{"title":"Chronic hepatitis B triggering antineutrophil cytoplasmic antibody-associated vasculitis complicated by glomerulonephritis: A case report.","authors":"Ming-Ru Li, Li-Ya Li, Juan Tang, Jian Sun","doi":"10.12998/wjcc.v13.i19.102212","DOIUrl":"10.12998/wjcc.v13.i19.102212","url":null,"abstract":"<p><strong>Background: </strong>Hepatitis B virus (HBV) infection can lead to renal involvement, commonly manifested as HBV-associated glomerulonephritis (HBV-GN), which typically presents as nephrotic or nephritic syndrome. Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a systemic disease characterized by immune necrotizing inflammation of small blood vessels involving multiple organs with complex and severe clinical implications. The coexistence of HBV-GN and AAV is sporadic, with limited data existing regarding its diagnosis, management, clinical outcomes, and prognosis, especially in patients with AAV.</p><p><strong>Case summary: </strong>This manuscript presents the case of an older male patient who presented with persistent foamy urine lasting over two weeks. Initial clinical findings included nephrotic syndrome and renal insufficiency, which subsequently progressed to involve the lungs, immune system, hematologic system, and other organ systems. The patient was diagnosed with HBV-GN complicated by AAV, a rare and complex condition. Despite receiving comprehensive treatment, including corticosteroids, cyclophosphamide for immune regulation, plasma exchange, and immunoadsorption targeting antineutrophil cytoplasmic antibody-associated antibodies, the patient required long-term dialysis and demonstrated a poor prognosis.</p><p><strong>Conclusion: </strong>HBV infection may trigger nephropathy with AAV. Early recognition and intervention are crucial for improving patient prognosis.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 19","pages":"102212"},"PeriodicalIF":1.0,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Necessity of collaboration between pain physicians and orthotists in pain medicine.","authors":"Jin-Bok Yi, Min Cheol Chang","doi":"10.12998/wjcc.v13.i19.104976","DOIUrl":"10.12998/wjcc.v13.i19.104976","url":null,"abstract":"<p><p>In this editorial, we comment on the article by Nagamine <i>et al</i>, published in the <i>World Journal of Clinical Cases</i>. The authors suggest that virtual reality technology has potential in alleviating pain by enhancing brain network functionality. Alongside virtual reality, various treatment methods are used to effectively manage musculoskeletal pain. One such method is the use of orthoses, which are applied in clinical settings. We emphasize the need for collaboration between pain physicians and orthotists when applying orthoses for pain management. The efficacy of orthoses is maximized when customized to the physical characteristics of each patient, type of disease, and location of pain. Orthoses are designed to restore anatomical alignment and biomechanical function; however, their success depends on the expertise of trained orthotists, who should effectively communicate with physicians and understand the mechanical principles of musculoskeletal alignment. The professional knowledge of orthotists is critical in ensuring that orthoses are appropriately designed and applied to achieve therapeutic efficacy. Since no single treatment modality typically offers sufficient relief for musculoskeletal pain, effective collaboration between pain physicians and orthotists is crucial to optimize the use of orthoses in the management of pain.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 19","pages":"104976"},"PeriodicalIF":1.0,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Delayed diagnosis of pulmonary tuberculosis with pleuritis due to ampicillin/sulbactam: A case report.","authors":"Munechika Hara, Toshitsugu Yashiro, Yasuaki Yashiro","doi":"10.12998/wjcc.v13.i19.104083","DOIUrl":"10.12998/wjcc.v13.i19.104083","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis (TB) remains a global health concern despite decreasing incidence. Delayed TB diagnosis can exacerbate patient outcomes and lead to broader public health issues such as mass infections. Differentiation between TB and bacterial pneumonia is often complicated by variable clinical and radiological manifestations of TB, leading to diagnostic delays.</p><p><strong>Case summary: </strong>An 89-year-old, Japanese male patient with a history of diabetes mellitus, hypertension, and hypothyroidism presented with right-sided chest pain. Based on the elevated inflammatory response, right pleural effusion, and infiltrating shadow in the lung field, the diagnosis of right pleurisy was made and the antibiotic, ampicillin/sulbactam, was administered. The patient's condition, inflammatory reaction, and right pleural effusion temporarily improved. However, persistent low-grade fever and malaise prompted further evaluation, revealing repeated right pleural effusion and inflammatory response. A right thoracentesis was performed; the patient was diagnosed with tuberculous pleurisy as a result of exudative effusion with lymphocyte predominance, elevated adenosine deaminase levels, and positive <i>Mycobacterium TB</i> polymerase chain reaction test. Anti-TB treatment, including isoniazid, rifampicin, and ethambutol was initiated, leading to significant clinical improvement. The patient successfully completed a 12-month course of TB therapy without recurrence or deterioration.</p><p><strong>Conclusion: </strong>There are cases of TB wherein temporary improvement apparently could be shown through treatment with antimicrobial agents other than anti-TB drugs, necessitating careful evaluation in atypical cases of bacterial pneumonia.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 19","pages":"104083"},"PeriodicalIF":1.0,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unusual foreign body in the buccal mucosa: A case report.","authors":"Ashwag Yagoub Aloyouny, Hamad Nasser Albagieh, Randa Aleyoni, Ghadah Jammali, Khawlah Alhuzali","doi":"10.12998/wjcc.v13.i19.103844","DOIUrl":"10.12998/wjcc.v13.i19.103844","url":null,"abstract":"<p><strong>Background: </strong>Intraoral honeybee stings are very rare. Stings by these insects occur 25% of the time in the head and neck region. In addition, a stinger intraorally can lead to persistent irritation, inflammation, and secondary infections if not promptly excised.</p><p><strong>Case summary: </strong>We report the case of a 52-year-old female patient who was stung in her mouth by a honeybee, causing a local irritation. The patient presented with a one-month history of pain, swelling, and redness in the left buccal mucosa. Inadvertently retained, the stinger was discovered during a clinical evaluation following initial treatment for facial swelling and erythema. After the stinger was removed, the patient's symptoms resolved without complications.</p><p><strong>Conclusion: </strong>This case emphasizes the importance of thorough examination and prompt management of insect stings to prevent prolonged discomfort and potential complications.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 19","pages":"103844"},"PeriodicalIF":1.0,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Treatment of immunoglobulin A nephropathy: Current perspective and future prospects.","authors":"Yusuf Ziya Şener, Seher Şener","doi":"10.12998/wjcc.v13.i19.101196","DOIUrl":"10.12998/wjcc.v13.i19.101196","url":null,"abstract":"<p><p>Immunoglobulin (Ig) A nephropathy is the most common type of primary glomerulonephritis globally. It typically manifests with microscopic hematuria and a spectrum of proteinuria, although rapidly progressive glomerulonephritis may occur in rare instances. Deposition of IgA in the mesangium seems to be the underlying disease mechanism. Despite current treatment, IgA nephropathy may progress into end-stage renal disease, indicating the necessity for the development of new therapeutic agents. Lifestyle modifications and anti-proteinuric treatment are recommended, and steroids have shown to be beneficial to high risk groups. Nevertheless, other conventional immunosuppressive agents, such as cyclophosphamide and mycophenolate mofetil, may be considered, despite the lack of sufficient evidence to support their efficacy. A considerable proportion of cases remain unresponsive to these treatments, underscoring the need for novel therapeutic approaches. There are several promising immunosuppressive drugs, such as B-cell lineage depleting agents or complement system inhibitors, that are currently undergoing clinical trials. These therapies may be considered for use in selected cases.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 19","pages":"101196"},"PeriodicalIF":1.0,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Henri Stephan, Hady Rihani, Elie Dagher, Jad El Choueiri
{"title":"Diced cartilage in capsula based on diced cartilage in fascia technique: A case report.","authors":"Henri Stephan, Hady Rihani, Elie Dagher, Jad El Choueiri","doi":"10.12998/wjcc.v13.i19.104400","DOIUrl":"10.12998/wjcc.v13.i19.104400","url":null,"abstract":"<p><strong>Background: </strong>The Turkish Delight technique, initially described by Erol in 2000, involves the use of diced cartilage wrapped in oxidized cellulose (Surgicel™) for nasal grafting in secondary rhinoplasty.</p><p><strong>Case summary: </strong>This paper presents a novel adaptation called Diced Cartilage in Capsula, where diced cartilage is wrapped in the periprosthetic capsule material formed from a previous breast augmentation procedure instead of fascia, a technique based on the Diced Cartilage in Fascia method. Utilizing autologous, biocompatible material minimizes foreign body reactions and enhances graft integration. This innovative approach demonstrates the potential for specific practices in cosmetic surgery by optimizing patient-specific resources and improving surgical outcomes.</p><p><strong>Conclusion: </strong>The report compares traditional Turkish Delight applications with this new method, discussing biocompatibility, technique efficacy, and benefits in rhinoplasty.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 19","pages":"104400"},"PeriodicalIF":1.0,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giovanni Miotti, Davide Quaglia, Luca De Marco, Pier Camillo Parodi, Fabiana D'Esposito, Mutali Musa, Daniele Tognetto, Caterina Gagliano, Marco Zeppieri
{"title":"Surgical management of patients with corneal lesions due to lid pathologies.","authors":"Giovanni Miotti, Davide Quaglia, Luca De Marco, Pier Camillo Parodi, Fabiana D'Esposito, Mutali Musa, Daniele Tognetto, Caterina Gagliano, Marco Zeppieri","doi":"10.12998/wjcc.v13.i19.101889","DOIUrl":"10.12998/wjcc.v13.i19.101889","url":null,"abstract":"<p><strong>Background: </strong>The surgical management of corneal lesions resulting from eyelid pathologies requires a comprehensive approach to ensure optimal patient outcomes. Eyelid lesions, ranging from benign to malignant, can lead to corneal damage through mechanisms such as mechanical abrasion, secondary infection, or inflammatory responses.</p><p><strong>Aim: </strong>To assess the surgical methodologies utilized in the treatment of corneal lesions resulting from eyelid disorders and evaluate their effects on patient outcomes, recurrence rates, and postoperative complications. The incorporation of advanced imaging techniques, including optical coherence tomography and ultrasound biomicroscopy, in conjunction with histopathological analysis, is addressed to improve surgical accuracy and patient outcomes.</p><p><strong>Methods: </strong>The authors searched online databases (PubMed and Cochrane) for publications on the surgical management of lid lesions. Records received from the two databases were checked for duplicates and relevance. Only records with full texts and in English language were included.</p><p><strong>Results: </strong>A total of 28 records were obtained following the screening for relevancy and duplication. The review underscores essential surgical approaches employed in the treatment of corneal lesions resulting from common eyelid diseases, focusing on operative efficacy, complication rates, and long-term results.</p><p><strong>Conclusion: </strong>This systematic review emphasizes the significance of choosing suitable surgical techniques tailored to individual patient characteristics and stresses the need for interdisciplinary collaboration in ophthalmic care. The results indicate that sophisticated imaging techniques and careful preoperative preparation markedly improve surgical accuracy and long-term results.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 19","pages":"101889"},"PeriodicalIF":1.0,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiao-Xiao Yuan, Qiong-Qiong Tan, Chen Chen, Qing-Qing He, Yan-Ning Li
{"title":"Lumbar methicillin-resistant <i>Staphylococcus aureus</i> infection caused by a peripherally inserted central catheter: A case report.","authors":"Xiao-Xiao Yuan, Qiong-Qiong Tan, Chen Chen, Qing-Qing He, Yan-Ning Li","doi":"10.12998/wjcc.v13.i19.104294","DOIUrl":"10.12998/wjcc.v13.i19.104294","url":null,"abstract":"<p><strong>Background: </strong>Peripherally inserted central catheters (PICCs) are widely used for administering chemotherapy to breast cancer patients due to their long-term indwelling capability, versatility in drug administration, and flexibility. PICCs infection are a relatively common occurrence, yet there were no reported instances that it can metastasise to the lumbar spine.</p><p><strong>Case summary: </strong>This case report describes a breast cancer patient who developed a methicillin-resistant Staphylococcus aureus lumbar vertebral infection secondary to a PICC-related infection during chemotherapy. Following PICC removal, bacterial culture confirmed the presence of highly virulent methicillin-resistant Staphylococcus aureus. The patient presented with fever and severe lumbar pain. Lumbar magnetic resonance imaging revealed paraspinal muscle edema from L1 to L3 with abnormal signal intensity in the affected regions, suggestive of vertebral osteomyelitis. Prompt initiation of appropriate antibiotic therapy based on the culture results led to significant improvement in the patient's lumbar pain.</p><p><strong>Conclusion: </strong>This case highlights the importance of vigilant infection prevention and control measures to minimize the risk of PICC-related complications, such as bloodstream infections and subsequent metastatic infections.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 19","pages":"104294"},"PeriodicalIF":1.0,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiong Jiang, Hai-Tao Shi, Jie Wu, Su-Mei Sha, Shang-Xuan Cai, Xin Liu
{"title":"Successful treatment of depressed esophageal squamous papilloma with interferon- alpha 2a: A case report.","authors":"Jiong Jiang, Hai-Tao Shi, Jie Wu, Su-Mei Sha, Shang-Xuan Cai, Xin Liu","doi":"10.12998/wjcc.v13.i19.99311","DOIUrl":"10.12998/wjcc.v13.i19.99311","url":null,"abstract":"<p><strong>Background: </strong>Esophageal squamous papilloma (ESP) is a rare benign tumor of the esophagus, typically characterized by an exophytic and warty appearance, with a diameter of less than 5 mm. Endoscopic resection is considered the most effective treatment for these tumors.</p><p><strong>Case summary: </strong>In this paper, we discussed the pathogenesis, clinical characteristics, and therapeutic options of ESP based on our experience with a case presenting a depressed appearance and treated with interferon-alpha 2a (IFNα2a) injection.</p><p><strong>Conclusion: </strong>This paper reports the first successful clinical case of using the human IFNα2a for the treatment of ESP with a depressed endoscopic appearance. However, the efficacy of interferon treatment requires to validation in a large number of subsequent cases.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 19","pages":"99311"},"PeriodicalIF":1.0,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Wernicke encephalopathy presenting as a stroke mimic: A case report.","authors":"Ermir Roçi, Emili Mara, Stela Dodaj, Gentian Vyshka","doi":"10.12998/wjcc.v13.i19.103585","DOIUrl":"10.12998/wjcc.v13.i19.103585","url":null,"abstract":"<p><strong>Background: </strong>Several conditions may present with acute neurological symptoms, thus mimicking the presentation of stroke. Although the underlying disorder can be diagnosed after careful medical, neurological, and radiological examinations, a few conditions, such as Wernicke encephalopathy (WE), may present a particular diagnostic difficulty. WE is a neurological disorder caused by deficiency of thiamine (B1 vitamin), most often resulting from alcoholism, malnutrition, hyperemesis gravidarum or bariatric surgery. The diagnosis of WE in a certain historical, clinical setting is easily suggested, but in a few cases presenting with acute neurological deficits, it can be particularly challenging.</p><p><strong>Case summary: </strong>We present the case of a 63-year-old man who was brought to the emergency department after developing weakness of the left extremities, dizziness and a confusional state, which had lasted for approximately 30 minutes. The patient had a similar episode of a confusional state approximately two months earlier; at that time, a transient ischemic attack was suspected and he was started on aspirin. The initial clinical evaluation and imaging findings were unremarkable for stroke, but the patient's symptoms, history of chronic alcohol abuse and abnormal liver function tests prompted the consideration of WE. Magnetic resonance imaging findings in subthalamic areas and electroencephalogram data of diffuse delta activity supported this diagnosis.</p><p><strong>Conclusion: </strong>Through this case report, we aim to underscore the importance of considering WE as a differential diagnosis in patients presenting with symptoms suggestive of stroke, especially when the presentation is atypical or when risk factors for thiamine deficiency are present. Since intravenous thiamine significantly improves outcomes, delayed recognition and treatment in some cases might be deleterious.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 19","pages":"103585"},"PeriodicalIF":1.0,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}