World Journal of Clinical Cases最新文献

{"title":"Convergence of diabetic ketoacidosis, acute pancreatitis, and malaria: A case report.","authors":"Koffi Isidore Kouame, Paterne Michael N'kan Mobio, Judith Kouesseu Bouh, Jean Kouassi Konan, Theodore Klinnan Coulibaly, Cyrille Wallamitien Toure, Lauraine Armande Assoh Diebi, Jose Ndjassipli Homawoo Kouakou, Bable Essuy Koffi, Paul Yapo Yapo","doi":"10.12998/wjcc.v13.i23.106321","DOIUrl":"10.12998/wjcc.v13.i23.106321","url":null,"abstract":"<p><strong>Background: </strong>Type 1 diabetes is an autoimmune disease leading to insulin deficiency, and it is mainly diagnosed in young adults. One of the major acute complications of type 1 diabetes is diabetic ketoacidosis (DKA), which is a metabolic emergency that can be triggered by stress, infection, or poor blood glucose control. The association of DKA with conditions such as acute pancreatitis and malaria is rare and therefore represents a major diagnostic and therapeutic challenge.</p><p><strong>Case summary: </strong>A 20-year-old female was admitted to the emergency room for abdominal pelvic pain, fever, asthenia, polyuria, and polydipsia with a progressive deterioration of her state of consciousness. At admission, she was in a mild coma (Glasgow score: 9), had a fever of 38.5 °C, and had hyperglycemia (6 g/dL). The tests revealed severe DKA, hypertriglyceridemia, hyperamylasemia, and hyperlipasemia as well as malaria parasite density. The computed tomography scan confirmed acute stage E pancreatitis. The diagnosis was that of inaugural ketoacidosis of type 1 diabetes unbalanced by pancreatitis and malaria. Treatment included insulin therapy, rehydration, and antimalarial and analgesic treatment. After 10 days, the outcome was favorable with a normalization of the blood sugar, and an endocrine follow-up was recommend.</p><p><strong>Conclusion: </strong>Rapid and multidisciplinary management of DKA, pancreatitis, and malaria led to a favorable and stable prognosis.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 23","pages":"106321"},"PeriodicalIF":1.0,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractory ventricular fibrillation caused by coronary insufficiency after Bentall procedure: A case report.","authors":"Min Zhu, Miao-Miao Tang, Rong-Hua Zhou","doi":"10.12998/wjcc.v13.i23.106886","DOIUrl":"10.12998/wjcc.v13.i23.106886","url":null,"abstract":"<p><strong>Background: </strong>In open heart surgery requiring cardiopulmonary bypass (CPB), ventricular fibrillation (VF) is common, but refractory recurrent VF is uncommon but perilous.</p><p><strong>Case summary: </strong>This article reports a 58-year-old male patient with an ascending aortic aneurysm who presented for a Bentall procedure and subsequently experienced multiple occurrences of unexplained VF after weaning from CPB. The recurrent episodes of VF in this case were felt to be related to coronary insufficiency after reconstruction of the aortic root. Coronary artery bypass grafting (CABG) of the proximal right coronary artery and the left anterior descending artery successfully resolved VF. Finally, this patient was safely transferred to the postoperative intensive care unit, and was discharged successfully after subsequent supportive treatment.</p><p><strong>Conclusion: </strong>In aortic root replacement, coronary insufficiency is a potential cause of VF episodes and should be considered in the differential diagnosis. CABG is the sole effective treatment for VF caused by coronary insufficiency.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 23","pages":"106886"},"PeriodicalIF":1.0,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and reliability of the Thai \"Rome IV diagnostic questionnaires\" for functional gastrointestinal disorders in neonates and toddlers.","authors":"Kanticha Chatpermporn, Yuda Chongpison, Thitima Ngoenmak, Suporn Treepongkaruna, Palittiya Sintusek","doi":"10.12998/wjcc.v13.i23.105022","DOIUrl":"10.12998/wjcc.v13.i23.105022","url":null,"abstract":"<p><strong>Background: </strong>The Rome Foundation's questionnaires, including the latest version, Rome IV diagnostic criteria since 2016, are widely used globally for diagnosing functional gastrointestinal disorders (FGIDs). However, a tailored Thai version for diagnosing FGIDs in neonates and toddlers is yet to be developed.</p><p><strong>Aim: </strong>To develop and validate the Thai version of the Rome IV diagnostic questionnaire for FGIDs in neonates and toddlers.</p><p><strong>Methods: </strong>This study was conducted at a tertiary hospital in Bangkok. The Rome IV diagnostic questionnaire for neonates and toddlers was translated into Thai following Rome Foundation guidelines. Validity was assessed using item-objective congruence. The final version was administered to 65 caregivers of children under 4 years. Reliability was evaluated using Cronbach's alpha and intraclass correlation coefficient based on test-retest responses collected over a 4-15 day interval.</p><p><strong>Results: </strong>A total of 58 complete questionnaires were returned. The median interval between the first and second time was 7 days (range: 4 days to 15 days). The item-objective congruence index for the Thai-adapted Rome IV diagnostic questionnaire was 0.74. Internal consistency, as indicated by Cronbach's alpha, was 0.753, 0.712, and 0.750 for the three respective sections. The intraclass correlation coefficients for test-retest reliability were 0.782, 0.782, and 0.807.</p><p><strong>Conclusion: </strong>The Thai Rome IV diagnostic questionnaire for FGIDs in neonates and toddlers demonstrates acceptable validity and reliability, supporting its use in future clinical and research applications.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 23","pages":"105022"},"PeriodicalIF":1.0,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring macrophage polarization as a prognostic indicator for colorectal cancer: Unveiling the impact of metalloproteinase mutations.","authors":"Eduardo Brambilla, Daniel Jun Funatsu Brambilla, Aline Caldart Tregnago, Floriano Riva, Fabio Firmbach Pasqualotto, Jonathan Soldera","doi":"10.12998/wjcc.v13.i23.105011","DOIUrl":"10.12998/wjcc.v13.i23.105011","url":null,"abstract":"<p><strong>Background: </strong>Macrophages play a crucial role in the tumor microenvironment, displaying remarkable plasticity that allows them to either suppress or promote tumor progression. Their polarization into M1 or M2 phenotypes could have significant prognostic implications, and manipulating this polarization may offer a novel approach to controlling colorectal neoplasms.</p><p><strong>Aim: </strong>To evaluate the infiltration rates of M1 and M2 macrophages in colorectal neoplasia, specifically comparing cases with and without metalloproteinase mutations. Additionally, it sought to explore potential prognostic factors associated with the disease.</p><p><strong>Methods: </strong>The study involved two cohorts of patients diagnosed with colorectal neoplasia: 33 patients with metalloproteinase mutations and 33 without. Macrophage quantity and polarization were assessed using markers indicative of M1 (iNOS) and M2 (CD163, CD206) macrophages. Prognostic factors and survival outcomes related to colorectal cancer (CRC) were also analyzed.</p><p><strong>Results: </strong>Among the 61 patients, 28 (45.9%) exhibited metalloproteinase mutations, while 33 (54.1%) did not. Tumor staging revealed that 16.9% were in stage I, 34.2% in stage II, 42.4% in stage III, and 8.5% in stage IV. The study recorded 12 patient deaths (19.7%), with 21.2% from the control group and 17.9% from the mutation group. M2 macrophages, identified by CD163 and CD206 markers, had mean counts of 23 and 17, respectively, with standard deviations of 21 and 17. In contrast, M1 macrophages, identified by iNOS, had a mean count of five per site, with a standard deviation of 11.</p><p><strong>Conclusion: </strong>The study found no statistically significant differences in macrophage density between groups, irrespective of metalloproteinase mutation status, age, gender, tumor region, staging, TILS, tumor recurrence, or clinical outcomes. No association was observed between macrophage polarization and CRC prognosis or survival. However, patients with metalloproteinase mutations demonstrated a better survival rate, suggesting a potential protective role of this mutation in colorectal neoplasia.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 23","pages":"105011"},"PeriodicalIF":1.0,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver function improvement after human placental extract injections in patients with chronic liver disease: Thirty case reports.","authors":"Seung-Won Lee","doi":"10.12998/wjcc.v13.i23.102937","DOIUrl":"10.12998/wjcc.v13.i23.102937","url":null,"abstract":"<p><strong>Background: </strong>This case report describes a protocol developed by Danaun Medical Clinic for the introduction of a pioneering intervention comprising intravenous human placental extract (HPE) therapy to improve the liver function of patients with chronic liver disease (CLD).</p><p><strong>Case summary: </strong>This study involved data from patients whose chief complaint was reduced quality of life attributable to CLD. The new treatment approach resulted in improvements in the liver function and fatty liver of 30 patients with CLD. Improvements were observed using abdominal ultrasonography. Unlike traditional methods, this protocol provided more sustainable and meaningful results. Treatment with 10 mL of HPE administered intravenously once or twice per week significantly improved liver function. The observed improvements in fatty liver and liver function suggest the utility of this approach for the management of patients with CLD.</p><p><strong>Conclusion: </strong>This case series highlights the potential of innovative treatments for patients with CLD that could improve the quality of life of the patients.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 23","pages":"102937"},"PeriodicalIF":1.0,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Off-label use of treprostinil in adult patients in clinical cases.","authors":"Christina Mouratidou, Efstathios T Pavlidis, Georgios Katsanos, Serafeim-Chrysovalantis Kotoulas, Georgios Tsoulfas, Eleni Mouloudi, Ioannis A Taitzoglou, Ioannis N Galanis, Theodoros E Pavlidis","doi":"10.12998/wjcc.v13.i23.107279","DOIUrl":"10.12998/wjcc.v13.i23.107279","url":null,"abstract":"<p><p>Treprostinil is a relatively new tricyclic prostacyclin analog with a stable structure, extended half-life and improved potency. Currently, treprostinil is indicated by the Food and Drug Administration in the United States for the treatment of pulmonary arterial hypertension (group 1 in the pulmonary hypertension classification of the World Health Organization). It has a potent vasodilating effect along with the inhibition of platelet aggregation and the attenuation of the inflammatory response in pulmonary and systemic circulation. It is available in the following formulations: Subcutaneous, intravenous, inhaled and oral. Although unknown to many clinicians, several encouraging reports of off-label treprostinil use in the adult population suggest its potential effectiveness in other clinical conditions. Currently under investigation are digital ischemia secondary to systemic sclerosis, chronic limb ischemia, hepatic ischemia-reperfusion injury and group 3 and 4 pulmonary hypertension. Based on review and analysis of the available literature, this article provides a thorough update on the off-label use of treprostinil in adult patients.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 23","pages":"107279"},"PeriodicalIF":1.0,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demanding sleeve gastrectomy procedure in a patient with severe intraabdominal adhesions: A case report and review of the literature.","authors":"Egemen Cicek, Yahya Kaan Karatepe, Tarık Recep Kantarcı, Tevfik Tolga Sahin","doi":"10.12998/wjcc.v13.i23.104807","DOIUrl":"10.12998/wjcc.v13.i23.104807","url":null,"abstract":"<p><strong>Background: </strong>Severe intraabdominal adhesions and ventral hernias pose significant technical challenges in bariatric surgery, especially in patients with a history of complex abdominal procedures.</p><p><strong>Case summary: </strong>This report describes a case involving a 30-year-old morbidly obese man who previously underwent a right lobe hepatectomy for living donor liver transplantation. The patient presented with a body mass index of 40.7 kg/m² and a giant incisional hernia, compounded by extensive intraabdominal adhesions from multiple previous surgeries. A laparoscopic sleeve gastrectomy was performed as the initial step of a staged surgical plan. Adhesiolysis was conducted carefully to address the dense intraabdominal adhesions, and the procedure was completed successfully using standard stapling techniques. Postoperative recovery was smooth, with significant weight loss achieved within the first month.</p><p><strong>Conclusion: </strong>This case highlights the need for personalized surgical planning and precise techniques in bariatric surgery for patients with past abdominal operations.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 23","pages":"104807"},"PeriodicalIF":1.0,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acinar cystic transformation of the pancreas: A rare case report.","authors":"Xiao-Ying Zhong, Zi-Jian Liang, Meng-Long Lan, Xiao-Gang Xu, Li Yuan, Ji-Xiao Zeng","doi":"10.12998/wjcc.v13.i23.107096","DOIUrl":"10.12998/wjcc.v13.i23.107096","url":null,"abstract":"<p><strong>Background: </strong>Acinar cystic transformation (ACT) of the pancreas is a rare non-neoplastic transformation of the pancreas. Adult women are the majority of patients with ACT, but few cases have been reported in pediatric patients. Given that there are currently no guidelines for the treatment of ACT, current treatment is based primarily on expert opinions and clinical experiences. Here, we report the case of the youngest child with ACT to date. Additionally, a literature review on pediatric ACT cases was performed to summarize previous clinical experience and treatment methods.</p><p><strong>Case summary: </strong>A 1-year-old Chinese girl presented with progressive abdominal distension for 6 months. A detailed consultation revealed an uneventful history. The patient showed no signs of fever or abdominal pain and had a good appetite and normal feces. A mass of about 20 cm × 10 cm × 10 cm in size was detected in the abdomen. Both abdominal ultrasound and computed tomography examination revealed a multilocular cystic mass about 21.7 cm × 16.8 cm × 8.9 cm in size. At first, due to the large size and the possible retroperitoneal origin of the cyst, a total resection of the lesion was not possible. A single-port laparoscopic lymphangioma puncture and Pingyangmycin injection were performed in March 2023. One month after surgery, the abdominal cyst rapidly enlarged to its pre-operative size. After consulting with the experts in the angiology department and interventional department, sclerotherapy combined with oral sirolimus was performed in May 2023. After confirming that the tumor was not sensitive to sclerotherapy combined with oral sirolimus, our surgical team performed tumor reduction in August 2023. This surgery confirmed that the polycystic mass originated from the head of the pancreas, and pathological and immunohistochemical findings diagnosed pancreatic ACT. The patient showed no signs of cyst lesions after 6 months of follow-up and remains in good health up to the time of this report.</p><p><strong>Conclusion: </strong>ACT is a rare non-neoplastic transformation of the pancreas, more rarely seen in children. Manifestation and examinations show no specificity for diagnosis, and final diagnosis is mainly based on histological findings. To reach a specific diagnosis and rule out malignancy is a priority in clinical practice, and repeated biopsy or radical surgery should be considered before malignancy is ruled out. However, once a diagnosis of ACT is made, a conservative treatment with consecutive follow-up is recommended until symptoms present or obvious enlargement occurs because ACT is considered a slow-growing and benign tumor.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 23","pages":"107096"},"PeriodicalIF":1.0,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrograde approach of Angiojet catheter for the acute occlusion of aortoiliac artery stent: A case report.","authors":"Sungsin Cho, Jin-Hyun Joh","doi":"10.12998/wjcc.v13.i23.105671","DOIUrl":"10.12998/wjcc.v13.i23.105671","url":null,"abstract":"<p><strong>Background: </strong>Aortoiliac artery stenting has been accepted as the preferred option for the treatment of aortoiliac artery disease because of lower morbidity and mortality compared with bypass surgery. However, acute stent occlusion is a troublesome complication due to the need for open surgery or the risk of distal embolization. Herein, we reported a novel approach to treat the acute thrombotic occlusion of an aortoiliac stent using both hemolytic and conventional mechanical thrombectomy coupled with a large diameter sheath.</p><p><strong>Case summary: </strong>A 64-year-old male patient presented with severe claudication of the right leg. The patient's history included multiple prior interventions for aortoiliac lesions. The preoperative computed tomography (CT) imaging showed a thrombotic occlusion of right aortoiliac stenting. An Angiojet Omni thrombectomy catheter (Boston Scientific, Marlborough, MA, United States) was used to remove the thrombus in a retrograde fashion after the successful placement of the large-diameter sheath in the right common femoral artery for prevention of distal embolization. The remnant organized thrombus was removed with an over-the-wire Fogarty catheter (Edwards Lifesciences, Irvine, CA, United States). Completion angiogram and postoperative CT imaging demonstrated complete removal of thrombus and no evidence of distal embolization.</p><p><strong>Conclusion: </strong>This novel approach provides successful management of acute thrombotic occlusion of aortoiliac stent without distal embolization.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 23","pages":"105671"},"PeriodicalIF":1.0,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ulcerated benign jejunal gastrointestinal stromal tumor causing gastrointestinal bleeding: A case report.","authors":"Rick Maity, Roger B Rathna, Arkadeep Dhali, Nathaniel Fernandes, Jyotirmoy Biswas, Gurpreet S Kapoor, Gopal K Dhali","doi":"10.12998/wjcc.v13.i23.106140","DOIUrl":"10.12998/wjcc.v13.i23.106140","url":null,"abstract":"<p><strong>Background: </strong>Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors that rarely present with gastrointestinal (GI) bleeding due to tumor erosion. GISTs commonly arise in the stomach, followed by the small bowel. They are typically diagnosed through histopathology and immunohistochemistry. The presence of mucosal ulceration and tumor locations outside the stomach are linked with a greater risk of tumor progression to malignancy. This case highlights a benign ulcerated jejunal GIST presenting as GI bleeding.</p><p><strong>Case summary: </strong>A 42-year-old male presented with dark stools and light-headedness over five days. On examination, he was hypotensive, tachycardic, tachypneic, and had pallor. Laboratory tests revealed normocytic normochromic anemia, with a significant one-day drop in hemoglobin (from 7.2 g/dL to 6.4 g/dL). Upper GI endoscopy and colonoscopy were normal, but double-balloon enteroscopy revealed a subepithelial lesion distal to the duodenojejunal flexure, and an overlying ulcer. These findings were suggestive of GIST and were corroborated by a contract-enhanced computed tomography abdomen scan, which revealed a well-defined, homogenously-enhancing solid exophytic lesion (30 mm × 22 mm × 26 mm) arising from the proximal jejunal loops. He underwent resection anastomosis with complete <i>en-bloc</i> surgical removal of the lesion. Histopathological analysis of the resected specimen confirmed a GIST with presence of spindle cells and positive CD117 staining. His hemoglobin levels were stable on regular follow-ups, and there was no documented recurrence six months later.</p><p><strong>Conclusion: </strong>GISTs should be suspected in cases of unexplained GI bleeding. Early diagnosis and complete surgical resection are key to favorable outcomes.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 23","pages":"106140"},"PeriodicalIF":1.0,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}