World Journal of Clinical Cases最新文献

{"title":"Bullous pemphigoid associated with acquired hemophilia A: A case report.","authors":"Su-Ye Hu, Meng-Can Li, Zi-Jia Hao, Xu-Ya Chai, Pei-Sai Li, Yang Liu, Li-Xia Liu, Ying Xu, Pan-Pan Yang, Ling-E Li","doi":"10.12998/wjcc.v13.i4.94294","DOIUrl":"10.12998/wjcc.v13.i4.94294","url":null,"abstract":"<p><strong>Background: </strong>Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disorder caused by circulating autoantibodies against factor VIII (FVIII). In approximately 50% of the patients, the condition is associated with autoimmune diseases, cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid (BP) is a chronic autoimmune subepidermal blistering disease associated with tissue-bound and circulating autoantibodies against BP antigens 180 (BP180) and 230 (BP230). AHA-associated BP has a high mortality rate; hence, the understanding of this disease must improve.</p><p><strong>Case summary: </strong>A 69-year-old man presented with erythema, blisters, blood blisters, and crusts accompanied by severe pruritus for more than 20 days, and ecchymosis and swelling on his left upper arm for 3 days. Pathological examination revealed a subepidermal blister that contained eosinophils. Laboratory tests showed that the BP180 autoantibody levels had increased, isolated activated partial thromboplastin time was notably prolonged (115.6 s), and coagulation FVIII activity was extremely low (< 1.0%). Furthermore, the FVIII inhibitor titer had greatly increased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospital for effective treatment; however, he died after 2 days.</p><p><strong>Conclusion: </strong>AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effective treatment are necessary.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 4","pages":"94294"},"PeriodicalIF":1.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brachioradialis tendon transfer and palmaris longus tendon graft for thumb avulsion: A case report and review of literature.","authors":"Pierre Curings, Sonia Ramos-Pascual, Kinga Michalewska, Nicolas Gibert, Lionel Erhard, Mo Saffarini, Alexis Nogier","doi":"10.12998/wjcc.v13.i4.100651","DOIUrl":"10.12998/wjcc.v13.i4.100651","url":null,"abstract":"<p><strong>Background: </strong>Thumb replantation following complete traumatic avulsion requires complex techniques to restore function, especially in cases of avulsion at the level of the metacarpophalangeal joint (MCP I) and avulsion of the flexor pollicis longus (FPL) at the musculotendinous junction. Possible treatments include direct tendon suture or tendon transfer, most commonly from the ring finger. To optimize function and avoid donor finger complications, we performed thumb replantation with flexion restoration using brachioradialis (BR) tendon transfer with palmaris longus (PL) tendon graft.</p><p><strong>Case summary: </strong>A 20-year-old left-handed male was admitted for a complete traumatic left thumb amputation following an accident while sliding from the top of a handrail. The patient presented with skin and bone avulsion at the MCP I, avulsion of the FPL tendon at the musculotendinous junction (zone 5), avulsion of the extensor pollicis longus tendon (zone T3), and avulsion of the thumb's collateral arteries and nerves. The patient was treated with two stage thumb repair. The first intervention consisted of thumb replantation with MCP I arthrodesis, resection of avulsed FPL tendon and implantation of a silicone tendon prosthesis. The second intervention consisted of PL tendon graft and BR tendon transfer. Follow-up at 10 months showed good outcomes with active interphalangeal flexion of 70°, grip strength of 45 kg, key pinch strength of 15 kg and two-point discrimination threshold of 4 mm.</p><p><strong>Conclusion: </strong>Flexion restoration after complete thumb amputation with FPL avulsion at the musculotendinous junction can be achieved using BR tendon transfer with PL tendon graft.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 4","pages":"100651"},"PeriodicalIF":1.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiomics and molecular analysis: Bridging the gap for predicting hepatocellular carcinoma prognosis.","authors":"Chun-Han Cheng, Wen-Rui Hao, Tzu-Hurng Cheng","doi":"10.12998/wjcc.v13.i4.98550","DOIUrl":"10.12998/wjcc.v13.i4.98550","url":null,"abstract":"<p><p>This editorial examines a recent study that used radiomics based on computed tomography (CT) to predict the expression of the fibroblast-related gene enhancer of zeste homolog 2 (<i>EZH2</i>) and its correlation with the survival of patients with hepatocellular carcinoma (HCC). By integrating radiomics with molecular analysis, the study presented a strategy for accurately predicting the expression of <i>EZH2</i> from CT scans. The findings demonstrated a strong link between the radiomics model, <i>EZH2</i> expression, and patient prognosis. This noninvasive approach provides valuable insights into the therapeutic management of HCC.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 4","pages":"98550"},"PeriodicalIF":1.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful emergency surgical intervention in acute non-ST-segment elevation myocardial infarction with rupture: A case report.","authors":"Xing-Po Li, Zi-Shan Wang, Hong-Xia Yu, Shan-Shan Wang","doi":"10.12998/wjcc.v13.i4.100375","DOIUrl":"10.12998/wjcc.v13.i4.100375","url":null,"abstract":"<p><strong>Background: </strong>The incidence of acute myocardial infarction (AMI) is rising, with cardiac rupture accounting for approximately 2% of deaths in patients with acute ST-segment elevation myocardial infarction (STEMI). Ventricular free wall rupture (FWR) occurs in approximately 2% of AMI patients and is notably rare in patients with non-STEMI. Types of cardiac rupture include left ventricular FWR, ventricular septal rupture, and papillary muscle rupture. The FWR usually leads to acute cardiac tamponade or electromechanical dissociation, where standard resuscitation efforts may not be effective. Ventricular septal rupture and papillary muscle rupture often result in refractory heart failure, with mortality rates over 50%, even with surgical or percutaneous repair options.</p><p><strong>Case summary: </strong>We present a rare case of an acute non-STEMI patient who suffered sudden FWR causing cardiac tamponade and loss of consciousness immediate before undergoing coronary angiography. Prompt resuscitation and emergency open-heart repair along with coronary artery bypass grafting resulted in successful patient recovery.</p><p><strong>Conclusion: </strong>This case emphasizes the risks of AMI complications, shares a successful treatment scenario, and discusses measures to prevent such complications.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 4","pages":"100375"},"PeriodicalIF":1.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating foot reflexology as a proposed treatment for sensorineural hearing loss: A critical review.","authors":"Carina McClean, Brandon Lucke-Wold","doi":"10.12998/wjcc.v13.i4.99500","DOIUrl":"10.12998/wjcc.v13.i4.99500","url":null,"abstract":"<p><p>This editorial critically evaluates the application of foot reflexology as a treatment for sensorineural hearing loss (SNHL) in infants, as proposed in a case report published in the <i>World of Clinical Cases</i>. SNHL is a condition characterized by damage to the cochlea or the neural pathways that transmit auditory information to the brain. The etiology of SNHL is often complex, involving genetic mutations, prenatal factors, or perinatal insults. Reflexology, an alternative therapy involving the application of pressure to specific points on the feet, is based on the hypothesis that these points correspond to different organs and systems in the body, including the auditory system. However, the biological plausibility and clinical efficacy of foot reflexology in addressing SNHL lack empirical support. This editorial examines the pathophysiology of SNHL, assesses the clinical claims of reflexology practitioners, and emphasizes the necessity of evidence-based approaches in treating infant hearing loss. While complementary therapies may provide ancillary benefits, they should not supplant validated medical treatments in managing SNHL in infants. Further research is needed to evaluate the safety and efficacy of foot reflexology and other alternative therapies in pediatric audiology.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 4","pages":"99500"},"PeriodicalIF":1.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imperative for long-term management and surveillance in Kawasaki disease.","authors":"Yan Pan, Fu-Yong Jiao","doi":"10.12998/wjcc.v13.i4.99637","DOIUrl":"10.12998/wjcc.v13.i4.99637","url":null,"abstract":"<p><p>Kawasaki disease (KD) is a significant pediatric vasculitis known for its potential to cause severe coronary artery complications. Despite the effectiveness of initial treatments, such as intravenous immunoglobulin, KD patients can experience long-term cardiovascular issues, as evidenced by a recent case report of an adult who suffered a ST-segment elevation myocardial infarction due to previous KD in the <i>World Journal of Clinical Cases</i>. This editorial emphasizes the critical need for long-term management and regular surveillance to prevent such complications. By drawing on recent research and case studies, we advocate for a structured approach to follow-up care that includes routine cardiac evaluations and preventive measures.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 4","pages":"99637"},"PeriodicalIF":1.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between longitudinal changes in lipid composition and ischemic stroke among hypertensive patients.","authors":"Cheng-Cheng Wei, Yu-Qing Huang, Cheng-Hong Yu","doi":"10.12998/wjcc.v13.i4.95803","DOIUrl":"10.12998/wjcc.v13.i4.95803","url":null,"abstract":"<p><strong>Background: </strong>Dyslipidemia was strongly linked to stroke, however the relationship between dyslipidemia and its components and ischemic stroke remained unexplained.</p><p><strong>Aim: </strong>To investigate the link between longitudinal changes in lipid profiles and dyslipidemia and ischemic stroke in a hypertensive population.</p><p><strong>Methods: </strong>Between 2013 and 2014, 6094 hypertension individuals were included in this, and ischemic stroke cases were documented to the end of 2018. Longitudinal changes of lipid were stratified into four groups: (1) Normal was transformed into normal group; (2) Abnormal was transformed into normal group; (3) Normal was transformed into abnormal group; and (4) Abnormal was transformed into abnormal group. To examine the link between longitudinal changes in dyslipidemia along with its components and the risk of ischemic stroke, we utilized multivariate Cox proportional hazards models with hazard ratio (HR) and 95%CI.</p><p><strong>Results: </strong>The average age of the participants was 62.32 years ± 13.00 years, with 329 women making up 54.0% of the sample. Over the course of a mean follow-up of 4.8 years, 143 ischemic strokes happened. When normal was transformed into normal group was used as a reference, after full adjustments, the HR for dyslipidemia and ischemic stroke among abnormal was transformed into normal group, normal was transformed into abnormal group and abnormal was transformed into abnormal group were 1.089 (95%CI: 0.598-1.982; <i>P</i> = 0.779), 2.369 (95%CI: 1.424-3.941; <i>P</i> < 0.001) and 1.448 (95%CI: 1.002-2.298; <i>P</i> = 0.047) (<i>P</i> for trend was 0.233), respectively.</p><p><strong>Conclusion: </strong>In individuals with hypertension, longitudinal shifts from normal to abnormal in dyslipidemia-particularly in total and low-density lipoprotein cholesterol-were significantly associated with the risk of ischemic stroke.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 4","pages":"95803"},"PeriodicalIF":1.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary parenchymal squamous cell carcinoma of the kidney: A case report.","authors":"Zhi-Hui Zheng, Bo Shao, Chao-Min Xu, Ke Wang, Jia-Zhu Wen, Li-Kang Luo, Jia-Cheng Guan","doi":"10.12998/wjcc.v13.i4.100037","DOIUrl":"10.12998/wjcc.v13.i4.100037","url":null,"abstract":"<p><strong>Background: </strong>Primary squamous cell carcinoma (SCC) of the renal parenchyma is extremely rare, with only nine cases reported.</p><p><strong>Case summary: </strong>This study reports a 51-year-old man with primary SCC of the renal parenchyma. The patient was admitted with recurrent dull pain and discomfort in the right lumbar region, which had worsened over 2 weeks, accompanied by painful gross hematuria. SCC antigen (SCCA) levels were elevated, and imaging revealed a renal mass with associated calculi. The patient underwent laparoscopic unilateral nephrectomy and lymph node dissection. Postoperative pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma, with negative renal pelvis and ureter. The pathological stage was Pt3aN1M0. Four months after surgery, the tumor recurred with involvement of the liver, right psoas major muscle, and inferior vena cava. The patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease progression.</p><p><strong>Conclusion: </strong>We report a case of primary SCC of the renal parenchyma, a rare renal malignancy. The clinical symptoms, laboratory tests, and imaging findings are nonspecific, making accurate and timely diagnosis challenging. According to the literature, for patients with renal calculi accompanied by a renal mass, elevated serum SCCA levels, and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement, the possibility of this disease should be considered.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 4","pages":"100037"},"PeriodicalIF":1.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metaverse for mental health disorders: Opportunities and challenges.","authors":"Subho Chakrabarti","doi":"10.12998/wjcc.v13.i4.97813","DOIUrl":"10.12998/wjcc.v13.i4.97813","url":null,"abstract":"<p><p>Several articles on the mental health impact of the metaverse and the need to balance its potential benefits with the risks of metaverse use has recently published. The metaverse consists of a combination of immersive technologies and artificial intelligence algorithms. The metaverse differs from the preceding digital psychiatric interventions due to its complex structure and interactions between components. The diverse functions of the metaverse ensure that it may have a substantial impact on mental health. However, the evidence for its efficacy in treating mental health disorders is limited to a few trials. The mental health benefits of immersive technologies are well-documented and suggest that metaverse-based psychiatric treatment may be similarly efficacious. The mental health risks of the metaverse are largely unknown, and it is not clear whether they will be greater than other digital psychiatric interventions. Much more research is needed to determine whether metaverse-based psychiatric treatment will meet the standards of appropriate mental healthcare.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 4","pages":"97813"},"PeriodicalIF":1.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterior mediastinal masses and thymic cysts.","authors":"Öner Özdemir","doi":"10.12998/wjcc.v13.i4.95035","DOIUrl":"10.12998/wjcc.v13.i4.95035","url":null,"abstract":"<p><p>Cystic lesions of the anterior mediastinum in children suggest a well-known group of benign lesions that are comparatively frequent. Thymic cysts (TCs) are mostly positioned in the anterior mediastinum and some patients in the neck. Benign TCs classified as congenital intra-thoracic mesothelial cysts are commonly asymptomatic and have slight clinical significance. Multilocular TC, which can mimic another anterior mediastinal cystic tumor and is seen in adults, is more clinically important. It is a sporadic mediastinal lesion thought to arise in the course of acquired inflammation. Congenital mediastinal cysts represent 3%-6% of all mediastinal tumors and 10%-18% of radiologically reported mediastinal masses. Mediastinal TCs are uncommon and it is hard to know their true incidence. About 60% of cases with mediastinal TCs are asymptomatic, and the remainder of patients complains of nonspecific symptoms (<i>e.g.,</i> chest pain, dyspnea, or cough). The literature suggests that most cysts are benign, but an indefinite percentage may have a neoplastic process and result in significant compressive symptoms over time. Clinical symptoms of TCs vary depending on the location. In addition, frequent symptoms at the appearance of enlarged benign thymic and mediastinal cysts generally contain compressive symptoms (<i>e.g.</i>, respiratory distress, thymic pain, and symptoms related to Horner syndrome, hoarseness, dysphonia, dyspnea, orthopnea, wheezing, and fever). Many TCs have cystic density and a neat border and are simple to diagnose with radiological imaging. However, some TCs are hard to identify before surgery and may be misidentified as thymomas depending on their site and computed tomography results. Excision by thoracotomy, median sternotomy, or video-assisted techniques is essential for conclusive diagnosis, management, and abolition of relapse of anterior mediastinal masses and TCs. Histopathologic examination may be required after surgery. Considering the extent of the mass and the preliminary inability to make a definitive diagnosis, <i>en bloc</i> excision of the cyst was thought to be preferred to circumvent likely complications (<i>e.g.,</i> perforation, spillage of the contents, or incomplete excision).</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 4","pages":"95035"},"PeriodicalIF":1.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}