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School-based mental health and psychosocial support interventions for children and adolescents with developmental disabilities in low- and middle-income countries: A systematic review. 低收入和中等收入国家针对发育性残疾儿童和青少年的以学校为基础的心理健康和社会心理支持干预措施:系统综述。
IF 2.3 4区 医学
Tropical Medicine & International Health Pub Date : 2025-08-01 Epub Date: 2025-06-24 DOI: 10.1111/tmi.70000
Maria Jose Alpuche De Lille, Renata Teixeira da Silva, Tracey Smythe
{"title":"School-based mental health and psychosocial support interventions for children and adolescents with developmental disabilities in low- and middle-income countries: A systematic review.","authors":"Maria Jose Alpuche De Lille, Renata Teixeira da Silva, Tracey Smythe","doi":"10.1111/tmi.70000","DOIUrl":"10.1111/tmi.70000","url":null,"abstract":"<p><strong>Objectives: </strong>To identify and evaluate the characteristics and reported effects of school-based mental health and psychosocial support interventions targeting children and adolescents with neurodevelopmental disorders (NDDs) in low- and middle-income countries, as well as those involving their parents, teachers or peers.</p><p><strong>Methods: </strong>A systematic search of MEDLINE, EMBASE, ERIC, Global Health and PsycINFO was conducted in October 2024. Eligible studies included randomised controlled trials, quasi-experimental and qualitative research on school-based interventions in low- and middle-income countries for children and adolescents with NDDs (including attention deficit hyperactivity disorder [ADHD], autism, intellectual disabilities, epilepsy, cerebral palsy and foetal alcohol syndrome), as well as those involving their caregivers, teachers or peers. Only studies published in English, Spanish or Portuguese were included. A narrative synthesis was performed.</p><p><strong>Results: </strong>A total of 2158 titles were screened, with 29 studies from 13 countries included. Most studies used a quasi-experimental design (n = 19, 66%). Nearly half focused on children and adolescents with NDDs only (n = 14, 48%), with intellectual disabilities being the most targeted condition (n = 12, 34%), followed by autism (n = 8, 23%) and ADHD (n = 8, 23%). Intervention strategies included multimodal approaches (n = 6, 21%) and educational workshops (n = 6, 21%). Targeted outcomes were social skills (n = 7, 16%) and knowledge attitudes and practice (n = 5, 12%). Lifelong learning (n = 11, 33%) and educational system-strengthening interventions (n = 10, 31%) were the primary content areas. The majority of studies exhibited a moderate to high risk of bias.</p><p><strong>Conclusions: </strong>Schools offer strategic platforms for delivering mental health and psychosocial support interventions to children and adolescents with NDDs in low- and middle-income countries, involving families, teachers and peers. While improvements in social skills and knowledge, attitudes and practices were reported, heterogeneity and methodological limitations constrain the generalisability of findings. Future research should address long-term impacts and expand to underrepresented conditions.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"763-781"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk factors for Taenia solium taeniasis: A case-control study in Lao PDR. 带状带绦虫病的危险因素:老挝人民民主共和国的病例对照研究。
IF 2.3 4区 医学
Tropical Medicine & International Health Pub Date : 2025-08-01 Epub Date: 2025-06-30 DOI: 10.1111/tmi.70001
Andrew Larkins, Davina Boyd, Vatsana Duangmala, Bounnaloth Insisiengmay, Malavanh Chittavong, Amanda Ash
{"title":"Risk factors for Taenia solium taeniasis: A case-control study in Lao PDR.","authors":"Andrew Larkins, Davina Boyd, Vatsana Duangmala, Bounnaloth Insisiengmay, Malavanh Chittavong, Amanda Ash","doi":"10.1111/tmi.70001","DOIUrl":"10.1111/tmi.70001","url":null,"abstract":"<p><strong>Introduction: </strong>Neurocysticercosis due to Taenia solium is the leading cause of epilepsy in low and middle-income countries yet remains under investigated in Lao PDR (Laos). People shedding T. solium eggs or proglottids from the adult tapeworm are the source of infection for those with cysticercosis.</p><p><strong>Methods: </strong>A matched case-control study of T. solium taeniasis was conducted in northern Laos. Cases were identified by rrnS PCR and sequencing. Risk factor data were collected by standardised questionnaire. Conditional logistic regression assessed the significance of risk factors.</p><p><strong>Results: </strong>Eighteen cases and 36 controls participated in the study. Only raw pork and undercooked grilled pork were significant risk factors (p < 0.05), however, fermented pork was very close to being significant (p = 0.05). Income, food insecurity, education, being a household head and the number of household members were clearly not significant (p ≥ 0.20).</p><p><strong>Conclusions: </strong>Raw and undercooked pork have different sources in northern Laos. Raw pork is almost only consumed from wild pigs that are opportunistically caught, whereas undercooked pork is consumed throughout the year from wild, local and commercial pigs. Food safety activities must consider these differences in supply chains.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"848-852"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of gaps in the continuum of maternal and neonatal care in a high-mortality setting: An observational study in rural Guinea-Bissau. 确定高死亡率环境中孕产妇和新生儿护理连续性的差距:几内亚比绍农村的一项观察性研究。
IF 2.3 4区 医学
Tropical Medicine & International Health Pub Date : 2025-08-01 Epub Date: 2025-06-09 DOI: 10.1111/tmi.14136
Sabine Margarete Damerow, Anita Magdalena Zalisz, Kimberly Raisa Nehal, Paula Marise Silva, Oides Furtado, Ane Bærent Fisker
{"title":"Identification of gaps in the continuum of maternal and neonatal care in a high-mortality setting: An observational study in rural Guinea-Bissau.","authors":"Sabine Margarete Damerow, Anita Magdalena Zalisz, Kimberly Raisa Nehal, Paula Marise Silva, Oides Furtado, Ane Bærent Fisker","doi":"10.1111/tmi.14136","DOIUrl":"10.1111/tmi.14136","url":null,"abstract":"<p><strong>Objectives: </strong>Coverage of the continuum of maternal and neonatal care, including antenatal care (ANC), childbirth and early postnatal care (PNC), is critically low across sub-Saharan Africa. Meanwhile, related monitoring remains neglected. We quantified coverage gaps along the continuum of maternal and neonatal care in rural Guinea-Bissau and assessed background factors associated with continuum-of-care completion.</p><p><strong>Methods: </strong>In a cross-sectional study using data from the Bandim Health Project's nationally representative rural health and demographic surveillance system (HDSS), we assessed individual-level obtainment of ≥1, ≥4 and ≥8 ANC contacts (ANC1/4/8), facility-based childbirth and PNC within 24 h postpartum for HDSS-registered births between 1 February 2023 and 31 January 2024. Among facility births, we also assessed postpartum admission ≥24 h. We defined continuum-of-care completion as the obtainment of ANC4, facility-based childbirth and PNC within 24 h and investigated associations between background factors (household assets, maternal age, education, parity, region, ethnicity, health facility distance and recall time) and continuum-of-care completion in regression models.</p><p><strong>Results: </strong>Among 2258 births, 35% (n = 798) completed the continuum of care; 22% (n = 494) obtained none of the contributing services. Individual service coverage ranged from 6% (ANC8, n = 128) to 99% (ANC1, n = 2236). Individual coverage of the services included in the continuum-of-care assessment was 62% (n = 1403) for ANC4, 56% (n = 1268) for facility-based childbirth and 52% (n = 1167) for PNC. Continuum-of-care completion differed by region and ethnicity. Living near a health facility, higher maternal education, more household assets, low parity and longer recall time were associated with higher continuum-of-care completion.</p><p><strong>Conclusions: </strong>Continuum-of-care completion is low in rural Guinea-Bissau and not fully reflected by individual coverage indicators. This calls for a higher focus on continuum-of-care coverage and related gaps, both locally and globally. Meanwhile, the identified higher reporting of continuum-of-care completion with longer maternal recall questions the use of survey data and beckons for monitoring based on timely routine data.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"812-822"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temporal analysis of non-communicable diseases and NCD-HIV/AIDS comorbidity in Malawi: A 4-year retrospective study 2020-2022. 马拉维非传染性疾病和非传染性疾病-艾滋病毒/艾滋病合并症的时间分析:2020-2022年4年回顾性研究
IF 2.3 4区 医学
Tropical Medicine & International Health Pub Date : 2025-08-01 Epub Date: 2025-06-03 DOI: 10.1111/tmi.14134
Ansley Kasambara, Mphatso S Kamndaya, Salule J Masangwi, Atupele Mulaga
{"title":"Temporal analysis of non-communicable diseases and NCD-HIV/AIDS comorbidity in Malawi: A 4-year retrospective study 2020-2022.","authors":"Ansley Kasambara, Mphatso S Kamndaya, Salule J Masangwi, Atupele Mulaga","doi":"10.1111/tmi.14134","DOIUrl":"10.1111/tmi.14134","url":null,"abstract":"<p><strong>Objective: </strong>Non-communicable diseases are on the increase in the Sub-Saharan region, which is also the epicentre of HIV/AIDS. There is limited published data on trends and forecasts of the comorbidity of non-communicable diseases and HIV/AIDS in low- and middle-income countries. Hence, the aim of the study was to examine current trends and forecasts for non-communicable diseases and non-communicable disease-HIV/AIDS comorbidity.</p><p><strong>Methods: </strong>Data on 30,686 patients from 2019 to 2022 were extracted from the non-communicable diseases Mastercards, from 70 health facilities in Malawi, using a form designed and implemented in KoboToolBox. All cases were aggregated to form weekly counts of non-communicable diseases and non-communicable disease-HIV/AIDS comorbidity and visualised using time series plots. Then the data was subset by the prominent non-communicable disease, which was hypertension and hypertension-HIV/AIDS comorbidity weekly counts. Extreme Gradient Boosting (XGBoost), a machine learning model, was used for model fitting, generating predictions, and forecasting.</p><p><strong>Results: </strong>The forecasts showed that the counts of cases per week will range from 137 to 185 cases. Then specifically, hypertension and hypertension-HIV/AIDS comorbidity case counts averaged approximately within the range of 111-124 new cases per week from 2023 to 2030. The hypertension-HIV/AIDS comorbidity had forecasts ranging from 2 to 9 new cases per week. Although the number of new case counts per week had a consistent progression, the number of cases was on an increasing trend over time. Therefore, whether cases in general, hypertension and hypertension-HIV/AIDS comorbidity cases, or hypertension-HIV/AIDS comorbidity cases, the counts per week imply cumulatively higher case counts.</p><p><strong>Conclusions: </strong>Despite the consistency in the projection to 2030, there is a need to consider the upward trend of these cases and implement intervention measures such as sensitisation to control the number of cases. Otherwise, Malawi may not be able to achieve SDG3 targets by 2030.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"782-800"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics and risk factors of drug-resistant tuberculosis in Sichuan, China: An observational study. 中国四川省耐药结核病的特点和危险因素:一项观察性研究。
IF 2.6 4区 医学
Tropical Medicine & International Health Pub Date : 2025-07-01 Epub Date: 2025-05-15 DOI: 10.1111/tmi.14126
Ning Han, Libo Yan, Man Yuan, Zhu Chen, Yilan Zeng, Hong Tang
{"title":"Characteristics and risk factors of drug-resistant tuberculosis in Sichuan, China: An observational study.","authors":"Ning Han, Libo Yan, Man Yuan, Zhu Chen, Yilan Zeng, Hong Tang","doi":"10.1111/tmi.14126","DOIUrl":"10.1111/tmi.14126","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to determine the epidemiological characteristics of drug-resistant tuberculosis (DR-TB) and investigate the risk factors associated with multidrug-resistant tuberculosis (MDR-TB) in Sichuan, China.</p><p><strong>Methods: </strong>The study involved 5180 clinical isolates collected from Sichuan since 2013, with non-tuberculous mycobacteria excluded. Drug susceptibility testing was conducted using four first-line anti-TB drugs, fluoroquinolones, and second-line injectable agents. Multivariable logistic regression analysis was used to assess risk factors for MDR-TB based on patients' treatment history, age, sex, ethnicity, health facility, living environment and human immunodeficiency virus (HIV) status.</p><p><strong>Results: </strong>Among the 5180 participants, resistance was highest for isoniazid (23.59%), followed by rifampin (18.42%), streptomycin (18.42%) and ethambutol (2.47%). The prevalence of MDR-TB was 774 (14.94%) among all cases, with 575 (14.20%) in newly diagnosed tuberculosis (TB) patients and 199 (17.60%) in previously treated patients. Additionally, 17 (0.33%) patients were diagnosed with MDR-TB. Furthermore, urban living was identified as a protective factor against MDR-TB (odds ratio [OR] 0.80, 95% confidence interval [CI] 0.68-0.94, p = 0.004). Notably, individuals younger than 60 were more likely to develop MDR-TB, especially those aged 32-45 (OR 2.22, 95% CI 1.74-2.83, p < 0.001). In addition, HIV-positive status was identified as a risk factor for MDR-TB (OR 2.06, 95% CI 1.21-3.49, p = 0.008).</p><p><strong>Conclusions: </strong>The study demonstrated that the prevalence of DR-TB among the study subjects exceeded the national level. Patients living in rural areas, those with a history of TB treatment, HIV-positive individuals, and younger patients were more likely to develop MDR-TB.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"704-711"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HIV-tuberculosis co-infection in conflict zones of Nigeria. 尼日利亚冲突地区的艾滋病毒-结核病合并感染。
IF 2.6 4区 医学
Tropical Medicine & International Health Pub Date : 2025-07-01 Epub Date: 2025-05-08 DOI: 10.1111/tmi.14112
Hamisu M Salihu, Hassan A Murtala, Adam M Murtala, Aisha A Abdullahi, Muhammad A Abbas, Abubakar L Yusuf, Muktar H Aliyu, Sani H Aliyu, Ololade D Adeyemi, Deepa Dongarwar, Jordi B Torrelles, Rahila A Mukhtar, Gambo Aliyu
{"title":"HIV-tuberculosis co-infection in conflict zones of Nigeria.","authors":"Hamisu M Salihu, Hassan A Murtala, Adam M Murtala, Aisha A Abdullahi, Muhammad A Abbas, Abubakar L Yusuf, Muktar H Aliyu, Sani H Aliyu, Ololade D Adeyemi, Deepa Dongarwar, Jordi B Torrelles, Rahila A Mukhtar, Gambo Aliyu","doi":"10.1111/tmi.14112","DOIUrl":"10.1111/tmi.14112","url":null,"abstract":"<p><strong>Background: </strong>Nigeria bears a high burden of infectious diseases, with the second-highest human immunodeficiency virus (HIV) prevalence globally and the largest tuberculosis (TB) burden in Africa. The country faces significant challenges from armed conflicts, insurgency, kidnapping and banditry, which severely strain its healthcare system, particularly for people living with HIV (PLHIV). This study hypothesizes that PLHIV in conflict-affected regions of Nigeria experience a higher burden of TB than those in non-conflict areas.</p><p><strong>Methods: </strong>This cross-sectional household survey utilised a two-stage cluster sampling design to examine HIV/TB co-infection and associated behaviours in Nigeria, based on data from the 2018 Nigeria HIV/ acquired immune deficiency syndrome (AIDS) Indicator and Impact Survey. The sample included adults aged 15 to 64 in the selected households. We mapped the distribution of HIV/TB co-infection across the country and calculated its prevalence, stratified by conflict and non-conflict zones. Adjusted odds ratios (AOR) and 95% confidence intervals (CIs) from survey-weighted logistic regression models were used to assess the likelihood of being diagnosed with TB disease among PLHIV.</p><p><strong>Results: </strong>We analysed weighted data from 1,319,719 PLHIV across Nigeria, with 200,201(15.2%) residing in conflict zones and 1,119,518 (84.8%) in non-conflict zones. Overall, the prevalence of HIV/TB co-infection was 40.4% (52,118), with PLHIV residents of conflict zones exhibiting a significantly higher prevalence (59%, 14,976) compared to those from non-conflict zones (36%, 37,413). After adjusting for confounders, PLHIV in conflict zones were more than four times more likely to acquire TB than those from non-conflict zones (AOR: 4.21, 95% CI: 1.72-10.5, p = 0.002).</p><p><strong>Conclusions: </strong>Conflicts amplify the risk of TB among PLHIV in Nigeria, highlighting an urgent need for targeted interventions to strengthen healthcare access in these regions. The efforts are essential in achieving the goals of reducing TB prevalence by 50% and TB mortality by 75% by 2025, as well as meeting the 95-95-95 targets to control HIV by 2030.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"625-632"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the performance of verbal autopsy for assigning cause of death in older adults: A population-based cohort study in Karonga, Malawi. 评估死因推断在老年人中的表现:马拉维Karonga的一项基于人群的队列研究。
IF 2.6 4区 医学
Tropical Medicine & International Health Pub Date : 2025-07-01 Epub Date: 2025-05-13 DOI: 10.1111/tmi.14120
Milly Marston, Alexandria Chung, Albert Dube, Estelle McLean, Samuel Clark, Amelia Crampin, Clara Calvert
{"title":"Evaluating the performance of verbal autopsy for assigning cause of death in older adults: A population-based cohort study in Karonga, Malawi.","authors":"Milly Marston, Alexandria Chung, Albert Dube, Estelle McLean, Samuel Clark, Amelia Crampin, Clara Calvert","doi":"10.1111/tmi.14120","DOIUrl":"10.1111/tmi.14120","url":null,"abstract":"<p><strong>Background: </strong>Verbal autopsy, where a close caregiver or relative of someone who recently died reports on the signs, symptoms and circumstances preceding death, is useful for producing population-based cause of death estimates. However, the performance of verbal autopsy for older adult deaths is poorly understood.</p><p><strong>Objectives: </strong>To evaluate the performance of verbal autopsy in assigning cause of death for adults aged 50+ in a rural area of Malawi.</p><p><strong>Methods: </strong>Cause of death was assigned to each death with a verbal autopsy in the Karonga Health and Demographic Surveillance site between 2002 and 2017 using two methods: (1) Physician review and (2) in silico verbal autopsy (a Bayesian probabilistic model). We calculated uncertainty in cause of death assignment for each method and calculated disagreement in cause of death between methods. Analyses were stratified by age group and sex.</p><p><strong>Results: </strong>A total of 2378 adult deaths were included (1360 aged 50+). Cause of death assignment showed greater uncertainty at older ages in both methods. For example, 59.7% of men aged 80+ were assigned a specific cause of death using physician review, versus 77.5% of men aged 30-49. Population-level, broad cause of death distributions were similar across methods, but at the individual level there was over 30% disagreement on broad cause of death categories in those aged 50+.</p><p><strong>Conclusions: </strong>Verbal autopsy becomes more uncertain at assigning cause of death at older ages. The inclusion of any reports of medical diagnoses from a doctor and using a two-stage process of cause of death assignment (with simple cause of deaths assigned using algorithms and more complex cases being reviewed by physicians) could improve cause of death ascertainment using verbal autopsy at older ages.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"652-661"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
VISITECT® CD4 advanced disease assay in routine use: Diagnostic accuracy and usability, Ethiopia and Indonesia. VISITECT®CD4晚期疾病检测在常规使用:诊断准确性和可用性,埃塞俄比亚和印度尼西亚。
IF 2.6 4区 医学
Tropical Medicine & International Health Pub Date : 2025-07-01 Epub Date: 2025-05-19 DOI: 10.1111/tmi.14124
Petra de Haas, Pamela Hepple, Yohannes Babo, Francisca Srioetami, Misikir Amare, Bihil Sherefdin, Andrii Slyzkyi, Denisa Widyaputri, Erni Juwita Nelwan, Jhon Sugiharto, Ahmed Bedru, Edine Tiemersma
{"title":"VISITECT® CD4 advanced disease assay in routine use: Diagnostic accuracy and usability, Ethiopia and Indonesia.","authors":"Petra de Haas, Pamela Hepple, Yohannes Babo, Francisca Srioetami, Misikir Amare, Bihil Sherefdin, Andrii Slyzkyi, Denisa Widyaputri, Erni Juwita Nelwan, Jhon Sugiharto, Ahmed Bedru, Edine Tiemersma","doi":"10.1111/tmi.14124","DOIUrl":"10.1111/tmi.14124","url":null,"abstract":"<p><p>We assessed the diagnostic accuracy and usability of the rapid semiquantitative point of care VISITECT® CD4 Advanced Disease Assay, compared to routinely obtained CD4 counts among people living with HIV in Ethiopia and Indonesia. We consecutively enrolled people living with HIV aged ≥10 years who were newly diagnosed, had interrupted antiretroviral treatment for ≥3 months, or were feeling unwell. Venous blood was drawn to obtain CD4 counts on routinely available test instruments and a VISITECT® CD4 Advanced Disease Assay result. The sensitivity of VISITECT® CD4 Advanced Disease Assay was high (97.8%, 95% confidence interval [CI], 94.4-99.4%), but the specificity was low (32.7%, 95%CI, 27.9-37.8%). It significantly increased to 42.5% (95%CI, 33.2-52.1%) after retraining of laboratory staff, but remained low. The low specificity of VISITECT® CD4 Advanced Disease Assay was due to poor capacity in test reading by routine staff. Reading the test strip is error-prone and requires intensive and regular training. Reading aids may improve the usability of this essential point of care test.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"685-693"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Longitudinal monitoring of cell adhesion molecules in acute Chagas disease patients and prognosis after treatment with benznidazole. 急性恰加斯病患者细胞粘附分子的纵向监测及苯并咪唑治疗后的预后。
IF 2.6 4区 医学
Tropical Medicine & International Health Pub Date : 2025-07-01 Epub Date: 2025-05-28 DOI: 10.1111/tmi.14131
Victor Vaitkevicius-Antão, Bruno Almeida Silva, Michelle da Silva Barros, Cíntia Nascimento da Costa-Oliveira, Luciane de Freitas Firmino, Wanderley Araújo Soares, Silvia Marinho Martins, Cristina Carrazone, Wilson Oliveira, Michelle Christiane da Silva Rabelo, Virginia Maria Barros de Lorena
{"title":"Longitudinal monitoring of cell adhesion molecules in acute Chagas disease patients and prognosis after treatment with benznidazole.","authors":"Victor Vaitkevicius-Antão, Bruno Almeida Silva, Michelle da Silva Barros, Cíntia Nascimento da Costa-Oliveira, Luciane de Freitas Firmino, Wanderley Araújo Soares, Silvia Marinho Martins, Cristina Carrazone, Wilson Oliveira, Michelle Christiane da Silva Rabelo, Virginia Maria Barros de Lorena","doi":"10.1111/tmi.14131","DOIUrl":"10.1111/tmi.14131","url":null,"abstract":"<p><p>Chagas disease is a public health concern endemic to Brazil, with several cases of oral transmission. Detection of patients during the acute phase is rare due to mild, nonspecific symptoms and limitations in diagnostic testing. Some molecules, such as cell adhesion molecules (CAMs), have been highlighted as potential diagnostic and prognostic markers for diseases. The aim of this study was to evaluate CAMs in patients with acute Chagas disease who were treated with benznidazole. In 2019, patients from Pernambuco, in northeastern Brazil, were diagnosed with Trypanosoma cruzi infection. These patients were treated for 60 days and monitored for 2 years. sVCAM-1, sP-selectin, sL-selectin, and sE-selectin were quantified from the serum of patients using a flow cytometer. sVCAM-1 showed significant potential to differentiate between negative and infected individuals before treatment (AUC = 0.875), with a positivity rate of 75%, like the gold standard (parasitological test) and higher than PCR tests. The sP-selectin also yielded good results in monitoring thrombocytopenia and changes in coagulation after treatment. Therefore, we conclude that CAMs are potential biomarkers for Chagas disease during its primary phase.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"730-736"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144162570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and determinants of modern contraception use among persons with disabilities in low- and middle-income countries: A systematic review and meta-analysis. 低收入和中等收入国家残疾人使用现代避孕药具的流行率和决定因素:系统回顾和荟萃分析。
IF 2.6 4区 医学
Tropical Medicine & International Health Pub Date : 2025-07-01 Epub Date: 2025-05-19 DOI: 10.1111/tmi.14130
Atika Rahman Chowdhury, Shimlin Jahan Khanam, Mohammad Zahidul Islam, Gulam Khandaker, Md Nuruzzaman Khan
{"title":"Prevalence and determinants of modern contraception use among persons with disabilities in low- and middle-income countries: A systematic review and meta-analysis.","authors":"Atika Rahman Chowdhury, Shimlin Jahan Khanam, Mohammad Zahidul Islam, Gulam Khandaker, Md Nuruzzaman Khan","doi":"10.1111/tmi.14130","DOIUrl":"10.1111/tmi.14130","url":null,"abstract":"<p><strong>Background: </strong>People with disabilities have the same need for contraception as the general population. However, their access to modern contraceptive methods is largely underexplored in low- and middle-income countries.</p><p><strong>Objective: </strong>This study aimed to explore the prevalence of modern contraception use among reproductive-aged (15-49 years) persons with disabilities in low- and middle-income countries and identify the key determinants.</p><p><strong>Methods: </strong>In June 2024, we conducted a systematic search across six databases including PubMed, Web of Science, Embase, Global Health, Medline and Scopus to identify studies on disability and modern contraception in low- and middle-income countries. The search terms included a combination of Medical Subject Headings (MeSH) terms and keywords related to disability, modern contraception and low- and middle-income countries integrated using the Boolean operators (AND, OR). All studies published between January 2015 and June 2024, in English, and conducted in low- and middle-income countries were included. The primary outcomes were the prevalence of modern contraception use and its determinants among persons with any disability. Summary estimates were calculated using meta-analysis with a fixed effects model for lower heterogeneity. Random effects meta-analysis was used for mid-level heterogeneity (50%-74%) and high-level heterogeneity (75%-100%).</p><p><strong>Results: </strong>A total of 18 studies from low- and middle-income countries were included, with 11 included in the meta-analysis. The pooled prevalence of modern contraception use among persons with disabilities was 31.4% (95% CI: 26.5, 36.2). Significant heterogeneity was observed across respondent characteristics (I<sup>2</sup> = 94.55%). Five factors were significantly associated with higher contraception use: being aged over 25 years, having some level of education, being in a higher wealth quintile, having adequate knowledge of family planning and being in a formal marital relationship.</p><p><strong>Conclusion: </strong>This study reveals a significantly lower prevalence of modern contraception use among persons with disabilities in low- and middle-income countries compared to the general population. Improving access to education, addressing social norms and strengthening healthcare systems may contribute to increasing access to contraception and uptake among persons with disabilities in low- and middle-income countries.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"588-597"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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