 566 laboratory-confirmed deaths from 2008 to 2022, Enterovirus A71 (EV71) was the predominant pathogen (91.62%,2 351/2 566). There have been noticeable changes in the pathogen composition since 2017, decreasing in EV71 and increasing in the proportion of fatalities caused by Coxsackievirus A16 (CV-A16) and other enteroviruses. <b>Conclusions:</b> From 2008 to 2022, the HFMD case fatality rates and mortality rates continuously declined, peaked in 2010. Since 2017, the decline of HFMD case fatality rates has been noticeably accelerated. Along with the decrease in the proportion of EV71 in HFMD fatal cases, the proportion of other enteroviruses appeared increasing. It is essential to continuously monitor the etiological spectrum of the fatal cases.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"45 12","pages":"1626-1632"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Knowledge, attitude, practice and influencing factors on influenza and influenza vaccine among pregnant women in Suzhou].","authors":"R Wang, Y Y Zhang, C Liu, P W Cui, F Xu, J R Jiang, L L Chen, H B Yang, F Liu","doi":"10.3760/cma.j.cn112338-20240731-00467","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240731-00467","url":null,"abstract":"<p><p><b>Objective:</b> To understand the current knowledge, attitude, and practice (KAP) on influenza and influenza vaccine among pregnant women in Suzhou and to analyze its influencing factors to provide technical support data for public health strategies for promoting influenza vaccination in pregnant women. <b>Methods:</b> A questionnaire was designed, and a stratified sampling method was used to conduct a face-to-face survey among pregnant women at different stages of pregnancy who received antenatal examinations at different levels of medical institutions in Suzhou, Jiangsu Province, in 2023. KAP status and influencing factors were analyzed by <i>χ</i>² test and logistic regression analysis. <b>Results:</b> A total of 2 195 valid questionnaires were collected in this survey. The <i>M</i>(<i>Q</i>₁, <i>Q</i>₃) of knowledge about influenza and influenza vaccine among pregnant women in Suzhou was 7.60 (5.23, 9.80) points, and the score range was 0.20-14.71 points, the passing rate was 34.12%, the awareness rate of influenza vaccine was 57.45%, and the vaccination rate of influenza vaccine was 1.91% within one year before the survey. The willingness to receive influenza vaccine during pregnancy was only 3.57%. Multivariate analysis of influenza and influenza vaccine-related knowledge scores showed that the passing rate was positively correlated with education level and gestational age. In contrast, family income was negatively correlated with living in rural areas, working as migrant workers, and having no medical insurance. Multivariate analysis of vaccination intention showed that decreased effectiveness of influenza vaccine and increased adverse reactions decreased vaccination intention during pregnancy. <b>Conclusions:</b> The pregnant women in Suzhou pay more attention to influenza, and vaccination rates and intentions are generally low. Pregnant women with early and second trimester of pregnancy, low education, living in rural areas, working as migrant workers, and not purchasing medical insurance are the key groups to popularize the knowledge about influenza and influenza vaccine.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"45 12","pages":"1672-1678"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Study on the mediating and moderating effects of food intake on blood glucose levels].","authors":"M R Liu, Z H Wang, H J Wang, C Su, H R Jiang, L S Wang, W Y Li, C Xiang, G G Ding","doi":"10.3760/cma.j.cn112338-20240723-00450","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240723-00450","url":null,"abstract":"<p><p><b>Objective:</b> Analyze the mediating and moderating effects of the relationship between food intake and blood glucose levels. <b>Methods:</b> This study uses data from the China Health and Nutrition Survey project in the survey 2018, involving 11 043 adults aged 18 years or older, who have complete dietary data, waist circumference (WC), glycated hemoglobin A1c (HbA1c) indicators, and other key variables. Food consumption data was gathered via three consecutive 24-hour dietary recalls and weighing accounting method, which included two weekdays and one weekend day. The average daily intake of various foods and total energy intake were calculated. The mediation effect and moderation effect analysis were conducted using simple mediation models, direct moderation effect models, and moderated mediation analysis theoretical models. The confidence interval method (bootstrap method) was performed for testing and analysis. <b>Results:</b> A total of 4 951 males and 6 092 females were included in the stratified analysis by gender. The mediating effects on the rice, wheat, and red meat→WC→HbA1c were all statistically significant in males. The standardized coefficients were -0.009 (<i>P</i><0.001), 0.013 (<i>P</i><0.001), and -0.005 (<i>P</i>=0.008), respectively. In females, the mediating effect on the wheat→WC→HbA1c was statistically significant, and the standardized coefficient was 0.017 (<i>P</i><0.001); the impact of red meat intake on HbA1c is negatively regulated by the intake of dark vegetables, with a direct moderating effect; the standardized coefficient of the interaction term between red meat and dark vegetables was -0.024 (<i>P</i>=0.008). Dark vegetables have a moderated mediator on the pathway from rice to WC and HbA1c (<i>a</i>₃<i>b</i>₁=-0.003, <i>P</i>=0.041) in males. The mediating effect of WC is negatively regulated by the intake of dark vegetables (mediation effect difference <i>U</i>_1/-1=-0.006, <i>P</i>=0.048). Dark vegetables showed a moderated mediator on the pathway from wheat to WC and HbA1c (<i>a</i>₃<i>b</i>₁=-0.004, <i>P</i>=0.045) in females. The mediating effect of WC is negatively regulated by the intake of dark vegetables (mediation effect difference <i>U</i>_1/-1=-0.009, <i>P</i>=0.049). <b>Conclusions:</b> Changes in WC indicators caused by rice, wheat, and red meat intake. WC could mediate between rice, wheat, red meat, and HbA1c. Dark vegetables directly or indirectly regulate HbA1c levels by interacting with rice, wheat, and red meat.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"45 12","pages":"1726-1735"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Challenges and coping strategies of cancer screening research and practice in China: Taking esophageal cancer as an example].","authors":"Z H He, Y Ke","doi":"10.3760/cma.j.cn112338-20240524-00304","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240524-00304","url":null,"abstract":"<p><p>For most cancers, clear intervention targets for primary prevention are lacking, due to unidentified high-risk causal factors. Consequently, the focus of cancer prevention and control in China has shifted towards early screening and treatment within the general population. This review outlines the significant challenges in research and practice of cancer prevention and control in China, including: ①inadequate understanding of the natural history of cancer; ② limited high-level evidence supporting cancer screening effectiveness and value; ③compromised efficiency and accuracy in current screening modality; and ④ insufficient universality and sustainability of the current screening practices, taking esophageal cancer as an example. To address these challenges, we propose potential coping strategies: ① establishing tailored technologies and pathways for cancer prevention and control based on population-based and clinical epidemiological studies using high-quality designs; ②breaking conventional constraints to establish a novel, efficient, and precision cancer screening strategy and modality that aligned with the frontline needs of cancer prevention and control; and ③establishing enhanced communication platforms among government policymaking departments, scientific research teams, and industrial institutions to foster collaboration and translation in the field of cancer prevention and control. Ultimately, through the collaboration of multiple disciplines and departments, we will jointly achieve the long-term goal of cancer prevention and treatment.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"45 12","pages":"1720-1725"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Construction of evidence graph for modifiable risk factors for diabetic retinopathy].","authors":"S Y Shi, Q X Zhou, H Y Sun, S Y Zhan, F Sun, S Y Zhang","doi":"10.3760/cma.j.cn112338-20240425-00217","DOIUrl":"10.3760/cma.j.cn112338-20240425-00217","url":null,"abstract":"<p><p><b>Objective:</b> Diabetic retinopathy (DR) has been reported as the leading cause of blindness among diabetic adults, which is closely related to poor quality of life and increased burden of disability. This study aimed to aggregate the optimally available evidence on modifiable risks of DR. <b>Methods:</b> Until June 2023, PubMed, Cochrane Library, CNKI, and Wanfang databases were used to retrieve Meta-analysis about various risk factors for DR, and Meta-analysis were analyzed and summarized. R 4.3.2 software was used for each Meta-analytic association to calculate the effect size, 95%<i>CI</i>, heterogeneity, small-study effects, excess significance bias, and 95% prediction intervals. The credibility of significant evidence was graded. <b>Results:</b> We captured 23 eligible papers (72 associations) covering a wide range of medication use, concomitant diseases, daily intervention, biomarkers, lifestyle, and physical measurement index. Among them, higher HbA1c variability (<i>RR</i>=1.45, 95%<i>CI</i>: 1.26-1.66) and urine microalbumin positive (<i>OR</i>=2.44, 95%<i>CI</i>: 1.99-2.97) were convincing (grade Ⅰ) evidence, and insulin use (<i>RR</i>=3.48, 95%<i>CI</i>: 2.14-5.67) was highly suggestive (grade Ⅱ) evidence. Moreover, hypertension (<i>OR</i>=2.03, 95%<i>CI</i>: 1.06-3.97), poor glycemic control (<i>OR</i>=4.35, 95%<i>CI</i>: 1.47-12.85), positive macroalbuminuria (<i>OR</i>=8.42, 95%<i>CI</i>: 3.52-20.15), long sleep duration (<i>OR</i>=2.05, 95%<i>CI</i>: 1.37-3.05), vitamin D deficiency (<i>OR</i>=2.02, 95%<i>CI</i>: 1.17-3.50), periodontitis (<i>OR</i>=4.51, 95%<i>CI</i>: 1.76-11.55) were the main risk factors for DR. Intensive blood pressure intervention (<i>RR</i>=0.78, 95%<i>CI</i>: 0.65-0.94), dietary control (<i>OR</i>=0.64, 95%<i>CI</i>: 0.47-0.89) and moderate intensity physical activity (<i>RR</i>=0.76, 95%<i>CI</i>: 0.59-0.97) yielded significant protective associations with DR. <b>Conclusions:</b> Intensive blood pressure glycemic control, and a healthy lifestyle pattern could reduce the risk of DR. This study provides the evidence to identify high-risk populations and recommends rational treatment options and healthy living interventions.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"45 12","pages":"1736-1744"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Designs and appropriate choices for diagnostic test accuracy study].","authors":"X L Liu, N Wu, Y F Li","doi":"10.3760/cma.j.cn112338-20240617-00356","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240617-00356","url":null,"abstract":"<p><p>Diagnostic tests are indispensable tools in clinical practice and are rigorously evaluated through scientifically designed accuracy studies before the clinical practice. The accuracy of these tests directly affects the correctness of the diagnosis and the rationality of treatment decisions. This article introduces the types of designs and their characteristics used in diagnostic test accuracy studies, including single-group studies, diagnostic case-control studies, single-group paired studies, and parallel-group studies. It recommends appropriate design types based on the research question stage, the diagnostic test's role in the clinical diagnostic pathway, and the actual clinical application scenario to provide suggestions for further standardizing the design of current clinical diagnostic test accuracy research. This article may help clinical researchers better understand and choose the appropriate type of diagnostic test accuracy study design to improve diagnostic test accuracy research quality.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"45 12","pages":"1705-1714"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Birth cohorts and their current status and prospects in China].","authors":"Y Jiang, W He, F Yang, Y W Shi, W J Wang, Q Shu, J L Tang, S K Zhu","doi":"10.3760/cma.j.cn112338-20240814-00503","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240814-00503","url":null,"abstract":"<p><p>In the context of delayed marriage and parenthood, decreased willingness in having children, and population aging in China, maternal and child health has become an important and urgent issue. Being essential platforms for research in maternal and child health, the importance of birth cohorts has been widely recognized. In the past 20 years, tens of birth cohorts have been established in major cities and regions of China, with cohorts ranging from thousands to hundreds of thousands. These cohorts, particularly those large ones launched in recent years, have collected a wide spectrum of data and biological samples from mothers and children. Although they have made considerable preliminary achievements, there remain difficulties and challenges. The significant challenges include small and medium-sized cohorts' lacking of clear research themes; insufficient recognition of and emphasis on behavioral and social determinants of health while emphasizing biological determinants of health; variations in types of variables and quality of data collected, which make it difficult for cohorts to be merged and shared; lack of and difficulties in long-term follow-up; significant uncertainties in resources for long-term sustention of the cohorts, and so on. So, we argue that birth cohorts should focus on essential and urgent issues in maternal and child health in the country and seek recognition and support from the government and the entire society. Last but not least, the overall success of birth cohorts in the country requires scientists to be not only academically capable, but also realistic, persistent, altruistic, and collaborative.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"45 12","pages":"1745-1750"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Mortality risk of nervous system disease attributed to extreme temperature events in Jiangsu Province].","authors":"Z X Li, D X Jiang, H Yu, R Q Han, J H Guo, J Li, J Y Zhou, S D Huang","doi":"10.3760/cma.j.cn112338-20240520-00290","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240520-00290","url":null,"abstract":"<p><p><b>Objective:</b> To assess the influence of extreme temperature events on the mortality risk of nervous system diseases in residents of Jiangsu Province and identify patients with nervous system diseases who are susceptible to extreme temperature events. <b>Methods:</b> Acase-crossover design was used to investigate the cumulative lagged effects of extreme temperature events on the mortality risk of nervous system disease in local residents by using the data on causes of death from nervous system diseases in Jiangsu from 2014 to 2020 with conditional logistic regression model. The final definition of extreme temperature events was established using Akaike information criterion. The heat wave was defined as 4 or more consecutive days with daily mean temperatures above the 92.5^th percentile of annual daily mean temperatures, and the cold spell was defined as 2 or more consecutive days with daily mean temperatures below the 10^th percentile of annual daily mean temperatures. Furthermore, stratified analyses was conducted to compare the effects of extreme temperature events on mortality risk in populations in different gender, age and marital status groups to identify susceptible populations to extreme temperature event. <b>Results:</b> Statistical results showed that the effect values of heat wave and cold spell on the mortality risk of nervous system diseases all peaked at the 7^th day of the cumulative lag, with <i>OR</i> of 1.60 (95%<i>CI</i>: 1.44-1.76) and 1.33 (95%<i>CI</i>: 1.13-1.56), respectively. Heat wave exposure increased mortality risk for individuals with Alzheimer's and Parkinson's diseases, while cold spell exposure increased the mortality risk for those with Alzheimer's disease. Stratified analyses showed that the mortality risk for nervous system disease and Alzheimer's disease was higher in partnerless population after heat wave exposure. <b>Conclusions:</b> Heat wave and cold spell were associated with increased mortality risks for nervous system disease, highlighting the need for improved early warning systems for extreme temperature event. In the context of heat wave, interventions to protect individuals with nervous system disease should prioritize partnerless population.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"45 11","pages":"1544-1549"},"PeriodicalIF":0.0,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application and case study of group-based multi-trajectory model in longitudinal data research].","authors":"X Y Wang, X B Sun, Y M Ji, T Zhang, Y X Liu","doi":"10.3760/cma.j.cn112338-20240529-00314","DOIUrl":"https://doi.org/10.3760/cma.j.cn112338-20240529-00314","url":null,"abstract":"<p><p>The development of longitudinal cohorts has made the identification and surveillance of multiple biological markers and behavioral factors which influence disease course or health status become possible. However, traditional statistical methods typically use univariate longitudinal data for research, failing to fully exploit the information from multivariate longitudinal data. The group-based multi-trajectory model (GBMTM) emerged as a method to study the developmental trajectory of multivariate data in recent years. GBMTM has distinct advantages in analyzing multivariate longitudinal data by identifying potential subgroups of populations following similar trajectories by multiple indicators that influence the outcome of interest. In this study, we introduced the application of GBMTM by explaining the fundamental principles and using the data from a health management study in the elderly by using smart wearing equipment to investigate the relationship between multiple life-related variables and hypertension to promote the wider use of GBMTM in longitudinal cohort studies.</p>","PeriodicalId":23968,"journal":{"name":"中华流行病学杂志","volume":"45 11","pages":"1590-1597"},"PeriodicalIF":0.0,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}