{"title":"Recurrence of acyclovir-resistant herpes encephalitis in an immunocompromised patient: A case report.","authors":"Daisuke Usuda, Daiki Furukawa, Rikako Imaizumi, Rikuo Ono, Yuki Kaneoka, Eri Nakajima, Masashi Kato, Yuto Sugawara, Runa Shimizu, Tomotari Inami, Kenji Kawai, Shun Matsubara, Risa Tanaka, Makoto Suzuki, Shintaro Shimozawa, Yuta Hotchi, Ippei Osugi, Risa Katou, Sakurako Ito, Kentaro Mishima, Akihiko Kondo, Keiko Mizuno, Hiroki Takami, Takayuki Komatsu, Tomohisa Nomura, Manabu Sugita","doi":"10.12998/wjcc.v13.i34.111438","DOIUrl":"10.12998/wjcc.v13.i34.111438","url":null,"abstract":"<p><strong>Background: </strong>Acyclovir (ACV)-resistant herpes simplex virus (HSV) strains have emerged and gradually increased in number. Prolonged treatment, such as for immunocompromised patients, has been observed on many occasions to lead to the development of resistance. Additionally, some strains of HSV exist that are ACV resistant, and they can cause severe complications that may be impossible to treat with current therapies. We report the first case of ACV-resistant herpes encephalitis (ARHE) recurring in an immunocompromised adult patient without neurosurgical intervention.</p><p><strong>Case summary: </strong>A 58-year-old man with a fever of 38°C had tremors. Evaluation revealed 14 points on the Glasgow Coma Scale with 39°C fever but unremarkable physical examination. Diagnosis was infection of unknown origin; fever continued, and the Glasgow Coma Scale worsened to 8. Imaging showing a high-intensity area between the left temporal lobe and insular cortex suggested herpes encephalitis. ACV was started. Cerebrospinal fluid (CSF) was positive for HSV DNA, confirming the diagnosis. However, unresolved symptoms suggested ARHE; therefore, we initiated vidarabine treatment. Later testing confirmed ARHE. Foscarnet was started based on a hospital day 25 blood test revealing pancytopenia, possibly from vidarabine. Consciousness improved, and the patient moved to rehabilitation. However, symptoms worsened, suggesting recurrence. Diffusion-weighted magnetic resonance imaging revealed a high high-intensity area around the right temporal lobe; CSF was positive for HSV DNA, confirming recurrent herpes encephalitis. ACV and foscarnet were initiated. Fever decreased, consciousness improved, and HSV DNA on hospital days 78 and 93 was CSF negative. Treatment was terminated on hospital day 86.</p><p><strong>Conclusion: </strong>ARHE recurred in the patient following remission; therefore, it is necessary to discuss the length of the treatment period.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 34","pages":"111438"},"PeriodicalIF":1.0,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12687077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145726391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xi Deng, Li-Yuan Lv, Su-Xiang Jiang, Jian-Xian Huang, Xin-Yuan Chen, Meng-Fei Zhang, Jian Qi, Man Yang
{"title":"Low-grade appendiceal mucinous neoplasm: A case report.","authors":"Xi Deng, Li-Yuan Lv, Su-Xiang Jiang, Jian-Xian Huang, Xin-Yuan Chen, Meng-Fei Zhang, Jian Qi, Man Yang","doi":"10.12998/wjcc.v13.i34.111668","DOIUrl":"10.12998/wjcc.v13.i34.111668","url":null,"abstract":"<p><strong>Background: </strong>Low-grade appendiceal mucinous neoplasms are papillary or flat mucinous tumors with low-grade cytologic atypia. They are the most frequent source of pseudomyxoma peritonei. They can be easily misdiagnosed, due to unspecific symptoms, with acute appendicitis, retroperitoneal tumors or adnexal mass. Cases of huge appendiceal mucinous neoplasms are even more extremely rare.</p><p><strong>Case summary: </strong>We report a 54-year-old patient who presented with a 10-month history of constant dull distension accompanied by nausea. A surgical procedure of total hysterectomy, bilateral adnexectomy, appendectomy, greater omentectomy and right hemicolectomy was performed as a result of the findings on ultrasound, computed tomography scan and magnetic resonance imaging. Diagnosis was made after the pathological examination, which revealed low-grade appendiceal mucinous neoplasm. The patient received hyperthermic intraperitoneal chemotherapy with cisplatin and was discharged from the hospital.</p><p><strong>Conclusion: </strong>Low-grade appendiceal mucinous adenomas are rare tumors that are easily misdiagnosed, and a more thorough clinical workup is required to make a definitive diagnosis.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 34","pages":"111668"},"PeriodicalIF":1.0,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12687106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145726325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatima Sial, Abdul Basit, Nabeela Ghafoor, Warda Sial, Abdul M Basil
{"title":"Mixed connective tissue disease and tuberculosis coexistence as a diagnostic dilemma: A case report.","authors":"Fatima Sial, Abdul Basit, Nabeela Ghafoor, Warda Sial, Abdul M Basil","doi":"10.12998/wjcc.v13.i33.109866","DOIUrl":"10.12998/wjcc.v13.i33.109866","url":null,"abstract":"<p><strong>Background: </strong>Mixed connective tissue disease (MCTD) is a rare autoimmune disorder characterized by overlapping features of systemic lupus erythematosus, systemic sclerosis, and polymyositis, and presence of anti-U1 ribonucleoprotein antibodies. Coexistence with tuberculosis (TB), a common infectious disease in endemic areas, poses a significant diagnostic challenge due to overlapping clinical and radiological features.</p><p><strong>Case summary: </strong>We report a 35-year-old Pakistani female presenting with oral ulcers, body rash, worsening dyspnea, and a history of joint pains initially treated as rheumatoid arthritis. She was on antituberculous therapy (ATT) for presumed pulmonary TB. Laboratory findings revealed anemia, leukopenia, raised erythrocyte sedimentation rate, positive anti-Sm/RNP, anti-dsDNA, and anti-SSA/Ro antibodies, confirming MCTD with clinical features of systemic lupus erythematosus, Sjogren syndrome, and systemic sclerosis. The patient was also positive for hepatitis C and active TB. Treatment involved corticosteroids alongside continuation of ATT, resulting in significant clinical improvement over 12 days, with resolution of symptoms and improved laboratory parameters. The patient remained stable on follow-up with hydroxychloroquine and prednisolone.</p><p><strong>Conclusion: </strong>This case highlights the diagnostic complexity when autoimmune diseases coexist with TB, particularly in TB-endemic regions. Early recognition and integrated management of both conditions are crucial to improving outcomes. Clinicians should maintain a broad differential diagnosis and perform comprehensive immunological workup in patients with overlapping symptoms.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 33","pages":"109866"},"PeriodicalIF":1.0,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12678965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Squamous cell carcinoma of unknown primary in the pelvis after complete remission following chemoradiotherapy: A case report.","authors":"Anupam K Gupta, Harsha Polavarapu","doi":"10.12998/wjcc.v13.i33.112160","DOIUrl":"10.12998/wjcc.v13.i33.112160","url":null,"abstract":"<p><strong>Background: </strong>Pelvic squamous cell carcinoma of unknown primary (CUP) is extremely rare, accounting for less than one percent of all CUP cases, and its infrequency has limited the development of standardized diagnostic and treatment guidelines.</p><p><strong>Case summary: </strong>A 77-year-old female with a history of resected lung adenocarcinoma presented with worsening constipation. Imaging revealed a 2.5 cm mass adjacent to the right levator ani muscle. Biopsy confirmed poorly differentiated squamous cell carcinoma, positive for pancytokeratin and p40, and negative for p16, cytokeratin 7, cytokeratin 20, and neuroendocrine markers. No primary lesion was identified despite extensive evaluation. She underwent five cycles of 5-fluorouracil (1000 mg/m<sup>2</sup> continuous infusion, days 1-4) and mitomycin-C (10 mg/m<sup>2</sup> on day 1) with concurrent pelvic radiotherapy (50.4 Gy in 28 fractions). Follow-up imaging demonstrated complete remission sustained for 12 months. Electrocorticography performance status improved from 2 at diagnosis to 1 during follow-up.</p><p><strong>Conclusion: </strong>This case highlights the potential role of chemoradiotherapy in managing pelvic squamous cell CUP, achieving durable remission in selected patients.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 33","pages":"112160"},"PeriodicalIF":1.0,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12678909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Muscle matters: Transforming the care of intensive care unit acquired sarcopenia and myosteatosis.","authors":"Sahil Kataria, Saketh Vinjamuri, Deven Juneja","doi":"10.12998/wjcc.v13.i33.110976","DOIUrl":"10.12998/wjcc.v13.i33.110976","url":null,"abstract":"<p><p>Intensive care unit (ICU) acquired sarcopenia and myosteatosis are increasingly recognized complications of critical illness, characterized by a rapid loss of skeletal muscle mass, quality, and function. These conditions result from a complex interplay of systemic inflammation, immobilization, catabolic stress, mitochondrial dysfunction, and immune dysregulation, often culminating in impaired recovery, prolonged hospitalization, and increased long-term mortality. First identified in survivors of sepsis and prolonged mechanical ventilation, these muscle abnormalities were initially described using computed tomography-based assessments of muscle area and density. Subsequent advances in imaging, biomarker discovery, and functional testing have enabled earlier detection and risk stratification across diverse ICU populations. While nutritional optimization and early mobilization form the cornerstone of current prevention and treatment strategies, the emergence of novel approaches, including automated artificial intelligence-based screening, neuromuscular electrical stimulation, and targeted pharmacologic therapies, has broadened the clinical scope of interventions. Despite their significant prognostic implications, ICU-acquired sarcopenia and myosteatosis remain under-recognized in routine critical care practice. This mini-review aims to synthesize current knowledge regarding their pathophysiology, available diagnostic modalities, prognostic relevance, and the evolving landscape of therapeutic strategies for long-term functional recovery in critically ill patients.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 33","pages":"110976"},"PeriodicalIF":1.0,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12678907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beyond COL1A1::PDGFB: Rare fusions and their clinical implications in dermatofibrosarcoma protuberans.","authors":"Sumanta Das, Sunita Ahlawat","doi":"10.12998/wjcc.v13.i33.113167","DOIUrl":"10.12998/wjcc.v13.i33.113167","url":null,"abstract":"<p><p>Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous intermediate-grade soft tissue tumor characterized by COL1A1::PDGFB fusion in most cases. This fusion drives tumorigenesis and forms the basis for imatinib treatment, which acts by blocking platelet-derived growth factor receptor-beta kinase activity. Apart from this canonical fusion, there is an expanding spectrum of rare fusions, including COL6A3::PDGFD, EMILIN::PDGFD, TNC::PDGFD, <i>etc.</i>, through molecular profiling. These atypical rearrangements may be encountered in morphologically classic DFSP, unusual anatomic sites, or diagnostically challenging variants such as fibrosarcomatous DFSP. Their recognition is clinically relevant, as they may influence tumor biology, response to targeted therapy, and eligibility for clinical trials. This newly documented DFSP involving the lacrimal sac was initially misdiagnosed as a solitary fibrous tumor, emphasizing the diagnostic pitfalls in anatomically constrained regions and the importance of integrated diagnosis combining histology, immunohistochemistry, and molecular testing. In this editorial commentary, we briefly highlight the ever-growing genomic landscape of DFSP, report rare fusions and their biological implications, and examine the role of expanded molecular diagnostics in refining diagnosis, guiding therapy, and informing prognosis. Incorporating comprehensive fusion analysis into routine workup may be critical for accurate classification, especially in unusual presentations where reliance on morphology alone risks misdiagnosis.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 33","pages":"113167"},"PeriodicalIF":1.0,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12678971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Disseminated herpes simplex virus type 1 treated with ixekizumab in a patient with erythrodermic psoriasis: A case report.","authors":"Ahmad Berjawi, Rana Attieh, Marcella Younes, Karen Beydoun, Issam Fassih, Zeina Tannous","doi":"10.12998/wjcc.v13.i33.113751","DOIUrl":"10.12998/wjcc.v13.i33.113751","url":null,"abstract":"<p><strong>Background: </strong>Erythrodermic psoriasis (EP) is a rare and life-threatening form of psoriasis associated with significant morbidity and mortality. Systemic immunosuppressive therapies are often required but may predispose to opportunistic infections. Disseminated herpes simplex virus type-1 (HSV-1) is an unusual complication in otherwise immunocompetent patients and has not been reported in association with ixekizumab therapy for EP.</p><p><strong>Case summary: </strong>We describe a 49-year-old man with longstanding severe plaque psoriasis, liver cirrhosis, and bipolar disorder who developed EP involving > 90% of body surface area [Psoriasis Area and Severity Index (PASI) 45]. Following initial stabilization, he was admitted to the intensive care unit (ICU) with hemodynamic instability, leukocytosis with eosinophilia, and diffuse desquamation. Ixekizumab was initiated with high-dose topical clobetasol. During his ICU stay, he developed recurrent bacteremias and neurologic decline (Glasgow Coma Scale 7/15), followed by the appearance of widespread vesicles and hemorrhagic crusts. HSV-1 infection was confirmed by polymerase chain reaction (PCR). Immunosuppressive therapy was withheld, and intravenous acyclovir was started, leading to progressive improvement. After ten days, ixekizumab was reintroduced with careful monitoring, resulting in marked clinical improvement (PASI 9.7 at six weeks). The patient remained stable on long-term follow-up with oral acyclovir prophylaxis.</p><p><strong>Conclusion: </strong>This case highlights the diagnostic and therapeutic challenges of managing EP in the setting of biologic therapy. Disseminated cutaneous HSV-1 should be considered in immunosuppressed patients presenting with new vesicular eruptions, and prompt PCR testing with early antiviral therapy is essential. A multidisciplinary approach is critical to balance immunosuppression for disease control with infection risk.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 33","pages":"113751"},"PeriodicalIF":1.0,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12678927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tarek Abdeldayem, Saif Memon, Muntaser Omari, Mohaned Egred, Bilal Bawamia, Mohamed Farag, Mohammad Alkhalil
{"title":"Thrombectomy in acute myocardial infarction: Current evidence, challenges, and emerging technologies.","authors":"Tarek Abdeldayem, Saif Memon, Muntaser Omari, Mohaned Egred, Bilal Bawamia, Mohamed Farag, Mohammad Alkhalil","doi":"10.12998/wjcc.v13.i33.107990","DOIUrl":"10.12998/wjcc.v13.i33.107990","url":null,"abstract":"<p><p>Thrombus burden significantly increases risk of no-reflow and microvascular obstruction and subsequently impacts outcomes in acute myocardial infarction (AMI). While initial studies suggested benefits of thrombus aspiration (TA), recent large trials have questioned its routine use. This review examines the role of thrombectomy in the management of AMI, focusing on its potential to improve myocardial perfusion and mitigate no-reflow risk. Attention should be focused on recognising high thrombus burden and its effect on major adverse cardiovascular events and impaired myocardial reperfusion. Similarly, standardising TA techniques and ensuring appropriate patients' selection may also improve enhance our understanding of the role of thrombectomy in AMI. Emerging technologies such as stent retrievals and mechanical thrombectomy may overcome the limitations of manual thrombectomy devices.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 33","pages":"107990"},"PeriodicalIF":1.0,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12678950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Abdominal compartment syndrome with colonic hypoganglionosis and massive colonic distension in a young adult: A case report.","authors":"Eric Bergeron, Adrian Gologan","doi":"10.12998/wjcc.v13.i33.112684","DOIUrl":"10.12998/wjcc.v13.i33.112684","url":null,"abstract":"<p><strong>Background: </strong>Hypoganglionosis is a rare gastrointestinal acquired motility disorder that resembles Hirschsprung's disease and can manifest in the adult life. Abdominal compartment syndrome, a condition characterized by an increase in intra-abdominal pressure with physiological disturbance can be caused by severe massive fecal impaction.</p><p><strong>Case summary: </strong>A 33-year-old female presented to the emergency room with massive abdominal distension that rapidly progressed to abdominal compartment syndrome. The patient was diagnosed with hypoganglionosis. Life-saving emergent proctocolectomy was performed to save the patient.</p><p><strong>Conclusion: </strong>Abdominal compartment syndrome can develop secondary to excessive colonic distension. This extreme but rare situation must be addressed immediately. Hypoganglionosis is a potential cause of severe constipation that may present in adulthood.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 33","pages":"112684"},"PeriodicalIF":1.0,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12678952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thyroid nodules as predictors of adenomatous colonic polyps: A systematic review and meta-analysis.","authors":"Hyder Osman Mirghani, Salah Alghamdi","doi":"10.12998/wjcc.v13.i33.112241","DOIUrl":"10.12998/wjcc.v13.i33.112241","url":null,"abstract":"<p><strong>Background: </strong>Thyroid nodules (TN) are increasingly diagnosed worldwide; investigating the association between TN and colon polyps could be helpful in early detection and management. To our knowledge no meta-analysis has assessed the relationship between TN and adenomatous colonic polyps.</p><p><strong>Aim: </strong>To assess the association between adenomatous colonic polyps, thyroid-stimulating hormone, and TN.</p><p><strong>Methods: </strong>We searched PubMed, MEDLINE, Cochrane Library, EBSCO, and the first 100 articles in Google for articles published in English from inception until April 2025. We included prospective cohorts, retrospective studies, case-control studies, and cross-sectional studies. The keywords thyroid nodules, adenomatous colon polyps, thyroid volume, metabolic syndrome, insulin resistance, and thyroid malignancy were used.</p><p><strong>Results: </strong>Out of 237 articles, 25 full texts were reviewed, and 5 full texts were included in the final meta-analysis. No relationship was found between TN, colonic polyps, and thyroid-stimulating hormone levels [odd ratio (OR): 1.78, 95% confidence interval (CI)<i>:</i> 0.55-5.74, <i>P</i> = 0.33]. Colonic polyps were more common among patients with TN when addressing heterogeneity (OR: 0.42, 95%CI: 0.30-0.52, <i>P</i> < 0.001 and OR: 0.08, 95%CI: 0.70-0.86, <i>P</i> = 0.85).</p><p><strong>Conclusion: </strong>TN were similar among patients with and without adenomatous colonic polyps. However, TN was more common among colon polyps when addressing the heterogeneity. Thyroid-stimulating hormone was not different between those with and without TN. Age, sex, adiposity, and smoking effects might explain the higher rate observed by the included studies. Further studies controlling for the same are needed.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 33","pages":"112241"},"PeriodicalIF":1.0,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12678903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}