World Journal of Clinical Cases最新文献

{"title":"Pulp health and calcific healing of a complicated crown-root fracture with additional root fracture in a maxillary incisor: A case report.","authors":"Na Li, Yue-Yue Ren, Ying Tang, Qi Yang, Tian-Tian Meng, Song Li, Jing Zhang","doi":"10.12998/wjcc.v13.i3.98104","DOIUrl":"10.12998/wjcc.v13.i3.98104","url":null,"abstract":"<p><strong>Background: </strong>Complicated crown-root fracture (CRF) involves severe injury to the crown, root, and pulp, and may be accompanied by multiple root fractures. The loss of a tooth has lifelong consequences for children and teenagers, but the maintenance of pulp health and the calcific healing of multiple root fractures are rarely reported in the literature.</p><p><strong>Case summary: </strong>This case reports healing of a permanent tooth with complicated crown-root and additional root fractures, in which pulp health was maintained. A 10-year-old girl fell and fractured the root of her maxillary left central incisor at the cervical level. After the coronal fragment was repositioned, the tooth was splinted until the tooth was no longer mobile, 2 years later. Eight years after treatment, the tooth has remained asymptomatic with vital pulp and localized gingival overgrowth. Cone-beam computed tomography revealed not only calcified healing of the CRF but also spontaneous healing in an additional undiagnosed root fracture. The fracture line on the enamel could not be healed by hard tissue and formed a groove in the cervical crown. It was speculated that the groove was related to the localized gingival overgrowth.</p><p><strong>Conclusion: </strong>This case provides a clinical perspective of the treatment of a tooth with a complicated CRF and an additional root fracture.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 3","pages":"98104"},"PeriodicalIF":1.0,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11577523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wilson's disease in two siblings from Ecuador: Two case reports.","authors":"Enrique Carrera, Jonathan Alvarado, Martina Astudillo, Galo Pillajo","doi":"10.12998/wjcc.v13.i3.99558","DOIUrl":"10.12998/wjcc.v13.i3.99558","url":null,"abstract":"<p><strong>Background: </strong>Wilson's disease (WD) is a rare metabolic disorder of copper accumulation in organs such as liver, brain, and cornea. Diagnoses and treatments are challenging in settings, where advanced diagnostic tests are unavailable, copper chelating agents are frequently scarce, healthcare professionals lack disease awareness, and medical follow-ups are limited. Prompt diagnoses and treatments help prevent complications, improve patients' quality of life, and ensure a normal life expectancy. The clinical presentations and outcomes of WD can vary within a single family.</p><p><strong>Case summary: </strong>We present the cases of two siblings (19 and 27 years) from a consanguineous family in rural Ecuador, diagnosed as having WD during a family screening. The male patient, diagnosed at age 19 after his brother's death from acute liver failure, presented with compensated cirrhosis, neurological symptoms, and bilateral Kayser-Fleischer rings. He developed progressive neurological deterioration during an irregular treatment with D-penicillamine due to medication shortages. His condition improved upon switching to trientine tetrahydrochloride, and his neurological symptoms improved over an 8-year period of follow-ups. The female patient, diagnosed at age 10, exhibited only biochemical alterations. Her treatment history was similar; however, she remained asymptomatic without disease progression over the same follow-up period. We discuss the potential influence of epigenetic mechanisms and modifier genes on the various phenotypes, emphasizing the need for research in these areas to optimize therapeutic strategies.</p><p><strong>Conclusion: </strong>Our patients' medical histories show how early diagnosis and treatment can prevent disease progression; and, how suboptimal treatments impact disease outcomes.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 3","pages":"99558"},"PeriodicalIF":1.0,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11577529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microplastic and nanoplastic exposure and risk of diabetes mellitus.","authors":"Hui-Yi Hsiao, Chung-Yi Nien, Ruei-Feng Shiu, Wei-Chun Chin, Tzung-Hai Yen","doi":"10.12998/wjcc.v13.i3.98110","DOIUrl":"10.12998/wjcc.v13.i3.98110","url":null,"abstract":"<p><p>The issue of plastic pollutants has become a growing concern. Both microplastics (MPs) (particle size < 5 mm) and nanoplastics (NPs) (particle size < 1 µm) can cause DNA damage, cytotoxicity, and oxidative stress in various organisms. The primary known impacts of microplastic/nanoplastic are observed in the liver and respiratory system, leading to hepatotoxicity and chronic obstructive pulmonary disease. Although research on the effects of MPs and NPs on diabetes is still in its early stages, there are potential concerns. This editorial highlights the risk to diabetics from co-exposure to contaminants and MPs/NPs, supported by evidence from animal studies and the various chemical compositions of MPs/NPs.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 3","pages":"98110"},"PeriodicalIF":1.0,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11577526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of nutrition in diabetes mellitus and infections.","authors":"Xue-Lu Yu, Li-Yun Zhou, Xiao Huang, Xin-Yue Li, Ming-Ke Wang, Ji-Shun Yang","doi":"10.12998/wjcc.v13.i3.94389","DOIUrl":"10.12998/wjcc.v13.i3.94389","url":null,"abstract":"<p><p>In this editorial, we have commented on the article that has been published in the recent issue of <i>World Journal of Clinical Cases</i>. The authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus (DM). We have focused on the role of nutrition in the association between DM and infection. Patients with DM are at a high risk of infection, which could also be attributed to nutrition-related factors. Nutritional interventions for patients with diabetes are mainly based on a low-calorie diet, which can be achieved by adhering to a low-carbohydrate diet. However, dietary fiber supplementation is recommended to maintain the diversity of the gut microbiota. Furthermore, high-quality protein can prevent the increased risk of infection due to malnutrition. Supplementation of vitamins C, vitamins A, vitamins D, and folic acid improves blood sugar control and facilitates immune regulation. Mineral deficiencies augment the risk of infection, but the relationship with diabetes is mostly U-shaped and a good intake should be maintained.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 3","pages":"94389"},"PeriodicalIF":1.0,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11577521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of virtual reality technology improves the functionality of brain networks in individuals experiencing pain.","authors":"Takahiko Nagamine","doi":"10.12998/wjcc.v13.i3.97856","DOIUrl":"10.12998/wjcc.v13.i3.97856","url":null,"abstract":"<p><p>Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body. Recently, efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality (VR) technology. VR has been demonstrated to be an effective treatment for pain associated with medical procedures, as well as for chronic pain conditions for which no effective treatment has been established. The precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be elucidated. However, the provision of positive images through VR-based visual stimulation may enhance the functionality of brain networks. The salience network is diminished, while the default mode network is enhanced. Additionally, the medial prefrontal cortex may establish a stronger connection with the default mode network, which could result in a reduction of pain and anxiety. Further research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 3","pages":"97856"},"PeriodicalIF":1.0,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11577525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multilocular thymic cysts- a diagnostic challenge on computed tomography.","authors":"Nirmal Kumar Reddy Onteddu, Naga Sai Rasagna Mareddy, Sai Swarupa R Vulasala, Jayabharath Onteddu, Mayur Virarkar","doi":"10.12998/wjcc.v13.i3.95167","DOIUrl":"10.12998/wjcc.v13.i3.95167","url":null,"abstract":"<p><p>A recent case report provided a patient scenario, wherein, a 39-year-old male patient presented with occasional palpitations, headache, and fever. Evaluation of tumor markers did not show any abnormal results. Subsequently, a computed tomography (CT) scan was undertaken, and its findings were affirmative of thymic cancer. Finally, the postoperative histopathological assessment of the mass, after its resection, confirmed it as an anterior mediastinal multilocular thymic cyst (MTC), with concurrent acute upper respiratory tract infection and acute myocarditis. Accordingly, this case report advocates the need for a preoperative histopathological examination with CT imaging to minimize the risk of confusing an MTC with a malignant thymic tumor.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 3","pages":"95167"},"PeriodicalIF":1.0,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11577524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and improvement strategies in the hospitalization of chronic multimorbid patients.","authors":"Andres Fontalba-Navas, Francisco Pozo Muñoz, Rogelio Garcia Cisneros, Maria Jose Garcia Larrosa, Maria Del Mar Callejon Gil, Ignacio Garcia Delgado, Maria Belen Jimenez Martinez","doi":"10.12998/wjcc.v13.i3.98284","DOIUrl":"10.12998/wjcc.v13.i3.98284","url":null,"abstract":"<p><strong>Background: </strong>Addressing the growing challenge of hospitalizing chronic multimorbid patients, this study examines the strain these conditions impose on healthcare systems at a local level, focusing on a pilot program. Chronic diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient outcomes. If proven effective, this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid patients.</p><p><strong>Aim: </strong>To evaluate the effectiveness of the high complexity unit (HCU) in managing chronic multimorbid patients through a multidisciplinary care model and to compare it with standard hospital care.</p><p><strong>Methods: </strong>The study employed a descriptive longitudinal approach, analyzing data from the Basic Minimum Data Set (BMDS) to compare hospitalization variables among the HCU, the Internal Medicine Service, and other services at Antequera Hospital throughout 2022. The HCU, designed for patients with complex chronic conditions, integrates a patient-centered model emphasizing multidisciplinary care and continuity post-discharge.</p><p><strong>Results: </strong>The study employed a descriptive longitudinal approach, analyzing data from the BMDS to compare hospitalization variables among the HCU, the Internal Medicine Service, and other services at Antequera Hospital throughout 2022. The HCU, designed for patients with complex chronic conditions, integrates a patient-centered model emphasizing multidisciplinary care and continuity post-discharge.</p><p><strong>Conclusion: </strong>This study demonstrates the effectiveness of the HCU in managing patients with complex chronic diseases through a multidisciplinary approach. The coordinated care provided by the HCU results in improved patient outcomes, reduced unnecessary hospitalizations, and better management of patient complexity. The superiority of the HCU compared to standard care is evident in key outcomes such as fewer readmissions and higher patient satisfaction, reinforcing its value as a model of care to be replicated.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 3","pages":"98284"},"PeriodicalIF":1.0,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11577520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irreversible electroporation for metastatic pancreatic carcinoma with liver metastasis: What does the evidence say.","authors":"Ranit Seal, Akash Bararia, Bitan Kumar Chattopadhyay, Nilabja Sikdar","doi":"10.12998/wjcc.v13.i3.98452","DOIUrl":"10.12998/wjcc.v13.i3.98452","url":null,"abstract":"<p><p>Irreversible electroporation is a promising non-thermal ablation method that has been shown to increase overall survival in locally advanced pancreatic cancer in some studies. However, higher quality studies with proper controls and randomization are required to establish its superiority when added with neoadjuvant chemotherapy over the current management of choice, which is chemotherapy alone. Further studies are required before establishment of any survival benefit in metastatic pancreatic carcinoma, and such evidence is lacking at present.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 3","pages":"98452"},"PeriodicalIF":1.0,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11577528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mimicking aneurysm in a patient with chronic occlusion of the left middle cerebral artery.","authors":"Xue-Jian Wang","doi":"10.12998/wjcc.v13.i3.98048","DOIUrl":"10.12998/wjcc.v13.i3.98048","url":null,"abstract":"<p><p>The chronic occlusion of intracranial arteries generally has no or mild clinical symptoms, and the clinical symptoms of acute cerebral artery occlusion are mostly manifested as severe cerebral infarction symptoms, which often make early diagnosis difficult, thus losing the best treatment opportunity. Once cerebral infarction occurs, the consequences are difficult to recover. This is also an important reason for the high misdiagnosis rate and mortality of this disease. In this paper, the characteristics of the disease were analyzed to provide clinical reference.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 3","pages":"98048"},"PeriodicalIF":1.0,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11577527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing healthcare through laboratory on a chip technology: Transforming microorganism identification and diagnostics.","authors":"Carlos M Ardila","doi":"10.12998/wjcc.v13.i3.97737","DOIUrl":"10.12998/wjcc.v13.i3.97737","url":null,"abstract":"<p><p>In a recent case report in the <i>World Journal of Clinical Cases</i>, emphasized the crucial role of rapidly and accurately identifying pathogens to optimize patient treatment outcomes. Laboratory-on-a-chip (LOC) technology has emerged as a transformative tool in health care, offering rapid, sensitive, and specific identification of microorganisms. This editorial provides a comprehensive overview of LOC technology, highlighting its principles, advantages, applications, challenges, and future directions. Success studies from the field have demonstrated the practical benefits of LOC devices in clinical diagnostics, epidemiology, and food safety. Comparative studies have underscored the superiority of LOC technology over traditional methods, showcasing improvements in speed, accuracy, and portability. The future integration of LOC with biosensors, artificial intelligence, and data analytics promises further innovation and expansion. This call to action emphasizes the importance of continued research, investment, and adoption to realize the full potential of LOC technology in improving healthcare outcomes worldwide.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 3","pages":"97737"},"PeriodicalIF":1.0,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11577522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}