Tropical Medicine & International Health最新文献

{"title":"HBV, HCV and HIV among inmates in Latin America and the Caribbean: A systematic review and meta-analysis.","authors":"Mariana Cavalheiro Magri, Caroline Manchiero, Bianca Peixoto Dantas, Wanderley Marques Bernardo, Edson Abdala, Fátima Mitiko Tengan","doi":"10.1111/tmi.14070","DOIUrl":"10.1111/tmi.14070","url":null,"abstract":"<p><strong>Objectives: </strong>Hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) affect 340 million people worldwide and have a high impact on vulnerable populations. The aim of this systematic review and meta-analysis was to estimate the prevalence of these infections among inmates in Latin America and the Caribbean.</p><p><strong>Methods: </strong>Searches were conducted in Medline, Embase, LILACS and Web of Science databases on 17 May 2024, without time or language restriction, according to PRISMA guidelines. The Joanna Briggs Institute Critical Appraisal Checklist was used to assess the bias risk in the selected studies. Meta-analysis was performed by using the random-effects model and heterogeneity between studies was assessed with I² statistic. Subgroup analyses and meta-regression were performed to investigate possible sources of heterogeneity.</p><p><strong>Results: </strong>Seventy-nine studies were included, encompassing over 230,000 inmates. The estimated prevalences of HBV, HCV and HIV were 1.0% (95% CI: 0.0-1.0), 7.0% (95% CI: 6.0-8.0) and 4.0% (95% CI: 3.0-4.0), respectively. Subgroup analysis showed the following prevalences: HBV among females was 1.0% (95% CI: 0.0-3.0) and among males was 10.0% (95% CI: 3.0-17.0); HCV among females and males was 12.0% (95% CI: 7.0%-17.0%); and HIV among females was 10.0% (95% CI: 5.0-15.0) and among males was 8.0% (95% CI: 6.0-10.0).</p><p><strong>Conclusions: </strong>A substantial proportion of inmates in Latin America and the Caribbean are infected with HBV, HCV or HIV, underscoring the need for viral infection testing, primary care for inmates and increased efforts to promote public health policies for the prison system.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"4-13"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of poor water, sanitation, and hygiene and parasite burden with markers of environmental enteric dysfunction in preschool-age children infected with Schistosoma mansoni in Uganda.","authors":"Susannah Colt, Andrew Edielu, David Lewander, Hannah W Wu, Emily L Webb, Patrice A Mawa, Racheal Nakyesige, A Gloria K Ayebazibwe, Jennifer F Friedman, Amaya L Bustinduy","doi":"10.1111/tmi.14061","DOIUrl":"10.1111/tmi.14061","url":null,"abstract":"<p><strong>Background: </strong>Environmental enteric dysfunction (EED) is an acquired subclinical condition of the small intestine with lasting health implications for nutritional status, linear growth and development among children. EED is characterised by structural and functional changes to the gut barrier. There are no standardised diagnostic criteria, however, a number of biomarkers have been evaluated to capture EED domains. While the causes of EED are not fully understood, risk factors include poor water, sanitation and hygiene conditions and exposure to enteric pathogens. Very few studies have evaluated the impact of schistosomiasis on EED despite repeated intestinal damage from parasite eggs passing across the gut barrier.</p><p><strong>Methods: </strong>In a cohort of 354 preschool-aged children aged 12-47 months with Schistosoma mansoni infection recruited from the Lake Albert region of Uganda, we assessed exposure to water, sanitation and hygiene conditions and measured markers from each EED domain: intestinal inflammation (faecal calprotectin), epithelial damage (serum intestinal fatty-acid binding-protein), increased permeability (urine lactulose to mannitol ratio and faecal alpha-1 antitrypsin) and microbial translocation (serum endotoxin core antibody).</p><p><strong>Results: </strong>In multivariable linear regression models, we found that children whose drinking water was sourced from Lake Albert had higher concentrations of intestinal fatty-acid binding-protein (β = 0.48, 95% CI 0.20-0.76, p < 0.001), and lack of toilet/latrine access was associated with higher concentrations of calprotectin (β = 0.48, 95% CI 0.18-0.78, p < 0.01). Higher schistosomiasis intensity (eggs per gram of stool) was associated with higher calprotectin (β = 0.10, 95% CI 0.02-0.17, p = 0.01), but not with other EED markers.</p><p><strong>Conclusions: </strong>Few studies have investigated schistosomiasis-related morbidities in very young children infected with schistosomiasis. Our findings from Uganda show that poor water, sanitation and hygiene conditions and heavier schistosomiasis burden are associated with intestinal inflammation and damage, contributing to EED. Improved treatment coverage for preschool-aged children infected with schistosomiasis may reduce the burden from EED and associated long-term morbidities.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"14-21"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in clinical, radiological and laboratory parameters between elderly and young patients with newly diagnosed smear-positive pulmonary tuberculosis in Vietnam.","authors":"Khanh Linh Duong, Duc Manh Bui, Khanh Linh Dang, Manh Cuong Nguyen, Thi Huong Quynh Pham, Thi Huyen Trang Tran, Thi Thuy Vo, Van Du Pham, Van Duc Doan, Nang Trong Hoang, Thi Van Anh Tran, Xuan Thuy Tran, Thi Hanh Nguyen, Trung Kien Nguyen, Thi Han Bui, Philippe Gautret, Van Thuan Hoang, Thi Loi Dao","doi":"10.1111/tmi.14068","DOIUrl":"10.1111/tmi.14068","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the differences in clinical, radiological and laboratory parameters between elderly and young patients with newly diagnosed smear-positive pulmonary tuberculosis in Vietnam.</p><p><strong>Methods: </strong>This retrospective analysis included all patients hospitalised with newly diagnosed pulmonary tuberculosis with acid-fast bacilli-positive smear. Clinical symptoms, laboratory results and chest X-ray findings were collected using a standardised questionnaire. Elderly was defined as those patients aged 65 years and older.</p><p><strong>Results: </strong>A total of 183 patients diagnosed with new acid-fast bacilli-positive pulmonary tuberculosis were included in this study, with a mean age of 56.2 ± 16.3 years (minimum = 18 and maximum = 87 years). Seventy-seven participants were aged ≥65 years, accounting for 42.1% of participants. A total of 147 (80.3%) patients were male, and the sex ratio of male/female was 4.1. Night sweats were statistically more frequent among younger patients (34.9% vs. 20.8%, p = 0.04), whereas muscle and joint pain were more predominant among the elderly (7.6% vs. 22.1%, p = 0.01). A proportion of 67.0% of younger patients and 63.6% of the elderly group were bilaterally affected. Cavitation lesions were significantly more frequent in the younger group (55.7% vs. 39.0%, p = 0.03), whereas pulmonary fibrosis occurred more frequently in elderly patients (29.3% vs. 45.4%, p = 0.02). No other significant differences in clinical symptoms, laboratory results and chest X-ray findings were observed.</p><p><strong>Conclusion: </strong>These findings underscore the importance of considering age-related variations in the clinical and radiological presentation of tuberculosis, which can guide tailored approaches in diagnosis, management and treatment strategies for different age groups.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"51-56"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mpox as an emerging health threat for survivors of sex trafficking.","authors":"Olabode Ekerin, Deborah Oluwaseun Shomuyiwa, Isaac Olushola Ogunkola, Yusuff Adebayo Adebisi, Emery Manirambona","doi":"10.1111/tmi.14064","DOIUrl":"10.1111/tmi.14064","url":null,"abstract":"<p><p>The resurgence of mpox, declared a Public Health Emergency of International Concern by the World Health Organization in 2024, highlights gaps in global preparedness, particularly for marginalised populations. While much of the focus has been on men who have sex with men, survivors of sex trafficking remain overlooked, despite being highly vulnerable to mpox transmission. These individuals face significant health disparities, including limited access to healthcare, exposure to violence and forced sexual encounters in unsafe conditions, which amplify their risk of infection. The clandestine nature of trafficking further complicates public health interventions like contact tracing and vaccination efforts, leaving survivors at heightened risk of infection and limited access to critical health resources. Addressing these inequities requires targeted interventions, such as confidential testing, outreach, culturally sensitive healthcare and integrating mpox awareness into existing survivor support programmes. Additionally, public health systems must ensure equitable vaccine distribution, enhance surveillance and collaborate with anti-trafficking organisations to improve prevention and care. A holistic approach that includes mental health support is crucial to address the unique challenges faced by trafficking survivors, ensuring they receive the protection and care needed during this global outbreak.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"1-3"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of laboratory-based and non-laboratory-based cardiovascular risk prediction tools in rural India.","authors":"Mulugeta Molla Birhanu, Ayse Zengin, Roger G Evans, Joosup Kim, Muideen T Olaiya, Michael A Riddell, Kartik Kalyanram, Kamakshi Kartik, Oduru Suresh, Nihal Thomas, Velandai K Srikanth, Amanda G Thrift","doi":"10.1111/tmi.14069","DOIUrl":"10.1111/tmi.14069","url":null,"abstract":"<p><strong>Background: </strong>Non-laboratory-based cardiovascular risk prediction tools are feasible alternatives to laboratory-based tools in low- and middle-income countries. However, their effectiveness compared to their laboratory-based counterparts has not been adequately tested.</p><p><strong>Aim: </strong>We compared estimates from laboratory-based and non-laboratory-based risk prediction tools in a low- and middle-income country setting.</p><p><strong>Methods: </strong>Using a cross-sectional design, residents of the Rishi Valley region, Andhra Pradesh, India, were surveyed from 2012 to 2015. Ten-year absolute risk was compared for laboratory-based and non-laboratory-based Framingham Risk Score (FRS), World Health Organization-Risk Score (WHO-RS) and risk prediction tool for global populations (Globorisk). An agreement was assessed using ordinary least-products (OLP) regression (for RS) and quadratic weighted kappa (κ_w, for risk band).</p><p><strong>Results: </strong>Among 2847 participants aged 40-74 years, the mean age was 54.0 years. Cardiovascular RS increased with age and was greater in men than women in each age group. For all tools, regardless of whether laboratory or non-laboratory-based, over 80% of the participants were classified in the same risk band. There was strong agreement between laboratory-based and non-laboratory-based tools, greatest for the WHO-RS tools (OLP slope = 0.96, κ_w = 0.93) and least for the FRS (OLP slope = 0.84, κ_w = 0.88). The level of agreement was greater among women than men, less in those with hypercholesterolaemia or hypertension than those without, and was particularly poor among those with diabetes.</p><p><strong>Conclusions: </strong>Non-laboratory-based Framingham, WHO-RS and Globorisk tools performed relatively well compared with their laboratory-based counterparts in rural India. However, they may be less useful for risk stratification when applied to individuals with diabetes.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"57-64"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sporothrix brasiliensis as the major causative species of the zoonotic outbreak of human sporotrichosis in the Brazilian Amazon.","authors":"Guilherme Caldas de Souza, Euzenio Moreira de Brito, Débora Cristina de Lima Fernandes, Maria Zeli Moreira Frota, Felipe Jules de Araújo Santos, Cynthia de Oliveira Ferreira, Camila Gurgel Dos Santos Silva, Silvia Rocha Nakajima, Silmara Navarro Pennini, Sinesio Talhari, Valderiza Lourenço Pedrosa, Marcelo Mira, Helio Amante Miot, Carolina Talhari, André Luiz Leturiondo","doi":"10.1111/tmi.14065","DOIUrl":"10.1111/tmi.14065","url":null,"abstract":"<p><strong>Background: </strong>Sporotrichosis is a neglected tropical disease and the most common subcutaneous mycosis, mainly caused by Sporothrix species, particularly S. brasiliensis, S. schenckii and S. globosa, which exhibit varying biological behaviours and virulence. The epidemic of sporotrichosis in Brazil, initiated in Rio de Janeiro in the late 1990s, rapidly spread to other states, including Amazonas in 2021. This study aimed to identify the specific Sporothrix species responsible for the human sporotrichosis outbreak in the Brazilian Amazon.</p><p><strong>Methods: </strong>A cross-sectional study was conducted by enrolling clinically suspected cases of sporotrichosis attended at a reference dermatologic centre, in Manaus (Brazil). Biological material was collected from their skin lesions for culture (Mycosel) and for species identification (qPCR).</p><p><strong>Results: </strong>Sporothrix cultures were obtained from 150 cases. Sporotrichosis predominantly affected females (67.3%), aged 44.5 years on average, with lymphocutaneous lesions (72.7%). Sporothrix brasiliensis was identified in 89.3% of patients. Up to 83.3% of these patients reported contact with cats previously to the skin lesion, and the time-spatial progression of the human cases followed the notification of cases in cats, in the metropolitan region of Manaus.</p><p><strong>Conclusion: </strong>Sporothrix brasiliensis is the dominant species in the zoonotic outbreak of human sporotrichosis in the Brazilian Amazon, with cats identified as the primary vectors. Effective sanitary control measures, education and responsible pet ownership are crucial to mitigating zoonotic sporotrichosis' impact in Brazil and preventing its spread to neighbouring Latin American cities.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"65-69"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Intestinal schistosomiasis among preschool and school-aged children in a rural setting near Alexandria: Initiative for elimination\".","authors":"","doi":"10.1111/tmi.14054","DOIUrl":"10.1111/tmi.14054","url":null,"abstract":"","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"1062"},"PeriodicalIF":2.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the incidence of influenza before and after the COVID-19 pandemic in South Korea.","authors":"Hayeon Kim, Hyeon S Son","doi":"10.1111/tmi.14055","DOIUrl":"10.1111/tmi.14055","url":null,"abstract":"<p><strong>Objectives: </strong>Influenza outbreaks of varying size occur every year, but during the COVID-19 pandemic, many countries experienced influenza at lower levels. However, following the relaxation of COVID-19 prevention measures in 2022, the incidence of influenza began to increase gradually. Thus, this study compared the occurrence of influenza from week 36 of 2017, before the COVID-19 outbreak, until 2023.</p><p><strong>Methods: </strong>The analysis was conducted using influenza-like illness occurrence data available from the Korea Disease Control and Prevention Agency infectious disease website. Additionally, to examine the changes in COVID-19 and influenza occurrence during the pandemic, COVID-19 incidence data from 20 January 2020 to 31 August 2023 were obtained from the KDCA Coronavirus Disease 19 homepage.</p><p><strong>Results: </strong>During the COVID-19 pandemic, which corresponds to the 2020/2021 and 2021/2022 influenza seasons, there was no seasonal influenza epidemic, and the incidence rates were below the usual outbreak levels. However, in the 2022/2023 season, when the spread of COVID-19 had eased, a seasonal pattern similar to that observed before the COVID-19 pandemic was noted. Furthermore, correlation analysis between the rates of influenza-like illness and COVID-19 incidence showed no significant correlation during the entire period. However, a significant correlation emerged in 2023 (r = 0.393, p <0.05). These results suggest that influenza was suppressed during the COVID-19 pandemic but returned to typical seasonal patterns after the COVID-19 prevention policies were eased.</p><p><strong>Conclusion: </strong>The positive correlation observed between the incidences of COVID-19 and influenza in 2023 indicates that COVID-19, no longer a novel pandemic-causing infectious disease, may have transitioned to an endemic pattern similar to seasonal influenza.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"1018-1025"},"PeriodicalIF":2.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11613300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of preventive chemotherapy for neglected tropical diseases in Indonesia from 1992 to 2022: A systematic review and meta-analysis.","authors":"Elsa Herdiana Murhandarwati, Ari Probandari, Rizqiani Amalia Kusumasari, Astri Ferdiana, Christina Yeni Kustanti, Kharisma Dewi, Siti Nadia Tarmizi, Luh Putu Lila Wulandari, Gill Schierhout, Lucia Romani, John Kaldor, Susana Vaz Nery","doi":"10.1111/tmi.14057","DOIUrl":"10.1111/tmi.14057","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to describe the prevalence of lymphatic filariasis (LF), soil-transmitted helminthiasis (STH) and schistosomiasis (SC) in Indonesia before and after PC implementation through a systematic review and meta-analysis.</p><p><strong>Methods: </strong>Embase, MEDLINE, PubMed, Scopus, Web of Science and Google Scholar were searched for articles published between 1 January 1992 and 31 December 2022, reporting LF, STH and SC in Indonesia. Using the Ministry of Health lists of districts receiving PC programs, we identified whether data collection was conducted before or after PC implementation in that particular district. A meta-analysis was performed with a random-effects model applied to pool pre- and post-PC prevalence of LF, STH and SC.</p><p><strong>Results: </strong>Overall, 195 studies were included. The pooled prevalence of LF was 9.72% (95% CI, 5.56%-13.87%). The pre-PC pooled prevalence of LF was 11.48% (95% CI, 5.52%-17.45%). The prevalence decreased after PC implementation, and the pooled prevalence was 7.12% (95% CI, 1.79%-12.44%). The overall prevalence of STH was 35.16% (95% CI, 30.36%-39.96%). The pre-PC prevalence of STH was 36.29% (95% CI, 30.37%-42.20%). The post-PC prevalence of STH decreased at 31.93% (95% CI, 24.25%-39.62%), although the difference between before and after PC was not significant (p = 0.379). Only nine studies investigated the prevalence of SC; based on the random-effects model, the pooled prevalence was 21.90% (95% CI, 4.88%-38.92%). Owing to the scarcity of studies, we could not perform the funnel tests for publication bias and moderating variables of the pooled prevalence for SC.</p><p><strong>Conclusions: </strong>The prevalence of LF and STH decreased after PC implementation, although it was not significant. The difference for SC could not be assessed because of limited post-PC data. The uneven distribution of research and the lack of standardised sampling methods may not fully capture the situation.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"995-1005"},"PeriodicalIF":2.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of haematological and inflammatory biomarkers with brain volume in patients with sickle cell anaemia: A cross-sectional retrospective study.","authors":"Naif A Majrashi, Ali M Hendi, Turki M Dhayihi, Abdullah M Khamesi, Mohammed A Masmali, Khalid J Hakami, Ali S Alyami, Bandar Alwadani, Wael A Ageeli, Yahia Madkhali, Ali Hakamy, Turkey A Refaee","doi":"10.1111/tmi.14056","DOIUrl":"10.1111/tmi.14056","url":null,"abstract":"<p><p>Sickle cell disease is a genetic disorder characterised by abnormal haemoglobin production. This study aims to investigate the associations between haematological and inflammatory biomarkers and brain volumes in patients with sickle cell anaemia and compare brain structure between patients with sickle cell anaemia and healthy controls. This retrospective cross-sectional study included 130 participants (70 sickle cell anaemia patients and 60 healthy controls) who underwent brain MRI examinations at King Fahad Central Hospital between January 2010 and October 2022. Demographic data and haematological and inflammatory biomarkers were collected to examine their relationships with brain volumes. Brain volumes were measured using FreeSurfer. Specific haematological and inflammatory biomarkers were correlated with brain volume in patients with sickle cell anaemia, p < 0.05. Sickle cell anaemia patients exhibited smaller volumes in the brainstem, corpus callosum and amygdala compared to healthy controls. Males had significantly higher iron levels (p < 0.001) and larger various brain structure volumes (p < 0.05) than females. This study demonstrates significant associations between specific biomarkers and brain volume in sickle cell anaemia patients, underscoring the importance of monitoring these biomarkers for early detection and management of neurological complications in sickle cell anaemia.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"1026-1040"},"PeriodicalIF":2.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}