World Journal of Clinical Cases最新文献

{"title":"Efficacy of free-flap-transfer and plate-fixation for Gustilo IIIB fractures in type II diabetic patients: A retrospective study.","authors":"Qi Bao, Sun-Wen Pan, Xiao-Kang Gong, Bo Wang, Zhi-Nan Wei, Yong-Qing Xu, Yue-Liang Zhu, Zhen Shi","doi":"10.12998/wjcc.v13.i28.108710","DOIUrl":"10.12998/wjcc.v13.i28.108710","url":null,"abstract":"<p><strong>Background: </strong>Managing Gustilo type IIIB fractures in patients with type 2 diabetes is challenging due to delayed healing and elevated complication risks. This retrospective study highlights the successful use of free-flap transfer combined with plate fixation, contributing insights into effective management strategies for these complex cases.</p><p><strong>Aim: </strong>To evaluate free-flap transfer with plate fixation for managing Gustilo IIIB fractures in diabetic patients, focusing on outcomes.</p><p><strong>Methods: </strong>A retrospective analysis of six cases was conducted with a minimum follow-up period of three years. Patients underwent free-flap transfer and plate fixation for fracture management. Outcomes assessed included bone union, flap viability, and complications requiring intervention or plate removal. The follow-up period ranged from three to four years. Persistent infections beneath the flap developed in two patients, necessitating daily wound care.</p><p><strong>Results: </strong>Bone healing occurred within 17 to 34 months, with plate removal required in three patients after fracture consolidation. Traumatic osteomyelitis was observed in at least one patient. Despite challenges such as sinus formation and variations in flap pedicle anatomy, successful bone union and flap viability were achieved in all cases. Free-flap transfer combined with plate fixation shows promise for treating Gustilo type IIIB fractures in patients with diabetes. While infection and the need for plate removal surgeries were observed, consistent success in bone healing and flap viability highlights the potential of this approach.</p><p><strong>Conclusion: </strong>Free-flap transfer with plate fixation effectively manages Gustilo IIIB fractures in diabetics, achieving bone/flap healing despite infection risks. Careful patient selection and further validation are critical.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 28","pages":"108710"},"PeriodicalIF":1.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholecysto-biliary fistula mimicking type 1 Mirizzi syndrome: A case report.","authors":"Anupam K Gupta, Anudeep Surendranath","doi":"10.12998/wjcc.v13.i28.108437","DOIUrl":"10.12998/wjcc.v13.i28.108437","url":null,"abstract":"<p><strong>Background: </strong>Mirizzi syndrome is a rare complication of chronic gallstone disease in which an impacted stone causes compression or erosion of the common hepatic duct. Accurate preoperative diagnosis is crucial but often challenging. We report a case that was preoperatively diagnosed as type 1 Mirizzi syndrome but was found intraoperatively to be type 4, involving a cholecysto-biliary fistula and complete erosion of the common hepatic duct.</p><p><strong>Case summary: </strong>A 74-year-old woman presented with right upper quadrant discomfort. Initial workup including ultrasound and magnetic resonance cholangiopancreatography suggested Mirizzi syndrome type 1 due to extrinsic compression of the common hepatic duct. Endoscopic retrograde cholangiopancreatography confirmed a large stone without evidence of fistula. The patient underwent robotic-assisted cholecystectomy, during which a 4 cm stone was found eroding into the common hepatic duct, consistent with type 4 Mirizzi syndrome. Intraoperative cholangioscopy confirmed the fistula and allowed primary repair. The patient recovered uneventfully and was discharged on postoperative day one.</p><p><strong>Conclusion: </strong>Preoperative imaging may fail to identify fistula formation in Mirizzi syndrome. Intraoperative assessment remains critical for accurate diagnosis and safe surgical management.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 28","pages":"108437"},"PeriodicalIF":1.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraocular pressure variation (ocular hypertension) in diabetes mellitus.","authors":"Sony Sinha, Prateek Nishant, Arvind Kumar Morya, Ranjeet Kumar Sinha, Arshi Singh","doi":"10.12998/wjcc.v13.i28.107263","DOIUrl":"10.12998/wjcc.v13.i28.107263","url":null,"abstract":"<p><p>Ocular hypertension (OHT), defined as increased intraocular pressure (IOP, > 21 mmHg) in eyes without optic disc changes or visual field changes, is a condition that puts an eye at higher risk of developing glaucomatous optic neuropathy and may be related to the translaminar pressure gradient, individual differences in IOP-related glaucoma susceptibility, effects of arterial blood pressure on the optic nerve head, and vasospastic factors. IOP remains the most common modifiable risk factor to protect eyes against the development of glaucoma. The association between OHT and diabetes mellitus (DM) is poorly understood, although ocular effects of both conditions are related to vascular compromise of retinal and optic nerve circulation. Increased IOP in diabetic patients is attributable to increased aqueous osmotic gradient and accumulation of extracellular matrix constituents in the trabecular meshwork. Autonomic dysfunction and genetic factors may also play a role. Apart from eyes without diabetic retinopathy (DR) changes, OHT can also be observed in eyes with DR, where it can develop with or without antecedent vitreoretinal intervention. For example, photocoagulation of the retina in earlier stages of proliferative DR protects against the development of OHT, whereas intraocular silicone oil injection promotes it. While IOP has been directly implicated as an independent risk factor for DR, the retinopathy in DM is also related to comorbidities, like hypertension and heart disease, that are also correlated with OHT. All these factors are discussed in a comprehensive review exploring the association of OHT and DM in detail.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 28","pages":"107263"},"PeriodicalIF":1.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic resonance imaging spectrum of acute hemorrhagic leukoencephalitis: Four case reports.","authors":"Ankit Shukla, Nishant Nayyar, Pooja Kumari, Ankush Kumar, Preeti Takkar","doi":"10.12998/wjcc.v13.i28.107759","DOIUrl":"10.12998/wjcc.v13.i28.107759","url":null,"abstract":"<p><strong>Background: </strong>Acute hemorrhagic leukoencephalitis (AHLE), also known as Weston-Hurst syndrome, is a very rare and fulminant form of demyelinating disorder. It is considered a hyperacute and severe variant of acute disseminated encephalomyelitis. Clinically, patients present with fever, headache, seizures, and altered sensorium, which can rapidly progress to coma or death. Magnetic resonance imaging (MRI) is the investigation of choice and plays a pivotal role in diagnosing AHLE. The purpose of this article is to make readers familiar with the typical MRI features of AHLE and to discuss differentials.</p><p><strong>Case summary: </strong>This case series reports the clinical presentation and typical neuroimaging findings in four patients diagnosed with AHLE. All patients presented with acute neurological symptoms, such as severe headaches, seizures, and altered consciousness, often following a history of fever suggesting an infectious etiology. Additionally, laboratory investigations demonstrated elevated levels of serum inflammatory markers and neutrophilic pleocytosis on cerebrospinal fluid analysis, supporting a post-infectious etiology. MRI findings consistently revealed characteristic white matter lesions with hemorrhagic foci and vasogenic edema, indicative of widespread demyelination characteristic of AHLE. The outcomes varied, with two patients surviving but experiencing neurological sequelae, while two others unfortunately succumbed to the disease. The clinical data, laboratory results, and imaging findings from this case series were systematically compared with those from previously published studies. The key similarities and differences in clinical presentation, imaging characteristics, and outcomes are presented in a tabulated format.</p><p><strong>Conclusion: </strong>AHLE is associated with high morbidity and mortality rates, emphasizing the need for early recognition, prompt intervention, and multidisciplinary management. Further research is needed to explain the pathophysiological mechanisms underlying AHLE, identify potential biomarkers for early diagnosis, and develop targeted therapies to improve patient outcomes.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 28","pages":"107759"},"PeriodicalIF":1.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpected ocular morbidity after middle meningeal artery embolization: Lessons learned from a case of anastomotic-related diplopia.","authors":"Ju Tian","doi":"10.12998/wjcc.v13.i28.109679","DOIUrl":"10.12998/wjcc.v13.i28.109679","url":null,"abstract":"<p><p>Middle meningeal artery embolization (MMAE) has revolutionized chronic subdural hematoma management, yet procedural risks persist due to anatomical variability. We analyze a case report by Zhao <i>et al</i> describing transient diplopia caused by inadvertent embolization of the lacrimal artery <i>via</i> a dynamic middle meningeal-ophthalmic anastomosis. This correspondence advances three critical innovations in MMAE safety. First, intraoperative anastomotic unmasking-exposing occult middle meningeal-ophthalmic collaterals during particle injection-reveals dynamic vascular behavior missed by preoperative angiography, underscoring the need for adaptive imaging protocols. Second, hybrid embolization (liquid agents for proximal occlusion + particles for distal control) balances precision and safety, reducing reflux risks compared to monotherapy. Third, a 108-day follow-up establishes a benchmark for functional recovery, challenging assumptions about irreversible cranial nerve injuries and emphasizing structured postprocedural care. Collectively, these findings advocate for procedural agility, multimodal embolic strategies, and sustained rehabilitation to optimize MMAE outcomes while minimizing iatrogenic harm.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 28","pages":"109679"},"PeriodicalIF":1.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Euglycemic diabetic ketoacidosis associated with etogliflozin in post-pancreatitis diabetes: A case report.","authors":"Jiang-Tao Chai, Xin-Hui Li, Zhao-Shun Jiang","doi":"10.12998/wjcc.v13.i27.108550","DOIUrl":"10.12998/wjcc.v13.i27.108550","url":null,"abstract":"<p><strong>Background: </strong>Sodium-glucose cotransporter-2 (SGLT-2) inhibitors improve cardiovascular and renal outcomes in diabetes but may induce euglycemic diabetic ketoacidosis (euDKA) <i>via</i> insulin-independent mechanisms. Post-pancreatitis diabetes mellitus (PPDM) patients with impaired β-cell function face undefined risks with these agents.</p><p><strong>Case summary: </strong>A 29-year-old man with PPDM developed euDKA 1 week after initiating etogliflozin (5 mg/day). On admission, laboratory tests revealed blood ketones > 4.5 mmol/L, pH 7.1, and glucose 10.78 mmol/L. Discontinuation of SGLT-2 inhibitor, insulin pump therapy (basal 12 U/day, premeal bolus 4 U), aggressive hydration (6000 mL first 2 days), and nutritional support normalized ketosis and acidosis within 24 hours.</p><p><strong>Conclusion: </strong>Caution is warranted with SGLT-2 inhibitors in PPDM. Insulin therapy is preferred to prevent euDKA.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 27","pages":"108550"},"PeriodicalIF":1.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Median nerve neuropathy after flexor pollicis longus tendon reconstruction: A case report.","authors":"Ji Woong Ho, Young-Keun Lee","doi":"10.12998/wjcc.v13.i27.108003","DOIUrl":"10.12998/wjcc.v13.i27.108003","url":null,"abstract":"<p><strong>Background: </strong>To treat flexor pollicis longus (FPL) muscle function loss, the 4^th flexor digitorum superficialis (FDS) to the FPL tendon transfer is preferred as a reconstruction method. Various complications can occur during transfer. However, median nerve neuropathy has not been reported yet. We present a case of median nerve neuropathy caused by irritation of suture knots of the 4^th FDS to the FPL tendon transfer with a review of the literature.</p><p><strong>Case summary: </strong>A 52-year-old male patient presented with paresthesia along median nerve distribution of right hand after tendon transfer. He complained of right thumb flexion limitation due to FPL function loss so authors performed the 4^th FDS to FPL transfer using Pulvertaft weave technique. FPL function loss was due to adhesion resulting from repeated surgery of radius shaft. He had a history of radius shaft open fracture 9 years ago and nonunion 7 years ago. During surgery, FPL muscle was severely adhered and indistinguishable. However, tendon continuity remained intact. After tendon transfer, he experienced paresthesia along median nerve distribution upon movement of thumb. He was diagnosed with median nerve neuropathy caused by irritation of tendon suture knots. Exploration was then performed. The median nerve was irritated by suture knots of transferred tendon. Thus, knots were removed. Twelve months later, he demonstrated thumb flexion of 80°. Additionally, median nerve neuropathy symptoms fully resolved.</p><p><strong>Conclusion: </strong>Median nerve neuropathy can occur after tendon transfer from irritation of suture knots. Covering knots using surrounding tissue is recommended.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 27","pages":"108003"},"PeriodicalIF":1.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute pancreatitis secondary to small-cell lung cancer metastasis: A case report and literature review.","authors":"Miguel Suárez, Soraya Simón, Raquel Martínez, Jas Crespo","doi":"10.12998/wjcc.v13.i27.107805","DOIUrl":"10.12998/wjcc.v13.i27.107805","url":null,"abstract":"<p><strong>Background: </strong>Acute pancreatitis (AP) is commonly encountered in gastroenterology, with biliary and alcohol-related causes being predominant. Among less frequent etiologies, metabolic and drug-induced origin are the most prevalent. As an exception, non-pancreatobiliary malignancies may trigger AP, representing less than 1% of cases. We present a case of AP secondary to an uncommon oncologic etiology.</p><p><strong>Case summary: </strong>We describe the case of a 50-year-old male recently diagnosed with small-cell lung cancer (SCLC). The patient was admitted to the emergency department with acute abdominal pain and subsequently diagnosed with AP. He was hospitalized under the care of the gastroenterology service. During the etiological workup, metastatic pancreatic lesions were identified on imaging, which had not been observed on the initial cancer staging. Following resolution of the initial episode, oral intake was introduced, but the patient experienced recurrent abdominal pain and laboratory abnormalities consistent with new episodes of AP. This pattern repeated over the following days. After several episodes, and with suspicion of a metastatic origin, the case was discussed in multidisciplinary meeting. In agreement with the patient and given the need to initiate treatment for the primary tumor as well, chemotherapy was started. This treatment successfully alleviated symptoms, allowing dietary progression without complications and discharge from the hospital.</p><p><strong>Conclusion: </strong>Oncologic treatment can be considered as part of the therapeutic approach in AP secondary to SCLC metastasis, especially chemotherapy.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 27","pages":"107805"},"PeriodicalIF":1.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ishihara color plates utilized as an assessment for simultanagnosia in posterior cortical atrophy: A case report.","authors":"Francesco Pellegrini, Alessandra Cuna, Mutali Musa, Fabiana D'Esposito, Rosa Giglio, Daniele Tognetto, Caterina Gagliano, Marco Zeppieri","doi":"10.12998/wjcc.v13.i27.108868","DOIUrl":"10.12998/wjcc.v13.i27.108868","url":null,"abstract":"<p><strong>Background: </strong>Simultanagnosia is a neurological disorder that impairs an individual's ability to perceive more than one object at a time visually. While the individual may acknowledge the presence of multiple objects in his field of view, he cannot generally summarize the overall percept.</p><p><strong>Case summary: </strong>We describe a case of simultanagnosia in Posterior Cortical Atrophy, evidenced by the Ishihara color test. A 54-year-old woman complained of reading problems despite normal visual acuity and a structural eye exam. The patient failed to identify any of the Ishihara color plates in either eye despite adequate naming of colors. Automated visual field testing showed a homonymous hemianopia. Structural and functional neuroimaging and cerebrospinal fluid analysis were consistent with posterior cortical atrophy.</p><p><strong>Conclusion: </strong>Simultanagnosia can be tested with the Ishihara pseudoisochromatic plates because the recognition of embedded number patterns in the test requires appreciation of a collection of individual stimuli.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 27","pages":"108868"},"PeriodicalIF":1.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of circulating miR-146, miR-221 and miR-222 in papillary thyroid cancer: A systematic review and meta-analysis.","authors":"Benjamin Dean, Georgios Geropoulos, Toby Richardson-Jones, Massimiliano Fornasiero, Michail Papapanou, Christos Konstantinidis, Nikolaos Madouros, Dimitrios Spinos, Georgios Koimtzis, Dimitrios Giannis, Christos Athanasiou, Kyriakos Psarras","doi":"10.12998/wjcc.v13.i27.104916","DOIUrl":"10.12998/wjcc.v13.i27.104916","url":null,"abstract":"<p><strong>Background: </strong>Papillary thyroid cancer (PTC) often recurs following surgical excision, necessitating reliable long-term screening techniques after initial management. Ultrasound scans have a poor predictive value and biopsy and genetic testing have a low sensitivity. Biomarker detection, including thyroglobulin, has reduced accuracy as residual thyroid tissue remains following surgery. Serum/tissue microRNA detection offers a promising alternative to screen for thyroid malignancy. Based on our previous systematic review, miR-146, miR-221 and miR-222 appear most strongly associated with PTC.</p><p><strong>Aim: </strong>To perform a systematic review and meta-analysis, evaluating the use of circulating miR-146, miRNA-221 and miR-222 in PTC diagnosis and staging.</p><p><strong>Methods: </strong>A systematic literature search of MEDLINE, Scopus and the EMBASE library was performed. Human participants of any age, sex or geographical distribution were considered. Original studies assessing the diagnostic and prognostic accuracy of circulating serum miRNAs in histologically-confirmed PTC were included. Proportion and regression meta-analyses (logit-transformed) were conducted. PRISMA guidelines were followed throughout the process.</p><p><strong>Results: </strong>Among the 1530 studies screened, 6 met the inclusion criteria, reporting non-overlapping populations. For the diagnosis of PTC <i>vs</i> benign nodules (BN), the pooled sensitivity of miR-146 was 80.7% (95%CI: 65.2%-90.4%), specificity was 66.9% (95%CI: 55.5%-76.6%), and false positive rate was 33.1% (95%CI: 23.4%-44.5%). Pooled sensitivity, specificity and false positive rate of miR-222 for diagnosis of PTC <i>vs</i> BN was 64.3% (95%CI: 50.3%-76.2%), 88.8% (95%CI: 82.4%-93%) and 11.2% (95%CI: 7%-17.6%) respectively. Pooled sensitivity, specificity and false positive rate of miR-221 in this population demonstrated reduced accuracy. Pooled sensitivity and specificity of PTC <i>vs</i> healthy controls for total serum miRNAs were 82% (95%CI: 77%-86%) and 84% (95%CI: 76%-90%) respectively. The summary area under receiver operating characteristic curve value for the same analysis was 0.89 (95%CI: 0.86-0.92).</p><p><strong>Conclusion: </strong>miRNA-146 and miRNA-222 were most sensitive, validating their efficacy in PTC diagnosis. Larger studies are needed for confident population generalisability. Use of two-MRNA types in conjunction needs to be assessed.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 27","pages":"104916"},"PeriodicalIF":1.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}