World Journal of Clinical Cases最新文献_第2页

Differential diagnosis of uterine vascular anomalies: Uterine pseudoaneurysm as a cause of massive hemorrhage.

IF 1 4区医学

World Journal of Clinical Cases Pub Date : 2025-03-26 DOI: 10.12998/wjcc.v13.i9.99671

Teresa Gastañaga-Holguera, Isabel Campo Gesto, Laura Gómez-Irwin, Marta Calvo Urrutia

{"title":"Differential diagnosis of uterine vascular anomalies: Uterine pseudoaneurysm as a cause of massive hemorrhage.","authors":"Teresa Gastañaga-Holguera, Isabel Campo Gesto, Laura Gómez-Irwin, Marta Calvo Urrutia","doi":"10.12998/wjcc.v13.i9.99671","DOIUrl":"10.12998/wjcc.v13.i9.99671","url":null,"abstract":"In this article, we comment on the paper by Kakinuma et al published recently. We focus specifically on the diagnosis of uterine pseudoaneurysm, but we also review other uterine vascular anomalies that may be the cause of life-threating hemorrhage and the different causes of uterine pseudoaneurysms. Uterine artery pseudoaneurysm is a complication of both surgical gynecological and non-traumatic procedures. Massive hemorrhage is the consequence of the rupture of the pseudoaneurysm. Uterine artery pseudoaneurysm can develop after obstetric or gynecological procedures, being the most frequent after cesarean or vaginal deliveries, curettage and even during pregnancy. However, there are several cases described unrelated to pregnancy, such as after conization, hysteroscopic surgery or laparoscopic myomectomy. Hemorrhage is the clinical manifestation and it can be life-threatening so suspicion of this vascular lesion is essential for early diagnosis and treatment. However, there are other uterine vascular anomalies that may be the cause of severe hemorrhage, which must be taken into account in the differential diagnosis. Computed tomography angiography and embolization is supposed to be the first therapeutic option in most of them.","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 9","pages":"99671"},"PeriodicalIF":1.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11670028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relevance of epidemiology data in trauma management.

IF 1 4区医学

World Journal of Clinical Cases Pub Date : 2025-03-26 DOI: 10.12998/wjcc.v13.i9.101115

Krishna Kumar Govindarajan

引用次数: 0

Pulmonary artery stent thrombosis and symptomatic pulmonary hypertension following COVID-19 infection in Alagille patient: A case report.

IF 1 4区医学

World Journal of Clinical Cases Pub Date : 2025-03-26 DOI: 10.12998/wjcc.v13.i9.96897

Shimon Izhakian, Miriam Korlansky, Dror Rosengarten, Elchanan Bruckheimer, Mordechai Reuven Kramer

{"title":"Pulmonary artery stent thrombosis and symptomatic pulmonary hypertension following COVID-19 infection in Alagille patient: A case report.","authors":"Shimon Izhakian, Miriam Korlansky, Dror Rosengarten, Elchanan Bruckheimer, Mordechai Reuven Kramer","doi":"10.12998/wjcc.v13.i9.96897","DOIUrl":"10.12998/wjcc.v13.i9.96897","url":null,"abstract":"Background: Alagille syndrome is a multisystem disease that results in various vascular anomalies, commonly involving the cardiac and pulmonary systems. To the best of our knowledge, there is no literature regarding the cardiovascular outcomes of these patients in association with coronavirus disease 2019 (COVID-19).Case summary: A 34-year-old woman with a history of Alagille syndrome who underwent successful atrial septal defect with partial anomalous pulmonary veins and patent ductus arteriosus repair, as well as left pulmonary artery catheterization and stenting in childhood due to pulmonary stenosis. The patient was without any respiratory symptoms and was a dancer prior to contracting COVID-19. Several weeks after her COVID-19 infection, she developed left pulmonary artery stent thrombosis and subsequent symptomatic pulmonary hypertension. A treatment strategy of anticoagulation alongside pharmacological agents for pulmonary hypertension for 3 months followed by balloon pulmonary artery angioplasty to reopen the stenosis was unsuccessful.Conclusion: In the era of COVID-19, patients with pulmonary vascular malformations and endovascular stents are at an increased risk for chronic thromboembolic disease. Patients may benefit from prophylactic antiplatelet or anticoagulation therapy. Stent thrombosis is a devastating phenomenon and should be treated urgently and aggressively with balloon pulmonary angioplasty, and/or a thrombolytic agent.","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 9","pages":"96897"},"PeriodicalIF":1.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11670020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of triggering receptor expressed on myeloid cells 1/2 in secondary injury after cerebral hemorrhage.

IF 1 4区医学

World Journal of Clinical Cases Pub Date : 2025-03-26 DOI: 10.12998/wjcc.v13.i9.100312

Fan Yi, Hao Wu, Hai-Kang Zhao

{"title":"Role of triggering receptor expressed on myeloid cells 1/2 in secondary injury after cerebral hemorrhage.","authors":"Fan Yi, Hao Wu, Hai-Kang Zhao","doi":"10.12998/wjcc.v13.i9.100312","DOIUrl":"10.12998/wjcc.v13.i9.100312","url":null,"abstract":"Intracerebral hemorrhage (ICH) is a common severe emergency in neurosurgery, causing tremendous economic pressure on families and society and devastating effects on patients both physically and psychologically, especially among patients with poor functional outcomes. ICH is often accompanied by decreased consciousness and limb dysfunction. This seriously affects patients' ability to live independently. Although rapid advances in neurosurgery have greatly improved patient survival, there remains insufficient evidence that surgical treatment significantly improves long-term outcomes. With in-depth pathophysiological studies after ICH, increasing evidence has shown that secondary injury after ICH is related to long-term prognosis and that the key to secondary injury is various immune-mediated neuroinflammatory reactions after ICH. In basic and clinical studies of various systemic inflammatory diseases, triggering receptor expressed on myeloid cells 1/2 (TREM-1/2), and the TREM receptor family is closely related to the inflammatory response. Various inflammatory diseases can be upregulated and downregulated through receptor intervention. How the TREM receptor functions after ICH, the types of results from intervention, and whether the outcomes can improve secondary brain injury and the long-term prognosis of patients are unknown. An analysis of relevant research results from basic and clinical trials revealed that the inhibition of TREM-1 and the activation of TREM-2 can alleviate the neuroinflammatory immune response, significantly improve the long-term prognosis of neurological function in patients with cerebral hemorrhage, and thus improve the ability of patients to live independently.","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 9","pages":"100312"},"PeriodicalIF":1.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11670023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scapular metastasis from acinic cell carcinoma of parotid gland: A case report.

IF 1 4区医学

World Journal of Clinical Cases Pub Date : 2025-03-26 DOI: 10.12998/wjcc.v13.i9.99964

Deng-Qun Sun, Chang-Chun Chen, Duo-An Zheng, Hai-Yan Xing, Xue Peng

引用次数: 0

Atezolizumab and bevacizumab combination in advanced hepatocellular carcinoma patients: The imperative for safety assessment studies.

IF 1 4区医学

World Journal of Clinical Cases Pub Date : 2025-03-26 DOI: 10.12998/wjcc.v13.i9.99043

Mina Tharwat, Ahmed Tawheed, Mohamed El-Kassas

引用次数: 0

Ulcerative colitis and bullous pemphigoid: Direct association or a medication side effect: A case report.

IF 1 4区医学

World Journal of Clinical Cases Pub Date : 2025-03-26 DOI: 10.12998/wjcc.v13.i9.101363

Gaelle-Christie Haddad, Anthony El Dada, Sergio Sbeih, Tony Kazzi, Karam Karam, Louis A Chaptini

{"title":"Ulcerative colitis and bullous pemphigoid: Direct association or a medication side effect: A case report.","authors":"Gaelle-Christie Haddad, Anthony El Dada, Sergio Sbeih, Tony Kazzi, Karam Karam, Louis A Chaptini","doi":"10.12998/wjcc.v13.i9.101363","DOIUrl":"10.12998/wjcc.v13.i9.101363","url":null,"abstract":"Background: Bullous pemphigoid (BP) is an autoimmune blistering skin disorder. It is associated with other autoimmune disorders and the use of certain drugs. We describe a case of BP in a patient with ulcerative colitis (UC) treated with mesalamine.Case summary: A 38-year-old male patient with UC and a history of multiple flares was maintained on mesalamine with good clinical response. One year after starting mesalamine, he sought medical care following the onset of a severe itchy rash of several weeks' duration with a recent appearance of skin bullae. A biopsy of the skin revealed subepidermal blistering dermatitis with focal eosinophilic spongiosis. Direct immunofluorescence studies revealed linear IgG and C3 immune reactant deposits at the dermoepidermal junction, consistent with the diagnosis of BP. Prednisone therapy alleviated his symptoms. However, tapering prednisone led to re-eruption of the bullae.Conclusion: BP should be considered when patients with UC develop skin manifestations. Although BP is not one of the extraintestinal manifestations of UC, there may be an association between these two conditions. Whether treatment with mesalamine or other therapeutic agents plays a role in the development of BP remains unclear.","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 9","pages":"101363"},"PeriodicalIF":1.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11670022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small cell lung cancer with peripheral neuropathy as the first symptom: Two case reports.

IF 1 4区医学

World Journal of Clinical Cases Pub Date : 2025-03-26 DOI: 10.12998/wjcc.v13.i9.99421

Man Luo, Xiao-Xi Lu, Dan-Yang Meng, Jin Hu

{"title":"Small cell lung cancer with peripheral neuropathy as the first symptom: Two case reports.","authors":"Man Luo, Xiao-Xi Lu, Dan-Yang Meng, Jin Hu","doi":"10.12998/wjcc.v13.i9.99421","DOIUrl":"10.12998/wjcc.v13.i9.99421","url":null,"abstract":"Background: Small cell lung cancer (SCLC) is the most malignant type of lung cancer. Even in the latent period and early stage of the tumor, SCLC is prone to produce distant metastases with complex and diverse clinical manifestations. SCLC is most closely related to paraneoplastic syndrome, and some cases present as paraneoplastic peripheral neuropathy (PPN). PPN in SCLC appears early, lacks specificity, and often occurs before diagnosis of the primary tumor. It is easy to be misdiagnosed as a primary disease of the nervous system, leading to missed diagnosis and delayed diagnosis and treatment.Case summary: This paper reports two cases of SCLC with limb weakness as the first symptom. The first symptoms of one patient were rash, limb weakness, and abnormal electromyography. The patient was repeatedly referred to the hospital for limb weakness and rash for > 1 year, during which time, treatment with hormones and immunosuppressants did not lead to significant improvement, and the condition gradually aggravated. The patient was later diagnosed with SCLC, and the dyskinesia did not worsen as the dermatomyositis improved after antineoplastic and hormone therapy. The second case presented with limb numbness and weakness as the first symptom, but the patient did not pay attention to it. Later, the patient was diagnosed with SCLC after facial edema caused by tumor thrombus invading the vein. However, he was diagnosed with extensive SCLC and died 1 year after diagnosis.Conclusion: The two cases had PPN and abnormal electromyography, highlighting its correlation with early clinical indicators of SCLC.","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 9","pages":"99421"},"PeriodicalIF":1.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11670026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression rates of p16, p53 in head and neck cutaneous squamous cell carcinoma based on human-papillomavirus positivity.

IF 1 4区医学

World Journal of Clinical Cases Pub Date : 2025-03-26 DOI: 10.12998/wjcc.v13.i9.99463

Ha-Jong Nam, Heongrae Ryu, Da-Woon Lee, Je Yeon Byeon, Jun Hyuk Kim, Ji Hye Lee, Soomin Lim, Hwan Jun Choi

{"title":"Expression rates of p16, p53 in head and neck cutaneous squamous cell carcinoma based on human-papillomavirus positivity.","authors":"Ha-Jong Nam, Heongrae Ryu, Da-Woon Lee, Je Yeon Byeon, Jun Hyuk Kim, Ji Hye Lee, Soomin Lim, Hwan Jun Choi","doi":"10.12998/wjcc.v13.i9.99463","DOIUrl":"10.12998/wjcc.v13.i9.99463","url":null,"abstract":"Background: The high prevalence of human papillomavirus (HPV) infection in oropharyngeal squamous cell carcinoma (SCC) is well established, and p16 expression is a strong predictor. HPV-related tumors exhibit unique mechanisms that target p16 and p53 proteins. However, research on HPV prevalence and the combined predictive value of p16 and p53 expression in head and neck cutaneous SCC (HNCSCC), particularly in Asian populations, remains limited. This retrospective study surveyed 62 patients with HNSCC (2011-2020), excluding those with facial warts or other skin cancer.Aim: To explore the prevalence of HPV and the predictive value of p16 and p53 expression in HNCSCC in Asian populations.Methods: All patients underwent wide excision and biopsy. Immunohistochemical staining for HPV, p16, and p53 yielded positive and negative results. The relevance of each marker was investigated by categorizing the tumor locations into high-risk and middle-risk zones based on recurrence frequency.Results: Of the 62 patients, 20 (32.26%) were male, with an average age of 82.27 years (range 26-103 years). High-risk included 19 cases (30.65%), with the eyelid and lip being the most common sites (five cases, 8.06%). Middle-risk included 43 cases (69.35%), with the cheek being the most common (29 cases, 46.77%). The p16 expression was detected in 24 patients (38.71%), p53 expression in 42 patients (72.58%), and HPV in five patients (8.06%). No significant association was found between p16 expression and the presence of HPV (P > 0.99), with a positive predictive value of 8.33%.Conclusion: This study revealed that p16, a surrogate HPV marker in oropharyngeal SCC, is not reliable in HNCSCC, providing valuable insights for further research in Asian populations.","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 9","pages":"99463"},"PeriodicalIF":1.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11670024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity paradox in patients with community-acquired pneumonia: Have you fully considered the confounding factors?

IF 1 4区医学

World Journal of Clinical Cases Pub Date : 2025-03-26 DOI: 10.12998/wjcc.v13.i9.97915

Jin-Ke Sun, Hui Tian

引用次数: 0