{"title":"Journey to diagnosis: An unfinished exploration of IgG4-related sclerosing cholangitis.","authors":"Ming-Xing Liang, Ya Chen, Ya He, Yi-Huai He","doi":"10.12998/wjcc.v12.i33.6608","DOIUrl":"10.12998/wjcc.v12.i33.6608","url":null,"abstract":"<p><p>IgG4-related sclerosing cholangitis (IgG4-SC) is an inflammatory disease that leads to bile duct stricture, characterized by the infiltration of IgG4-positive plasma cells into the bile duct wall, thickening of the bile duct wall, and narrowing of the lumen. The differential diagnosis of IgG4-SC mainly includes primary sclerosing cholangitis, cholangiocarcinoma, and pancreatic cancer. IgG4-SC is often associated with autoimmune pancreatitis and can be accurately diagnosed based on clinical diagnostic criteria. However, isolated IgG4-SC is difficult to distinguish from biliary tumors. Given the significant differences in biological behavior, treatment, and prognosis between these diseases, accurately identifying isolated IgG4-SC has very important clinical significance.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"12 33","pages":"6608-6612"},"PeriodicalIF":1.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Flexner's legacy and the future of medical education: Embracing challenge and opportunity.","authors":"Quzhen Zeren, Yan Zeng, Jun-Wen Zhang, Jian Yang","doi":"10.12998/wjcc.v12.i33.6650","DOIUrl":"10.12998/wjcc.v12.i33.6650","url":null,"abstract":"<p><p>This editorial comments on the article by Alzerwi. We focus on the development course, present challenges, and future perspectives of medical education. Modern medical education is gradually undergoing significant and profound changes worldwide. The emergence of new ideas, methodologies, and techniques has created opportunities for medical education developments and brought new concerns and challenges, ultimately promoting virtuous progress in medical education reform. The sustainable development of medical education needs joint efforts and support from governments, medical colleges, hospitals, researchers, administrators, and educators.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"12 33","pages":"6650-6654"},"PeriodicalIF":1.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Secondary diabetes due to different etiologies: A problem worthy of attention.","authors":"Zhao Wei, Xue-Jian Wang","doi":"10.12998/wjcc.v12.i33.6647","DOIUrl":"10.12998/wjcc.v12.i33.6647","url":null,"abstract":"<p><p>There are many factors in the occurrence of diabetes, which can result in insufficient insulin secretion and insulin receptor resistance. Including pituitary tumors, can also lead to the occurrence of diabetes, if the primary disease can not be well controlled in time, such secondary diabetes control is more difficult. In the process of clinical diagnosis and treatment, these factors need to be taken into account, timely detection and treatment of primary diseases, so as to reduce the possibility of clinical missed diagnosis.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"12 33","pages":"6647-6649"},"PeriodicalIF":1.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prothrombotic state and thrombotic events in COVID-19 pandemic period, including portal vein and splenic artery thromboses.","authors":"Ozgur Karcioglu, Canan Akman, Göksu Afacan Ozturk","doi":"10.12998/wjcc.v12.i33.6595","DOIUrl":"10.12998/wjcc.v12.i33.6595","url":null,"abstract":"<p><p>This editorial article is intended to perform a discussion on the manuscript entitled \"Simultaneous portal vein thrombosis and splenic vein thrombosis in a COVID-19 patient: A case report and review of literature\" written by Abramowitz <i>et al</i>. The article focuses on the diagnostic processes in a 77-year-old-male patient with a simultaneous portal vein and splenic artery thrombosis accompanying coronavirus disease 2019 (COVID-19). The authors postulated that splanchnic thrombosis should be on the list of differential diagnoses in a patient presenting with abdominal pain in presence of a COVID-19 infection. The tendency for venous and arterial thrombosis in COVID-19 patients is encountered, largely attributed to hypercoagulopathy. In general, venous thromboembolism mostly manifest as deep vein thrombosis (DVT), pulmonary embolism (PE) or catheter-related thromboembolic events. Acute PE, DVT, cerebrovascular events and myocardial infarction are seen as the most common thromboembolic complications in COVID-19 patients. COVID-19-associated hemostatic abnormalities include mild thrombocytopenia and increased D-dimer level. Similar to other coagulopathies, the treatment of the underlying condition is the mainstay. Addition of antiplatelet agents can be considered in critically ill patients at low bleeding risk, not on therapeutic anticoagulation, and receiving gastric acid suppression Early administration of antithrombotic drugs will have a beneficial effect in both the prevention and treatment of thrombotic events, especially in non-ambulatory patients. Low molecular weight heparin (LMWH) should be started if there is no contraindication, including in non-critical patients who are at risk of hospitalization LMWH (enoxaparin) is preferred to standard heparin.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"12 33","pages":"6595-6603"},"PeriodicalIF":1.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Targeting nuclear factor erythroid 2-related factor 2-regulated ferroptosis to treat nervous system diseases.","authors":"Ye-Qi Huang, Zheng-Wei Huang, Xue-Juan Zhang","doi":"10.12998/wjcc.v12.i33.6655","DOIUrl":"10.12998/wjcc.v12.i33.6655","url":null,"abstract":"<p><p>By critically examining the work, we conducted a comprehensive bibliometric analysis on the role of nuclear factor erythroid 2-related factor 2 (NRF2) in nervous system diseases. We also proposed suggestions for future bibliometric studies, including the integration of multiple websites, analytical tools, and analytical approaches, The findings presented provide compelling evidence that ferroptosis is closely associated with the therapeutic challenges of nervous system diseases. Targeted modulation of NRF2 to regulate ferroptosis holds substantial potential for effectively treating these diseases. Future NRF2-related research should not only focus on discovering new drugs but also on designing rational drug delivery systems. In particular, nanocarriers offer substantial potential for facilitating the clinical translation of NRF2 research and addressing existing issues related to NRF2-related drugs.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"12 33","pages":"6655-6659"},"PeriodicalIF":1.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advancements and challenges in gastrointestinal imaging.","authors":"Eun Jeong Gong, Chang Seok Bang","doi":"10.12998/wjcc.v12.i33.6591","DOIUrl":"10.12998/wjcc.v12.i33.6591","url":null,"abstract":"<p><p>A recent review by Gulinac <i>et al</i>, provides an in-depth analysis of current clinical issues and challenges in gastrointestinal imaging. This editorial highlights the advancements in imaging techniques, including the integration of artificial intelligence and functional imaging modalities, and discusses the ongoing relevance of traditional nuclear medicine tests. The future of gastrointestinal imaging looks promising, with continuous improvements in resolution, enhanced ability to analyze color and texture beyond visual diagnosis, faster image processing, and the application of molecular imaging and nanoparticles expected to enhance diagnostic accuracy and clinical outcomes.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"12 33","pages":"6591-6594"},"PeriodicalIF":1.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Current evidence on artificial intelligence in regional anesthesia.","authors":"Bhanu Pratap Swain, Deb Sanjay Nag, Rishi Anand, Himanshu Kumar, Pradip Kumar Ganguly, Niharika Singh","doi":"10.12998/wjcc.v12.i33.6613","DOIUrl":"10.12998/wjcc.v12.i33.6613","url":null,"abstract":"<p><p>The recent advancement in regional anesthesia (RA) has been largely attributed to ultrasound technology. However, the safety and efficiency of ultrasound-guided nerve blocks depend upon the skill and experience of the performer. Even with adequate training, experience, and knowledge, human-related limitations such as fatigue, failure to recognize the correct anatomical structure, and unintentional needle or probe movement can hinder the overall effectiveness of RA. The amalgamation of artificial intelligence (AI) to RA practice has promised to override these human limitations. Machine learning, an integral part of AI can improve its performance through continuous learning and experience, like the human brain. It enables computers to recognize images and patterns specifically useful in anatomic structure identification during the performance of RA. AI can provide real-time guidance to clinicians by highlighting important anatomical structures on ultrasound images, and it can also assist in needle tracking and accurate deposition of local anesthetics. The future of RA with AI integration appears promising, yet obstacles such as device malfunction, data privacy, regulatory barriers, and cost concerns can deter its clinical implementation. The current mini review deliberates the current application, future direction, and barrier to the application of AI in RA practice.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"12 33","pages":"6613-6619"},"PeriodicalIF":1.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dan-Xiang Shen, Yu-Wei Wang, Zhi-Min Lin, Di Jin, Zhen-Hua Ying, Chen Li
{"title":"Early screening to identify and diagnose primary nasal tuberculosis in patients with tumor necrosis factor inhibitors.","authors":"Dan-Xiang Shen, Yu-Wei Wang, Zhi-Min Lin, Di Jin, Zhen-Hua Ying, Chen Li","doi":"10.12998/wjcc.v12.i33.6604","DOIUrl":"10.12998/wjcc.v12.i33.6604","url":null,"abstract":"<p><p>In this editorial, we comment on the article by Liu <i>et al</i>. Based on our analysis of a case report, we consider that early screening and recognition of primary nasal tuberculosis are crucial for patients undergoing treatment with tumor necrosis factor inhibitor (TNFi). While TNFi therapy increases the risk of reactivating latent tuberculosis, primary nasal tuberculosis remains rare due to the protective mechanisms of the nasal mucosa. Risk factors for primary nasal tuberculosis include minimally invasive nasal surgery, diabetes, and human immunodeficiency virus. Patients with early symptoms such as nasal congestion, rhinorrhea, altered olfaction, epistaxis, or ulceration, and unresponsive to conventional antibiotics and antihistamines should undergo early rhinoscopy, possibly followed by repeated tissue biopsies and acid-fast bacilli culture when necessary. When diagnosis is challenging, it is essential to consider local tuberculosis epidemiology and the efficacy of diagnostic anti-tuberculosis treatment. The preferred method for tuberculosis screening is the Interferon Gamma Release Assay, with a general recommendation for screening at 3 and 6 months after initial treatment and then every six months. However, the optimal frequency is not yet consensus-driven and may be increased in economically viable settings.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"12 33","pages":"6604-6607"},"PeriodicalIF":1.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Dimova, Martin Boroš, Stefan Dimov, Janja Konjevod, Maja Svetec
{"title":"Platelet-rich plasma treatment for chronic wounds: A case report and literature review.","authors":"Ana Dimova, Martin Boroš, Stefan Dimov, Janja Konjevod, Maja Svetec","doi":"10.12998/wjcc.v12.i33.6635","DOIUrl":"10.12998/wjcc.v12.i33.6635","url":null,"abstract":"<p><strong>Background: </strong>Wound healing is a complicated process that can be heavily influenced by patient comorbidities, in some cases leading to a chronic non-healing wound. Evidence presented in the medical literature supporting the clinical use of autologous platelet-rich plasma (PRP) in treatment of such wounds is becoming increasingly compelling. Mechanisms involved include complex interactions between the patient's thrombocytes, cytokines, and growth factors.</p><p><strong>Case summary: </strong>We present a case of a 72-year-old male patient with a long-standing chronic wound and multiple comorbidities. Over the course of more than 7 months, the patient was unsuccessfully treated with all routinely used measures, including different dressing approaches. Multiple antibiotic regimens were administered for wound infection, with repeated evaluation of microbiological swab results. Finally, after three PRP applications, the wound showed clinical improvement with complete restitution of the epithelial layer of the skin.</p><p><strong>Conclusion: </strong>PRP treatment may be beneficial to reduce healing time in chronic wounds.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"12 33","pages":"6635-6643"},"PeriodicalIF":1.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tricuspid mass-curious case of Li-Fraumeni syndrome: A letter to the editor.","authors":"Mohammad S Al-Haggar, Zahraa A Abdelmoneim","doi":"10.12998/wjcc.v12.i33.6644","DOIUrl":"10.12998/wjcc.v12.i33.6644","url":null,"abstract":"<p><p>We focus specifically on the rare occurrence of cardiac thrombi in Li-Fraumeni syndrome (LFS). LFS is a hereditary risk to a diverse range of specific, uncommon, malignancies. Children and young adults have a heightened susceptibility to many malignancies, particularly soft-tissue and bone tumors, breast malignancies, central nervous system malignancies, adrenocortical carcinoma, and blood cancers. Additionally, LFS patients may experience other cancer types such as gastrointestinal, lung, kidney, thyroid, and skin cancers, along with those affecting gonadal organs (ovaries, testicles, and prostate). An accurate diagnosis of LFS is crucial to enable affected families to access appropriate genetic counseling and undergo surveillance for early cancer detection.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"12 33","pages":"6644-6646"},"PeriodicalIF":1.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}