Tropical Medicine & International Health最新文献

{"title":"Eco-Epidemiological Study of Seropositivity Against Rickettsia and Leptospira Agents in Rural Areas of Urabá, Colombia.","authors":"Mariana Torres-Bustamante, Omar Cantillo-Barraza, Albert I Ko, Elsio A Wunder, Juan C Quintero-Vélez","doi":"10.1111/tmi.70200","DOIUrl":"10.1111/tmi.70200","url":null,"abstract":"<p><strong>Introduction: </strong>Rickettsioses and leptospirosis are infectious diseases often underdiagnosed due to limited knowledge about their epidemiology, pathophysiology, and clinical aspects.</p><p><strong>Objectives: </strong>To characterize the seroprevalence and seroincidence of Rickettsia and Leptospira agents and determine their associated factors in rural areas of Urabá, Antioquia, Colombia.</p><p><strong>Methods: </strong>Analysis of seropositivity of a prospective study exploring sociocultural and ecological aspects of Rickettsia and Leptospira infection. A multinomial mixed logistic regression model analysed factors linked to seroprevalent cases, with descriptive analyses of seroincident cases.</p><p><strong>Results: </strong>Concomitant seroprevalence against Rickettsia and Leptospira was 9.38% (95% CI: 6.08%-13.37%). Associated factors included age (ORa = 1.02; 95% CI 1.007-1.03), male gender (ORa = 3.06; 95% CI: 1.75-5.37), fever history (ORa = 1.71; 95% CI: 1.06-2.77), presence of breeding pigs (ORa = 2.29; 95% CI 1.36-3.88), peridomicile yucca crops (ORa = 2.5; 95% CI 1.1-5.62), and deforestation practices (ORa = 1.74; 95% CI 1.06-2.87). Concomitant seroincidence was 1.09% (3/274) (95% CI: 0.29%-4.05%). All seroincident cases were female, median age 31.83 years (IQR: 8.69-56.99), with similar housing characteristics (soil floors, wooden walls, zinc roofs) and exposure to domestic and synanthropic animals.</p><p><strong>Conclusions: </strong>There is evidence of concomitant seroprevalent and seroincident cases against both microorganisms in rural Urabá, Colombia. These findings can improve public health surveillance systems in preventing, detecting, and managing clinical cases caused by these pathogens.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148391838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of Tuberculin Skin Testing Compared With Interferon-Gamma Release Assays Foreign-Born Individuals.","authors":"Andrés Marco, Neus Solé, Raquel Prieto-García, Indiana Jesús Abdo, Joan Pau Millet, Elisabet Turu","doi":"10.1111/tmi.70183","DOIUrl":"https://doi.org/10.1111/tmi.70183","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the prevalence of Mycobacterium tuberculosis infection among foreign-born individuals entering prison and to evaluate the performance of the tuberculin skin test (TST) in vaccinated individuals (Bacillus Calmette-Guérin vaccine, BCG), using interferon gamma release assays (IGRAS) as the reference standard.</p><p><strong>Methods: </strong>We conducted a prospective observational study including foreign-born individuals admitted to prisons in Catalonia (Spain) between 1 March 2023 and 30 June 2023. A TST was performed if there was no prior positive TST or prior TB infection, or if the TST was negative for more than 1 year. Current TB was excluded by clinical and radiological evaluation. BCG vaccination status was assessed using medical records, identification of a vaccination scar, and the BCG World Atlas. TST positivity was analysed according to BCG vaccination status. Among BCG-vaccinated individuals with a positive TST, IGRA results were used to estimate the positive predictive value (PPV) of the TST overall and by TST induration diameter.</p><p><strong>Results: </strong>Among 1075 foreign-born individuals admitted during the study period, 32 (3.0%) had a previous diagnosis of active TB. Of the remaining 1043, 86.4% were classified as BCG-vaccinated. Overall, 45.2% had a positive TST, with no significant difference between vaccinated individuals and unvaccinated individuals (46.1% vs. 39.9%; p = 0.08). Among BCG-vaccinated individuals with a positive TST, IGRA testing was performed in 71%, yielding an overall TST PPV of 65%. The PPV increased with induration diameter, from 51.6% (10-14 mm) to 81.8% (≥ 20 mm).</p><p><strong>Conclusions: </strong>Foreign-born individuals entering prison show a high prevalence of M. tuberculosis infection. In BCG-vaccinated individuals, the TST shows limited predictive value, particularly at lower induration thresholds. While further studies are needed, these findings support the preferential use of IGRA-based strategies for LTBI screening in this setting.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148377159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-Occurrence of Malaria, Pneumonia, and Diarrheal Disease Among Households: A Cohort Study in Rural Western Uganda.","authors":"Annika K Gunderson, Abel Bwambale, Emmanuel Baguma, Dana Giandomenico, Bonnie E Shook-Sa, Raquel Reyes, Moses Ntaro, Edgar M Mulogo, Ross M Boyce","doi":"10.1111/tmi.70188","DOIUrl":"10.1111/tmi.70188","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to identify patterns associated with clustering and co-occurrence of malaria, pneumonia, and diarrhoea, the leading causes of death in children under age five in sub-Saharan Africa, in western Uganda to generate evidence for integrated prevention and control measures.</p><p><strong>Methods: </strong>We conducted a prospective longitudinal study complemented by passive surveillance at local clinics. All households in the three selected villages were eligible to participate. Household-level socioeconomic and geographic data were linked to clinically diagnosed disease outcomes. Co-occurrence of diseases within households, defined as the diagnoses of two of the three diseases of interest (malaria, pneumonia, and diarrhoea) within a four-week period, was assessed using a Poisson model with a log link. Multinomial logistic regression models were fit to assess the association between patterns of malaria and pneumonia occurrence with socioeconomic and geographic factors.</p><p><strong>Results: </strong>A total of 399 households were enrolled and completed baseline surveys. The smallest village accounted for 68.5%, 43.2%, and 38.1% of malaria, pneumonia, and diarrhoea cases, respectively. After adjusting for village, socioeconomic status, and the mean age of children in the home, households in Kasanzi had a higher relative risk of having both malaria and pneumonia versus neither disease compared to households in Bunyangoni (RRR: 33.84, 95% CI: 7.10, 161.24). For models replacing village with elevation, households in at higher elevations had a higher relative risk of having both malaria and pneumonia versus neither disease compared to households in at lower elevations (RRR: 26.59, 95% CI: 2.53, 279.84). No clear associations were found between malaria and pneumonia co-occurrence and SES.</p><p><strong>Conclusions: </strong>Findings demonstrate that within small geographic areas, disease burden can vary dramatically across communities. Targeted, community-level interventions, rather than broad regional programs, are essential to address the distinct transmission dynamics and overlapping risks faced by high-burden communities.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13570563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148377239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dried Serum Spots for External Quality Assurance of Scrub Typhus IgM Serology: A Multicentre Pilot Study From India.","authors":"Haripriya Sivakumar, Dinakaran Vasudevan, Ratchagadasse Vimal Raj, Ferdinamarie Sharmila Philomenadin, Harmanmeet Kaur, Rahul Dhodapkar","doi":"10.1111/tmi.70132","DOIUrl":"10.1111/tmi.70132","url":null,"abstract":"<p><strong>Objective: </strong>Scrub typhus, caused by Orientia tsutsugamushi , is a significant contributor to acute undifferentiated febrile illness in South and Southeast Asia. Laboratory confirmation of infection has a crucial role in timely management; nevertheless, lack of standardisation in inter-laboratory performance of IgM enzyme-linked immunosorbent assay (ELISA) has been a long-standing challenge. In resource-constrained countries, quality assurance schemes have an important role in improving laboratory performance. The aim of this pilot study was to assess the applicability of dried serum spots (DSS) as a suitable sample format for quality assurance schemes of O. tsutsugamushi IgM ELISA in India.</p><p><strong>Methods: </strong>Well-characterised positive and negative serum samples were processed into DSS panels and were systematically validated for homogeneity and short-term stability according to ISO/IEC 17043 and ISO 13528 using two commercially available IgM ELISA kits (InBios International Inc. and J. Mitra Scrub Typhus IgM Microlisa). Distribution was done for 10 participating laboratories across India. The laboratories tested DSS panels under routine diagnostic conditions using standardised protocols. The results were evaluated for qualitative accuracy, inter-laboratory concordance and overall performance.</p><p><strong>Results: </strong>DSS panels exhibited a high degree of homogeneity and stability under simulated transport and storage conditions, thereby not requiring cold chain distribution. On initial testing, 8 of 10 laboratories (80%) showed complete qualitative concordance across the five-sample panel. Following repeat testing and procedural review, all laboratories achieved concordant qualitative results, with minor disagreement noted only in borderline reactive samples.</p><p><strong>Conclusions: </strong>Dried serum spots are a feasible, reliable and cost-effective alternative to conventional liquid serum for external quality assurance of O. tsutsugamushi IgM ELISA. The initial discordance observed underscores the importance of EQA in identifying procedural variability, while the final concordance confirms the robustness and suitability of DSS for EQA implementation in resource-limited, endemic settings like India.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"868-874"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Donor Fatigue and Its Impact on Vaccination Coverage in Africa: Challenges and the Path Forward.","authors":"Michael Sarfo, Daniel Akuamoah Asirifi, John Kwame Agbenyeavu, Kwaku Obeng Boateng, Nelson Obeng, Sandra Konadu Bonnah, Betelhem Abebe Andargie, Gilbert Eshun","doi":"10.1111/tmi.70139","DOIUrl":"10.1111/tmi.70139","url":null,"abstract":"","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"769-771"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two Decades of Dengue in Bangladesh (2001-2024): Epidemiologic Trends, Geographic Spread and Climatic Drivers.","authors":"Awnon Bhowmik, Mahmudul Hasan, Goutam Saha, Huaiping Zhu","doi":"10.1111/tmi.70136","DOIUrl":"10.1111/tmi.70136","url":null,"abstract":"<p><p>Bangladesh has experienced a marked escalation in dengue since 2001, culminating in 321,179 reported cases and 1705 deaths in 2023. The objective of this narrative review is to analyse 24 years of surveillance data to describe temporal trends, the transition from urban-centric to nationwide endemicity and the influence of climatic drivers. This review synthesises national surveillance and published reports from 2001 to 2024 to assess demographic risk, geographic spread and environmental factors. Young adults (21-30 years) consistently account for the largest share of infections (28.82% in 2024). In contrast, adults over 50 years suffer disproportionate mortality (15.65% of deaths in 2024) despite a smaller share of infections (7.15%). Since 2019, transmission has extended beyond urban centres such as Dhaka into peri-urban and other districts. This geographical diffusion is driven by the rapid urbanisation of other peripheries, infrastructure development that creates new vector habitats and accelerated population mobility which connects hyper-endemic urban hubs with susceptible rural communities. We identify priority actions such as targeted risk communication for young adults, improved access to healthcare for older adults and climate-adaptive vector control strategies integrated with urban services and strengthened surveillance. It is essential to address these factors to reduce the dengue burden and improve health outcomes in Bangladesh to control mosquito populations. Lessons are transferable to other dengue-affected countries when adapted to local demographic and environmental contexts and embedded in regional collaboration and climate-responsive policy.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"772-795"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serious Bacterial Infections in Hospitalized Neonates in Eastern Ethiopia: Investigating the Emerging Pathogen Pantoea dispersa Compared With Klebsiella pneumoniae.","authors":"Yunus Edris, Faisel A Hassen, Desalegn A Ayana, Fami Ahmed, Haleluya Leulseged, Dadi Marami, Jabir Aliye, Belete G Alem, Zelalem T Mariam, Gezahang Mengesha, Nega Assefa, Alexander M Aiken, J Anthony G Scott, Lola Madrid","doi":"10.1111/tmi.70140","DOIUrl":"10.1111/tmi.70140","url":null,"abstract":"<p><strong>Background: </strong>Serious bacterial infections (SBIs) are major contributors to neonatal morbidity and mortality in low-income countries. We describe the aetiology and risk factors for neonatal bacteraemia and in-hospital mortality in eastern Ethiopia, focusing on Pantoea dispersa, a rarely studied pathogen, and Klebsiella pneumoniae .</p><p><strong>Methods: </strong>Prospective surveillance was conducted at Hiwot Fana Comprehensive Specialized Hospital (HFCSH), Harar, from December 2021 to November 2023. Blood for culture was drawn from neonates admitted with the WHO clinical definition of possible-SBI (pSBI). Isolates were identified using API kits and antimicrobial susceptibility tested by Kirby-Bauer method.</p><p><strong>Findings: </strong>Among 1375 neonates with pSBI, blood was cultured from 1335 (97%), and 356 (27%) cultured pathogens. The commonest infections were Pantoea species (n = 145, 40.7%) and K. pneumoniae (n = 63, 17.7%); 128 Pantoea isolates were identified as P. dispersa by Matrix-Assisted Laser Desorption Ionization-Time of Flight. Case-fatality-ratios were 25% (32/128), 19% (9/47) and 19% (30/160) for P. dispersa , K. pneumoniae and other monomicrobial infections, respectively. P. dispersa showed resistance to ampicillin (99%) and cefotaxime (85%) but was otherwise broadly susceptible, while K. pneumoniae showed resistance to cefotaxime (100%) and gentamicin (89%), remaining susceptible only to amikacin and meropenem. Compared to non-bacteraemic admissions, P. dispersa bacteraemia was associated with health-facility delivery outside HFCSH (aOR 1.9 [95% CI, 1.21-2.97]), low birth weight (aOR 2.1 [95% CI,1.22-3.47]), and the dry season (aOR 9.7, [95% CI, 4.61-20.31]). K. pneumoniae bacteraemia was associated with health-facility delivery outside HFCSH (aOR, 2.2, [95% CI, 1.09-4.27]) alone. Among admissions with pSBI, death was associated with low birth weight and P. dispersa bacteraemia.</p><p><strong>Interpretation: </strong>Bacteraemia was prevalent among neonates admitted with pSBI to HFCSH. P. dispersa and K. pneumoniae predominated and both had high mortality risks. Rigorous diagnostics and epidemiological associations support the interpretation of P. dispersa as a pathogen, necessitating local investigation into transmission and infection control interventions.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"933-943"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13331537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Contribution of Entomological Surveillance to the Control of Chagas Disease in Endemic Regions: An Integrative Literature Review.","authors":"Daniel Rodrigo de Lima Gomes, Gilliard do Nascimento, Pedro Mariano da Silva Rodrigues, Ana Beatriz da Silva, Ysabele Yngrydh Valente Silva, Ekarinny Myrela Brito de Medeiros, Cléber de Mesquita Andrade, Thales Allyrio Araújo de Medeiros Fernandes, José Antonio da Silva Júnior, Ellany Gurgel Cosme do Nascimento","doi":"10.1111/tmi.70128","DOIUrl":"10.1111/tmi.70128","url":null,"abstract":"<p><p>Chagas disease remains a significant public health challenge in various endemic regions of Latin America. The persistence of vector-borne transmission highlights the complexity of the issue and the limitations of traditional strategies. In this context, entomological surveillance plays a strategic and multifaceted role, not only in the early detection of triatomine bugs but also in guiding control actions tailored to territorial realities. This study aimed to analyse the contributions of entomological surveillance to the control of Chagas disease in endemic regions, considering the integration of traditional approaches, technological innovations, and participatory strategies. An integrative literature review was conducted based on the guiding question: 'How does entomological surveillance contribute to the control of Chagas disease in different endemic regions?' This study is an integrative review conducted in the PubMed, EMBASE, BVS and Web of Science databases, with no time restriction, including primary studies in Portuguese, English and Spanish. A total of 484 studies were identified. After screening and application of the eligibility criteria, 79 articles comprised the final sample, which were analysed through thematic categorisation and descriptive synthesis of the findings. Publications in Portuguese, English, and Spanish, with no time restrictions, were classified into six thematic categories: entomological indices and spatial mapping; factors associated with household invasion; vector control strategies; surveillance methods; professionals' perceptions; and challenges to the sustainability of actions. The findings revealed that entomological surveillance significantly contributes to the control of Chagas disease, especially when it integrates classical indicators, technological tools, and community-based strategies. The role of entomological indices, interventions in peridomestic ecotopes, and the training of field agents stands out as essential pillars for the effectiveness of interventions. However, vector resistance to insecticides remains a critical obstacle, reinforcing the need for multisectoral, localised and sustainable actions.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"832-842"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13331536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic Trends and Molecular Mechanisms of Helicobacter pylori Antibiotic Resistance in Bangladesh: A Scoping Review.","authors":"Mohammod K Islam, Ali Dway, Aasma Karki","doi":"10.1111/tmi.70129","DOIUrl":"10.1111/tmi.70129","url":null,"abstract":"<p><strong>Objective: </strong>To comprehensively map the phenotypic prevalence, temporal trends, and molecular mechanisms of antimicrobial resistance in Helicobacter pylori isolates among patients in Bangladesh.</p><p><strong>Method: </strong>Scoping review conducted in accordance with the JBI methodology and reported using the PRISMA-ScR checklist. A systematic search was conducted in PubMed, MEDLINE, Scopus, and BanglaJOL to identify peer-reviewed observational studies published between 1 January 2000 and 30 April 2025.</p><p><strong>Results: </strong>Ten studies were reviewed. Metronidazole resistance remained persistently high (77.5%-96.4%), while clarithromycin rates surged from ~10% to > 39%. Levofloxacin resistance also reached critical levels (up to 66.1%). In contrast, amoxicillin (< 10%) and tetracycline (< 20%) retained efficacy. Genomic analysis linked resistance primarily to 23S rRNA (A2142G, A2143G) and gyrA mutations within hpAsia2 and hpEurope lineages.</p><p><strong>Conclusion: </strong>The available evidence indicates a high and increasing burden of H. pylori antibiotic resistance in Bangladesh, particularly to clarithromycin, metronidazole, and levofloxacin. These findings highlight the need for updated, evidence-informed treatment strategies and expanded molecular surveillance to support effective eradication therapy.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"796-806"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Climatic, Socioecological and Environmental Determinants of Aedes spp. Dynamics at the Community Interface: A Systematic Review With Reflections From a One Health Perspective.","authors":"Ana Izabel Passarella Teixeira, Giovanna Rotondo de Araújo, Diogo Tavares Cardoso, David Soeiro Barbosa, Christina Pettan-Brewer, Joaquim Pinto Nunes Neto, Ruana Renosto Delai, Cláudia Turra Pimpão, Lívia Medeiros Neves Casseb","doi":"10.1111/tmi.70131","DOIUrl":"10.1111/tmi.70131","url":null,"abstract":"<p><strong>Background and objectives: </strong>Mosquitoes of the genus Aedes, including but not limited to Aedes aegypti , are major vectors of arboviruses such as dengue, Zika and other related diseases. Their global expansion is driven by climate change, globalisation, urbanisation and human mobility. Understanding how these factors shape their reproduction, survival and persistence is crucial for strengthening integrated vector control within a One Health framework. This review synthesises current evidence on these determinants to support more sustainable control strategies.</p><p><strong>Methods: </strong>A systematic review was conducted following PRISMA guidelines across PubMed/MEDLINE and SciELO through June 2025. Search strategies combined terms related to Aedes spp., environmental, climatic, socio-ecological determinants and One Health. Eligible studies examined factors influencing reproduction, survival or persistence of any Aedes species under natural or semi-natural conditions. Case reports, clinically focused studies and laboratory experiments lacking ecological realism were excluded. Two reviewers independently screened records and extracted data. Findings were synthesised descriptively.</p><p><strong>Results: </strong>From 1007 records screened, 98 were included. Most were conducted in Brazil (18.4%), China (12.2%) and Argentina (11.2%). Ecological-epidemiological studies (30.6%) and environmentally oriented laboratory simulations (24.5%) were predominant. The evidence highlighted: (i) microenvironmental factors-such as water quality, nutrient availability, pollutants, and artificial light-affecting larval development and vector competence; (ii) climatic variables, especially temperature, rainfall, and humidity, as major drivers of mosquito abundance and transmission potential; (iii) urbanisation, inadequate housing, socioeconomic vulnerability, and irregular water supply as key amplifiers of infestation; and (iv) widespread insecticide resistance and the limited impact of conventional larvicides as major barriers to control.</p><p><strong>Conclusions: </strong>Environmental, climatic and socio-ecological determinants critically shape Aedes persistence and arbovirus transmission. Integrating these determinants into surveillance and vector control programs through a One Health approach enables earlier detection, more targeted interventions and the development of sustainable strategies to reduce the global burden of arboviral diseases.</p>","PeriodicalId":23962,"journal":{"name":"Tropical Medicine & International Health","volume":" ","pages":"807-821"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13331526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}