World Journal of Clinical Cases最新文献_第3页

Genetic insights in infectious diseases: Insights from a case report and implications for personalized medicine. 传染病的遗传见解：来自病例报告的见解及其对个性化医疗的影响。

IF 1 4区医学

World Journal of Clinical Cases Pub Date : 2025-05-06 DOI: 10.12998/wjcc.v13.i13.101438

Suryasnata Bhowmik, Adrija Hajra, Dhrubajyoti Bandyopadhyay

{"title":"Genetic insights in infectious diseases: Insights from a case report and implications for personalized medicine.","authors":"Suryasnata Bhowmik, Adrija Hajra, Dhrubajyoti Bandyopadhyay","doi":"10.12998/wjcc.v13.i13.101438","DOIUrl":"https://doi.org/10.12998/wjcc.v13.i13.101438","url":null,"abstract":"The relationship between genetics and infectious diseases is important in shaping our understanding of disease susceptibility, progression, and treatment. Recent research shows the impact of genetic variations, such as heme-oxygenase promoter length, on diseases like malaria and sepsis, revealing both protective and inconclusive effects. Studies on vaccine responses highlight genetic markers like human leukocyte antigens, emphasizing the potential for personalized immunization strategies. The ongoing battle against drug-resistant tuberculosis (TB) illustrates the complexity of genomic variants in predicting resistance, highlighting the need for integrated diagnostic tools. Additionally, genome-wide association studies reveal antibiotic resistance mechanisms in bacterial genomes, while host genetic polymorphisms, such as those in solute carrier family 11 member 1 and vitamin D receptor, demonstrate their role in TB susceptibility. Advanced techniques like metagenomic next-generation sequencing promise detailed pathogen detection but face challenges in cost and accessibility. A case report involving a highly virulent Mycobacterium TB strain with the pks1 gene further highlights the need for genetic insights in understanding disease severity and developing targeted interventions. This evolving landscape emphasizes the role of genetics in infectious diseases, while also addressing the need for standardized studies and accessible technologies.","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 13","pages":"101438"},"PeriodicalIF":1.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebral complications after unilateral biportal endoscopic surgery: A case report. 单侧双门静脉内窥镜手术后脑并发症1例。

IF 1 4区医学

World Journal of Clinical Cases Pub Date : 2025-05-06 DOI: 10.12998/wjcc.v13.i13.101444

Chao Han, Zhan-Yun Ren, Zhen-Huan Jiang, Yi-Feng Luo

{"title":"Cerebral complications after unilateral biportal endoscopic surgery: A case report.","authors":"Chao Han, Zhan-Yun Ren, Zhen-Huan Jiang, Yi-Feng Luo","doi":"10.12998/wjcc.v13.i13.101444","DOIUrl":"https://doi.org/10.12998/wjcc.v13.i13.101444","url":null,"abstract":"Background: Unilateral biportal endoscopic (UBE) surgery has developed rapidly during the past decade. Continuous epidural space irrigation is generally considered the principal reason for cerebral complications following UBE surgery. We present a case of mental symptoms during the general anesthesia awakening period due to pneumocephalus.Case summary: A 70-year-old woman with lumbar disc herniation underwent UBE surgery stably under general anesthesia. Uncontrollable hypertension occurred immediately after transfer to the postoperative care unit, accompanied by increased heart rate and tachypnea. During the recovery process, the patient responded to external stimuli but was confused and unable to complete command actions. Neck stiffness and significantly increased muscle strength on the left side indicated the presence of de-cerebrate rigidity. An urgent brain computed tomography scan showed pneumocephalus compressing the brainstem. After receiving analgesia and sedation treatment, the patient was conscious three hours later and recovered rapidly. She was discharged on the fifth postoperative day and followed up for 3 months with no surgical or brain complications.Conclusion: Cerebral complications emerging during the general anesthesia awakening period following UBE surgery are not entirely due to increased intracranial pressure. Pneumocephalus induced by dural injury may also be a potential cause.","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 13","pages":"101444"},"PeriodicalIF":1.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: High expression of autophagy-related gene EIF4EBP1 could promote tamoxifen resistance and predict poor prognosis in breast cancer. 更正：自噬相关基因EIF4EBP1高表达可促进乳腺癌对他莫昔芬的耐药，预示预后不良。

IF 1 4区医学

World Journal of Clinical Cases Pub Date : 2025-05-06 DOI: 10.12998/wjcc.v13.i13.100700

Shan Yang, Tian-Li Hui, Hao-Qi Wang, Xi Zhang, Yun-Zhe Mi, Meng Cheng, Wei Gao, Cui-Zhi Geng, Sai-Nan Li

引用次数: 0

Mandibular left first premolar with three roots and three canals: A case report. 下颌左第一前磨牙三根三管1例。

IF 1 4区医学

World Journal of Clinical Cases Pub Date : 2025-05-06 DOI: 10.12998/wjcc.v13.i13.100822

Cheng-Yi Lin, Yue-Yuan Yu

引用次数: 0

Pegaspargase induced multiple organ failure with acute lymphoblastic leukemia: A case report. Pegaspargase诱导急性淋巴细胞白血病多器官功能衰竭1例。

IF 1 4区医学

World Journal of Clinical Cases Pub Date : 2025-05-06 DOI: 10.12998/wjcc.v13.i13.100735

Su-Xia Bao, Xiao-Ling Yuan, Lei Yan, Jie Xu

引用次数: 0

Percheron syndrome with memory impairment as chief manifestation: A case report. 以记忆障碍为主要表现的Percheron综合征1例报告。

IF 1 4区医学

World Journal of Clinical Cases Pub Date : 2025-05-06 DOI: 10.12998/wjcc.v13.i13.98937

Xi-Feng Nong, Xiao Cao, Xing-Lin Tan, Li-Yan Jing, Hao Liu

{"title":"Percheron syndrome with memory impairment as chief manifestation: A case report.","authors":"Xi-Feng Nong, Xiao Cao, Xing-Lin Tan, Li-Yan Jing, Hao Liu","doi":"10.12998/wjcc.v13.i13.98937","DOIUrl":"https://doi.org/10.12998/wjcc.v13.i13.98937","url":null,"abstract":"Background: Percheron acute artery occlusion is a rare type of acute cerebral infarction.Case summary: An elderly male presented with sudden-onset near-memory and sensory impairments for 5 days. Upon admission, based on symptoms, signs, magnetic resonance imaging, and computed tomography findings, a diagnosis of Percheron syndrome was made. Subsequently, anti-platelet therapy, lipid-lowering treatment, cerebral circulation enhancement (such as the administration of calcium channel blockers to improve cerebral blood flow), and neurotrophic support (such as the use of drugs like citicoline to protect nerve cells) were immediately implemented, along with additional symptomatic treatments. The patient's symptoms were alleviated, following which he was discharged.Conclusion: The diagnosis of acute occlusion of the Percheron artery requires rich clinical expertise and accurate imaging tools. Timely intervention and effective follow-up hold significant implications for optimizing patient recovery.","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 13","pages":"98937"},"PeriodicalIF":1.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Life-threatening bleeding caused by artery pseudoaneurysm after endoscopic procedure successfully treated by artery embolization. 内窥镜手术后动脉栓塞成功治疗动脉假性动脉瘤引起的危及生命的出血。

IF 1 4区医学

World Journal of Clinical Cases Pub Date : 2025-05-06 DOI: 10.12998/wjcc.v13.i13.99278

Sergio Pérez-Holanda

{"title":"Life-threatening bleeding caused by artery pseudoaneurysm after endoscopic procedure successfully treated by artery embolization.","authors":"Sergio Pérez-Holanda","doi":"10.12998/wjcc.v13.i13.99278","DOIUrl":"https://doi.org/10.12998/wjcc.v13.i13.99278","url":null,"abstract":"The Kakinuma et al's case report shows that non-pregnancy-related arterial pseudoaneurysm is a relatively rare, little known by some gynecologists, endoscopists, surgeons or radiologists, which can cause massive bleeding. Arterial pseudoaneurysm is a condition in which the wall of a blood vessel collapses due to some invasive event, and the resulting leaked blood is engulfed by soft tissues, forming a cavity that is in communication with the vessel. It is a potentially life-threatening complication that could occurs after some deliveries and some gynecological invasive procedures. Remarkably, an undetermined percentage of pseudoaneurysms are asymptomatic, and in an asymptomatic patient it is difficult to predict the risk of haemorrhage and the attitude to follow, which depends on several factors, such as, the size and location of the vessel involved, changes in the size of the pseudoaneurysm, or the available therapeutic resources to be offered to patients, among others circumstances. The management of abdominal arterial pseudoaneurysm does not have consistent scientific evidence, but it seems that, regardless of the associated circumstances, the pseudoaneurysm could be treated at least initially, and mainly, through endovascular procedures, as done by Kakinuma et al.","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 13","pages":"99278"},"PeriodicalIF":1.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bivalirudin for anticoagulation in elderly acute coronary syndrome: Effects on myocardial microcirculation and adverse events. 比伐鲁定用于老年急性冠脉综合征抗凝：对心肌微循环和不良事件的影响。

IF 1 4区医学

World Journal of Clinical Cases Pub Date : 2025-05-06 DOI: 10.12998/wjcc.v13.i13.98008

Chun-Yao Cheng, Wen-Rui Hao, Tzu-Hurng Cheng

{"title":"Bivalirudin for anticoagulation in elderly acute coronary syndrome: Effects on myocardial microcirculation and adverse events.","authors":"Chun-Yao Cheng, Wen-Rui Hao, Tzu-Hurng Cheng","doi":"10.12998/wjcc.v13.i13.98008","DOIUrl":"https://doi.org/10.12998/wjcc.v13.i13.98008","url":null,"abstract":"The management of acute coronary syndrome (ACS) in older patients remains challenging because standard anticoagulants often fail to yield optimal outcomes. Bivalirudin, a direct inhibitor of thrombin, serves as an alternative to traditional therapies. This drug is particularly effective in enhancing myocardial microcirculation and reducing adverse events after clinical interventions. The present article explores the findings of a recent study that highlighted the clinical benefits of bivalirudin by investigating its effects on myocardial microcirculation and adverse cardiac events after percutaneous coronary intervention in older patients with ACS. Compared with unfractionated heparin, bivalirudin markedly reduced the emergency response time and improved cardiac function indicators. It further mitigated the risks of cardiovascular events and recurrent myocardial infarctions. These findings suggest that bivalirudin can enhance myocardial perfusion and reduce bleeding complications, thus serving as a safe, effective anticoagulation agent for older patients with ACS. Nonetheless, further large-scale, high-quality trials are needed to establish optimal usage guidelines and assess long-term outcomes. Integrating bivalirudin into ACS treatment protocols for older patients may help optimize patient care, balancing efficacy and safety. Continual research and consensus building are necessary for the widespread clinical application of bivalirudin and the improvement of ACS outcomes in older patients.","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 13","pages":"98008"},"PeriodicalIF":1.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Difficulty removing a totally implantable venous access port: A case report. 难以移除完全植入式静脉通路1例报告。

IF 1 4区医学

World Journal of Clinical Cases Pub Date : 2025-05-06 DOI: 10.12998/wjcc.v13.i13.102457

Jing Chen, Mu Tang, Qin-Yuan Han, Lei Tang, Teng-Hua Yu, Yan-Ping Zhao, Chong-Wu He

{"title":"Difficulty removing a totally implantable venous access port: A case report.","authors":"Jing Chen, Mu Tang, Qin-Yuan Han, Lei Tang, Teng-Hua Yu, Yan-Ping Zhao, Chong-Wu He","doi":"10.12998/wjcc.v13.i13.102457","DOIUrl":"https://doi.org/10.12998/wjcc.v13.i13.102457","url":null,"abstract":"Background: This case report examines the challenges associated with removing a totally implantable venous access port (TIVAP) used for long-term chemotherapy in a patient with breast cancer. Prolonged use of TIVAPs can result in complications such as catheter kinking, thrombosis, and adhesions between the catheter and surrounding tissues, potentially complicating their removal.Case summary: A breast cancer patient with bone metastasis presented with difficulty aspirating blood from a TIVAP that had been placed in the right internal jugular vein for 3 years. Initial removal attempts at the Department of Venous Access Center were unsuccessful, likely due to adhesions, necessitating a subsequent successful catheter extraction in a hybrid operating room. Imaging revealed no abnormalities, and the catheter was removed using a mosquito clamp to detach it from surrounding tissues.Conclusion: This case highlights the challenges of removing TIVAPs inserted via the internal jugular vein, particularly when the catheter traverses the sternocleidomastoid muscle. Repeated neck movements might lead to significant adhesions around the catheter, complicating its removal. Careful consideration should be given during catheter placement to avoid muscle-related adhesions and facilitate smoother extraction in long-term use.","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 13","pages":"102457"},"PeriodicalIF":1.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bronchopleural fistula following application of Hem-o-lock clip at bronchial stump after lobectomy: A case report. 肺叶切除术后支气管残端应用Hem-o-lock夹致支气管胸膜瘘1例。

IF 1 4区医学

World Journal of Clinical Cases Pub Date : 2025-05-06 DOI: 10.12998/wjcc.v13.i13.102108

Qian-Yu Li, Xiao-Long Wang, Feng Zhang, Hai-Tao Wei

引用次数: 0