Evaluating modifiable hypertension risk in Nigerian adults-The Nigerian diet risk score.

IF 2.6 4区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Tropical Medicine & International Health Pub Date : 2025-04-01 Epub Date: 2025-02-10 DOI:10.1111/tmi.14089
Nimisoere P Batubo, Carolyn I Auma, J Bernadette Moore, Michael A Zulyniak
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引用次数: 0

Abstract

Aims: Our study aimed to derive and validate a diet risk score for clinical use in Nigeria to screen for hypertension risk and evaluate its association against a panel of cardiovascular biomarkers.

Methods: The Nigerian dietary screening tool was used to collect dietary intake data from 151 participants visiting the River State University Teaching Hospital, Port Harcourt, Nigeria, for routine medical care. Blood samples were collected from a subsample (n = 94) for biomarker assessment. Multiple logistic regression was used to derive the Nigerian diet risk score for hypertension. Internal validation of the Nigerian diet risk score for hypertension was performed using measures of discrimination and calibration. Mediation analysis was used to evaluate the biomarker-mediated effects of the diet risk score for hypertension on hypertension. All statistical analyses were performed in R.

Results: Each one-point increment in Nigerian diet risk score (on a scale of 0 to 30) was associated with a twofold increase in odds of hypertension (odds ratio: 2.04, 95% confidence interval [CI]: 1.16, 3.58, p = 0.01), with the highest score associated with >18-fold increased odds of hypertension, compared to lowest Nigerian diet risk score for hypertension. The score demonstrated good discrimination (area under the curve: 0.92, 95% CI: 0.80, 1.00) with a high sensitivity (0.85) and specificity (0.94). Additionally, mediation analysis suggested that the association between Nigerian diet risk score for hypertension and blood pressure is partly explained by shared biological pathways that mediate cholesterol, triglycerides, LDL-C, CRP and homocysteine levels.

Conclusion: The resulting Nigerian diet risk score for hypertension is a valuable tool for clinicians to identify individuals at risk of hypertension, and will advance community efforts in the prevention and management of hypertension in Nigeria.

评估尼日利亚成年人可改变的高血压风险-尼日利亚饮食风险评分。
目的:我们的研究旨在推导和验证尼日利亚临床使用的饮食风险评分,以筛查高血压风险并评估其与一组心血管生物标志物的相关性。方法:采用尼日利亚膳食筛查工具收集151名在尼日利亚哈科特港河州立大学教学医院接受常规医疗护理的参与者的膳食摄入数据。从亚样本(n = 94)中采集血液样本用于生物标志物评估。采用多元logistic回归得到尼日利亚饮食高血压风险评分。采用辨别法和校准法对尼日利亚高血压饮食风险评分进行内部验证。采用中介分析评估高血压饮食风险评分对高血压的生物标志物介导作用。结果:尼日利亚饮食风险评分每增加1分(在0到30的范围内),患高血压的几率增加2倍(优势比:2.04,95%可信区间[CI]: 1.16, 3.58, p = 0.01),与尼日利亚饮食风险评分最低的高血压患者相比,得分最高的患者患高血压的几率增加18倍。该评分具有良好的鉴别能力(曲线下面积:0.92,95% CI: 0.80, 1.00),具有较高的敏感性(0.85)和特异性(0.94)。此外,中介分析表明,尼日利亚饮食高血压风险评分与血压之间的关联部分可以通过介导胆固醇、甘油三酯、LDL-C、CRP和同型半胱氨酸水平的共同生物学途径来解释。结论:由此得出的尼日利亚高血压饮食风险评分是临床医生识别高血压风险个体的宝贵工具,并将推动尼日利亚社区在高血压预防和管理方面的努力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Tropical Medicine & International Health
Tropical Medicine & International Health 医学-公共卫生、环境卫生与职业卫生
CiteScore
4.80
自引率
0.00%
发文量
129
审稿时长
6 months
期刊介绍: Tropical Medicine & International Health is published on behalf of the London School of Hygiene and Tropical Medicine, Swiss Tropical and Public Health Institute, Foundation Tropical Medicine and International Health, Belgian Institute of Tropical Medicine and Bernhard-Nocht-Institute for Tropical Medicine. Tropical Medicine & International Health is the official journal of the Federation of European Societies for Tropical Medicine and International Health (FESTMIH).
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